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Aliases for CERS6 Gene

Aliases for CERS6 Gene

  • Ceramide Synthase 6 2 3 3 5
  • LAG1 Homolog, Ceramide Synthase 6 2 3
  • LASS6 3 4
  • LAG1 Longevity Assurance Homolog 6 (S. Cerevisiae) 2
  • LAG1 Longevity Assurance Homolog 6 4
  • Longevity Assurance Homolog 6 3
  • CERS5 3
  • CerS6 4

External Ids for CERS6 Gene

Previous HGNC Symbols for CERS6 Gene

  • LASS6

Previous GeneCards Identifiers for CERS6 Gene

  • GC02P169313

Summaries for CERS6 Gene

GeneCards Summary for CERS6 Gene

CERS6 (Ceramide Synthase 6) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS5.

UniProtKB/Swiss-Prot for CERS6 Gene

  • May be involved in sphingolipid synthesis or its regulation.

Additional gene information for CERS6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS6 Gene

Genomics for CERS6 Gene

GeneHancer (GH) Regulatory Elements for CERS6 Gene

Promoters and enhancers for CERS6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J168454 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 660 3.8 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B CERS6 LOC102724081 GC02M168444
GH02J168545 Enhancer 0.9 Ensembl ENCODE dbSUPER 16.8 +90.0 89980 1.4 CTBP1 CREB1 FOS WT1 GC02M168537 CERS6 MIR4774
GH02J168432 Enhancer 0.7 ENCODE dbSUPER 16.8 -22.7 -22740 1.5 GATA3 PKNOX1 IKZF1 BATF ATF2 RUNX3 CERS6 GC02M168440 LOC105373734 LOC102724081
GH02J168582 Enhancer 1 Ensembl ENCODE dbSUPER 11.3 +128.2 128247 2.6 PKNOX1 MAFG ZEB1 ZSCAN21 JUND ZNF692 SCRT2 PRDM10 NFE2 RUNX3 MIR4774 RNU6-766P CERS6 GC02M168607
GH02J168521 Enhancer 1 Ensembl ENCODE dbSUPER 10.9 +65.7 65734 1.2 SMARCE1 HDAC1 MEIS2 KLF1 SOX6 NRF1 CBFA2T3 CEBPG ZNF148 JUND CERS6 GC02M168480 GC02M168537
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CERS6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CERS6 Gene

Genomic Locations for CERS6 Gene
319,276 bases
Plus strand
319,273 bases
Plus strand

Genomic View for CERS6 Gene

Genes around CERS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERS6 Gene

Proteins for CERS6 Gene

  • Protein details for CERS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ceramide synthase 6
    Protein Accession:
    Secondary Accessions:
    • Q32M63
    • Q8N617

    Protein attributes for CERS6 Gene

    384 amino acids
    Molecular mass:
    44890 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH30800.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for CERS6 Gene


neXtProt entry for CERS6 Gene

Post-translational modifications for CERS6 Gene

Other Protein References for CERS6 Gene

No data available for DME Specific Peptides for CERS6 Gene

Domains & Families for CERS6 Gene

Gene Families for CERS6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CERS6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CERS6: view

No data available for UniProtKB/Swiss-Prot for CERS6 Gene

Function for CERS6 Gene

Molecular function for CERS6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sphingolipid synthesis or its regulation.

Phenotypes From GWAS Catalog for CERS6 Gene

Gene Ontology (GO) - Molecular Function for CERS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003677 DNA binding IEA --
GO:0016410 N-acyltransferase activity IBA --
GO:0050291 sphingosine N-acyltransferase activity TAS --
genes like me logo Genes that share ontologies with CERS6: view
genes like me logo Genes that share phenotypes with CERS6: view

Animal Models for CERS6 Gene

MGI Knock Outs for CERS6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERS6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CERS6 Gene

Localization for CERS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS6 Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CERS6 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
nucleus 3
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CERS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CERS6: view

Pathways & Interactions for CERS6 Gene

genes like me logo Genes that share pathways with CERS6: view

Pathways by source for CERS6 Gene

Gene Ontology (GO) - Biological Process for CERS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006629 lipid metabolic process IEA,IBA --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0046513 ceramide biosynthetic process IBA --
genes like me logo Genes that share ontologies with CERS6: view

No data available for SIGNOR curated interactions for CERS6 Gene

Drugs & Compounds for CERS6 Gene

(4) Drugs for CERS6 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Coenzyme A Investigational Nutra 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
sphinganine Pharma 0
genes like me logo Genes that share compounds with CERS6: view

Transcripts for CERS6 Gene

mRNA/cDNA for CERS6 Gene

(6) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CERS6 Gene

Ceramide synthase 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERS6

Alternative Splicing Database (ASD) splice patterns (SP) for CERS6 Gene

No ASD Table

Relevant External Links for CERS6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CERS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CERS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CERS6 Gene

This gene is overexpressed in Lung (15.4), Fetal Brain (10.7), Testis (9.7), and Fetal gut (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CERS6 Gene

Protein tissue co-expression partners for CERS6 Gene

NURSA nuclear receptor signaling pathways regulating expression of CERS6 Gene:


SOURCE GeneReport for Unigene cluster for CERS6 Gene:


Evidence on tissue expression from TISSUES for CERS6 Gene

  • Intestine(4.4)
  • Liver(4.3)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with CERS6: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CERS6 Gene

Orthologs for CERS6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CERS6 34
  • 100 (a)
LASS6 33
  • 99.74 (n)
(Canis familiaris)
Mammalia CERS6 34 33
  • 93.8 (n)
(Bos Taurus)
Mammalia CERS6 34 33
  • 93.14 (n)
(Mus musculus)
Mammalia Cers6 16 34 33
  • 90.28 (n)
(Rattus norvegicus)
Mammalia Cers6 33
  • 90.19 (n)
(Monodelphis domestica)
Mammalia CERS6 34
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia CERS6 34
  • 81 (a)
(Gallus gallus)
Aves CERS6 34 33
  • 77.5 (n)
(Anolis carolinensis)
Reptilia CERS6 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cers6 33
  • 77.35 (n)
(Danio rerio)
Actinopterygii cers6 34 33
  • 72.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta schlank 34
  • 39 (a)
(Caenorhabditis elegans)
Secernentea hyl-1 34
  • 27 (a)
hyl-2 34
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G26200 33
  • 45.66 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9504 34
  • 44 (a)
Species where no ortholog for CERS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERS6 Gene

Gene Tree for CERS6 (if available)
Gene Tree for CERS6 (if available)
Evolutionary constrained regions (ECRs) for CERS6: view image

Paralogs for CERS6 Gene

Paralogs for CERS6 Gene

(5) SIMAP similar genes for CERS6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CERS6: view

Variants for CERS6 Gene

Sequence variations from dbSNP and Humsavar for CERS6 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000001760 -- 168,586,457(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000010841 -- 168,627,448(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000020918 -- 168,684,578(+) T/A 5_prime_UTR_variant, intron_variant
rs1000022069 -- 168,731,976(+) G/T intron_variant
rs1000043957 -- 168,597,588(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CERS6 Gene

Variant ID Type Subtype PubMed ID
dgv2088n106 CNV deletion 24896259
dgv64n68 CNV gain 17160897
esv1631379 CNV deletion 17803354
esv1682076 CNV deletion 17803354
esv1983529 CNV deletion 18987734
esv2350302 CNV deletion 18987734
esv2428031 CNV deletion 19546169
esv2567946 CNV deletion 19546169
esv2663091 CNV deletion 23128226
esv2667449 CNV deletion 23128226
esv2721102 CNV deletion 23290073
esv2721103 CNV deletion 23290073
esv2721104 CNV deletion 23290073
esv2721105 CNV deletion 23290073
esv2721107 CNV deletion 23290073
esv2721108 CNV deletion 23290073
esv3022022 CNV deletion 24192839
esv3263 CNV loss 18987735
esv3304185 CNV mobile element insertion 20981092
esv3391091 CNV insertion 20981092
esv3440550 CNV insertion 20981092
esv3560503 CNV deletion 23714750
esv3560507 CNV deletion 23714750
esv3593311 CNV loss 21293372
esv3593313 CNV loss 21293372
esv3593314 CNV loss 21293372
esv3593317 CNV loss 21293372
esv4907 CNV loss 18987735
esv6815 CNV loss 19470904
esv999398 CNV deletion 20482838
nsv1072042 CNV deletion 25765185
nsv1114148 CNV deletion 24896259
nsv215317 CNV deletion 16902084
nsv428405 CNV loss 18775914
nsv473657 CNV novel sequence insertion 20440878
nsv475427 CNV novel sequence insertion 20440878
nsv821785 CNV loss 20364138
nsv834450 CNV gain 17160897
nsv954725 CNV deletion 24416366

Variation tolerance for CERS6 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 43.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CERS6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS6 Gene

Disorders for CERS6 Gene

Additional Disease Information for CERS6

No disorders were found for CERS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERS6 Gene

Publications for CERS6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  5. Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region. (PMID: 26887952) Sassa T … Kihara A (The Journal of biological chemistry 2016) 3 58

Products for CERS6 Gene

Sources for CERS6 Gene

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