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CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
CERK (Ceramide Kinase) is a Protein Coding gene. Diseases associated with CERK include Retinitis Pigmentosa 26 and Cochlear Disease. Among its related pathways are Ceramide Pathway and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and diacylglycerol kinase activity. An important paralog of this gene is CERKL.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IDA | 10947957 |
GO:0001727 | lipid kinase activity | IBA | 21873635 |
GO:0001729 | ceramide kinase activity | TAS | -- |
GO:0003951 | NAD+ kinase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IDA | 11956206 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Sphingolipid metabolism | ||
2 | Ceramide Pathway |
Ceramide Pathway
.32
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TNF-Induced Apoptosis Implicating Sphingolipids
.32
|
3 | Metabolism |
.40
|
|
4 | Integrated Breast Cancer Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006665 | sphingolipid metabolic process | IBA | 21873635 |
GO:0006672 | ceramide metabolic process | TAS | 11956206 |
GO:0006687 | glycosphingolipid metabolic process | TAS | -- |
GO:0016310 | phosphorylation | IEA,IBA | 21873635 |
GO:0046834 | lipid phosphorylation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
NVP 231 | Pharma | CerK inhibitor | 0 | |||
Calcium | Nutra | 6556 | ||||
Necrostatin-1 | Pharma | RIP1 inhibitor, RIPK1 inhibitor; inhibits necroptosis | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
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Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
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Cer(d18:0/12:0) |
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Cer(d18:0/14:0) |
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Cer(d18:0/16:0) |
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Cer(d18:0/18:0) |
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Compound | Action | Cas Number |
---|---|---|
MRT 68601 hydrochloride | Potent TBK1 inhibitor | |
MRT 68921 dihydrochloride | Potent ULK inhibitor; inhibits autophagy | |
Necrostatin-1 | RIPK1 inhibitor; inhibits necroptosis | 4311-88-0 |
TNP | Inhibitor of IP6K; also inhibits IP3K | 519178-28-0 |
XL 413 hydrochloride | Potent and selective Cdc7 inhibitor | 1169562-71-3 |
Compound | Action | Cas Number |
---|---|---|
NVP 231 | CerK inhibitor | 362003-83-6 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CERK 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CERK 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cerk 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cerk 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CERK 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CERK 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CERK 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CERK 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CERK 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100487080 30 |
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Str.10087 30 |
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African clawed frog (Xenopus laevis) |
Amphibia | Xl.9645 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | cerk 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002932 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Cerk 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | T10B11.2 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | LCB4 31 |
|
ManyToMany | |
LCB5 31 |
|
ManyToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G51290 30 |
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Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
731194 | Benign: not provided | 46,690,151(-) | G/A | MISSENSE_VARIANT | |
777761 | Benign: not provided | 46,690,006(-) | A/T | SYNONYMOUS_VARIANT | |
787511 | Benign: not provided | 46,720,126(-) | G/A | SYNONYMOUS_VARIANT | |
rs13057352 | - | p.Leu306Phe | |||
rs16995615 | - | p.Ile191Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2469n106 | OTHER | inversion | 24896259 |
esv2022578 | CNV | deletion | 18987734 |
esv2673353 | CNV | deletion | 23128226 |
esv2724451 | CNV | deletion | 23290073 |
esv2724452 | CNV | deletion | 23290073 |
esv2724453 | CNV | deletion | 23290073 |
esv3558271 | CNV | deletion | 23714750 |
esv3647960 | CNV | loss | 21293372 |
esv3647961 | CNV | loss | 21293372 |
esv3647962 | CNV | loss | 21293372 |
nsv1060721 | CNV | gain | 25217958 |
nsv1122058 | CNV | deletion | 24896259 |
nsv1123607 | CNV | deletion | 24896259 |
nsv1152661 | OTHER | inversion | 26484159 |
nsv191421 | CNV | deletion | 16902084 |
nsv589137 | CNV | gain | 21841781 |
nsv829281 | CNV | gain | 20364138 |
nsv829293 | CNV | gain | 20364138 |
nsv834227 | CNV | loss | 17160897 |
nsv955179 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
retinitis pigmentosa 26 |
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cochlear disease |
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breast fibrosarcoma |
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hereditary sensory and autonomic neuropathy type 1 |
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retinitis pigmentosa |
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