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Aliases for CERS5 Gene

Aliases for CERS5 Gene

  • Ceramide Synthase 5 2 3 4 5
  • LAG1 Longevity Assurance Homolog 5 3 4
  • LAG1 Homolog, Ceramide Synthase 5 2 3
  • LASS5 3 4
  • LAG1 Longevity Assurance Homolog 5 (S. Cerevisiae) 2
  • TRAM Homolog 4 3
  • EC 2.3.1.24 4
  • CerS5 4
  • Trh4 3

External Ids for CERS5 Gene

Previous HGNC Symbols for CERS5 Gene

  • LASS5

Previous GeneCards Identifiers for CERS5 Gene

  • GC12M050524

Summaries for CERS5 Gene

Entrez Gene Summary for CERS5 Gene

  • This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for CERS5 Gene

CERS5 (Ceramide Synthase 5) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS6.

UniProtKB/Swiss-Prot for CERS5 Gene

  • Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity).

Additional gene information for CERS5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS5 Gene

Genomics for CERS5 Gene

GeneHancer (GH) Regulatory Elements for CERS5 Gene

Promoters and enhancers for CERS5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J050166 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 632.8 +0.7 661 3.3 HDGF SP1 CC2D1A ZFX MNT NKRF POLR2A MLLT1 YY1 SP7 CERS5 ENSG00000257964 CSRNP2 PRPF40B GC12P050120 GC12M050135 ENSG00000272368
GH12J050106 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 28.6 +57.3 57255 7 HDGF MTA3 SP1 ELF3 ZFX CTCF MNT SIX5 NKRF POLR2A COX14 GC12M050105 ENSG00000272368 CERS5 ATF1 LIMA1 FAM186B LMBR1L TROAP BCDIN3D
GH12J050056 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 30.2 +109.3 109269 2.7 ZNF148 ZSCAN21 ZBTB7A SP7 ZNF548 KLF14 MZF1 CREB1 GLIS2 ZBTB8A ASIC1 KMT2D LIMA1 SMARCD1 LMBR1L ATF1 BCDIN3D CERS5 LOC101927267 SPATS2
GH12J050279 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 27 -114.6 -114581 5.4 SP1 CC2D1A ZFX ZKSCAN8 NKRF POLR2A MLLT1 ZNF121 GTF2F1 ZNF687 LIMA1 LARP4 GC12P050283 CERS5 ATF1 SMARCD1 BCDIN3D FAM186A DIP2B GC12M050258
GH12J050200 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 29.6 -35.0 -34954 4.6 SP1 FOSL2 CREB1 POLR2A ZIC2 ZNF24 CTBP1 SMARCC1 BRCA1 CEBPB LIMA1 CERS5 RNU6-1093P COX14 LARP4 FAM186A ATF1 PIR58326 ENSG00000257298 GC12M050135
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CERS5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CERS5 Gene

Genomic Locations for CERS5 Gene
chr12:50,129,306-50,167,533
(GRCh38/hg38)
Size:
38,228 bases
Orientation:
Minus strand
chr12:50,523,575-50,561,288
(GRCh37/hg19)
Size:
37,714 bases
Orientation:
Minus strand

Genomic View for CERS5 Gene

Genes around CERS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERS5 Gene

Proteins for CERS5 Gene

  • Protein details for CERS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5B7-CERS5_HUMAN
    Recommended name:
    Ceramide synthase 5
    Protein Accession:
    Q8N5B7
    Secondary Accessions:
    • B4DV54

    Protein attributes for CERS5 Gene

    Size:
    392 amino acids
    Molecular mass:
    45752 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CERS5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CERS5 Gene

Post-translational modifications for CERS5 Gene

  • Glycosylation at isoforms=26
  • Ubiquitination at isoforms=2121 and isoforms=2113
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CERS5 Gene

Domains & Families for CERS5 Gene

Gene Families for CERS5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CERS5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59959, moderately similar to LAG1 longevity assurance homolog 5 (B4DQR7_HUMAN)
  • cDNA FLJ59438, highly similar to LAG1 longevity assurance homolog 5 (B4DV54_HUMAN)
  • LAG1 longevity assurance homolog 5 (LASS5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CERS5: view

No data available for UniProtKB/Swiss-Prot for CERS5 Gene

Function for CERS5 Gene

Molecular function for CERS5 Gene

UniProtKB/Swiss-Prot Function:
Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+); Xref=Rhea:RHEA:23768, ChEBI:CHEBI:15378, ChEBI:CHEBI:52639, ChEBI:CHEBI:57287, ChEBI:CHEBI:57756, ChEBI:CHEBI:58342; EC=2.3.1.24;.

Enzyme Numbers (IUBMB) for CERS5 Gene

Phenotypes From GWAS Catalog for CERS5 Gene

Gene Ontology (GO) - Molecular Function for CERS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0016740 transferase activity IEA --
GO:0050291 sphingosine N-acyltransferase activity IDA,IEA 16951403
genes like me logo Genes that share ontologies with CERS5: view
genes like me logo Genes that share phenotypes with CERS5: view

Animal Models for CERS5 Gene

MGI Knock Outs for CERS5:
  • Cers5 Cers5<tm2b(KOMP)Mbp>

Animal Model Products

CRISPR Products

miRNA for CERS5 Gene

miRTarBase miRNAs that target CERS5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERS5

Clone Products

  • Applied Biological Materials (abm): Clones for CERS5 - Now 50% OFF >
  • * CERS5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CERS5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CERS5 Gene

Localization for CERS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS5 Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CERS5 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 4
plasma membrane 3
mitochondrion 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CERS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CERS5: view

Pathways & Interactions for CERS5 Gene

genes like me logo Genes that share pathways with CERS5: view

Pathways by source for CERS5 Gene

UniProtKB/Swiss-Prot Q8N5B7-CERS5_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism.

Gene Ontology (GO) - Biological Process for CERS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0046513 ceramide biosynthetic process IDA 16951403
genes like me logo Genes that share ontologies with CERS5: view

No data available for SIGNOR curated interactions for CERS5 Gene

Drugs & Compounds for CERS5 Gene

(3) Drugs for CERS5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Coenzyme A Investigational Nutra 0
sphinganine Pharma 0

(109) Additional Compounds for CERS5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
genes like me logo Genes that share compounds with CERS5: view

Transcripts for CERS5 Gene

Unigene Clusters for CERS5 Gene

Ceramide synthase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERS5

Clone Products

  • Applied Biological Materials (abm): Clones for CERS5 - Now 50% OFF >
  • * CERS5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CERS5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CERS5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b ^ 11 ^ 12a · 12b ·
SP1: - - - - - - - - - -
SP2:
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - -
SP10: - -
SP11: - - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - -
SP14:
SP15:
SP16: - - - - - - - - -
SP17: - - - - - - -
SP18: - - - - - - - - - - -
SP19:
SP20:
SP21:

ExUns: 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19a · 19b · 19c
SP1: - - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - - - -
SP16:
SP17:
SP18:
SP19:
SP20: - - -
SP21: -

Relevant External Links for CERS5 Gene

GeneLoc Exon Structure for
CERS5
ECgene alternative splicing isoforms for
CERS5

Expression for CERS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CERS5 Gene

Protein differential expression in normal tissues from HIPED for CERS5 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (55.8) and Heart (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CERS5 Gene



Protein tissue co-expression partners for CERS5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CERS5 Gene:

CERS5

SOURCE GeneReport for Unigene cluster for CERS5 Gene:

Hs.270525

Evidence on tissue expression from TISSUES for CERS5 Gene

  • Intestine(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with CERS5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CERS5 Gene

Orthologs for CERS5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LASS5 34
  • 99.19 (n)
CERS5 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CERS5 35 34
  • 91.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CERS5 34
  • 90.46 (n)
LASS5 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cers5 17 35 34
  • 82.57 (n)
rat
(Rattus norvegicus)
Mammalia Cers5 34
  • 81.76 (n)
chicken
(Gallus gallus)
Aves CERS5 35 34
  • 74.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CERS5 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cers5 34
  • 68.94 (n)
Str.2155 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.17394 34
zebrafish
(Danio rerio)
Actinopterygii cers5 35 34
  • 66.93 (n)
OneToOne
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3018 34
fruit fly
(Drosophila melanogaster)
Insecta schlank 35 34
  • 53.16 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001761 34
  • 50.73 (n)
worm
(Caenorhabditis elegans)
Secernentea hyl-1 35 34
  • 47.28 (n)
ManyToMany
hyl-2 35
  • 30 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LOH2 34
  • 45.59 (n)
rice
(Oryza sativa)
Liliopsida Os03g0264000 34
  • 47.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9504 35
  • 40 (a)
OneToMany
Species where no ortholog for CERS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERS5 Gene

ENSEMBL:
Gene Tree for CERS5 (if available)
TreeFam:
Gene Tree for CERS5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CERS5: view image

Paralogs for CERS5 Gene

Paralogs for CERS5 Gene

(14) SIMAP similar genes for CERS5 Gene using alignment to 13 proteins:

  • CERS5_HUMAN
  • B4DQR7_HUMAN
  • F8VQZ6_HUMAN
  • F8VSK7_HUMAN
  • F8VXY1_HUMAN
  • F8VY42_HUMAN
  • F8W1K4_HUMAN
  • F8W1N7_HUMAN
  • F8W1Z3_HUMAN
  • H0YHG4_HUMAN
  • H0YHK2_HUMAN
  • H0YI10_HUMAN
  • H0YIG1_HUMAN
genes like me logo Genes that share paralogs with CERS5: view

Variants for CERS5 Gene

Sequence variations from dbSNP and Humsavar for CERS5 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000002868 -- 50,158,422(-) T/C/G intron_variant
rs1000046868 -- 50,135,126(-) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000181253 -- 50,141,892(-) A/G/T intron_variant
rs1000202158 -- 50,154,685(-) TTTTTT/TTTTTTT intron_variant
rs1000286327 -- 50,163,002(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CERS5 Gene

Variant ID Type Subtype PubMed ID
esv2672487 CNV deletion 23128226
esv2674859 CNV deletion 23128226
esv3629472 CNV loss 21293372
esv3629473 CNV loss 21293372
nsv1144622 CNV deletion 24896259
nsv558840 CNV loss 21841781

Variation tolerance for CERS5 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CERS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CERS5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS5 Gene

Disorders for CERS5 Gene

Additional Disease Information for CERS5

No disorders were found for CERS5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERS5 Gene

Publications for CERS5 Gene

  1. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. (PMID: 16100120) Lahiri S … Futerman AH (The Journal of biological chemistry 2005) 3 23 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. [Investigating the role of ceramide metabolism-associated CERS5 (LASS5) gene in atherosclerosis pathogenesis in endothelial cells]. (PMID: 28424433) Çoban N … Erginel Ünaltuna N (Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CERS5 Gene

Sources for CERS5 Gene

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