Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CERNA2 Gene

Subcategory (RNA class) for CERNA2 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for CERNA2 Gene

  • Competing Endogenous LncRNA 2 For MicroRNA Let-7b 2 3
  • Human Ovarian Cancer-Specific Transcript 2 3
  • Human Ovarian Cancer Specific Transcript 2 2
  • LncRNA-HOST2 3
  • HOST2 3

External Ids for CERNA2 Gene

Summaries for CERNA2 Gene

Entrez Gene Summary for CERNA2 Gene

  • This gene produces a long non-coding transcript that functions in ovarian carcinogenesis by promoting tumor cell migration, invasion and proliferation. It binds to the microRNA let-7b (MIRLET7B), which is a potent tumor suppressor, thereby inhibiting the functions of that microRNA by modulating its availability to its targets. [provided by RefSeq, Dec 2015]

GeneCards Summary for CERNA2 Gene

CERNA2 (Competing Endogenous LncRNA 2 For MicroRNA Let-7b) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with CERNA2 include Ovarian Epithelial Cancer and Ovarian Cancer.

Additional gene information for CERNA2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERNA2 Gene

Genomics for CERNA2 Gene

GeneHancer (GH) Regulatory Elements for CERNA2 Gene

Promoters and enhancers for CERNA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J084171 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 650.7 -0.6 -576 2.8 HDGF PKNOX1 SMAD1 RB1 BACH1 PAX8 EBF1 POLR2A NFATC1 EED CERNA2 C10orf99 CDHR1 LRIT2
GH10J084156 Enhancer 0.9 Ensembl ENCODE 0.4 +15.2 15160 0.8 CTCF HDAC1 MEIS2 PKNOX1 JUN MAX CEBPG ZIC2 FOSL1 POLR2B CDHR1 LRIT2 RNU1-65P ENSG00000271933 C10orf99 CERNA2
GH10J084163 Enhancer 0.3 dbSUPER 0.4 +8.3 8269 1.1 KLF17 CDHR1 LRIT2 LRIT1 CERNA2 ENSG00000271933
GH10J084161 Enhancer 0.3 ENCODE 0.4 +11.0 11028 0.2 USF1 CDHR1 LRIT2 LRIT1 CERNA2 ENSG00000271933
GH10J084148 Enhancer 0.4 ENCODE 0.3 +24.0 23998 0.1 CTCF ZNF143 RAD21 CDHR1 ENSG00000271933 GHITM CERNA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CERNA2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CERNA2 Gene

Genomic Locations for CERNA2 Gene
chr10:84,167,228-84,172,188
(GRCh38/hg38)
Size:
4,961 bases
Orientation:
Minus strand

Genomic View for CERNA2 Gene

Genes around CERNA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERNA2 Gene

Proteins for CERNA2 Gene

Post-translational modifications for CERNA2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CERNA2 Gene

Domains & Families for CERNA2 Gene

Gene Families for CERNA2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CERNA2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CERNA2 Gene

Function for CERNA2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CERNA2 Gene

Localization for CERNA2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CERNA2 Gene

Pathways & Interactions for CERNA2 Gene

SuperPathways for CERNA2 Gene

No Data Available

Interacting Proteins for CERNA2 Gene

Gene Ontology (GO) - Biological Process for CERNA2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CERNA2 Gene

Drugs & Compounds for CERNA2 Gene

No Compound Related Data Available

Transcripts for CERNA2 Gene

mRNA/cDNA for CERNA2 Gene

(1) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for CERNA2 Gene

No ASD Table

Relevant External Links for CERNA2 Gene

GeneLoc Exon Structure for
CERNA2
ECgene alternative splicing isoforms for
CERNA2

Expression for CERNA2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CERNA2 Gene

Orthologs for CERNA2 Gene

No data available for Orthologs and Evolution for CERNA2 Gene

Paralogs for CERNA2 Gene

No data available for Paralogs for CERNA2 Gene

Variants for CERNA2 Gene

Sequence variations from dbSNP and Humsavar for CERNA2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000229759 -- 84,168,970(-) T/A intron_variant
rs1000322501 -- 84,169,223(-) G/C intron_variant
rs1000456378 -- 84,173,063(-) C/T upstream_transcript_variant
rs1001195109 -- 84,172,541(-) G/A upstream_transcript_variant
rs1001215036 -- 84,173,262(-) C/T upstream_transcript_variant

Additional Variant Information for CERNA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CERNA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CERNA2 Gene

Disorders for CERNA2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CERNA2 Gene - From: LncRNADisease and GeneCards

Disorder Aliases PubMed IDs
ovarian epithelial cancer
  • eoc
ovarian cancer
  • ovarian cancer, somatic
breast cancer
  • breast cancer, familial
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CERNA2

genes like me logo Genes that share disorders with CERNA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CERNA2 Gene

Publications for CERNA2 Gene

  1. Effects of LncRNA-HOST2 on cell proliferation, migration, invasion and apoptosis of human hepatocellular carcinoma cell line SMMC-7721. (PMID: 28143959) Liu RT … Lv HT (Bioscience reports 2017) 2 3 58
  2. LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b. (PMID: 25292198) Gao Y … Hui N (Human molecular genetics 2015) 2 3 58
  3. Effects of the Long Non-Coding RNA HOST2 On the Proliferation, Migration, Invasion and Apoptosis of Human Osteosarcoma Cells. (PMID: 28854422) Wang W … Yang CY (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  4. Characterization of novel human ovarian cancer-specific transcripts (HOSTs) identified by serial analysis of gene expression. (PMID: 14562052) Rangel LB … Morin PJ (Oncogene 2003) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for CERNA2 Gene

Sources for CERNA2 Gene

Content
Loading form....