Aliases for CERK Gene
Aliases for CERK Gene
External Ids for CERK Gene
- HGNC: 19256
- Entrez Gene: 64781
- Ensembl: ENSG00000100422
- OMIM: 610307
- UniProtKB: Q8TCT0
Previous GeneCards Identifiers for CERK Gene
- GC22M043648
- GC22M045292
- GC22M045400
- GC22M047080
- GC22M030025
Summaries for CERK Gene
-
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CERK Gene
CERK (Ceramide Kinase) is a Protein Coding gene. Diseases associated with CERK include Retinitis Pigmentosa 26 and Retinitis Pigmentosa. Among its related pathways are Integrated Breast Cancer Pathway and Metabolism. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and diacylglycerol kinase activity. An important paralog of this gene is CERKL.
UniProtKB/Swiss-Prot for CERK Gene
-
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERK Gene
Genomics for CERK Gene
GeneHancer (GH) Regulatory Elements for CERK Gene
Promoters and enhancers for CERK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CERK on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CERK Gene
Genomic Locations for CERK Gene
- chr22:46,684,410-46,738,261
- (GRCh38/hg38)
- Size:
- 53,852 bases
- Orientation:
- Minus strand
- chr22:47,080,307-47,134,158
- (GRCh37/hg19)
Genomic View for CERK Gene
Genes around CERK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.31 by Entrez Gene
- 22q13.31 by HGNC
- 22q13.31 by Ensembl
CERK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CERK Gene
Proteins for CERK Gene
-
Protein details for CERK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TCT0-CERK1_HUMAN
- Recommended name:
- Ceramide kinase
- Protein Accession:
- Q8TCT0
- A0JNT4
- A8K611
- Q6NX59
- Q9BYB3
- Q9UGE5
Protein attributes for CERK Gene
- Size:
- 537 amino acids
- Molecular mass:
- 59977 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
- No Data Available
Protein Expression for CERK Gene
Post-translational modifications for CERK Gene
Other Protein References for CERK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CERK
- Novus Biologicals Antibodies for CERK
- Invitrogen Antibodies for CERK
- GeneTex CERK Antibody for CERK
-
Boster Bio Antibodies for CERK
-
Santa Cruz Biotechnology (SCBT) Antibodies for CERK
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CERK
- Origene Custom Protein Services for CERK
- antibodies-online: Search results for 4 available CERK Proteins ranked by validation data
- Compare Top CERK Proteins
-
Quality Products:
- Search GeneTex for Proteins for CERK
Assay Products
- antibodies-online: Search results for 11 available CERK Elisa Kits ranked by validation data
- Compare Top CERK Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CERK Gene
Domains & Families for CERK Gene
Gene Families for CERK Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for CERK Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CERK Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CERK Gene
Function for CERK Gene
Molecular function for CERK Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + ceramide = ADP + ceramide 1-phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by sulfatide.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Optimum pH is 6.0-7.5.;
Enzyme Numbers (IUBMB) for CERK Gene
Phenotypes From GWAS Catalog for CERK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 10947957 |
| GO:0001729 | ceramide kinase activity | TAS | -- |
| GO:0003951 | NAD+ kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for CERK Gene
- MGI mutant phenotypes for CERK:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CERK:
-
- Decreased telomerase activity
- Increased viability after TNF/CHX stimulation
- Increased cell death HMECs cells
- Decreased ionizing radiation sensitivity
- Decreased viability in esophageal squamous lineage
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Apoptosis resistance
- Increased viability
- Increased transferrin (TF) endocytosis
- Decreased shRNA abundance
Animal Model Products
-
Taconic Biosciences Mouse Models for CERK
- Cyagen custom Knockout/knockin (KOKI) mouse models for CERK
-
CRISPR Products
-
OriGene CRISPR knockouts for CERK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CERK
- genomics-online: gRNA clones - Search results for 108 available CERK gene related products
- Overview of 108 available CERK gene related products
- Applied Biological Materials CRISPR for CERK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CERK
- GenScript: Design CRISPR guide RNA sequences for CERK
miRNA for CERK Gene
- miRTarBase miRNAs that target CERK
-
- hsa-mir-128-3p (MIRT022006)
- hsa-mir-101-3p (MIRT027241)
- hsa-mir-26b-5p (MIRT029316)
- hsa-mir-615-3p (MIRT040252)
- hsa-mir-3614-3p (MIRT088251)
- hsa-mir-6516-5p (MIRT479334)
- hsa-mir-455-3p (MIRT479335)
- hsa-mir-16-1-3p (MIRT479336)
- hsa-mir-503-5p (MIRT479337)
- hsa-mir-144-3p (MIRT479338)
- hsa-mir-541-5p (MIRT479339)
- hsa-mir-3680-3p (MIRT696930)
- hsa-mir-557 (MIRT696931)
- hsa-mir-507 (MIRT696932)
- hsa-mir-450b-5p (MIRT696933)
- hsa-mir-448 (MIRT696934)
- hsa-mir-153-3p (MIRT696935)
- hsa-mir-500a-3p (MIRT696936)
- hsa-mir-19b-2-5p (MIRT696937)
- hsa-mir-19b-1-5p (MIRT696938)
- hsa-mir-19a-5p (MIRT696939)
- hsa-mir-2052 (MIRT696940)
- hsa-mir-6827-5p (MIRT696941)
- hsa-mir-505-5p (MIRT696942)
- hsa-mir-767-5p (MIRT696943)
- hsa-mir-7113-5p (MIRT696944)
- hsa-mir-6754-5p (MIRT696945)
- hsa-mir-4441 (MIRT696946)
- hsa-mir-4270 (MIRT696947)
- hsa-mir-449b-3p (MIRT696948)
- hsa-mir-6753-5p (MIRT696949)
- hsa-mir-5582-3p (MIRT696950)
- hsa-mir-548f-3p (MIRT696951)
- hsa-mir-548e-3p (MIRT696952)
- hsa-mir-548az-3p (MIRT696953)
- hsa-mir-548ar-3p (MIRT696954)
- hsa-mir-548a-3p (MIRT696955)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CERK
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERK
- genomics-online: shRNA clones - Search results for 108 available CERK gene related products
- Overview of 108 available CERK gene related products
Clone Products
- Sino Biological Human cDNA Clone for CERK
- VectorBuilder custom plasmid, inducible vectors for CERK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CERK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CERK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CERK
- Applied Biological Materials Clones for CERK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CERK
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CERK Gene
Localization for CERK Gene
Subcellular locations from UniProtKB/Swiss-Prot for CERK Gene
- Cytoplasm. Membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| mitochondrion | 3 |
| nucleus | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IDA | 11956206 |
Pathways & Interactions for CERK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sphingolipid metabolism | ||
| 2 | Ceramide Pathway |
.32
|
|
| 3 | Metabolism |
.37
|
|
| 4 | Integrated Breast Cancer Pathway | ||
Pathways by source for CERK Gene
2 BioSystems pathways for CERK Gene
4 Reactome pathways for CERK Gene
1 KEGG pathway for CERK Gene
2 Qiagen pathways for CERK Gene
Interacting Proteins for CERK Gene
Selected Interacting proteins:
Q8TCT0-CERK1_HUMAN
ENSP00000216264
for CERK Gene via
IID
STRING
UniProtKB
GPS-Prot Interaction Network for CERK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006672 | ceramide metabolic process | TAS | 11956206 |
| GO:0006687 | glycosphingolipid metabolic process | TAS | -- |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0046834 | lipid phosphorylation | IEA | -- |
No data available for SIGNOR curated interactions for CERK Gene
Drugs & Compounds for CERK Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 | |||
| Magnesium | Approved | Nutra | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 | ||
| NVP 231 | Pharma | CerK inhibitor | 0 | |||
| Necrostatin-1 | Pharma | RIP1 inhibitor, RIPK1 inhibitor; inhibits necroptosis | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
||
| Cer(d18:0/12:0) |
|
|
||||
| Cer(d18:0/14:0) |
|
|
||||
| Cer(d18:0/16:0) |
|
|
||||
| Cer(d18:0/18:0) |
|
|
(5) Tocris Compounds for CERK Gene
| Compound | Action | Cas Number |
|---|---|---|
| MRT 68601 hydrochloride | Potent TBK1 inhibitor | |
| MRT 68921 dihydrochloride | Potent ULK inhibitor; inhibits autophagy | |
| Necrostatin-1 | RIPK1 inhibitor; inhibits necroptosis | 4311-88-0 |
| TNP | Inhibitor of IP6K; also inhibits IP3K | 519178-28-0 |
| XL 413 hydrochloride | Potent and selective Cdc7 inhibitor | 1169562-71-3 |
(1) ApexBio Compounds for CERK Gene
| Compound | Action | Cas Number |
|---|---|---|
| NVP 231 | CerK inhibitor | 362003-83-6 |
Transcripts for CERK Gene
mRNA/cDNA for CERK Gene
- (189) Selected AceView cDNA sequences:
- (16) Additional mRNA sequences :
- (3) REFSEQ mRNAs :
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000216264 4450 bps (uc003bia.4)
- ENST00000443629 1760 bps (uc062fgf.1)
- ENST00000460254 434 bps (uc062fgh.1)
- ENST00000471929 567 bps (uc062fgg.1)
CRISPR Products
-
OriGene CRISPR knockouts for CERK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CERK
- genomics-online: gRNA clones - Search results for 108 available CERK gene related products
- Overview of 108 available CERK gene related products
- Applied Biological Materials CRISPR for CERK
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CERK
- GenScript: Design CRISPR guide RNA sequences for CERK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CERK
- Browse OriGene Inhibitory RNA Products For CERK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERK
- genomics-online: shRNA clones - Search results for 108 available CERK gene related products
- Overview of 108 available CERK gene related products
Clone Products
- Sino Biological Human cDNA Clone for CERK
- VectorBuilder custom plasmid, inducible vectors for CERK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CERK
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CERK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CERK
- Applied Biological Materials Clones for CERK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CERK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Cartilage (Muscoskeletal System)
- Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
- Brain (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
This gene is overexpressed in Urine (41.5) and Lung (24.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CERK Gene
NURSA nuclear receptor signaling pathways regulating expression of CERK Gene:
CERKSOURCE GeneReport for Unigene cluster for CERK Gene:
Hs.200668mRNA Expression by UniProt/SwissProt for CERK Gene:
Q8TCT0-CERK1_HUMAN
Tissue specificity:
High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.
Evidence on tissue expression from TISSUES for CERK Gene
- Nervous system(4.7)
Primer Products
-
OriGene qPCR primer pairs for CERK
- genomics-online: primer clones - Search results for 108 available CERK gene related products
- Overview of 108 available CERK gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CERK Gene
Orthologs for CERK Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CERK 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CERK 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cerk 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cerk 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | CERK 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CERK 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CERK 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CERK 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CERK 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100487080 33 |
|
||
| Str.10087 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9645 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cerk 34 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002932 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Cerk 34 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | T10B11.2 34 33 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | LCB4 34 |
|
ManyToMany | |
| LCB5 34 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G51290 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for CERK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CERK Gene
- ENSEMBL:
- Gene Tree for CERK (if available)
- TreeFam:
- Gene Tree for CERK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CERK: view image
Paralogs for CERK Gene
Variants for CERK Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000033302 | -- | 46,705,994(-) | T/A | intron_variant | |
| rs1000052802 | -- | 46,694,670(-) | T/C | intron_variant | |
| rs1000111192 | -- | 46,706,249(-) | AGA/A | intron_variant | |
| rs1000124360 | -- | 46,688,078(-) | C/T | intron_variant | |
| rs1000150390 | -- | 46,728,761(-) | G/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2469n106 | OTHER | inversion | 24896259 |
| esv2022578 | CNV | deletion | 18987734 |
| esv2673353 | CNV | deletion | 23128226 |
| esv2724451 | CNV | deletion | 23290073 |
| esv2724452 | CNV | deletion | 23290073 |
| esv2724453 | CNV | deletion | 23290073 |
| esv3558271 | CNV | deletion | 23714750 |
| esv3647960 | CNV | loss | 21293372 |
| esv3647961 | CNV | loss | 21293372 |
| esv3647962 | CNV | loss | 21293372 |
| nsv1060721 | CNV | gain | 25217958 |
| nsv1122058 | CNV | deletion | 24896259 |
| nsv1123607 | CNV | deletion | 24896259 |
| nsv1152661 | OTHER | inversion | 26484159 |
| nsv191421 | CNV | deletion | 16902084 |
| nsv589137 | CNV | gain | 21841781 |
| nsv829281 | CNV | gain | 20364138 |
| nsv829293 | CNV | gain | 20364138 |
| nsv834227 | CNV | loss | 17160897 |
| nsv955179 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.08;
60.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CERK Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERK Gene
Disorders for CERK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 26 |
|
|
| retinitis pigmentosa |
|
Search CERK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CERK
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CERK Gene
Publications for CERK Gene
- A lipid binding domain in sphingosine kinase 2. (PMID: 19168031) Don AS … Rosen H (Biochemical and biophysical research communications 2009) 2 3 4 22 58
- The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity. (PMID: 16081073) Kim TJ … Igarashi Y (FEBS letters 2005) 3 4 22 58
- Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. (PMID: 11956206) Sugiura M … Kohama T (The Journal of biological chemistry 2002) 2 3 4 58
- Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
Products for CERK Gene
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- Custom Antibody ServicesOriGene Antibodies for CERK
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- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CERK
- Sino Biological Human cDNA Clone for CERK
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CERK
- Novus Biologicals proteins and lysates for CERK
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for CERK
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CERK
- ApexBio compounds for CERK
- Cyagen custom Knockout/knockin (KOKI) mouse models for CERK
- VectorBuilder custom plasmid, inducible vectors for CERK
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CERK
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CERK
- antibodies-online: Search results for 86 available CERK Antibodies ranked by validation data
- Compare Top CERK Antibodies
- antibodies-online: Search results for 11 available CERK Elisa Kits ranked by validation data
- Compare Top CERK Elisa Kits
- Quality Products:
- antibodies-online: Search results for 4 available CERK Proteins ranked by validation data
- Compare Top CERK Proteins
- Quality Products:
- GeneTex CERK Antibody for CERK
- Search GeneTex for Proteins for CERK
- Santa Cruz Biotechnology (SCBT) Antibodies for CERK
- Search Santa Cruz Biotechnology (SCBT) for CERK siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CERK
- Horizon Cell Lines for CERK
- genomics-online: cdna clones - Search results for 108 available CERK gene related products
- Overview of 108 available CERK gene related products
- orf clones - Search results for 108 available CERK gene related products
- Overview of 108 available CERK gene related products
- genomics-online: gRNA clones - Search results for 108 available CERK gene related products
- Overview of 108 available CERK gene related products
- genomics-online: primer clones - Search results for 108 available CERK gene related products
- Overview of 108 available CERK gene related products
- genomics-online: shRNA clones - Search results for 108 available CERK gene related products
- Overview of 108 available CERK gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CERK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CERK
- GeneCopoeia miRNA 3'UTR Target clone products for CERK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERK
- Boster Bio Antibodies for CERK
- Browse Boster Bio ELISA Kits
Sources for CERK Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio