Aliases for CERS5 Gene
External Ids for CERS5 Gene
Previous HGNC Symbols for CERS5 Gene
Previous GeneCards Identifiers for CERS5 Gene
This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for CERS5 Gene
CERS5 (Ceramide Synthase 5) is a Protein Coding gene. Among its related pathways are Sphingolipid signaling pathway and Metabolism. Gene Ontology (GO) annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS6.
UniProtKB/Swiss-Prot Summary for CERS5 Gene
Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068). Can use other acyl donors, but with less efficiency (By similarity).