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Aliases for CEP85 Gene

Aliases for CEP85 Gene

  • Centrosomal Protein 85 2 3 5
  • Coiled-Coil Domain-Containing Protein 21 3 4
  • Centrosomal Protein 85kDa 2 3
  • CCDC21 3 4
  • Coiled-Coil Domain Containing 21 2
  • Centrosomal Protein Of 85 KDa 3
  • Cep85 4

External Ids for CEP85 Gene

Previous HGNC Symbols for CEP85 Gene

  • CCDC21

Previous GeneCards Identifiers for CEP85 Gene

  • GC01P026561

Summaries for CEP85 Gene

Entrez Gene Summary for CEP85 Gene

  • This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for CEP85 Gene

CEP85 (Centrosomal Protein 85) is a Protein Coding gene. An important paralog of this gene is CEP85L.

UniProtKB/Swiss-Prot for CEP85 Gene

  • Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856).

Additional gene information for CEP85 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP85 Gene

Genomics for CEP85 Gene

GeneHancer (GH) Regulatory Elements for CEP85 Gene

Promoters and enhancers for CEP85 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J026233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 662.6 +0.4 432 2.3 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 CEP85 ARID1A HMGN2 CD52 ZNF593 NPM1P39 UBXN11 ENSG00000261349 LOC101928324 LOC101928728
GH01J026269 Promoter 1 EPDnew 660.8 +35.1 35111 0.1 ZNF280A FOSL1 CC2D1A CTBP1 CBX5 NCOR1 POLR2A FOS TRIM24 AFF1 CEP85 CD52 UBXN11 LIN28A ENSG00000236782 ZNF593 CRYBG2 FAM110D TRIM63 PDIK1L
GH01J026274 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.5 +49.7 49741 19.1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 NBN SH3BGRL3 HMGN2 ARID1A LOC101928324 CD52 GPN2 NPM1P39 UBXN11 CEP85 LIN28A
GH01J026348 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.9 +120.8 120780 12.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 CD52 UBXN11 CEP85 ARID1A CNKSR1 CRYBG2 RPL17P9 HMGN2 LIN28A DHDDS
GH01J026313 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.9 +84.0 84017 8.4 HDGF PKNOX1 SMAD1 ARNT ARID4B ZNF2 IRF4 ZNF766 ZNF213 E2F8 CD52 UBXN11 SH3BGRL3 ZNF683 CRYBG2 LIN28A CEP85 ZNF593 ENSG00000236782 FAM110D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEP85 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CEP85 Gene

Genomic Locations for CEP85 Gene
chr1:26,234,153-26,279,038
(GRCh38/hg38)
Size:
44,886 bases
Orientation:
Plus strand
chr1:26,560,691-26,605,299
(GRCh37/hg19)
Size:
44,609 bases
Orientation:
Plus strand

Genomic View for CEP85 Gene

Genes around CEP85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP85 Gene

Proteins for CEP85 Gene

  • Protein details for CEP85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2H3-CEP85_HUMAN
    Recommended name:
    Centrosomal protein of 85 kDa
    Protein Accession:
    Q6P2H3
    Secondary Accessions:
    • B4DRL1
    • D3DPK4
    • F8W7K4
    • Q5VY68
    • Q5VY70
    • Q9H6Q1
    • Q9H828
    • Q9UF52

    Protein attributes for CEP85 Gene

    Size:
    762 amino acids
    Molecular mass:
    85639 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15203.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP85 Gene

Post-translational modifications for CEP85 Gene

  • Ubiquitination at Lys633, posLast=401401, Lys357, posLast=178178, and posLast=139139
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP85 Gene

Domains & Families for CEP85 Gene

Gene Families for CEP85 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CEP85 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP85 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P2H3

UniProtKB/Swiss-Prot:

CEP85_HUMAN :
  • Belongs to the CEP85 family.
Family:
  • Belongs to the CEP85 family.
genes like me logo Genes that share domains with CEP85: view

Function for CEP85 Gene

Molecular function for CEP85 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856).

Phenotypes From GWAS Catalog for CEP85 Gene

Gene Ontology (GO) - Molecular Function for CEP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18985028
genes like me logo Genes that share ontologies with CEP85: view
genes like me logo Genes that share phenotypes with CEP85: view

Animal Model Products

miRNA for CEP85 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP85 Gene

Localization for CEP85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP85 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus, nucleolus. Note=Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates at spindle poles (PubMed:21399614). Associated with the pericentriolar material. Localizes to centrosomes at a low level in G1 phase and a slightly increased level in S phase, with gradually elevated levels during G2 phase. The levels at centrosomes further increase at G2/M, reaching a peak at spindle poles at early mitotic stages and remain high until the end of anaphase (PubMed:26220856). {ECO:0000269 PubMed:21399614, ECO:0000269 PubMed:26220856}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP85 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
  • Nucleoli (3)
  • Cytosol (2)
  • Golgi apparatus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IDA 26220856
GO:0000922 spindle pole IEA,IDA 21399614
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA,IEA 21399614
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CEP85: view

Pathways & Interactions for CEP85 Gene

SuperPathways for CEP85 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IMP 26220856
GO:0007059 chromosome segregation IEA --
GO:0046602 regulation of mitotic centrosome separation IMP 26220856
genes like me logo Genes that share ontologies with CEP85: view

No data available for Pathways by source and SIGNOR curated interactions for CEP85 Gene

Drugs & Compounds for CEP85 Gene

No Compound Related Data Available

Transcripts for CEP85 Gene

Unigene Clusters for CEP85 Gene

Centrosomal protein 85kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP85 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7: -
SP8:

Relevant External Links for CEP85 Gene

GeneLoc Exon Structure for
CEP85
ECgene alternative splicing isoforms for
CEP85

Expression for CEP85 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP85 Gene

mRNA differential expression in normal tissues according to GTEx for CEP85 Gene

This gene is overexpressed in Muscle - Skeletal (x6.3).

Protein differential expression in normal tissues from HIPED for CEP85 Gene

This gene is overexpressed in Breast (52.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEP85 Gene



Protein tissue co-expression partners for CEP85 Gene

NURSA nuclear receptor signaling pathways regulating expression of CEP85 Gene:

CEP85

SOURCE GeneReport for Unigene cluster for CEP85 Gene:

Hs.63795

Evidence on tissue expression from TISSUES for CEP85 Gene

  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with CEP85: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP85 Gene

Orthologs for CEP85 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP85 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP85 34 33
  • 99.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CEP85 34 33
  • 91.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CEP85 34 33
  • 90.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cep85 16 34 33
  • 86.16 (n)
rat
(Rattus norvegicus)
Mammalia Cep85 33
  • 84.94 (n)
oppossum
(Monodelphis domestica)
Mammalia CEP85 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP85 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP85 34 33
  • 66.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP85 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8231 33
zebrafish
(Danio rerio)
Actinopterygii si:ch211-11i5.2 33
  • 57.35 (n)
CEP85 34
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
OneToMany
Species where no ortholog for CEP85 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP85 Gene

ENSEMBL:
Gene Tree for CEP85 (if available)
TreeFam:
Gene Tree for CEP85 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEP85: view image

Paralogs for CEP85 Gene

Paralogs for CEP85 Gene

(2) SIMAP similar genes for CEP85 Gene using alignment to 3 proteins:

  • CEP85_HUMAN
  • F8W7K4_HUMAN
  • H7BZW2_HUMAN
genes like me logo Genes that share paralogs with CEP85: view

Variants for CEP85 Gene

Sequence variations from dbSNP and Humsavar for CEP85 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000028397 -- 26,263,419(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000048576 -- 26,274,528(+) T/C intron_variant
rs1000074565 -- 26,274,872(+) C/G/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000188614 -- 26,238,874(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000271208 -- 26,258,446(+) G/ genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CEP85 Gene

Variant ID Type Subtype PubMed ID
nsv473502 CNV novel sequence insertion 20440878

Variation tolerance for CEP85 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEP85 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP85

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP85 Gene

Disorders for CEP85 Gene

Additional Disease Information for CEP85

No disorders were found for CEP85 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP85 Gene

Publications for CEP85 Gene

  1. Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. (PMID: 26220856) Chen C … Yu X (Journal of cell science 2015) 3 4 58
  2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L … Andersen JS (The EMBO journal 2011) 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CEP85 Gene

Sources for CEP85 Gene

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