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CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008] See more...
Aliases for CERK Gene
Aliases for CERK Gene
External Ids for CERK Gene
- HGNC: 19256
- NCBI Entrez Gene: 64781
- Ensembl: ENSG00000100422
- OMIM®: 610307
- UniProtKB/Swiss-Prot: Q8TCT0
Previous GeneCards Identifiers for CERK Gene
- GC22M043648
- GC22M045292
- GC22M045400
- GC22M047080
- GC22M030025
Summaries for CERK Gene
-
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CERK Gene
CERK (Ceramide Kinase) is a Protein Coding gene. Diseases associated with CERK include Retinitis Pigmentosa 26 and Cochlear Disease. Among its related pathways are Sphingolipid metabolism and Ceramide Pathway. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and diacylglycerol kinase activity. An important paralog of this gene is CERKL.
UniProtKB/Swiss-Prot Summary for CERK Gene
-
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:19168031). Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826). Binds phosphoinositides (PubMed:19168031).
Additional gene information for CERK Gene
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CERK Gene
Genomics for CERK Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CERK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CERK on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CERK
- Top Transcription factor binding sites by QIAGEN in the CERK gene promoter:
-
- AP-1
- ATF-2
- c-Fos
- c-Jun
- GATA-1
- Nkx2-5
- Pax-5
Genomic Locations for CERK Gene
Latest Assembly
- chr22:46,684,410-46,738,252
- (GRCh38/hg38)
- Size:
- 53,843 bases
- Orientation:
- Minus strand
Previous Assembly
- chr22:47,080,307-47,134,149
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 53,843 bases
- Orientation:
- Minus strand
Genomic View for CERK Gene
Genes around CERK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.31 by HGNC
- 22q13.31 by Entrez Gene
- 22q13.31 by Ensembl
CERK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CERK Gene
Proteins for CERK Gene
-
Protein details for CERK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TCT0-CERK1_HUMAN
- Recommended name:
- Ceramide kinase
- Protein Accession:
- Q8TCT0
- A0JNT4
- A8K611
- Q6NX59
- Q9BYB3
- Q9UGE5
Protein attributes for CERK Gene
- Size:
- 537 amino acids
- Molecular mass:
- 59977 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
- No Data Available
Protein Expression for CERK Gene
Post-translational modifications for CERK Gene
Other Protein References for CERK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences Ceramide Kinase / CERK Antibody (LS-A3369) and Ceramide Kinase / CERK Antibody (LS-A4556)
- GeneTex Anti-CERK antibody
-
Custom Antibody ServicesOriGene Antibodies for CERK
- Novus Biologicals Antibodies for CERK
-
Abcam antibodies for CERK
- Invitrogen Antibodies for CERK (AFLGC-CERK)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CERK
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CERK
- Origene Custom Protein Services for CERK
- Novus Biologicals proteins for CERK
- antibodies-online: Show 4 available CERK Proteins ranked by validation data
- Compare Top CERK Proteins
-
Quality Products:
-
Abcam proteins for CERK
Assay products for research
- antibodies-online: Show 14 available CERK Elisa Kits ranked by validation data
- Compare Top CERK Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CERK Gene
Domains & Families for CERK Gene
Gene Families for CERK Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for CERK Gene
- InterPro:
- Blocks:
-
- Pleckstrin-like
Suggested Antigen Peptide Sequences for CERK Gene
- GenScript: Design optimal peptide antigens:
-
- Lipid kinase 4 (CERK1_HUMAN)
- CERK protein (Q6I9Z0_HUMAN)
- Ceramide kinase (Q9H5N7_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CERK Gene
Function for CERK Gene
Molecular function for CERK Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:19168031). Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826). Binds phosphoinositides (PubMed:19168031).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+); Xref=Rhea:RHEA:17929, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52639, ChEBI:CHEBI:57674, ChEBI:CHEBI:456216; EC=2.7.1.138; Evidence={ECO:0000269|PubMed:11956206, ECO:0000269|PubMed:16269826, ECO:0000269|PubMed:19168031};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + N-(hexanoyl)sphing-4-enine = ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate; Xref=Rhea:RHEA:43312, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:63867, ChEBI:CHEBI:82959, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:16269826};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + N-(acetyl)-sphing-4-enine = ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate; Xref=Rhea:RHEA:47904, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46979, ChEBI:CHEBI:85375, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:16269826};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + N-hexadecanoylsphing-4-enine = ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate; Xref=Rhea:RHEA:46340, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:72959, ChEBI:CHEBI:72963, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:16269826};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + N-hexanoyl-(4R)-hydroxysphinganine = ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate; Xref=Rhea:RHEA:47916, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:88095, ChEBI:CHEBI:88096, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:16269826};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=187 uM for C8 ceramide {ECO:0000269|PubMed:11956206}; KM=30 uM for C6 ceramide {ECO:0000269|PubMed:16269826}; KM=22 uM for C2 ceramide {ECO:0000269|PubMed:16269826}; KM=400 uM for ATP (in the presence of 3 mM Mg(2+)) {ECO:0000269|PubMed:16269826}; KM=32 uM for ATP {ECO:0000269|PubMed:11956206}; Vmax=35 nmol/min/mg enzyme for C6 ceramide {ECO:0000269|PubMed:16269826}; pH dependence: Optimum pH is 6.0-7.8. {ECO:0000269|PubMed:11956206, ECO:0000269|PubMed:16269826};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by sulfatide (PubMed:19168031). Inhibited by sphinganine, sphingenine, and N,N-Dimethylsphingosine (DMS) (PubMed:16269826). Cardiolipin at 0.1 uM significantly increases activity, whereas at concentrations >1 uM has an inhibitory effect (PubMed:27725450).
Enzyme Numbers (IUBMB) for CERK Gene
Phenotypes From GWAS Catalog for CERK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IDA | 10947957 |
| GO:0001727 | lipid kinase activity | IBA | 21873635 |
| GO:0001729 | ceramide kinase activity | TAS | -- |
| GO:0003951 | NAD+ kinase activity | IEA | -- |
Phenotypes for CERK Gene
- MGI mutant phenotypes for CERK:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CERK:
-
- Increased vaccinia virus (VACV) infection
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased shRNA abundance
- no effect
- Decreased ionizing radiation sensitivity
- Increased cell death HMECs cells
- Decreased viability in ovarian lineage
- Increased viability
- Increased apoptosis
- Increased cell death in HCC-1954 cells
- Decreased viability
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
- Decreased viability after TNF/CHX stimulation
- Increased telomerase activity
Animal Models for research
-
Taconic Biosciences Mouse Models for CERK
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CERK - Starting at $85 >
- * CERK CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CERK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CERK
-
Santa Cruz Biotechnology (SCBT) CRISPR for CERK
miRNA for CERK Gene
- miRTarBase miRNAs that target CERK
-
- mmu-miR-124-3p (MIRT015672)
- hsa-miR-128-3p (MIRT022006)
- hsa-miR-101-3p (MIRT027241)
- hsa-miR-26b-5p (MIRT029316)
- hsa-miR-615-3p (MIRT040252)
- hsa-miR-3614-3p (MIRT088251)
- hsa-miR-6516-5p (MIRT479334)
- hsa-miR-455-3p (MIRT479335)
- hsa-miR-16-1-3p (MIRT479336)
- hsa-miR-503-5p (MIRT479337)
- hsa-miR-144-3p (MIRT479338)
- hsa-miR-541-5p (MIRT479339)
- hsa-miR-3680-3p (MIRT696930)
- hsa-miR-557 (MIRT696931)
- hsa-miR-507 (MIRT696932)
- hsa-miR-450b-5p (MIRT696933)
- hsa-miR-448 (MIRT696934)
- hsa-miR-153-3p (MIRT696935)
- hsa-miR-500a-3p (MIRT696936)
- hsa-miR-19b-2-5p (MIRT696937)
- hsa-miR-19b-1-5p (MIRT696938)
- hsa-miR-19a-5p (MIRT696939)
- hsa-miR-2052 (MIRT696940)
- hsa-miR-6827-5p (MIRT696941)
- hsa-miR-505-5p (MIRT696942)
- hsa-miR-767-5p (MIRT696943)
- hsa-miR-7113-5p (MIRT696944)
- hsa-miR-6754-5p (MIRT696945)
- hsa-miR-4441 (MIRT696946)
- hsa-miR-4270 (MIRT696947)
- hsa-miR-449b-3p (MIRT696948)
- hsa-miR-6753-5p (MIRT696949)
- hsa-miR-5582-3p (MIRT696950)
- hsa-miR-548f-3p (MIRT696951)
- hsa-miR-548e-3p (MIRT696952)
- hsa-miR-548az-3p (MIRT696953)
- hsa-miR-548ar-3p (MIRT696954)
- hsa-miR-548a-3p (MIRT696955)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CERK
- Browse OriGene Inhibitory RNA Products For CERK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERK
Clone products for research
- Applied Biological Materials (abm): Clones for CERK - Starting at $45 >
- * CERK as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CERK
- Addgene plasmids for CERK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CERK
Cell Lines for research
-
Horizon Cell Lines for CERK
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CERK Gene
Localization for CERK Gene
Subcellular locations from UniProtKB/Swiss-Prot for CERK Gene
- Cytoplasm. Cell membrane. Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 3 |
| extracellular | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endosome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IDA | 11956206 |
Pathways & Interactions for CERK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sphingolipid metabolism | ||
| 2 | Ceramide Pathway |
Ceramide Pathway
.32
|
TNF-Induced Apoptosis Implicating Sphingolipids
.32
|
| 3 | Metabolism |
.40
|
|
| 4 | Integrated Breast Cancer Pathway | ||
Pathways by source for CERK Gene
2 BioSystems pathways for CERK Gene
4 Reactome pathways for CERK Gene
1 KEGG pathway for CERK Gene
2 Qiagen pathways for CERK Gene
- Ceramide Pathway
- TNF-Induced Apoptosis Implicating Sphingolipids
Interacting Proteins for CERK Gene
Selected Interacting proteins:
Q8TCT0-CERK1_HUMAN
ENSP00000216264
for CERK Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CERK
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006665 | sphingolipid metabolic process | IBA | 21873635 |
| GO:0006672 | ceramide metabolic process | IBA,TAS | 11956206 |
| GO:0006687 | glycosphingolipid metabolic process | TAS | -- |
| GO:0016310 | phosphorylation | IEA,IBA | 21873635 |
| GO:0046834 | lipid phosphorylation | IEA | -- |
No data available for SIGNOR curated interactions for CERK Gene
Drugs & Compounds for CERK Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
58-64-0 |
|
|||
| Cer(d18:0/12:0) |
|
|
||||
| Cer(d18:0/14:0) |
|
67030-48-2 |
|
|||
| Cer(d18:0/16:0) |
|
5966-29-0 |
|
|||
| Cer(d18:0/18:1(11Z)) |
|
|
(5) Tocris Compounds for CERK Gene
| Compound | Action | Cas Number |
|---|---|---|
| MRT 68601 hydrochloride | Potent TBK1 inhibitor | |
| MRT 68921 dihydrochloride | Potent ULK inhibitor; inhibits autophagy | |
| Necrostatin-1 | RIPK1 inhibitor; inhibits necroptosis | 4311-88-0 |
| TNP | Inhibitor of IP6K; also inhibits IP3K | 519178-28-0 |
| XL 413 hydrochloride | Potent and selective Cdc7 inhibitor | 1169562-71-3 |
(1) ApexBio Compounds for CERK Gene
| Compound | Action | Cas Number |
|---|---|---|
| NVP 231 | CerK inhibitor | 362003-83-6 |
Transcripts for CERK Gene
mRNA/cDNA for CERK Gene
- 2 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000216264 4442 nts (view in UCSC)
- ENST00000443629 1760 nts (view in UCSC)
- ENST00000460254 434 nts (view in UCSC)
- ENST00000471929 567 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CERK - Starting at $85 >
- * CERK CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CERK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CERK
-
Santa Cruz Biotechnology (SCBT) CRISPR for CERK
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CERK
- Browse OriGene Inhibitory RNA Products For CERK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERK
Clone products for research
- Applied Biological Materials (abm): Clones for CERK - Starting at $45 >
- * CERK as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CERK
- Addgene plasmids for CERK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CERK
Relevant External Links for CERK Gene
- GeneLoc Exon Structure for
- CERK
Expression for CERK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Cartilage (Muscoskeletal System)
- Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
- Brain (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
This gene is overexpressed in Urine (41.5) and Lung (24.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CERK Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CERK
SOURCE GeneReport for Unigene cluster for CERK Gene:
Hs.200668mRNA Expression by UniProt/SwissProt for CERK Gene:
Q8TCT0-CERK1_HUMAN
Tissue specificity:
High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.
Evidence on tissue expression from TISSUES for CERK Gene
- Nervous system(4.8)
- Heart(2.4)
- Muscle(2.3)
- Kidney(2.1)
- Intestine(2.1)
- Blood(2.1)
Primer products for research
-
OriGene qPCR primer pairs for CERK
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CERK Gene
Orthologs for CERK Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CERK 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CERK 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cerk 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cerk 29 16 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CERK 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CERK 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CERK 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CERK 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CERK 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100487080 29 |
|
||
| Str.10087 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9645 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cerk 29 30 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002932 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cerk 29 30 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | T10B11.2 29 30 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | LCB4 30 |
|
ManyToMany | |
| LCB5 30 |
|
ManyToMany | |||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G51290 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToOne |
- Species where no ortholog for CERK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CERK Gene
- ENSEMBL:
- Gene Tree for CERK (if available)
- TreeFam:
- Gene Tree for CERK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CERK: view image
- Alliance of Genome Resources:
- Additional Orthologs for CERK
Paralogs for CERK Gene
Variants for CERK Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CERK Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs148876291 | Benign: not provided | 46,690,151(-) |
G/A NM_022766.6(CERK):c.1382C>T (p.Thr461Met) |
MISSENSE | |
| rs34110809 | Benign: not provided | 46,690,006(-) |
A/T NM_022766.6(CERK):c.1527T>A (p.Pro509=) |
SYNONYMOUS | |
| rs9627541 | Benign: not provided | 46,720,126(-) |
G/A NM_022766.6(CERK):c.339C>T (p.His113=) |
SYNONYMOUS | |
| rs13057352 | -- |
p.Leu306Phe |
|||
| rs16995615 | -- |
p.Ile191Val |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2469n106 | OTHER | inversion | 24896259 |
| esv2022578 | CNV | deletion | 18987734 |
| esv2673353 | CNV | deletion | 23128226 |
| esv2724451 | CNV | deletion | 23290073 |
| esv2724452 | CNV | deletion | 23290073 |
| esv2724453 | CNV | deletion | 23290073 |
| esv3558271 | CNV | deletion | 23714750 |
| esv3647960 | CNV | loss | 21293372 |
| esv3647961 | CNV | loss | 21293372 |
| esv3647962 | CNV | loss | 21293372 |
| nsv1060721 | CNV | gain | 25217958 |
| nsv1122058 | CNV | deletion | 24896259 |
| nsv1123607 | CNV | deletion | 24896259 |
| nsv1152661 | OTHER | inversion | 26484159 |
| nsv191421 | CNV | deletion | 16902084 |
| nsv589137 | CNV | gain | 21841781 |
| nsv829281 | CNV | gain | 20364138 |
| nsv829293 | CNV | gain | 20364138 |
| nsv834227 | CNV | loss | 17160897 |
| nsv955179 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.08;
60.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CERK Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERK Gene
Disorders for CERK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 26 |
|
|
| cochlear disease |
|
|
| breast fibrosarcoma |
|
|
| hereditary sensory and autonomic neuropathy type 1 |
|
|
| retinitis pigmentosa |
|
|
Search CERK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CERK
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
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- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CERK Gene
Publications for CERK Gene
- A lipid binding domain in sphingosine kinase 2. (PMID: 19168031) Don AS … Rosen H (Biochemical and biophysical research communications 2009) 2 3 4 22
- Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies. (PMID: 16269826) Van Overloop H … Van Veldhoven PP (Journal of lipid research 2006) 3 4 22
- The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity. (PMID: 16081073) Kim TJ … Igarashi Y (FEBS letters 2005) 3 4 22
- Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. (PMID: 11956206) Sugiura M … Kohama T (The Journal of biological chemistry 2002) 2 3 4
- Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4
ExternalLinks
Products for CERK Gene
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Sources for CERK Gene
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