Aliases for CEP70 Gene

Aliases for CEP70 Gene

  • Centrosomal Protein 70 2 3 5
  • Centrosomal Protein Of 70 KDa 3 4
  • Centrosomal Protein 70kDa 2 3
  • P10-Binding Protein 3 4
  • BITE 3 4
  • Testicular Tissue Protein Li 36 3
  • Cep70 4

External Ids for CEP70 Gene

Previous GeneCards Identifiers for CEP70 Gene

  • GC03M139696
  • GC03M138213
  • GC03M135587

Summaries for CEP70 Gene

GeneCards Summary for CEP70 Gene

CEP70 (Centrosomal Protein 70) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition.

UniProtKB/Swiss-Prot Summary for CEP70 Gene

  • Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

Gene Wiki entry for CEP70 Gene

Additional gene information for CEP70 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEP70 Gene

Genomics for CEP70 Gene

GeneHancer (GH) Regulatory Elements for CEP70 Gene

Promoters and enhancers for CEP70 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J138593 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 755.8 +0.4 414 2.6 SP1 CTCF RBPJ POLR2A ATF1 CREB1 MIXL1 MYC CC2D1A NFYC CEP70 lnc-PIK3CB-1 FAIM COPB2 DZIP1L RBP1 piR-50968-087
GH03J138914 Promoter/Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas 12.3 -321.3 -321317 2.5 ZNF24 ZBTB40 CTCF MLX SMARCE1 RBPJ POLR2A ZNF362 CC2D1A ELF1 lnc-FOXL2-5 CEP70 PIK3CB FAIM LINC01391 FOXL2 FOXL2NB RF00017-4130
GH03J138888 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.2 -299.5 -299463 18.8 ZBTB40 SMARCE1 MYC HLF L3MBTL2 MAX CEBPG TFE3 SMARCA4 ZNF680 PIK3CB FAIM DBR1 DZIP1L CEP70 ENSG00000214280 A4GNT ATP5MC1P3 lnc-FOXL2-2-001 lnc-FOXL2-2-002
GH03J138942 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 10.3 -349.0 -348984 2.6 ZKSCAN8 ZFX MLLT1 SMARCA4 IKZF1 GTF2E2 REST ZNF740 ZNF512 ATF1 DBR1 CEP70 DZIP1L ACTG1P1 COPB2 MRAS FOXL2 LINC01391 lnc-FOXL2-5
GH03J138685 Enhancer 1.1 Ensembl ENCODE 11.4 -93.1 -93060 4 ZBTB6 SMARCE1 NR2F6 MIXL1 ZNF362 CC2D1A RAD21 TEAD4 RERE ELF3 FAIM CEP70 PIK3CB RF00017-4127 piR-51819-017
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEP70 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CEP70 gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • Egr-2
  • Egr-3
  • MZF-1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Zic3

Genomic Locations for CEP70 Gene

Genomic Locations for CEP70 Gene
chr3:138,494,339-138,594,538
(GRCh38/hg38)
Size:
100,200 bases
Orientation:
Minus strand
chr3:138,213,186-138,313,380
(GRCh37/hg19)
Size:
100,195 bases
Orientation:
Minus strand

Genomic View for CEP70 Gene

Genes around CEP70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP70 Gene

Proteins for CEP70 Gene

  • Protein details for CEP70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHQ1-CEP70_HUMAN
    Recommended name:
    Centrosomal protein of 70 kDa
    Protein Accession:
    Q8NHQ1
    Secondary Accessions:
    • B7Z5I8
    • B7Z7E8
    • D3DNE9
    • F5GZX8
    • Q96B31
    • Q9H2C3
    • Q9H2Z1
    • Q9H940

    Protein attributes for CEP70 Gene

    Size:
    597 amino acids
    Molecular mass:
    69752 Da
    Quaternary structure:
    • Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.

    Alternative splice isoforms for CEP70 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP70 Gene

Post-translational modifications for CEP70 Gene

  • Ubiquitination at Lys280, Lys315, Lys323, and Lys370
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP70 Gene

Domains & Families for CEP70 Gene

Gene Families for CEP70 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CEP70 Gene

Suggested Antigen Peptide Sequences for CEP70 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60498, highly similar to Centrosomal protein of 70 kDa (B7Z2D2_HUMAN)
  • p10-binding protein (CEP70_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHQ1

UniProtKB/Swiss-Prot:

CEP70_HUMAN :
  • The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.
Domain:
  • The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.
genes like me logo Genes that share domains with CEP70: view

Function for CEP70 Gene

Molecular function for CEP70 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

Phenotypes From GWAS Catalog for CEP70 Gene

Gene Ontology (GO) - Molecular Function for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 25416956
GO:0043015 gamma-tubulin binding IEA --
genes like me logo Genes that share ontologies with CEP70: view
genes like me logo Genes that share phenotypes with CEP70: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEP70

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP70 Gene

Localization for CEP70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP70 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP70 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA,IEA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CEP70: view

Pathways & Interactions for CEP70 Gene

genes like me logo Genes that share pathways with CEP70: view

Gene Ontology (GO) - Biological Process for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0060271 cilium assembly IEA --
GO:0070507 regulation of microtubule cytoskeleton organization IEA --
GO:0097711 ciliary basal body-plasma membrane docking TAS --
genes like me logo Genes that share ontologies with CEP70: view

No data available for SIGNOR curated interactions for CEP70 Gene

Drugs & Compounds for CEP70 Gene

No Compound Related Data Available

Transcripts for CEP70 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEP70

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP70 Gene

No ASD Table

Relevant External Links for CEP70 Gene

GeneLoc Exon Structure for
CEP70
ECgene alternative splicing isoforms for
CEP70

Expression for CEP70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP70 Gene

Protein differential expression in normal tissues from HIPED for CEP70 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CEP70 Gene



Protein tissue co-expression partners for CEP70 Gene

NURSA nuclear receptor signaling pathways regulating expression of CEP70 Gene:

CEP70

SOURCE GeneReport for Unigene cluster for CEP70 Gene:

Hs.531962

Evidence on tissue expression from TISSUES for CEP70 Gene

  • Skin(4.5)
  • Blood(4.4)
  • Nervous system(3.2)
  • Muscle(2.7)
  • Bone(2.3)
genes like me logo Genes that share expression patterns with CEP70: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP70 Gene

Orthologs for CEP70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP70 33 32
  • 99.27 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CEP70 33 32
  • 91.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CEP70 33 32
  • 88.7 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cep70 17 33 32
  • 83.87 (n)
rat
(Rattus norvegicus)
Mammalia Cep70 32
  • 82.87 (n)
oppossum
(Monodelphis domestica)
Mammalia CEP70 33
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP70 33 32
  • 63.32 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP70 33
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15467 32
zebrafish
(Danio rerio)
Actinopterygii cep70 33 32
  • 50.18 (n)
OneToOne
Species where no ortholog for CEP70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP70 Gene

ENSEMBL:
Gene Tree for CEP70 (if available)
TreeFam:
Gene Tree for CEP70 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEP70: view image

Paralogs for CEP70 Gene

No data available for Paralogs for CEP70 Gene

Variants for CEP70 Gene

Sequence variations from dbSNP and Humsavar for CEP70 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000005889 -- 138,513,430(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000007382 -- 138,537,680(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000079825 -- 138,557,666(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000093204 -- 138,503,392(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000102623 -- 138,509,418(-) G/A/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CEP70 Gene

Variant ID Type Subtype PubMed ID
dgv4908n100 CNV gain 25217958
esv3597916 CNV gain 21293372
esv3597917 CNV loss 21293372
esv3597918 CNV loss 21293372
nsv428422 CNV gain+loss 18775914
nsv522517 CNV loss 19592680
nsv999041 CNV gain 25217958

Variation tolerance for CEP70 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEP70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP70

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP70 Gene

Disorders for CEP70 Gene

Additional Disease Information for CEP70

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CEP70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP70 Gene

Publications for CEP70 Gene

  1. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen JS … Mann M (Nature 2003) 2 3 4 56
  2. CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly. (PMID: 21795687) Shi X … Zhou J (The Journal of biological chemistry 2011) 3 4 56
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 43 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for CEP70 Gene

Sources for CEP70 Gene