Aliases for CERCAM Gene

Aliases for CERCAM Gene

  • Cerebral Endothelial Cell Adhesion Molecule 2 3 4 5
  • GLT25D3 2 3 4
  • Inactive Glycosyltransferase 25 Family Member 3 3 4
  • Glycosyltransferase 25 Domain Containing 3 2 3
  • Cerebral Cell Adhesion Molecule 2 3
  • CEECAM1 3 4
  • Probable Inactive Glycosyltransferase 25 Family Member 3 3
  • Cerebral Endothelial Cell Adhesion Molecule 1 3
  • Glycosyltransferase 25 Family Member 3 3
  • KIAA1502 4
  • CERCAM 5

External Ids for CERCAM Gene

Previous HGNC Symbols for CERCAM Gene

  • CEECAM1

Previous GeneCards Identifiers for CERCAM Gene

  • GC09P130214
  • GC09P131174
  • GC09P100795
  • GC09P128411

Summaries for CERCAM Gene

GeneCards Summary for CERCAM Gene

CERCAM (Cerebral Endothelial Cell Adhesion Molecule) is a Protein Coding gene. An important paralog of this gene is COLGALT1.

UniProtKB/Swiss-Prot Summary for CERCAM Gene

  • Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CERCAM Gene

Genomics for CERCAM Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CERCAM Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CERCAM on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CERCAM

Top Transcription factor binding sites by QIAGEN in the CERCAM gene promoter:
  • AML1a
  • c-Myb
  • Cart-1
  • GR
  • MyoD
  • Pax-5
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for CERCAM Gene

Latest Assembly
chr9:128,405,994-128,437,351
(GRCh38/hg38)
Size:
31,358 bases
Orientation:
Plus strand

Previous Assembly
chr9:131,181,439-131,199,630
(GRCh37/hg19 by Entrez Gene)
Size:
18,192 bases
Orientation:
Plus strand

chr9:131,174,030-131,199,626
(GRCh37/hg19 by Ensembl)
Size:
25,597 bases
Orientation:
Plus strand

Genomic View for CERCAM Gene

Genes around CERCAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERCAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERCAM Gene

Proteins for CERCAM Gene

  • Protein details for CERCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4B2-GT253_HUMAN
    Recommended name:
    Inactive glycosyltransferase 25 family member 3
    Protein Accession:
    Q5T4B2
    Secondary Accessions:
    • A7MD00
    • C4AMA2
    • Q0VDF3
    • Q2VPJ4
    • Q4KMP2
    • Q5T4B1
    • Q8N107
    • Q96EZ5
    • Q9P226
    • Q9UMW5

    Protein attributes for CERCAM Gene

    Size:
    595 amino acids
    Molecular mass:
    67592 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH98432.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI19699.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI19700.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96026.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11040.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CERCAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CERCAM Gene

Post-translational modifications for CERCAM Gene

  • Glycosylation at Asn75, Asn153, Asn237, and Asn360
  • Ubiquitination at Lys386 and Lys570
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CERCAM Gene

Domains & Families for CERCAM Gene

Gene Families for CERCAM Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CERCAM Gene

Suggested Antigen Peptide Sequences for CERCAM Gene

GenScript: Design optimal peptide antigens:
  • Cerebral endothelial cell adhesion molecule (GT253_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T4B2

UniProtKB/Swiss-Prot:

GT253_HUMAN :
  • Belongs to the glycosyltransferase 25 family.
Family:
  • Belongs to the glycosyltransferase 25 family.
genes like me logo Genes that share domains with CERCAM: view

Function for CERCAM Gene

Molecular function for CERCAM Gene

UniProtKB/Swiss-Prot Function:
Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro.

Phenotypes From GWAS Catalog for CERCAM Gene

Gene Ontology (GO) - Molecular Function for CERCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0042802 identical protein binding IPI 32296183
GO:0050211 NOT procollagen galactosyltransferase activity IBA 21873635
genes like me logo Genes that share ontologies with CERCAM: view
genes like me logo Genes that share phenotypes with CERCAM: view

miRNA for CERCAM Gene

miRTarBase miRNAs that target CERCAM

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERCAM

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CERCAM Gene

Localization for CERCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERCAM Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CERCAM gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 4
extracellular 2
nucleus 2
mitochondrion 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CERCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005886 plasma membrane NAS 10608765
genes like me logo Genes that share ontologies with CERCAM: view

Pathways & Interactions for CERCAM Gene

PathCards logo

SuperPathways for CERCAM Gene

No Data Available

Gene Ontology (GO) - Biological Process for CERCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IDA 10608765
GO:0007159 leukocyte cell-cell adhesion TAS 10608765
GO:0018215 protein phosphopantetheinylation IEA --
genes like me logo Genes that share ontologies with CERCAM: view

No data available for Pathways by source and SIGNOR curated interactions for CERCAM Gene

Drugs & Compounds for CERCAM Gene

No Compound Related Data Available

Transcripts for CERCAM Gene

mRNA/cDNA for CERCAM Gene

2 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERCAM

Alternative Splicing Database (ASD) splice patterns (SP) for CERCAM Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - - - - -
SP6: - - - -
SP7: -
SP8: - - - - - - - - -
SP9: - -
SP10: - -
SP11: - - - - - - - - -
SP12: -

ExUns: 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CERCAM Gene

GeneLoc Exon Structure for
CERCAM

Expression for CERCAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CERCAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CERCAM Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.3), Brain - Putamen (basal ganglia) (x5.0), Brain - Substantia nigra (x4.7), and Brain - Hippocampus (x4.5).

Protein differential expression in normal tissues from HIPED for CERCAM Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CERCAM Gene



Protein tissue co-expression partners for CERCAM Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CERCAM

SOURCE GeneReport for Unigene cluster for CERCAM Gene:

Hs.495230

mRNA Expression by UniProt/SwissProt for CERCAM Gene:

Q5T4B2-GT253_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in secretory and nervous tissues.

Evidence on tissue expression from TISSUES for CERCAM Gene

  • Nervous system(4.9)
  • Muscle(4.2)
  • Pancreas(2.9)
genes like me logo Genes that share expression patterns with CERCAM: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CERCAM Gene

Orthologs for CERCAM Gene

This gene was present in the common ancestor of animals.

Orthologs for CERCAM Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CERCAM 29 30
  • 99.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CERCAM 29 30
  • 89.04 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CERCAM 29 30
  • 88.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cercam 29
  • 83.69 (n)
Mouse
(Mus musculus)
Mammalia Cercam 29 16 30
  • 82.73 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CERCAM 30
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CERCAM 30
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CERCAM 29 30
  • 72.15 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 67 (a)
ManyToMany
-- 30
  • 43 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100488028 29
  • 63.3 (n)
Zebrafish
(Danio rerio)
Actinopterygii cercam 29 30
  • 65.31 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG31915 30
  • 38 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea D2045.9 30
  • 31 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 44 (a)
OneToMany
Species where no ortholog for CERCAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CERCAM Gene

ENSEMBL:
Gene Tree for CERCAM (if available)
TreeFam:
Gene Tree for CERCAM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CERCAM: view image
Alliance of Genome Resources:
Additional Orthologs for CERCAM

Paralogs for CERCAM Gene

Paralogs for CERCAM Gene

(4) SIMAP similar genes for CERCAM Gene using alignment to 4 proteins:

  • GT253_HUMAN
  • B7ZBS8_HUMAN
  • B7ZBS9_HUMAN
  • B7ZBT0_HUMAN
genes like me logo Genes that share paralogs with CERCAM: view

Variants for CERCAM Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CERCAM Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CERCAM Gene

Variant ID Type Subtype PubMed ID
dgv1378e199 CNV deletion 23128226
esv3621807 CNV loss 21293372
esv3621808 CNV loss 21293372
nsv1132226 CNV deletion 24896259
nsv951774 CNV deletion 24416366

Variation tolerance for CERCAM Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CERCAM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CERCAM
Leiden Open Variation Database (LOVD)
CERCAM

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CERCAM Gene

Disorders for CERCAM Gene

Additional Disease Information for CERCAM

No disorders were found for CERCAM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERCAM Gene

Publications for CERCAM Gene

  1. Cerebral cell adhesion molecule: a novel leukocyte adhesion determinant on blood-brain barrier capillary endothelium. (PMID: 10608765) Starzyk RM … Tuomanen EI (The Journal of infectious diseases 2000) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. (PMID: 28986522) Antoniali G … Tell G (Nature communications 2017) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for CERCAM Gene

Sources for CERCAM Gene