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This gene codes for a choline/ethanolaminephosphotransferase, which functions in the synthesis of choline- or ethanolamine- containing phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016] See more...
Aliases for CEPT1 Gene
Aliases for CEPT1 Gene
External Ids for CEPT1 Gene
- HGNC: 24289
- Entrez Gene: 10390
- Ensembl: ENSG00000134255
- OMIM: 616751
- UniProtKB: Q9Y6K0
Previous GeneCards Identifiers for CEPT1 Gene
- GC01P112099
- GC01P110554
- GC01P110784
- GC01P110981
- GC01P111394
- GC01P111682
- GC01P109554
Summaries for CEPT1 Gene
-
This gene codes for a choline/ethanolaminephosphotransferase, which functions in the synthesis of choline- or ethanolamine- containing phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
GeneCards Summary for CEPT1 Gene
CEPT1 (Choline/Ethanolamine Phosphotransferase 1) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include phosphotransferase activity, for other substituted phosphate groups and ethanolaminephosphotransferase activity. An important paralog of this gene is CHPT1.
UniProtKB/Swiss-Prot Summary for CEPT1 Gene
-
Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
Additional gene information for CEPT1 Gene
- HGNC(24289)
- Entrez Gene(10390)
- Ensembl(ENSG00000134255)
- OMIM(616751)
- UniProtKB(Q9Y6K0)
- Open Targets Platform(ENSG00000134255)
- Search for CEPT1 at DataMed
- Search for CEPT1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEPT1 Gene
Genomics for CEPT1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CEPT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CEPT1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CEPT1
- Top Transcription factor binding sites by QIAGEN in the CEPT1 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-5
Genomic Locations for CEPT1 Gene
Genomic Locations for CEPT1 Gene
- chr1:111,139,383-111,185,104
- (GRCh38/hg38)
- Size:
- 45,722 bases
- Orientation:
- Plus strand
- chr1:111,682,249-111,727,724
- (GRCh37/hg19)
- Size:
- 45,476 bases
- Orientation:
- Plus strand
Genomic View for CEPT1 Gene
Genes around CEPT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3 by HGNC
- 1p13.3 by Entrez Gene
- 1p13.3 by Ensembl
CEPT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CEPT1 Gene
Proteins for CEPT1 Gene
-
Protein details for CEPT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6K0-CEPT1_HUMAN
- Recommended name:
- Choline/ethanolaminephosphotransferase 1
- Protein Accession:
- Q9Y6K0
- Q69YJ9
- Q9P0Y8
Protein attributes for CEPT1 Gene
- Size:
- 416 amino acids
- Molecular mass:
- 46554 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAF61194.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for CEPT1 Gene
Selected DME Specific Peptides for CEPT1 Gene
- Q9Y6K0:
-
- GGVGKNGST
- SPLGELFDHGCDS
- DGKQARRTNS
- YQSLDAIDGKQARRTNS
- AHWQTYVSG
- AHMTKSE
Post-translational modifications for CEPT1 Gene
Other Protein References for CEPT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Rabbit Anti-Human CEPT1 Polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for CEPT1
-
Abcam antibodies for CEPT1
- Invitrogen Antibodies for CEPT1 (AFLGC-CEPT1)
-
Biorbyt antibodies for CEPT1
Protein Products
-
OriGene Purified Proteins for CEPT1
- Search Origene for MassSpec and Protein Over-expression Lysates for CEPT1
- Origene Custom Protein Services for CEPT1
- antibodies-online: Show 3 available CEPT1 Proteins ranked by validation data
- Compare Top CEPT1 Proteins
-
Quality Products:
Assay Products
- antibodies-online: Show 8 available CEPT1 Elisa Kits ranked by validation data
- Compare Top CEPT1 Elisa Kits
-
Quality Products:
Domains & Families for CEPT1 Gene
Gene Families for CEPT1 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
- Transporters
Protein Domains for CEPT1 Gene
- InterPro:
- Blocks:
-
- CDP-alcohol phosphatidyltransferase
- ProtoNet:
Suggested Antigen Peptide Sequences for CEPT1 Gene
- GenScript: Design optimal peptide antigens:
-
- Choline/ethanolaminephosphotransferase 1 (CEPT1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y6K0UniProtKB/Swiss-Prot:
CEPT1_HUMAN :- Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
- Family:
-
- Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
Function for CEPT1 Gene
Molecular function for CEPT1 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:32943, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:64612; EC=2.7.8.1; Evidence={ECO:0000269|PubMed:10191259};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:32939, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57643, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377; EC=2.7.8.2; Evidence={ECO:0000269|PubMed:10191259};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54232, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:76979, ChEBI:CHEBI:78228; Evidence={ECO:0000269|PubMed:10191259};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54236, ChEBI:CHEBI:15378, ChEBI:CHEBI:18155, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:78226; Evidence={ECO:0000269|PubMed:10191259};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54240, ChEBI:CHEBI:15378, ChEBI:CHEBI:52333, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:74669; Evidence={ECO:0000269|PubMed:10191259};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54244, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:73001, ChEBI:CHEBI:75466; Evidence={ECO:0000269|PubMed:10191259};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:54248, ChEBI:CHEBI:15378, ChEBI:CHEBI:52333, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:74986; Evidence={ECO:0000269|PubMed:10191259};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:54252, ChEBI:CHEBI:15378, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:73007, ChEBI:CHEBI:75466; Evidence={ECO:0000269|PubMed:10191259};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54332, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:74963, ChEBI:CHEBI:82949; Evidence={ECO:0000269|PubMed:10191259};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54336, ChEBI:CHEBI:15378, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:83717, ChEBI:CHEBI:84417; Evidence={ECO:0000269|PubMed:10191259};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+); Xref=Rhea:RHEA:54340, ChEBI:CHEBI:15378, ChEBI:CHEBI:57876, ChEBI:CHEBI:60377, ChEBI:CHEBI:84417, ChEBI:CHEBI:138145; Evidence={ECO:0000269|PubMed:10191259};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54348, ChEBI:CHEBI:15378, ChEBI:CHEBI:44811, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:75936; Evidence={ECO:0000269|PubMed:10893425};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+); Xref=Rhea:RHEA:54352, ChEBI:CHEBI:15378, ChEBI:CHEBI:55430, ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:77184; Evidence={ECO:0000269|PubMed:10893425};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=37 uM for CDP-choline {ECO:0000269|PubMed:10191259, ECO:0000269|PubMed:12216837}; KM=101 uM for CDP-ethanolamine {ECO:0000269|PubMed:10191259, ECO:0000269|PubMed:12216837}; Vmax=10.5 nmol/min/mg enzyme with CDP-choline as substrate {ECO:0000269|PubMed:10191259, ECO:0000269|PubMed:12216837}; Vmax=4.35 nmol/min/mg enzyme with CDP-ethanolamine as substrate {ECO:0000269|PubMed:10191259, ECO:0000269|PubMed:12216837};
Enzyme Numbers (IUBMB) for CEPT1 Gene
Phenotypes From GWAS Catalog for CEPT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004142 | diacylglycerol cholinephosphotransferase activity | IBA | 21873635 |
| GO:0004307 | ethanolaminephosphotransferase activity | IBA | 21873635 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016780 | phosphotransferase activity, for other substituted phosphate groups | IEA,IBA | 21873635 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for CEPT1 Gene
- MGI mutant phenotypes for CEPT1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CEPT1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased viability
- Decreased viability of wild-type and TP53 knockout cells
- shRNA abundance <= 25%
- Decreased NF-kappaB reporter expression
- Increased hepcidin::fluc mRNA expression
- Increased shRNA abundance (Z-score > 2)
- Dynamic nuclei (hole, folded or small irregular), decreased viability (cell death)
- Decreased shRNA abundance (Z-score < -2)
Animal Model Products
-
Taconic Biosciences Mouse Models for CEPT1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CEPT1 - Select products 50% OFF >
- * CEPT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CEPT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CEPT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEPT1
miRNA for CEPT1 Gene
- miRTarBase miRNAs that target CEPT1
-
- hsa-miR-124-3p (MIRT023012)
- hsa-miR-23b-3p (MIRT023468)
- hsa-miR-183-5p (MIRT024992)
- hsa-miR-26a-5p (MIRT050143)
- hsa-miR-670-3p (MIRT444106)
- hsa-miR-580-3p (MIRT444107)
- hsa-miR-6770-5p (MIRT444108)
- hsa-miR-4797-3p (MIRT444109)
- hsa-miR-1253 (MIRT444110)
- hsa-miR-545-5p (MIRT444111)
- hsa-miR-100-3p (MIRT444112)
- hsa-miR-186-5p (MIRT444113)
- hsa-miR-3133 (MIRT444114)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CEPT1
- Browse OriGene Inhibitory RNA Products For CEPT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEPT1
Clone Products
- Applied Biological Materials (abm): Clones for CEPT1 - Select products 50% OFF >
- * CEPT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206581
- MG206582
- MR206581
- MR206581L3
- MR206581L4
- MR206582
- MR206582L3
- MR206582L4
- MR229795
- RC207566
- RC207566L1
- RC207566L2
- RC207566L3
- RC207566L4
- RC221019
- RC221019L3
- RC221019L4
- RG207566
- RG221019
- RR207172
- RR207172L3
- RR207172L4
- MR206581L3V
- MR206581L4V
- MR206582L3V
- MR206582L4V
- RC207566L1V
- RC207566L2V
- RC207566L3V
- RC207566L4V
- RC221019L3V
- RC221019L4V
- RR207172L3V
- RR207172L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CEPT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CEPT1
Cell Line Products
-
Horizon Cell Lines for CEPT1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEPT1 Gene
Localization for CEPT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CEPT1 Gene
- Endoplasmic reticulum membrane. Multi-pass membrane protein. Nucleus membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 4 |
| plasma membrane | 3 |
| peroxisome | 3 |
| nucleus | 3 |
| golgi apparatus | 3 |
| mitochondrion | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CEPT1 Gene
Pathways & Interactions for CEPT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycerophospholipid biosynthesis |
.01
|
|
| 2 | Metabolism |
.40
|
|
| 3 | Acyl chain remodelling of PE | ||
| 4 | Synthesis of PC | ||
| 5 | Glycerophospholipid Biosynthetic Pathway | ||
Pathways by source for CEPT1 Gene
3 BioSystems pathways for CEPT1 Gene
6 Reactome pathways for CEPT1 Gene
4 KEGG pathways for CEPT1 Gene
UniProtKB/Swiss-Prot Q9Y6K0-CEPT1_HUMAN
- Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.
- Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
Interacting Proteins for CEPT1 Gene
Selected Interacting proteins:
Q9Y6K0-CEPT1_HUMAN
ENSP00000441980
for CEPT1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CEPT1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | TAS | 10191259 |
| GO:0006646 | phosphatidylethanolamine biosynthetic process | IBA,TAS | -- |
| GO:0006656 | phosphatidylcholine biosynthetic process | TAS | -- |
| GO:0006657 | CDP-choline pathway | IEA | -- |
| GO:0008654 | phospholipid biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for CEPT1 Gene
Drugs & Compounds for CEPT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Choline | Approved | Nutra | Enzyme, substrate | 223 | ||
| Choline salicylate | Approved | Nutra | Enzyme, substrate | 0 | ||
| Citicoline | Approved, Experimental | Pharma | 0 | |||
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| Manganese | Approved | Nutra | 56 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| CDP-Ethanolamine |
|
3036-18-8 |
|
|||
| CMP-2-aminoethylphosphonate |
|
|
||||
| CMP-N-trimethyl-2-aminoethylphosphonate |
|
|
||||
| PC(18:1(9Z)e/2:0) |
|
|
||||
| PE(P-16:0e/16:0) |
|
|
Transcripts for CEPT1 Gene
mRNA/cDNA for CEPT1 Gene
- 3 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000498239 1957 nts (view in UCSC)
- ENST00000480324 2110 nts (view in UCSC)
- ENST00000476865 783 nts (view in UCSC)
- ENST00000357172 2203 nts (view in UCSC)
- ENST00000460443 851 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CEPT1 - Select products 50% OFF >
- * CEPT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CEPT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CEPT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEPT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CEPT1
- Browse OriGene Inhibitory RNA Products For CEPT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEPT1
Clone Products
- Applied Biological Materials (abm): Clones for CEPT1 - Select products 50% OFF >
- * CEPT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206581
- MG206582
- MR206581
- MR206581L3
- MR206581L4
- MR206582
- MR206582L3
- MR206582L4
- MR229795
- RC207566
- RC207566L1
- RC207566L2
- RC207566L3
- RC207566L4
- RC221019
- RC221019L3
- RC221019L4
- RG207566
- RG221019
- RR207172
- RR207172L3
- RR207172L4
- MR206581L3V
- MR206581L4V
- MR206582L3V
- MR206582L4V
- RC207566L1V
- RC207566L2V
- RC207566L3V
- RC207566L4V
- RC221019L3V
- RC221019L4V
- RR207172L3V
- RR207172L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CEPT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CEPT1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||
| SP5: |
Relevant External Links for CEPT1 Gene
- GeneLoc Exon Structure for
- CEPT1
Expression for CEPT1 Gene
This gene is overexpressed in Breast (12.0), Monocytes (11.5), and Placenta (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEPT1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CEPT1
SOURCE GeneReport for Unigene cluster for CEPT1 Gene:
Hs.363572mRNA Expression by UniProt/SwissProt for CEPT1 Gene:
Q9Y6K0-CEPT1_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for CEPT1 Gene
- Bone marrow(4.3)
- Pancreas(4.1)
- Liver(2.8)
- Nervous system(2.5)
- Kidney(2.2)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs for CEPT1
-
OriGene qPCR primer pairs and template standards for CEPT1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEPT1 Gene
Orthologs for CEPT1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CEPT1 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CEPT1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CEPT1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cept1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cept1 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | CEPT1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CEPT1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CEPT1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CEPT1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cept1 30 |
|
||
| Str.8915 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cept1-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cept1a 31 |
|
OneToMany | |
| cept1b 30 31 |
|
OneToMany | |||
| Dr.669 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG6016 32 |
|
|
|
| bbc 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | Y49A3A.1 30 32 |
|
||
| cept-1 31 |
|
ManyToMany | |||
| cept-2 31 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CPT1 31 33 |
|
ManyToMany | |
| EPT1 31 |
|
ManyToMany | |||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AAPT1 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0119800 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU03223 30 |
|
- Species where no ortholog for CEPT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CEPT1 Gene
- ENSEMBL:
- Gene Tree for CEPT1 (if available)
- TreeFam:
- Gene Tree for CEPT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CEPT1: view image
Paralogs for CEPT1 Gene
Variants for CEPT1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CEPT1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 775055 | Benign: not provided | 111,159,398(+) | A/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2455976 | CNV | deletion | 19546169 |
| nsv10639 | CNV | gain | 18304495 |
| nsv1113155 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.55;
29.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CEPT1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CEPT1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEPT1 Gene
Disorders for CEPT1 Gene
Additional Disease Information for CEPT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for CEPT1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEPT1 Gene
Publications for CEPT1 Gene
- PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1). (PMID: 12216837) Wright MM … McMaster CR (Lipids 2002) 2 3 4 23
- The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity. (PMID: 12221122) Henneberry AL … McMaster CR (Molecular biology of the cell 2002) 3 4 23
- Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine. (PMID: 10191259) Henneberry AL … McMaster CR (The Biochemical journal 1999) 2 3 4
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers JC … Kooner JS (Nature genetics 2011) 3 41
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
ExternalLinks
Products for CEPT1 Gene
- Custom Antibody ServicesOriGene Antibodies for CEPT1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CEPT1
- Search Origene for MassSpec and Protein Over-expression Lysates for CEPT1
- Origene Custom Protein Services for CEPT1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CEPT1
- Browse OriGene Inhibitory RNA Products For CEPT1
- OriGene qPCR primer pairs for CEPT1
- OriGene qPCR primer pairs and template standards for CEPT1
- OriGene CRISPR knockouts for CEPT1
- MG206581
- MG206582
- MR206581
- MR206581L3
- MR206581L4
- MR206582
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- RC207566L1V
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- RC207566L3V
- RC207566L4V
- RC221019L3V
- RC221019L4V
- RR207172L3V
- RR207172L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CEPT1
- Sino Biological Human cDNA Clone for CEPT1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Abcam antibodies for CEPT1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for CEPT1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CEPT1 (AFLGC-CEPT1)
- VectorBuilder Custom and pre-made DNA vectors for CEPT1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CEPT1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CEPT1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CEPT1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CEPT1
- antibodies-online: Show 10 available CEPT1 Antibodies ranked by validation data
- Compare Top CEPT1 Antibodies
- antibodies-online: Show 8 available CEPT1 Elisa Kits ranked by validation data
- Compare Top CEPT1 Elisa Kits
- Quality Products:
- antibodies-online: Show 3 available CEPT1 Proteins ranked by validation data
- Compare Top CEPT1 Proteins
- Quality Products:
- Horizon Cell Lines for CEPT1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CEPT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CEPT1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CEPT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEPT1
- Biorbyt antibodies for CEPT1
Sources for CEPT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB