This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier syste... See more...

Aliases for CES1 Gene

Aliases for CES1 Gene

  • Carboxylesterase 1 2 3 4 5
  • CES2 2 3 4
  • HMSE 2 3 4
  • SES1 2 3 4
  • CEH 2 3 4
  • Carboxylesterase 1 (Monocyte/Macrophage Serine Esterase 1) 2 3
  • Human Monocyte/Macrophage Serine Esterase 1 2 3
  • Methylumbelliferyl-Acetate Deacetylase 1 3 4
  • Monocyte/Macrophage Serine Esterase 3 4
  • Brain Carboxylesterase HBr1 3 4
  • Cholesteryl Ester Hydrolase 3 4
  • Triacylglycerol Hydrolase 3 4
  • Liver Carboxylesterase 1 3 4
  • Cocaine Carboxylesterase 3 4
  • Retinyl Ester Hydrolase 3 4
  • Serine Esterase 1 3 4
  • EC 3.1.1.1 4 50
  • Egasyn 3 4
  • HMSE1 2 3
  • HCE-1 3 4
  • ACAT 3 4
  • CE-1 3 4
  • REH 3 4
  • TGH 3 4
  • Acyl Coenzyme A:Cholesterol Acyltransferase 3
  • Acyl-Coenzyme A:Cholesterol Acyltransferase 4
  • Carboxylesterase 2 (Liver) 3
  • EC 3.1.1.13 4
  • EC 3.1.1.56 4
  • EC 3.1.1 50
  • CES1A1 2
  • CES1A2 2
  • PCE-1 3
  • CES1 5

External Ids for CES1 Gene

Previous GeneCards Identifiers for CES1 Gene

  • GC16M046044
  • GC16P055849
  • GC16P055518
  • GC16M055613
  • GC16M055615
  • GC16M054395
  • GC06P023997

Summaries for CES1 Gene

Entrez Gene Summary for CES1 Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for CES1 Gene

CES1 (Carboxylesterase 1) is a Protein Coding gene. Diseases associated with CES1 include Drug Metabolism, Altered, Ces1-Related and Egasyn. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and Phase I biotransformations, non P450. Gene Ontology (GO) annotations related to this gene include hydrolase activity and methylumbelliferyl-acetate deacetylase activity. An important paralog of this gene is CES2.

UniProtKB/Swiss-Prot Summary for CES1 Gene

  • Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:7980644, PubMed:9169443, PubMed:9490062, PubMed:18762277). Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester (PubMed:7980644, PubMed:9169443, PubMed:9490062, PubMed:18762277). Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine (PubMed:7980644). Catalyzes the transesterification of cocaine to form cocaethylene (PubMed:7980644). Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate (PubMed:7980644). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984). Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process (PubMed:18762277, PubMed:16024911, PubMed:11015575, PubMed:16971496). First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile (PubMed:18762277, PubMed:18599737, PubMed:16971496).

Gene Wiki entry for CES1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CES1 Gene

Genomics for CES1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CES1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J055832 Promoter/Enhancer 1.2 EPDnew ENCODE 265.6 +0.2 239 1.3 KLF9 CEBPA ATF3 YY1 MXD4 HOMEZ FOXA2 KDM6A SMAD4 RXRA CES1 CES1P1 CES1P2 piR-39858-253 SLC6A2
GH16J055834 Enhancer 0.6 FANTOM5 257.6 -0.9 -940 0.3 SPI1 BATF IKZF1 PKNOX1 KLF5 TARDBP IKZF2 MTA2 NBN DPF2 CES1 MMP2 HSALNG0111661 CES5A
GH16J055835 Enhancer 1.1 FANTOM5 ENCODE 14.3 -2.9 -2868 1.9 CEBPA YY1 CEBPB HOMEZ RAD51 EP300 FOXA2 MAFF RXRA SMAD4 CES1 MMP2 HSALNG0111661 CES5A
GH16J055760 Promoter 0.8 Ensembl 8.3 +72.5 72537 0.4 YY1 RXRA SAP130 ETV4 GABPB1 DRAP1 NR2F6 CEBPG REST MAX CES1P1 lnc-SLC6A2-2 CES1 CES1P2 piR-39858-252 SLC6A2
GH16J055757 Enhancer 0.9 FANTOM5 Ensembl 7.1 +75.8 75836 2.6 CEBPA YY1 CEBPB ZNF513 NONO FOXA2 RXRA NBN ZNF316 ZBTB33 CES1P1 CES1 CRNDE lnc-SLC6A2-2 HSALNG0111658 SLC6A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CES1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CES1

Top Transcription factor binding sites by QIAGEN in the CES1 gene promoter:
  • AP-1
  • ATF-2
  • TBP

Genomic Locations for CES1 Gene

Latest Assembly
chr16:55,802,851-55,833,337
(GRCh38/hg38)
Size:
30,487 bases
Orientation:
Minus strand

Previous Assembly
chr16:55,836,763-55,867,008
(GRCh37/hg19 by Entrez Gene)
Size:
30,246 bases
Orientation:
Minus strand

chr16:55,836,763-55,867,249
(GRCh37/hg19 by Ensembl)
Size:
30,487 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr16(ALT_REF_LOCI_1):26,724-57,001 (-)

Genomic View for CES1 Gene

Genes around CES1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CES1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CES1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES1 Gene

Proteins for CES1 Gene

  • Protein details for CES1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23141-EST1_HUMAN
    Recommended name:
    Liver carboxylesterase 1
    Protein Accession:
    P23141
    Secondary Accessions:
    • A6NIM1
    • A8K3K8
    • A8K844
    • E9PAU8
    • P82127
    • Q00015
    • Q13657
    • Q14062
    • Q16737
    • Q16788
    • Q549X7
    • Q549X8
    • Q86UK2
    • Q96EE8
    • Q9UC52
    • Q9UDG8
    • Q9UK77
    • Q9ULY2

    Protein attributes for CES1 Gene

    Size:
    567 amino acids
    Molecular mass:
    62521 Da
    Quaternary structure:
    • Homotrimer and homohexamer. Binds to beta-glucuronidase.
    SequenceCaution:
    • Sequence=AAA83932.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CES1 Gene

    Alternative splice isoforms for CES1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CES1 Gene

Selected DME Specific Peptides for CES1 Gene

P23141:
  • LSKMVMK
  • HRDAGAP
  • GHPSSPP
  • IQYRLGIWGFFST
  • PLGPLRF
  • AGCKTTTSA
  • GFFSTGD
  • EGYLQIG
  • FLGIPFA
  • HENVVVV
  • NIASFGG
  • WVQDNIA
  • CLRQKTE
  • SEDCLYLNI
  • PVMVWIHGG
  • PAEPWSFVK
  • AALRWVQ
  • HRAISESGV
  • LKEGASEEE

Post-translational modifications for CES1 Gene

  • Contains sialic acid.
  • Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19.
  • Glycosylation at Asn79
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Domains & Families for CES1 Gene

Gene Families for CES1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CES1 Gene

Suggested Antigen Peptide Sequences for CES1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57637, highly similar to Liver carboxylesterase 1 (EC 3.1.1.1) (B7Z795_HUMAN)
  • Triacylglycerol hydrolase (EST1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P23141

UniProtKB/Swiss-Prot:

EST1_HUMAN :
  • Belongs to the type-B carboxylesterase/lipase family.
Family:
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES1: view

Function for CES1 Gene

Molecular function for CES1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:7980644, PubMed:9169443, PubMed:9490062, PubMed:18762277). Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester (PubMed:7980644, PubMed:9169443, PubMed:9490062, PubMed:18762277). Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine (PubMed:7980644). Catalyzes the transesterification of cocaine to form cocaethylene (PubMed:7980644). Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate (PubMed:7980644). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984). Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process (PubMed:18762277, PubMed:16024911, PubMed:11015575, PubMed:16971496). First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile (PubMed:18762277, PubMed:18599737, PubMed:16971496).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10039, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+); Xref=Rhea:RHEA:12208, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17224, ChEBI:CHEBI:17763, ChEBI:CHEBI:30089; EC=3.1.1.56; Evidence={ECO:0000269|PubMed:18762277, ECO:0000269|PubMed:9169443};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a cholesterol ester + H2O = a fatty acid + cholesterol + H(+); Xref=Rhea:RHEA:36403, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:17002, ChEBI:CHEBI:28868; EC=3.1.1.13; Evidence={ECO:0000269|PubMed:11015575, ECO:0000269|PubMed:16024911, ECO:0000269|PubMed:16971496, ECO:0000269|PubMed:18762277};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+); Xref=Rhea:RHEA:33875, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30823, ChEBI:CHEBI:46898; Evidence={ECO:0000269|PubMed:11015575, ECO:0000269|PubMed:16024911, ECO:0000269|PubMed:16971496, ECO:0000269|PubMed:18762277};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence={ECO:0000269|PubMed:21049984};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2; Xref=Rhea:RHEA:48296, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:90230, ChEBI:CHEBI:606564; Evidence={ECO:0000269|PubMed:21049984};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha; Xref=Rhea:RHEA:48300, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:57404, ChEBI:CHEBI:90233; Evidence={ECO:0000269|PubMed:21049984};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=106.6 uM for p-nitrophenyl acetate {ECO:0000269|PubMed:18485328, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062}; KM=775.7 uM for L-methylphenidate {ECO:0000269|PubMed:18485328, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062}; KM=663.5 uM for D-methylphenidate {ECO:0000269|PubMed:18485328, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062}; KM=116 uM for cocaine {ECO:0000269|PubMed:18485328, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062}; KM=43 mM for ethanol {ECO:0000269|PubMed:18485328, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062}; KM=0.8 mM for 4-methylumbelliferyl acetate {ECO:0000269|PubMed:18485328, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062}; KM=6.3 mM for heroin {ECO:0000269|PubMed:18485328, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062}; KM=8.3 mM for 6-monoacetylmorphine {ECO:0000269|PubMed:18485328, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062}; KM=49 uM for 2-arachidonoylglycerol {ECO:0000269|PubMed:21049984}; KM=250 uM for prostaglandin E2 1-glyceryl ester {ECO:0000269|PubMed:21049984}; KM=93 uM for prostaglandin F2alpha 1-glyceryl ester {ECO:0000269|PubMed:21049984}; Vmax=493.9 nmol/min/mg enzyme with p-nitrophenyl acetate as substrate {ECO:0000269|PubMed:18485328, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062}; Vmax=1701.1 pmol/min/mg enzyme with L-methylphenidate as substrate {ECO:0000269|PubMed:18485328, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062}; Vmax=177.2 pmol/min/mg enzyme with D-methylphenidate as substrate {ECO:0000269|PubMed:18485328, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062}; Note=kcat is 59 min(-1), 29 min(-1), 90 min(-1) with 2-arachidonoylglycerol, prostaglandin F2alpha 1-glyceryl ester and prostaglandin E2 1-glyceryl ester as substrates, respectively. {ECO:0000269|PubMed:21049984}; pH dependence: Optimum pH is 6.5. {ECO:0000269|PubMed:18485328, ECO:0000269|PubMed:7980644, ECO:0000269|PubMed:9169443, ECO:0000269|PubMed:9490062};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by CHAPS (PubMed:9490062). Inhibited by chlorpyrifos oxon (IC(50)=0.21 nM), paraoxon (IC(50)=0.29 nM), or methyl paraoxon (IC(50)=49 nM) (PubMed:18762277).
GENATLAS Biochemistry:
carboxylesterase 1,expressed in brain,located in the endoplasmic reticulum,catalyzing the hydrolysis of temocapril,p-nitrophenyl-acetate and long chain acyl-CoA,putatively functioning as a blood-brain barrier to protect the CNS from ester or amide compounds

Enzyme Numbers (IUBMB) for CES1 Gene

Phenotypes From GWAS Catalog for CES1 Gene

Gene Ontology (GO) - Molecular Function for CES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004771 sterol esterase activity IEA,IDA 11015575
GO:0004806 triglyceride lipase activity IBA 21873635
GO:0005515 protein binding IPI --
GO:0016787 hydrolase activity IEA --
GO:0047374 methylumbelliferyl-acetate deacetylase activity IEA --
genes like me logo Genes that share ontologies with CES1: view
genes like me logo Genes that share phenotypes with CES1: view

Animal Models for CES1 Gene

MGI Knock Outs for CES1:

miRNA for CES1 Gene

miRTarBase miRNAs that target CES1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CES1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CES1 Gene

Localization for CES1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES1 Gene

Endoplasmic reticulum lumen. Cytoplasm. Lipid droplet. Note=Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the droplets and hydrolyzes cholesteryl esters more efficiently from mixed droplets. {ECO:0000269 PubMed:16024911}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CES1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
cytosol 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
lysosome 2
golgi apparatus 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IEA,IDA 16024911
GO:0005783 endoplasmic reticulum IDA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005811 lipid droplet IEA,IDA 16024911
genes like me logo Genes that share ontologies with CES1: view

Pathways & Interactions for CES1 Gene

genes like me logo Genes that share pathways with CES1: view

Pathways by source for CES1 Gene

1 KEGG pathway for CES1 Gene
1 GeneGo (Thomson Reuters) pathway for CES1 Gene
  • Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)

Gene Ontology (GO) - Biological Process for CES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002003 angiotensin maturation TAS --
GO:0006695 cholesterol biosynthetic process IDA 11015575
GO:0006805 xenobiotic metabolic process TAS --
GO:0008203 cholesterol metabolic process IDA 16024911
GO:0009636 response to toxic substance TAS 1918003
genes like me logo Genes that share ontologies with CES1: view

No data available for SIGNOR curated interactions for CES1 Gene

Drugs & Compounds for CES1 Gene

(97) Drugs for CES1 Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Capecitabine Approved, Investigational Pharma Enzyme, substrate RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1763
Oseltamivir Approved Pharma Enzyme, substrate 142
cholic acid Approved Pharma Target 0
Cocaine Approved, Illicit Pharma Target, Enzyme, substrate 616
Cyclandelate Approved Pharma Target 0

(210) Additional Compounds for CES1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Methylumbelliferyl acetate
  • 4-Methyl-7-acetyloxy coumarin
  • 7-(Acetyloxy)-4-methyl-2-benzopyrone
  • 7-(Acetyloxy)-4-methyl-2H-1-benzopyran-2-one
  • 7-Acetoxy-4-methylchromen-2-one
  • 7-Acetoxy-4-methylcoumarin
2747-05-9
(2S,4S,6S)-2-[2-(4-Hydroxy-3-meyhoxyphenyl)ethyl]tetrahydro-6-(4,5-dihydroxy-3-methoxyphenyl)-2H-pyran-4-yl 4-acetate
  • (2S,4S,6S)-2-[2-(4-Hydroxy-3-meyhoxyphenyl)ethyl]tetrahydro-6-(4,5-dihydroxy-3-methoxyphenyl)-2H-pyran-4-yl 4-acetic acid
  • 2-(3,4-Dihydroxy-5-methoxyphenyl)-6-[2-(4-hydroxy-3-methoxyphenyl)ethyl]oxan-4-yl acetic acid
  • (2S,4R,6S)-2-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]tetrahydro-6-(4,5-dihydroxy-3-methoxyphenyl)-2H-pyran-4-yl 4-acetic acid
182227-92-5
(R)-Byakangelicinn 2'-(3-methylbutanoate)
  • (R)-Byakangelicinn 2'-(3-methylbutanoic acid)
  • 3-Hydroxy-1-({4-methoxy-7-oxo-7H-furo[3,2-g]chromen-9-yl}oxy)-3-methylbutan-2-yl 3-methylbutanoic acid
(R)-Heraclenol 2'-(3-methyl-2-butenoate)
  • (R)-Heraclenol 2'-(3-methyl-2-butenoic acid)
  • 3-Hydroxy-3-methyl-1-({7-oxo-7H-furo[3,2-g]chromen-9-yl}oxy)butan-2-yl 3-methylbut-2-enoic acid
[3-(3,4-dihydroxyphenyl)-1-hydroxyprop-2-en-1-ylidene]({6-[(2-{[2-(3,4-dihydroxyphenyl)-7-hydroxy-5-oxo-5H-chromen-3-yl]oxy}-6-({[3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}methyl)-4,5-dihydroxyoxan-3-yl)oxy]-3,4,5-trihydroxyoxan-2-yl}methyl)oxidanium
genes like me logo Genes that share compounds with CES1: view

Transcripts for CES1 Gene

mRNA/cDNA for CES1 Gene

3 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CES1

Alternative Splicing Database (ASD) splice patterns (SP) for CES1 Gene

No ASD Table

Relevant External Links for CES1 Gene

GeneLoc Exon Structure for
CES1

Expression for CES1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CES1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CES1 Gene

This gene is overexpressed in Liver (x23.9).

Protein differential expression in normal tissues from HIPED for CES1 Gene

This gene is overexpressed in Liver (36.7) and Liver, secretome (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CES1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CES1

SOURCE GeneReport for Unigene cluster for CES1 Gene:

Hs.558865

mRNA Expression by UniProt/SwissProt for CES1 Gene:

P23141-EST1_HUMAN
Tissue specificity: Expressed predominantly in liver with lower levels in heart and lung (PubMed:10562416). Expressed in macrophages (PubMed:11015575, PubMed:21049984, PubMed:18762277).

Evidence on tissue expression from TISSUES for CES1 Gene

  • Liver(4.9)
  • Lung(4.8)
  • Blood(4.5)
  • Heart(4.5)
  • Nervous system(4.5)
  • Gall bladder(2.9)
  • Intestine(2.7)
  • Stomach(2.6)
  • Skin(2.5)
  • Muscle(2.5)
  • Spleen(2.4)
  • Kidney(2.2)
  • Pancreas(2.1)
  • Eye(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CES1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • lymphatic
  • skeleton
Regions:
Head and neck:
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • bone marrow
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with CES1: view

Primer products for research

No data available for Protein tissue co-expression partners for CES1 Gene

Orthologs for CES1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CES1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CES1 30
  • 89 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CES1 29 30
  • 83.76 (n)
OneToMany
-- 30
  • 77 (a)
OneToMany
BREH1 30
  • 72 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia CES1 29
  • 83.48 (n)
CESDD1 30
  • 80 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ces1d 29 16
  • 80.83 (n)
Ces1a 30
  • 74 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ces1d 29
  • 80.59 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 65 (a)
OneToMany
-- 30
  • 57 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 61 (a)
OneToMany
-- 30
  • 60 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CES1 29
  • 59.46 (n)
-- 30
  • 52 (a)
ManyToMany
-- 30
  • 50 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100493819 29
  • 56.46 (n)
LOC394897 29
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-93f2.1 29 30
  • 54.35 (n)
ManyToMany
ces3 30
  • 42 (a)
ManyToMany
ces2 30
  • 41 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG8424 31
  • 38 (a)
BcDNA:GH05741 31
  • 31 (a)
alpha-Est7 31
  • 31 (a)
alpha-Est8 31
  • 31 (a)
CG10175 31
  • 30 (a)
CG6414 31
  • 30 (a)
alpha-Est10 31
  • 30 (a)
alpha-Est6 31
  • 30 (a)
CG9289 31
  • 30 (a)
clt 31
  • 29 (a)
Est-6 31
  • 29 (a)
Est-P 31
  • 29 (a)
alpha-Est2 31
  • 29 (a)
CG3841 31
  • 28 (a)
CG5397 31
  • 28 (a)
CG6018 31
  • 28 (a)
alpha-Est4 31
  • 28 (a)
alpha-Est9 31
  • 28 (a)
CG10339 31
  • 26 (a)
CG7529 31
  • 26 (a)
Jhe 31
  • 26 (a)
Worm
(Caenorhabditis elegans)
Secernentea B0238.13 31
  • 38 (a)
R173.3 31
  • 37 (a)
Y75B8A.3 31
  • 35 (a)
Y71H2AM.13 31
  • 32 (a)
F13H6.3 31
  • 31 (a)
C52A10.1 31
  • 31 (a)
C52A10.2 31
  • 31 (a)
F15A8.6 31
  • 31 (a)
F07C4.12 31
  • 30 (a)
B0238.1 31
  • 29 (a)
F13H6.4 31
  • 29 (a)
T02B5.3 31
  • 28 (a)
ges-1 31
  • 28 (a)
B0238.7 31
  • 28 (a)
K11G9.2 31
  • 28 (a)
K11G9.1 31
  • 27 (a)
T07H6.1a 31
  • 27 (a)
K07C11.4 31
  • 27 (a)
T02B5.1 31
  • 26 (a)
ZC376.2 31
  • 25 (a)
Species where no ortholog for CES1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CES1 Gene

ENSEMBL:
Gene Tree for CES1 (if available)
TreeFam:
Gene Tree for CES1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CES1: view image
Alliance of Genome Resources:
Additional Orthologs for CES1

Paralogs for CES1 Gene

Paralogs for CES1 Gene

(12) SIMAP similar genes for CES1 Gene using alignment to 4 proteins:

  • EST1_HUMAN
  • H3BQR4_HUMAN
  • H3BQV8_HUMAN
  • H3BSU0_HUMAN

Pseudogenes.org Pseudogenes for CES1 Gene

genes like me logo Genes that share paralogs with CES1: view

Variants for CES1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CES1 Gene

EST1_HUMAN-P23141
Genetic variants in CES1 are associated with clinically significant alterations in pharmacokinetics and drug response of carboxylesterase 1 substrates [MIM:618057].

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CES1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
1032546 Pathogenic: DRUG METABOLISM, ALTERED, CES1-RELATED 55,819,579(-) G/A
NM_001025195.2(CES1):c.862C>T (p.Arg288Ter)
NONSENSE
rs121912777 Pathogenic: DRUG METABOLISM, ALTERED, CES1-RELATED 55,823,661(-) C/T
NM_001025195.2(CES1):c.428G>A (p.Gly143Glu)
MISSENSE
rs71647871 Drug Response: clopidogrel response - Efficacy; not provided 55,823,658(-) C/Tp.Gly143Glu
NM_001025195.2(CES1):c.431G>A (p.Gly144Glu)
MISSENSE
rs778068631 Pathogenic: DRUG METABOLISM, ALTERED, CES1-RELATED 55,820,389(-) CA/C
NM_001025195.2(CES1):c.783del (p.Asp261fs)
FRAMESHIFT
rs2307227 -- p.Asp203Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CES1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CES1 Gene

Variant ID Type Subtype PubMed ID
dgv122n111 CNV deletion 26073780
dgv15e197 OTHER inversion 19546169
dgv2987n100 CNV gain 25217958
dgv479n67 CNV gain 20364138
dgv5135n54 CNV gain 21841781
dgv5136n54 CNV gain 21841781
dgv5137n54 CNV gain 21841781
dgv523e214 CNV gain 21293372
dgv52e203 CNV gain+loss 21179565
dgv62e19 OTHER inversion 19470904
dgv840e212 CNV gain 25503493
dgv841e212 CNV loss 25503493
dgv842e212 CNV gain 25503493
dgv843e212 CNV gain 25503493
esv1010290 OTHER inversion 20482838
esv2758649 CNV gain 17122850
esv28619 CNV gain 19812545
esv2937123 CNV duplication 24192839
esv32573 CNV gain+loss 17666407
esv3336851 CNV insertion 20981092
esv3571320 CNV gain 25503493
esv3638688 CNV loss 21293372
esv3892862 CNV gain+loss 25118596
esv3892863 CNV loss 25118596
esv9659 OTHER inversion 19470904
esv9707 OTHER inversion 19470904
esv998750 OTHER inversion 20482838
nsv1077830 CNV duplication 25765185
nsv1110287 CNV duplication 24896259
nsv147 OTHER inversion 15895083
nsv148 OTHER inversion 15895083
nsv442724 CNV gain 18776908
nsv471382 CNV gain 19718026
nsv499134 OTHER inversion 21111241
nsv572632 CNV gain 21841781
nsv572635 CNV loss 21841781
nsv572687 CNV gain 21841781
nsv572688 CNV loss 21841781
nsv572690 CNV gain+loss 21841781
nsv572693 CNV loss 21841781
nsv7284 OTHER inversion 18451855
nsv820205 CNV gain 19587683
nsv827676 CNV gain 20364138
nsv9446 CNV gain 18304495
nsv977981 CNV duplication 23825009

Variation tolerance for CES1 Gene

Residual Variation Intolerance Score: 98.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CES1 Gene

Human Gene Mutation Database (HGMD)
CES1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CES1
Leiden Open Variation Database (LOVD)
CES1

SNP Genotyping and Copy Number Assays for research

Disorders for CES1 Gene

MalaCards: The human disease database

(18) MalaCards diseases for CES1 Gene - From: OMI, CVR, COP, and GCD

Disorder Aliases PubMed IDs
drug metabolism, altered, ces1-related
egasyn
  • esterase 22; es22
polycystic echinococcosis
  • human polycystic hydatid disease
large intestine adenoma
  • adenoma of large intestine
hemophagocytic lymphohistiocytosis, familial, 3
  • fhl3
- elite association - COSMIC cancer census association via MalaCards
Search CES1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CES1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CES1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CES1 Gene

Publications for CES1 Gene

  1. Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis. (PMID: 18485328) Zhu HJ … Markowitz JS (American journal of human genetics 2008) 3 4 22 40 72
  2. cDNA cloning and characterization of human monocyte/macrophage serine esterase-1. (PMID: 2070086) Zschunke F … Radzun HJ (Blood 1991) 2 3 4 22
  3. Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages. (PMID: 18762277) Crow JA … Ross MK (Biochimica et biophysica acta 2008) 3 4 22
  4. Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages. (PMID: 16971496) Zhao B … Ghosh S (American journal of physiology. Cell physiology 2007) 3 4 22
  5. Redistribution of macrophage cholesteryl ester hydrolase from cytoplasm to lipid droplets upon lipid loading. (PMID: 16024911) Zhao B … Ghosh S (Journal of lipid research 2005) 3 4 22

Products for CES1 Gene

Sources for CES1 Gene