This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] See more...

Aliases for CERS2 Gene

Aliases for CERS2 Gene

  • Ceramide Synthase 2 2 3 4 5
  • SP260 2 3 4
  • Longevity Assurance (LAG1, S. Cerevisiae) Homolog 2 2 3
  • Tumor Metastasis-Suppressor Gene 1 Protein 3 4
  • Sphingosine N-Acyltransferase CERS2 3 4
  • LAG1 Homolog, Ceramide Synthase 2 2 3
  • LASS2 3 4
  • TMSG1 3 4
  • LAG1 Longevity Assurance Homolog 2 (S. Cerevisiae) 2
  • LAG1 Longevity Assurance Homolog 2 4
  • LAG1 Longevity Assurance 2 3
  • EC 4
  • EC 2.3.1.- 4
  • FLJ10243 2
  • CERS2 5
  • CerS2 4
  • L3 3

External Ids for CERS2 Gene

Previous HGNC Symbols for CERS2 Gene

  • LASS2

Summaries for CERS2 Gene

Entrez Gene Summary for CERS2 Gene

  • This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CERS2 Gene

CERS2 (Ceramide Synthase 2) is a Protein Coding gene. Diseases associated with CERS2 include Myoclonic Epilepsy, Juvenile 3 and Hereditary Sensory And Autonomic Neuropathy Type 1. Among its related pathways are Sphingolipid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS3.

UniProtKB/Swiss-Prot Summary for CERS2 Gene

  • Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) chain as acyl donor.

Gene Wiki entry for CERS2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CERS2 Gene

Genomics for CERS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CERS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CERS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CERS2

Genomic Locations for CERS2 Gene

Latest Assembly
14,421 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
9,650 bases
Minus strand

(GRCh37/hg19 by Ensembl)
14,421 bases
Minus strand

Genomic View for CERS2 Gene

Genes around CERS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERS2 Gene

Proteins for CERS2 Gene

  • Protein details for CERS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ceramide synthase 2
    Protein Accession:
    Secondary Accessions:
    • D3DV06
    • Q5SZE5
    • Q9HD96
    • Q9NW79

    Protein attributes for CERS2 Gene

    380 amino acids
    Molecular mass:
    44876 Da
    Quaternary structure:
    • Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1 (PubMed:11543633). Interacts with ELOV1, HSD17B12 and TECR (PubMed:20937905).
    • Sequence=BAA91505.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for CERS2 Gene

Post-translational modifications for CERS2 Gene

  • Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation.
  • Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity.
  • Glycosylation at Asn19
  • Ubiquitination at Lys93 and Lys96
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CERS2_HUMAN (1105)

No data available for DME Specific Peptides for CERS2 Gene

Domains & Families for CERS2 Gene

Gene Families for CERS2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CERS2 Gene

  • Longevity-assurance protein (LAG1)
  • TRAM, LAG1 and CLN8 homology

Suggested Antigen Peptide Sequences for CERS2 Gene

GenScript: Design optimal peptide antigens:
  • Tumor metastasis-suppressor gene 1 protein (LASS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • The last loop motif confers selectivity toward behenoyl-CoA (docosanoyl-CoA; C22:0-CoA) and lignoceroyl-CoA (tetracosanoyl-CoA; C24:0-CoA) as acyl donors.
  • The last loop motif confers selectivity toward behenoyl-CoA (docosanoyl-CoA; C22:0-CoA) and lignoceroyl-CoA (tetracosanoyl-CoA; C24:0-CoA) as acyl donors.
genes like me logo Genes that share domains with CERS2: view

Function for CERS2 Gene

Molecular function for CERS2 Gene

UniProtKB/Swiss-Prot Function:
Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) chain as acyl donor.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=docosanoyl-CoA + sphinganine = CoA + H(+) + N-docosanoylsphinganine; Xref=Rhea:RHEA:36535, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:65059, ChEBI:CHEBI:67021; Evidence={ECO:0000269|PubMed:18165233, ECO:0000269|PubMed:22144673, ECO:0000269|PubMed:29632068};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=sphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinganine; Xref=Rhea:RHEA:33591, ChEBI:CHEBI:15378, ChEBI:CHEBI:52961, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:65052; Evidence={ECO:0000269|PubMed:12869556, ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:18165233, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:29632068};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexacosanoyl-CoA + sphinganine = CoA + H(+) + N-hexacosanoylsphinganine; Xref=Rhea:RHEA:33351, ChEBI:CHEBI:15378, ChEBI:CHEBI:52962, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:64868; Evidence={ECO:0000269|PubMed:12869556, ECO:0000269|PubMed:18165233};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(15Z)-tetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine; Xref=Rhea:RHEA:36667, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:74128, ChEBI:CHEBI:74130; Evidence={ECO:0000269|PubMed:18165233, ECO:0000269|PubMed:22661289, ECO:0000269|PubMed:26887952};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hydroxytetracosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine; Xref=Rhea:RHEA:36627, ChEBI:CHEBI:15378, ChEBI:CHEBI:52371, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:74118; Evidence={ECO:0000269|PubMed:18541923};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hydroxydocosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine; Xref=Rhea:RHEA:36619, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:67023, ChEBI:CHEBI:74117; Evidence={ECO:0000269|PubMed:18541923};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hydroxytetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine; Xref=Rhea:RHEA:36767, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:74215, ChEBI:CHEBI:74216; Evidence={ECO:0000269|PubMed:18541923};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=sphinganine + tetracosenoyl-CoA = an N-tetracosenoylsphinganine + CoA + H(+); Xref=Rhea:RHEA:36715, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:74146, ChEBI:CHEBI:74160; Evidence={ECO:0000269|PubMed:18541923};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=eicosanoyl-CoA + sphinganine = CoA + H(+) + N-eicosanoylsphinganine; Xref=Rhea:RHEA:36555, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:57817, ChEBI:CHEBI:67027; Evidence={ECO:0000269|PubMed:12869556, ECO:0000269|PubMed:18165233};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-hexacosenoylsphinganine; Xref=Rhea:RHEA:36719, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57817, ChEBI:CHEBI:74161, ChEBI:CHEBI:74162; Evidence={ECO:0000269|PubMed:18165233};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+); Xref=Rhea:RHEA:23768, ChEBI:CHEBI:15378, ChEBI:CHEBI:52639, ChEBI:CHEBI:57287, ChEBI:CHEBI:57756, ChEBI:CHEBI:77636; EC=; Evidence={ECO:0000269|PubMed:20937905};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=sphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-sphing-4-enine; Xref=Rhea:RHEA:37115, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57756, ChEBI:CHEBI:65052, ChEBI:CHEBI:72965; Evidence={ECO:0000269|PubMed:20937905};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=sphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine; Xref=Rhea:RHEA:37123, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57756, ChEBI:CHEBI:74146, ChEBI:CHEBI:74457; Evidence={ECO:0000269|PubMed:20937905};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=heptadecasphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine; Xref=Rhea:RHEA:36739, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:74166, ChEBI:CHEBI:74167; Evidence={ECO:0000269|PubMed:19728861};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-hexadecanoylsphing-4-enine; Xref=Rhea:RHEA:36687, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57756, ChEBI:CHEBI:72959; Evidence={ECO:0000250|UniProtKB:Q924Z4};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=octadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-octadecanoylsphing-4-enine; Xref=Rhea:RHEA:36691, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:57756, ChEBI:CHEBI:72961; Evidence={ECO:0000250|UniProtKB:Q924Z4};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=eicosanoyl-CoA + sphing-4-enine = CoA + H(+) + N-eicosanoyl-sphing-4-enine; Xref=Rhea:RHEA:45284, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380, ChEBI:CHEBI:57756, ChEBI:CHEBI:72962; Evidence={ECO:0000250|UniProtKB:Q924Z4};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=hexadecanoyl-CoA + sphinganine = CoA + H(+) + N-hexadecanoylsphinganine; Xref=Rhea:RHEA:36539, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:57817, ChEBI:CHEBI:67042; Evidence={ECO:0000269|PubMed:12869556};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + sphinganine = CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine; Xref=Rhea:RHEA:36575, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387, ChEBI:CHEBI:57817, ChEBI:CHEBI:74100; Evidence={ECO:0000269|PubMed:12869556};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.8 uM for sphinganine {ECO:0000269|PubMed:17977534}; KM=1.07 uM for sphingosine {ECO:0000269|PubMed:26887952}; KM=62.9 uM for (15Z)-tetracosenoyl-CoA {ECO:0000269|PubMed:26887952}; Vmax=0.51 pmol/min/ug enzyme with sphingosine as substrate {ECO:0000269|PubMed:26887952}; Vmax=0.76 pmol/min/ug enzyme with (15Z)-tetracosenoyl-CoA as substrate {ECO:0000269|PubMed:26887952};
UniProtKB/Swiss-Prot EnzymeRegulation:
Ceramide synthase activity is inhibited by sphingosine-1-phosphate.

Enzyme Numbers (IUBMB) for CERS2 Gene

Phenotypes From GWAS Catalog for CERS2 Gene

Gene Ontology (GO) - Molecular Function for CERS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 11543633
GO:0016410 N-acyltransferase activity IBA 21873635
GO:0016740 transferase activity IEA --
GO:0050291 sphingosine N-acyltransferase activity IEA,IDA 17977534
genes like me logo Genes that share ontologies with CERS2: view
genes like me logo Genes that share phenotypes with CERS2: view

miRNA for CERS2 Gene

miRTarBase miRNAs that target CERS2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERS2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CERS2 Gene

Localization for CERS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS2 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CERS2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
nucleus 3
extracellular 2
mitochondrion 2
cytosol 2
lysosome 2
golgi apparatus 2
cytoskeleton 1
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Nuclear membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CERS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IBA,IDA 18165233
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CERS2: view

Pathways & Interactions for CERS2 Gene

genes like me logo Genes that share pathways with CERS2: view

Pathways by source for CERS2 Gene

UniProtKB/Swiss-Prot Q96G23-CERS2_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism.

Gene Ontology (GO) - Biological Process for CERS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0030148 sphingolipid biosynthetic process IEA,TAS --
GO:0046513 ceramide biosynthetic process IEA,IDA 17977534
GO:0048681 negative regulation of axon regeneration IEA,ISS --
genes like me logo Genes that share ontologies with CERS2: view

No data available for SIGNOR curated interactions for CERS2 Gene

Drugs & Compounds for CERS2 Gene

(3) Drugs for CERS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Coenzyme A Investigational Nutra 0
sphinganine Pharma 0

(1) Additional Compounds for CERS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CERS2: view

Transcripts for CERS2 Gene

mRNA/cDNA for CERS2 Gene

13 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERS2

Alternative Splicing Database (ASD) splice patterns (SP) for CERS2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - -
SP9: - -
SP12: -

ExUns: 12b ^ 13a · 13b · 13c ^ 14 ^ 15
SP8: - -

Relevant External Links for CERS2 Gene

GeneLoc Exon Structure for

Expression for CERS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CERS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CERS2 Gene

This gene is overexpressed in Liver (x5.5).

Protein differential expression in normal tissues from HIPED for CERS2 Gene

This gene is overexpressed in Liver (7.2) and Bone (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CERS2 Gene

Protein tissue co-expression partners for CERS2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CERS2

SOURCE GeneReport for Unigene cluster for CERS2 Gene:


mRNA Expression by UniProt/SwissProt for CERS2 Gene:

Tissue specificity: Expressed in kidney, liver, brain, heart, placenta and lung.

Evidence on tissue expression from TISSUES for CERS2 Gene

  • Liver(4.7)
  • Kidney(4.6)
  • Skin(4.5)
  • Blood(4.4)
  • Nervous system(3.1)
  • Lung(2.7)
  • Adrenal gland(2.6)
  • Intestine(2.5)
  • Muscle(2.5)
  • Heart(2.5)
  • Stomach(2.5)
  • Thyroid gland(2.4)
  • Lymph node(2.4)
  • Gall bladder(2.3)
  • Pancreas(2.3)
  • Spleen(2.2)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with CERS2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CERS2 Gene

Orthologs for CERS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LASS2 29 30
  • 99.91 (n)
(Bos Taurus)
Mammalia CERS2 29 30
  • 93.33 (n)
(Ornithorhynchus anatinus)
Mammalia CERS2 30
  • 93 (a)
(Canis familiaris)
Mammalia CERS2 29 30
  • 92.54 (n)
(Monodelphis domestica)
Mammalia CERS2 30
  • 92 (a)
(Rattus norvegicus)
Mammalia Cers2 29
  • 91.14 (n)
(Mus musculus)
Mammalia Cers2 29 16 30
  • 90.88 (n)
(Gallus gallus)
Aves -- 30
  • 84 (a)
-- 30
  • 84 (a)
LOC100859441 29
  • 78.72 (n)
(Anolis carolinensis)
Reptilia CERS2 30
  • 78 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cers2 29
  • 70.63 (n)
Str.6992 29
(Danio rerio)
Actinopterygii cers2a 29 30
  • 66.58 (n)
cers2b 30
  • 64 (a)
trh3 29
Fruit Fly
(Drosophila melanogaster)
Insecta schlank 30
  • 36 (a)
(Caenorhabditis elegans)
Secernentea hyl-1 30
  • 30 (a)
hyl-2 30
  • 29 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAC1 32
Thale Cress
(Arabidopsis thaliana)
eudicotyledons LAG13 29
  • 46.54 (n)
(Oryza sativa)
Liliopsida Os02g0581300 29
  • 45.3 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 42 (a)
-- 30
  • 37 (a)
-- 30
  • 36 (a)
-- 30
  • 33 (a)
Species where no ortholog for CERS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CERS2 Gene

Gene Tree for CERS2 (if available)
Gene Tree for CERS2 (if available)
Evolutionary constrained regions (ECRs) for CERS2: view image
Alliance of Genome Resources:
Additional Orthologs for CERS2

Paralogs for CERS2 Gene

Paralogs for CERS2 Gene

(5) SIMAP similar genes for CERS2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with CERS2: view

Variants for CERS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CERS2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1571673661 Uncertain Significance: Marfanoid habitus and intellectual disability 150,968,135(-) G/A
NM_022075.5(CERS2):c.358C>T (p.Arg120Cys)
rs76805488 Benign: not provided 150,967,832(-) G/A
NM_022075.5(CERS2):c.456C>T (p.Ala152=)
rs78875607 Benign: not provided 150,967,407(-) A/G
NM_022075.5(CERS2):c.597T>C (p.Ser199=)
rs9435954 Benign: not provided 150,966,842(-) G/A
NM_022075.5(CERS2):c.762C>T (p.Tyr254=)
rs267738 -- p.Glu115Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CERS2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CERS2 Gene

Variant ID Type Subtype PubMed ID
nsv1008496 CNV gain 25217958
nsv1142781 CNV deletion 24896259
nsv522317 CNV loss 19592680
nsv522840 CNV gain 19592680
nsv952804 CNV deletion 24416366

Variation tolerance for CERS2 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CERS2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS2 Gene

Disorders for CERS2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CERS2 Gene - From: COP

Disorder Aliases PubMed IDs
myoclonic epilepsy, juvenile 3
  • myoclonic epilepsy, juvenile, susceptibility to, 3
hereditary sensory and autonomic neuropathy type 1
  • hereditary sensory and autonomic neuropathy type i
- elite association - COSMIC cancer census association via MalaCards
Search CERS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CERS2

genes like me logo Genes that share disorders with CERS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CERS2 Gene

Publications for CERS2 Gene

  1. Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PMID: 11543633) Pan H … Gu JR (Genomics 2001) 2 3 4 22
  2. Eleven residues determine the acyl chain specificity of ceramide synthases. (PMID: 29632068) Tidhar R … Futerman AH (The Journal of biological chemistry 2018) 3 4
  3. Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region. (PMID: 26887952) Sassa T … Kihara A (The Journal of biological chemistry 2016) 3 4
  4. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. (PMID: 20937905) Ohno Y … Kihara A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4
  5. Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response. (PMID: 19728861) Spassieva SD … Obeid LM (The Biochemical journal 2009) 3 4

Products for CERS2 Gene

  • Biorbyt antibodies for CERS2

Sources for CERS2 Gene