Aliases for CEP95 Gene

Aliases for CEP95 Gene

  • Centrosomal Protein 95 2 3 5
  • Coiled-Coil Domain-Containing Protein 45 3 4
  • Coiled-Coil Domain Containing 45 2 3
  • Centrosomal Protein Of 95 KDa 3 4
  • Centrosomal Protein 95kDa 2 3
  • CCDC45 3 4
  • CEP45 4
  • Cep95 4

External Ids for CEP95 Gene

Previous HGNC Symbols for CEP95 Gene

  • CCDC45

Previous GeneCards Identifiers for CEP95 Gene

  • GC17P062502

Summaries for CEP95 Gene

GeneCards Summary for CEP95 Gene

CEP95 (Centrosomal Protein 95) is a Protein Coding gene.

Additional gene information for CEP95 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEP95 Gene

Genomics for CEP95 Gene

GeneHancer (GH) Regulatory Elements for CEP95 Gene

Promoters and enhancers for CEP95 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEP95 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CEP95 Gene

Genomic Locations for CEP95 Gene
chr17:64,506,762-64,542,461
(GRCh38/hg38)
Size:
35,700 bases
Orientation:
Plus strand
chr17:62,502,706-62,538,579
(GRCh37/hg19)
Size:
35,874 bases
Orientation:
Plus strand

Genomic View for CEP95 Gene

Genes around CEP95 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP95 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP95 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP95 Gene

Proteins for CEP95 Gene

  • Protein details for CEP95 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GE4-CEP95_HUMAN
    Recommended name:
    Centrosomal protein of 95 kDa
    Protein Accession:
    Q96GE4
    Secondary Accessions:
    • B4DMD2
    • Q96M81

    Protein attributes for CEP95 Gene

    Size:
    821 amino acids
    Molecular mass:
    95297 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CEP95 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP95 Gene

Post-translational modifications for CEP95 Gene

  • Ubiquitination at Lys320, Lys387, and Lys704
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP95 Gene

Domains & Families for CEP95 Gene

Gene Families for CEP95 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CEP95 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP95 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54025, highly similar to Coiled-coil domain-containing protein 45 (B4DMD2_HUMAN)
  • Coiled-coil domain-containing protein 45 (CEP95_HUMAN)
genes like me logo Genes that share domains with CEP95: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CEP95 Gene

Function for CEP95 Gene

Phenotypes From GWAS Catalog for CEP95 Gene

Gene Ontology (GO) - Molecular Function for CEP95 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CEP95: view

Phenotypes for CEP95 Gene

genes like me logo Genes that share phenotypes with CEP95: view

Animal Model Products

CRISPR Products

miRNA for CEP95 Gene

miRTarBase miRNAs that target CEP95

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP95 Gene

Localization for CEP95 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP95 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP95 gene
Compartment Confidence
cytoskeleton 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Mitotic spindle (3)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEP95 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 21399614
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA,IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CEP95: view

Pathways & Interactions for CEP95 Gene

PathCards logo

SuperPathways for CEP95 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP95 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEP95 Gene

Drugs & Compounds for CEP95 Gene

No Compound Related Data Available

Transcripts for CEP95 Gene

mRNA/cDNA for CEP95 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP95 Gene

No ASD Table

Relevant External Links for CEP95 Gene

GeneLoc Exon Structure for
CEP95
ECgene alternative splicing isoforms for
CEP95

Expression for CEP95 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP95 Gene

Protein differential expression in normal tissues from HIPED for CEP95 Gene

This gene is overexpressed in Thyroid (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEP95 Gene



Protein tissue co-expression partners for CEP95 Gene

NURSA nuclear receptor signaling pathways regulating expression of CEP95 Gene:

CEP95

SOURCE GeneReport for Unigene cluster for CEP95 Gene:

Hs.569713

Evidence on tissue expression from TISSUES for CEP95 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with CEP95: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP95 Gene

Orthologs for CEP95 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP95 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP95 33 32
  • 99.35 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CEP95 33 32
  • 88.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CEP95 33 32
  • 87.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cep95 17 33 32
  • 79.85 (n)
rat
(Rattus norvegicus)
Mammalia Cep95 32
  • 78.64 (n)
oppossum
(Monodelphis domestica)
Mammalia CEP95 33
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP95 33
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP95 33 32
  • 61.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP95 33
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep95 32
  • 56.76 (n)
Str.11457 32
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 39 (a)
OneToMany
CSA.6755 33
  • 27 (a)
OneToMany
Species where no ortholog for CEP95 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEP95 Gene

ENSEMBL:
Gene Tree for CEP95 (if available)
TreeFam:
Gene Tree for CEP95 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEP95: view image

Paralogs for CEP95 Gene

(9) SIMAP similar genes for CEP95 Gene using alignment to 11 proteins:

  • CEP95_HUMAN
  • B4DMD2_HUMAN
  • B7ZAE2_HUMAN
  • H0YJW6_HUMAN
  • J3KRC3_HUMAN
  • J3KRW3_HUMAN
  • J3KS50_HUMAN
  • J3KST6_HUMAN
  • J3QLG4_HUMAN
  • K7ENV0_HUMAN
  • L8E9K4_HUMAN
genes like me logo Genes that share paralogs with CEP95: view

No data available for Paralogs for CEP95 Gene

Variants for CEP95 Gene

Sequence variations from dbSNP and Humsavar for CEP95 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000112549 -- 64,530,438(+) T/A intron_variant
rs1000114761 -- 64,511,644(+) G/A intron_variant
rs1000267629 -- 64,507,534(+) C/T intron_variant
rs1000479703 -- 64,504,972(+) C/T upstream_transcript_variant
rs1000495801 -- 64,529,232(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CEP95 Gene

Variant ID Type Subtype PubMed ID
nsv1066765 CNV gain 25217958
nsv819879 CNV gain 19587683
nsv828085 CNV loss 20364138

Variation tolerance for CEP95 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEP95 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP95

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP95 Gene

Disorders for CEP95 Gene

Additional Disease Information for CEP95

No disorders were found for CEP95 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP95 Gene

Publications for CEP95 Gene

  1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L … Andersen JS (The EMBO journal 2011) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for CEP95 Gene

Sources for CEP95 Gene