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Aliases for CERCAM Gene

Aliases for CERCAM Gene

  • Cerebral Endothelial Cell Adhesion Molecule 2 3 4 5
  • Glycosyltransferase 25 Domain Containing 3 2 3
  • Cerebral Cell Adhesion Molecule 2 3
  • CEECAM1 3 4
  • GLT25D3 3 4
  • Probable Inactive Glycosyltransferase 25 Family Member 3 3
  • Inactive Glycosyltransferase 25 Family Member 3 3
  • Cerebral Endothelial Cell Adhesion Molecule 1 3
  • Glycosyltransferase 25 Family Member 3 3
  • KIAA1502 4

External Ids for CERCAM Gene

Previous HGNC Symbols for CERCAM Gene

  • CEECAM1

Previous GeneCards Identifiers for CERCAM Gene

  • GC09P130214
  • GC09P131174
  • GC09P100795

Summaries for CERCAM Gene

GeneCards Summary for CERCAM Gene

CERCAM (Cerebral Endothelial Cell Adhesion Molecule) is a Protein Coding gene. An important paralog of this gene is COLGALT1.

UniProtKB/Swiss-Prot for CERCAM Gene

  • Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro.

Additional gene information for CERCAM Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERCAM Gene

Genomics for CERCAM Gene

GeneHancer (GH) Regulatory Elements for CERCAM Gene

Promoters and enhancers for CERCAM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J128419 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 663.8 +9.1 9141 3.2 HDGF CLOCK ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 E2F8 ZNF207 CERCAM LOC101929314 ENSG00000273186 URM1 ZNF79 NUP188 CIZ1 ENSG00000272696 LOC101929270 CDK9
GH09J128411 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 650.7 +0.2 246 1.6 ELF3 CTCF SIN3A RAD21 CC2D1A POLR2A ARID2 ZNF143 SMC3 ZSCAN29 CERCAM NAIF1 NUP188 ODF2 FAM102A ZNF79 SNORA65 TOR2A SLC25A25 DNM1
GH09J128410 Enhancer 0.6 dbSUPER 650.7 -1.7 -1734 0.7 SMARCA5 BCOR CTCF ZMYM3 REST RAD21 SMC3 KDM1A ZBTB33 EZH2 CERCAM ENSG00000207955
GH09J128770 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13 +360.0 360040 2.7 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC ZC3H11A ZER1 NUP188 CDK9 LOC101929314 ENSG00000272696 ENSG00000272593 SPOUT1 GLE1 SPTAN1 CERCAM
GH09J129136 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.7 +728.9 728919 8.2 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A FEZF1 YBX1 ZNF2 PTPA CRAT NUP188 GLE1 ENSG00000268707 URM1 TOR1B CIZ1 PKN3 CERCAM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CERCAM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CERCAM gene promoter:

Genomic Locations for CERCAM Gene

Genomic Locations for CERCAM Gene
chr9:128,411,575-128,437,351
(GRCh38/hg38)
Size:
25,777 bases
Orientation:
Plus strand
chr9:131,174,030-131,199,630
(GRCh37/hg19)

Genomic View for CERCAM Gene

Genes around CERCAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERCAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERCAM Gene

Proteins for CERCAM Gene

  • Protein details for CERCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4B2-GT253_HUMAN
    Recommended name:
    Inactive glycosyltransferase 25 family member 3
    Protein Accession:
    Q5T4B2
    Secondary Accessions:
    • A7MD00
    • C4AMA2
    • Q0VDF3
    • Q2VPJ4
    • Q4KMP2
    • Q5T4B1
    • Q8N107
    • Q96EZ5
    • Q9P226
    • Q9UMW5

    Protein attributes for CERCAM Gene

    Size:
    595 amino acids
    Molecular mass:
    67592 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH98432.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI19699.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI19700.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96026.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11040.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13495.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CERCAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CERCAM Gene

Post-translational modifications for CERCAM Gene

  • Glycosylation at posLast=360360, posLast=237237, Asn153, and posLast=7575
  • Ubiquitination at Lys570 and posLast=386386
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CERCAM Gene

Domains & Families for CERCAM Gene

Gene Families for CERCAM Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CERCAM Gene

Suggested Antigen Peptide Sequences for CERCAM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T4B2

UniProtKB/Swiss-Prot:

GT253_HUMAN :
  • Belongs to the glycosyltransferase 25 family.
Family:
  • Belongs to the glycosyltransferase 25 family.
genes like me logo Genes that share domains with CERCAM: view

Function for CERCAM Gene

Molecular function for CERCAM Gene

UniProtKB/Swiss-Prot Function:
Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro.

Phenotypes From GWAS Catalog for CERCAM Gene

genes like me logo Genes that share phenotypes with CERCAM: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERCAM

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CERCAM Gene

Localization for CERCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERCAM Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CERCAM gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 4
extracellular 2
nucleus 2
mitochondrion 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CERCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005886 plasma membrane NAS 10608765
genes like me logo Genes that share ontologies with CERCAM: view

Pathways & Interactions for CERCAM Gene

SuperPathways for CERCAM Gene

No Data Available

Gene Ontology (GO) - Biological Process for CERCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IDA 10608765
GO:0007159 leukocyte cell-cell adhesion TAS 10608765
genes like me logo Genes that share ontologies with CERCAM: view

No data available for Pathways by source and SIGNOR curated interactions for CERCAM Gene

Drugs & Compounds for CERCAM Gene

No Compound Related Data Available

Transcripts for CERCAM Gene

Unigene Clusters for CERCAM Gene

Cerebral endothelial cell adhesion molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CERCAM

Alternative Splicing Database (ASD) splice patterns (SP) for CERCAM Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - - - - -
SP6: - - - -
SP7: -
SP8: - - - - - - - - -
SP9: - -
SP10: - -
SP11: - - - - - - - - -
SP12: -

ExUns: 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CERCAM Gene

GeneLoc Exon Structure for
CERCAM
ECgene alternative splicing isoforms for
CERCAM

Expression for CERCAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CERCAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CERCAM Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.3), Brain - Putamen (basal ganglia) (x5.0), Brain - Substantia nigra (x4.7), and Brain - Hippocampus (x4.5).

Protein differential expression in normal tissues from HIPED for CERCAM Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CERCAM Gene



Protein tissue co-expression partners for CERCAM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CERCAM Gene:

CERCAM

SOURCE GeneReport for Unigene cluster for CERCAM Gene:

Hs.495230

mRNA Expression by UniProt/SwissProt for CERCAM Gene:

Q5T4B2-GT253_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in secretory and nervous tissues.

Evidence on tissue expression from TISSUES for CERCAM Gene

  • Nervous system(4.9)
  • Muscle(4.2)
  • Pancreas(2.9)
genes like me logo Genes that share expression patterns with CERCAM: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CERCAM Gene

Orthologs for CERCAM Gene

This gene was present in the common ancestor of animals.

Orthologs for CERCAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CERCAM 34 33
  • 99.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CERCAM 34 33
  • 89.04 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CERCAM 34 33
  • 88.89 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cercam 33
  • 83.69 (n)
mouse
(Mus musculus)
Mammalia Cercam 16 34 33
  • 82.73 (n)
oppossum
(Monodelphis domestica)
Mammalia CERCAM 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CERCAM 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves CERCAM 34 33
  • 72.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 67 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488028 33
  • 63.3 (n)
zebrafish
(Danio rerio)
Actinopterygii cercam 34 33
  • 65.31 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31915 34
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D2045.9 34
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
Species where no ortholog for CERCAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERCAM Gene

ENSEMBL:
Gene Tree for CERCAM (if available)
TreeFam:
Gene Tree for CERCAM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CERCAM: view image

Paralogs for CERCAM Gene

Paralogs for CERCAM Gene

(4) SIMAP similar genes for CERCAM Gene using alignment to 4 proteins:

  • GT253_HUMAN
  • B7ZBS8_HUMAN
  • B7ZBS9_HUMAN
  • B7ZBT0_HUMAN
genes like me logo Genes that share paralogs with CERCAM: view

Variants for CERCAM Gene

Sequence variations from dbSNP and Humsavar for CERCAM Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000025818 -- 128,432,507(+) C/G intron_variant
rs1000116297 -- 128,436,015(+) C/T intron_variant
rs1000289609 -- 128,404,464(+) T/A upstream_transcript_variant
rs1000304861 -- 128,436,933(+) C/G 3_prime_UTR_variant
rs1000335034 -- 128,420,706(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CERCAM Gene

Variant ID Type Subtype PubMed ID
dgv1378e199 CNV deletion 23128226
esv3621807 CNV loss 21293372
esv3621808 CNV loss 21293372
nsv1132226 CNV deletion 24896259
nsv951774 CNV deletion 24416366

Variation tolerance for CERCAM Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CERCAM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CERCAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERCAM Gene

Disorders for CERCAM Gene

Additional Disease Information for CERCAM

No disorders were found for CERCAM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERCAM Gene

Publications for CERCAM Gene

  1. Cerebral cell adhesion molecule: a novel leukocyte adhesion determinant on blood-brain barrier capillary endothelium. (PMID: 10608765) Starzyk RM … Tuomanen EI (The Journal of infectious diseases 2000) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for CERCAM Gene

Sources for CERCAM Gene

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