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Aliases for CERS2 Gene

Aliases for CERS2 Gene

  • Ceramide Synthase 2 2 3 3 5
  • Longevity Assurance (LAG1, S. Cerevisiae) Homolog 2 2 3
  • Tumor Metastasis-Suppressor Gene 1 Protein 3 4
  • LAG1 Homolog, Ceramide Synthase 2 2 3
  • LASS2 3 4
  • SP260 3 4
  • TMSG1 3 4
  • LAG1 Longevity Assurance Homolog 2 (S. Cerevisiae) 2
  • LAG1 Longevity Assurance Homolog 2 4
  • LAG1 Longevity Assurance 2 3
  • CerS2 4
  • L3 3

External Ids for CERS2 Gene

Previous HGNC Symbols for CERS2 Gene

  • LASS2

Summaries for CERS2 Gene

Entrez Gene Summary for CERS2 Gene

  • This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CERS2 Gene

CERS2 (Ceramide Synthase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS3.

UniProtKB/Swiss-Prot for CERS2 Gene

  • Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.

Gene Wiki entry for CERS2 Gene

Additional gene information for CERS2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS2 Gene

Genomics for CERS2 Gene

GeneHancer (GH) Regulatory Elements for CERS2 Gene

Promoters and enhancers for CERS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J150969 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 651.8 +0.0 47 10.6 CLOCK MLX ZFP64 DMAP1 YY1 E2F8 ZNF143 SP3 SSRP1 GLIS1 CERS2 ENSG00000231073 PRPF3 SETDB1 ZNF687 HORMAD1 PIP5K1A ARNT GOLPH3L PI4KB
GH01J151004 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 661 -32.4 -32441 5.2 CLOCK ZFP64 YBX1 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF610 GLIS1 PRUNE1 CERS2 MINDY1 SETDB1 PIP5K1A PI4KB PRPF3 ARNT MRPL9 UBE2D3P3
GH01J150925 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 +48.8 48767 2.5 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 SETDB1 PRPF3 HORMAD1 PI4KB CTSK SF3B4 GABPB2 UBE2D3P3 ARNT ZNF687
GH01J150998 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.4 -24.4 -24373 1.2 PKNOX1 ATF1 ARNT TCF12 ZNF766 E2F8 ATF7 NCOA1 ZNF592 MEF2D RNU6-884P CERS2 ENSG00000231073 BNIPL C1orf56 SCNM1 LYSMD1 TMOD4 MINDY1 ANXA9
GH01J151000 Enhancer 1 ENCODE dbSUPER 11.4 -26.3 -26291 0.7 PKNOX1 TAF9B ZNF366 ATF7 CREM ZBTB2 CEBPB REST ZNF398 ZEB2 RNU6-884P ENSG00000231073 CERS2 SEMA6C BNIPL C1orf56 SCNM1 LYSMD1 TMOD4 MINDY1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CERS2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CERS2 Gene

Genomic Locations for CERS2 Gene
chr1:150,960,583-150,975,004
(GRCh38/hg38)
Size:
14,422 bases
Orientation:
Minus strand
chr1:150,933,059-150,947,479
(GRCh37/hg19)

Genomic View for CERS2 Gene

Genes around CERS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERS2 Gene

Proteins for CERS2 Gene

  • Protein details for CERS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G23-CERS2_HUMAN
    Recommended name:
    Ceramide synthase 2
    Protein Accession:
    Q96G23
    Secondary Accessions:
    • D3DV06
    • Q5SZE5
    • Q9HD96
    • Q9NW79

    Protein attributes for CERS2 Gene

    Size:
    380 amino acids
    Molecular mass:
    44876 Da
    Quaternary structure:
    • Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR.
    SequenceCaution:
    • Sequence=BAA91505.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CERS2 Gene

Post-translational modifications for CERS2 Gene

  • Glycosylation at posLast=1919
  • Ubiquitination at Lys96 and Lys93
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CERS2 Gene

Domains & Families for CERS2 Gene

Gene Families for CERS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CERS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CERS2: view

No data available for UniProtKB/Swiss-Prot for CERS2 Gene

Function for CERS2 Gene

Molecular function for CERS2 Gene

UniProtKB/Swiss-Prot Function:
Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.

Phenotypes From GWAS Catalog for CERS2 Gene

Gene Ontology (GO) - Molecular Function for CERS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 11543633
GO:0016410 N-acyltransferase activity IBA --
GO:0050291 sphingosine N-acyltransferase activity TAS,IEA --
genes like me logo Genes that share ontologies with CERS2: view
genes like me logo Genes that share phenotypes with CERS2: view

Animal Model Products

CRISPR Products

miRNA for CERS2 Gene

miRTarBase miRNAs that target CERS2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERS2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CERS2 Gene

Localization for CERS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS2 Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CERS2 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
plasma membrane 3
golgi apparatus 2
extracellular 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Nuclear membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CERS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CERS2: view

Pathways & Interactions for CERS2 Gene

genes like me logo Genes that share pathways with CERS2: view

Pathways by source for CERS2 Gene

Gene Ontology (GO) - Biological Process for CERS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA,IBA --
GO:0030148 sphingolipid biosynthetic process TAS,IEA --
GO:0046513 ceramide biosynthetic process IEA,IBA --
GO:0048681 negative regulation of axon regeneration IEA,ISS --
GO:1900148 negative regulation of Schwann cell migration ISS,IEA --
genes like me logo Genes that share ontologies with CERS2: view

No data available for SIGNOR curated interactions for CERS2 Gene

Drugs & Compounds for CERS2 Gene

(3) Drugs for CERS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Coenzyme A Investigational Nutra 0
sphinganine Pharma 0

(1) Additional Compounds for CERS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CERS2: view

Transcripts for CERS2 Gene

Unigene Clusters for CERS2 Gene

Ceramide synthase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERS2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CERS2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - -
SP8:
SP9: - -
SP10:
SP11:
SP12: -

ExUns: 12b ^ 13a · 13b · 13c ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CERS2 Gene

GeneLoc Exon Structure for
CERS2
ECgene alternative splicing isoforms for
CERS2

Expression for CERS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CERS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CERS2 Gene

This gene is overexpressed in Liver (x5.5).

Protein differential expression in normal tissues from HIPED for CERS2 Gene

This gene is overexpressed in Liver (7.2) and Bone (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CERS2 Gene



Protein tissue co-expression partners for CERS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CERS2 Gene:

CERS2

SOURCE GeneReport for Unigene cluster for CERS2 Gene:

Hs.744017

mRNA Expression by UniProt/SwissProt for CERS2 Gene:

Q96G23-CERS2_HUMAN
Tissue specificity: Expressed in kidney, liver, brain, heart, placenta and lung.

Evidence on tissue expression from TISSUES for CERS2 Gene

  • Liver(4.7)
  • Kidney(4.6)
  • Skin(4.3)
  • Blood(4.1)
  • Nervous system(2.8)
  • Adrenal gland(2.2)
  • Thyroid gland(2.1)
  • Intestine(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with CERS2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CERS2 Gene

Orthologs for CERS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LASS2 34 33
  • 99.91 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CERS2 34 33
  • 93.33 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CERS2 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CERS2 34 33
  • 92.54 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CERS2 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cers2 33
  • 91.14 (n)
mouse
(Mus musculus)
Mammalia Cers2 16 34 33
  • 90.88 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 84 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
LOC100857262 33
  • 78.72 (n)
lizard
(Anolis carolinensis)
Reptilia CERS2 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cers2 33
  • 70.63 (n)
Str.6992 33
zebrafish
(Danio rerio)
Actinopterygii cers2a 34 33
  • 66.58 (n)
OneToMany
cers2b 34
  • 64 (a)
OneToMany
trh3 33
fruit fly
(Drosophila melanogaster)
Insecta schlank 34
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hyl-1 34
  • 30 (a)
ManyToMany
hyl-2 34
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAC1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons LAG13 33
  • 46.54 (n)
rice
(Oryza sativa)
Liliopsida Os02g0581300 33
  • 45.3 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
Species where no ortholog for CERS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERS2 Gene

ENSEMBL:
Gene Tree for CERS2 (if available)
TreeFam:
Gene Tree for CERS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CERS2: view image

Paralogs for CERS2 Gene

Paralogs for CERS2 Gene

(5) SIMAP similar genes for CERS2 Gene using alignment to 9 proteins:

  • CERS2_HUMAN
  • H0YKH6_HUMAN
  • H0YLQ6_HUMAN
  • H0YNU7_HUMAN
  • Q5SZE1_HUMAN
  • Q5SZE2_HUMAN
  • Q5SZE3_HUMAN
  • Q5SZE4_HUMAN
  • Q5SZE6_HUMAN
genes like me logo Genes that share paralogs with CERS2: view

Variants for CERS2 Gene

Sequence variations from dbSNP and Humsavar for CERS2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000107487 -- 150,965,780(-) T/C 3_prime_UTR_variant
rs1000373232 -- 150,967,635(-) A/C intron_variant
rs1000405833 -- 150,967,297(-) G/A intron_variant
rs1000826372 -- 150,976,657(-) CTCT/CT upstream_transcript_variant
rs1000882540 -- 150,973,347(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CERS2 Gene

Variant ID Type Subtype PubMed ID
nsv1008496 CNV gain 25217958
nsv1142781 CNV deletion 24896259
nsv522317 CNV loss 19592680
nsv522840 CNV gain 19592680
nsv952804 CNV deletion 24416366

Variation tolerance for CERS2 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CERS2 Gene

Human Gene Mutation Database (HGMD)
CERS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CERS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS2 Gene

Disorders for CERS2 Gene

Additional Disease Information for CERS2

No disorders were found for CERS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERS2 Gene

Publications for CERS2 Gene

  1. Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PMID: 11543633) Pan H … Gu JR (Genomics 2001) 2 3 4 22 58
  2. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. (PMID: 20937905) Ohno Y … Kihara A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PMID: 16263699) Lewandrowski U … Sickmann A (Molecular & cellular proteomics : MCP 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CERS2 Gene

Sources for CERS2 Gene

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