Aliases for CERK Gene
External Ids for CERK Gene
Previous GeneCards Identifiers for CERK Gene
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CERK Gene
CERK (Ceramide Kinase) is a Protein Coding gene. Diseases associated with CERK include Retinitis Pigmentosa 26 and Cochlear Disease. Among its related pathways are Sphingolipid metabolism and Ceramide Pathway. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and diacylglycerol kinase activity. An important paralog of this gene is CERKL.
UniProtKB/Swiss-Prot Summary for CERK Gene
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:19168031). Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826). Binds phosphoinositides (PubMed:19168031).