Aliases for CER1 Gene
External Ids for CER1 Gene
Previous GeneCards Identifiers for CER1 Gene
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for CER1 Gene
CER1 (Cerberus 1, DAN Family BMP Antagonist) is a Protein Coding gene. Diseases associated with CER1 include Central Corneal Ulcer and Norrie Disease. Among its related pathways are Signaling by NODAL and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BMP binding. An important paralog of this gene is DAND5.
UniProtKB/Swiss-Prot Summary for CER1 Gene
Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).