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Aliases for CEP55 Gene

Aliases for CEP55 Gene

  • Centrosomal Protein 55 2 3 5
  • Up-Regulated In Colon Cancer 6 3 4
  • Cancer/Testis Antigen 111 2 3
  • Centrosomal Protein 55kDa 2 3
  • C10orf3 3 4
  • URCC6 3 4
  • Chromosome 10 Open Reading Frame 3 2
  • Centrosomal Protein Of 55 KDa 3
  • CT111 3
  • MARCH 3
  • Cep55 4

External Ids for CEP55 Gene

Previous HGNC Symbols for CEP55 Gene

  • C10orf3

Previous GeneCards Identifiers for CEP55 Gene

  • GC10P095247
  • GC10P088884

Summaries for CEP55 Gene

GeneCards Summary for CEP55 Gene

CEP55 (Centrosomal Protein 55) is a Protein Coding gene. Diseases associated with CEP55 include Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly and Meckel Syndrome, Type 1. Among its related pathways are Cytoskeletal Signaling and DNA Damage.

UniProtKB/Swiss-Prot for CEP55 Gene

  • Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986).

Gene Wiki entry for CEP55 Gene

Additional gene information for CEP55 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP55 Gene

Genomics for CEP55 Gene

GeneHancer (GH) Regulatory Elements for CEP55 Gene

Promoters and enhancers for CEP55 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J093494 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 663.2 -0.5 -477 3.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF207 ZNF143 CEP55 ENSG00000273450 MYOF
GH10J093498 Enhancer 0.8 ENCODE dbSUPER 661.7 +1.9 1852 0.9 ZNF202 TCF12 ZNF658 HDAC2 NCOR1 ZNF366 TEAD4 CBFA2T3 CBFA2T2 CEP55 RPL17P34 PDE6C NOC3L GC10M093511 RNA5SP323
GH10J093455 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.1 -26.8 -26754 28.4 PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 YY1 ZNF143 FOS SP3 JUNB MYOF CEP55 ENSG00000273450 RPL17P34 PDE6C NOC3L IDE GC10M093419 GC10M093427
GH10J093514 Enhancer 0.6 Ensembl ENCODE dbSUPER 19.2 +19.1 19089 2.2 CEP55 FFAR4 CYP26A1 GC10M093511 RNA5SP323 GC10M093549
GH10J093412 Enhancer 0.7 Ensembl ENCODE dbSUPER 11.4 -83.3 -83314 2.2 SP7 MYOF CEP55 GC10M093427 GC10P093383
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEP55 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CEP55 gene promoter:
  • ATF-2
  • TBP
  • CUTL1
  • Evi-1
  • Nkx6-1

Genomic Locations for CEP55 Gene

Genomic Locations for CEP55 Gene
32,483 bases
Plus strand
32,481 bases
Plus strand

Genomic View for CEP55 Gene

Genes around CEP55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP55 Gene

Proteins for CEP55 Gene

  • Protein details for CEP55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Centrosomal protein of 55 kDa
    Protein Accession:
    Secondary Accessions:
    • B2RDG8
    • D3DR37
    • Q32WF5
    • Q3MV20
    • Q5VY28
    • Q6N034
    • Q96H32
    • Q9NVS7

    Protein attributes for CEP55 Gene

    464 amino acids
    Molecular mass:
    54178 Da
    Quaternary structure:
    • Homodimer (PubMed:16406728). Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1 (PubMed:16198290). Interacts with AKAP9/CG-NAP; the interaction occurs in interphase and is lost upon mitotic entry (PubMed:16198290). Interacts with PCNT/Kendrin; the interaction occurs in interphase and is lost upon mitotic entry (PubMed:16198290). Directly interacts with PDCD6IP; this interaction is required for PDCD6IP targeting to the midbody; CEP55 binds PDCD6IP in a 2:1 stoichiometry; PDCD6IP competes with TSG101 for the same binding site (PubMed:17853893, PubMed:17556548, PubMed:18641129, PubMed:18948538). Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis but not for viral budding (PubMed:17853893, PubMed:17556548, PubMed:18948538). Interacts with MVB12A, VPS37B, VPS37C and VPS28 (PubMed:17853893).
    • Sequence=BAA91670.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEP55 Gene

    Alternative splice isoforms for CEP55 Gene


neXtProt entry for CEP55 Gene

Post-translational modifications for CEP55 Gene

  • There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis, prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at the final stages of cell division to complete cytokinesis successfully.
  • Ubiquitination at posLast=442442, posLast=398398, posLast=367367, Lys341, posLast=233233, Lys222, Lys196, Lys180, Lys145, and posLast=129129
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP55 Gene

No data available for DME Specific Peptides for CEP55 Gene

Domains & Families for CEP55 Gene

Gene Families for CEP55 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CEP55 Gene


Suggested Antigen Peptide Sequences for CEP55 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP55: view

No data available for UniProtKB/Swiss-Prot for CEP55 Gene

Function for CEP55 Gene

Molecular function for CEP55 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986).

Phenotypes From GWAS Catalog for CEP55 Gene

Gene Ontology (GO) - Molecular Function for CEP55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CEP55: view
genes like me logo Genes that share phenotypes with CEP55: view

Human Phenotype Ontology for CEP55 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for CEP55 Gene

miRTarBase miRNAs that target CEP55

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP55 Gene

Localization for CEP55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP55 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody, Midbody ring. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loses affinity for the centrosome at the onset of prophase and diffuses throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis. {ECO:0000269 PubMed:16198290}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP55 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 3
extracellular 2
cytosol 2
endosome 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
  • Midbody (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEP55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 20186884
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IDA,IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CEP55: view

Pathways & Interactions for CEP55 Gene

SuperPathways for CEP55 Gene

SuperPathway Contained pathways
1 Cytoskeletal Signaling
2 DNA Damage
genes like me logo Genes that share pathways with CEP55: view

Pathways by source for CEP55 Gene

2 Cell Signaling Technology pathways for CEP55 Gene

SIGNOR curated interactions for CEP55 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CEP55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IGI 19638580
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0006997 NOT nucleus organization IMP 20616062
GO:0007049 cell cycle IEA --
GO:0007080 NOT mitotic metaphase plate congression IMP 20616062
genes like me logo Genes that share ontologies with CEP55: view

Drugs & Compounds for CEP55 Gene

No Compound Related Data Available

Transcripts for CEP55 Gene

Unigene Clusters for CEP55 Gene

Centrosomal protein 55kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP55 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7
SP2: -
SP3: - -
SP4: -

Relevant External Links for CEP55 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CEP55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP55 Gene

mRNA differential expression in normal tissues according to GTEx for CEP55 Gene

This gene is overexpressed in Testis (x5.7) and Esophagus - Mucosa (x4.4).

Protein differential expression in normal tissues from HIPED for CEP55 Gene

This gene is overexpressed in Plasma (44.7) and Testis (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEP55 Gene

Protein tissue co-expression partners for CEP55 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CEP55 Gene:


SOURCE GeneReport for Unigene cluster for CEP55 Gene:


mRNA Expression by UniProt/SwissProt for CEP55 Gene:

Tissue specificity: Expressed in embryonic brain (PubMed:28264986). Expressed in fetal brain ganglionic eminence, kidney tubules and multinucleate neurons in the temporal cortex (PubMed:28264986). Expressed in adult brain, cerebellum, kidney tubules, intestine and muscles (at protein level) (PubMed:28295209, PubMed:28264986). Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain.

Evidence on tissue expression from TISSUES for CEP55 Gene

  • Muscle(4.1)
genes like me logo Genes that share expression patterns with CEP55: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP55 Gene

Orthologs for CEP55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP55 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CEP55 34 33
  • 99.57 (n)
(Canis familiaris)
Mammalia CEP55 34 33
  • 90.5 (n)
(Bos Taurus)
Mammalia CEP55 34 33
  • 88.41 (n)
(Rattus norvegicus)
Mammalia Cep55 33
  • 81.1 (n)
(Mus musculus)
Mammalia Cep55 16 34 33
  • 80.16 (n)
(Monodelphis domestica)
Mammalia CEP55 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia CEP55 34
  • 54 (a)
(Gallus gallus)
Aves CEP55 34 33
  • 62.28 (n)
(Anolis carolinensis)
Reptilia CEP55 34
  • 50 (a)
(Danio rerio)
Actinopterygii cep55l 34 33
  • 53.43 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9181 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4811 34
  • 20 (a)
Species where no ortholog for CEP55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP55 Gene

Gene Tree for CEP55 (if available)
Gene Tree for CEP55 (if available)
Evolutionary constrained regions (ECRs) for CEP55: view image

Paralogs for CEP55 Gene

No data available for Paralogs for CEP55 Gene

Variants for CEP55 Gene

Sequence variations from dbSNP and Humsavar for CEP55 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs141458677 pathogenic, Hydranencephaly with renal aplasia-dysplasia 93,503,185(+) C/T 5_prime_UTR_variant, coding_sequence_variant, stop_gained
rs201430235 pathogenic, Hydranencephaly with renal aplasia-dysplasia 93,528,032(+) C/A coding_sequence_variant, stop_gained
rs1000086958 -- 93,508,634(+) A/G intron_variant
rs1000112075 -- 93,496,760(+) T/G 5_prime_UTR_variant
rs1000348341 -- 93,514,778(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CEP55 Gene

Variant ID Type Subtype PubMed ID
nsv825521 CNV loss 20364138

Variation tolerance for CEP55 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.64; 89.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEP55 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP55 Gene

Disorders for CEP55 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CEP55 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CEP55 in MalaCards View complete list of genes associated with diseases


  • Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly (MARCH) [MIM:236500]: An autosomal recessive, congenital disease characterized by severe hydranencephaly with multinucleated neurons, renal aplasia or dysplasia, and hypoplastic kidneys. Hydranencephaly is an anomaly leading to replacement of the cerebral hemispheres with a fluid-filled cyst. MARCH results in death in utero or in the perinatal period. {ECO:0000269 PubMed:28264986, ECO:0000269 PubMed:28295209}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CEP55

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CEP55: view

No data available for Genatlas for CEP55 Gene

Publications for CEP55 Gene

  1. The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody. (PMID: 16406728) Martinez-Garay I … Kutsche K (Genomics 2006) 3 4 22 58
  2. Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. (PMID: 16198290) Fabbro M … Khanna KK (Developmental cell 2005) 2 3 4 58
  3. A nonsense mutation in CEP55 defines a new locus for a Meckel-like syndrome, an autosomal recessive lethal fetal ciliopathy. (PMID: 28295209) Bondeson ML … Wilbe M (Clinical genetics 2017) 3 4 58
  4. A truncating mutation in CEP55 is the likely cause of MARCH, a novel syndrome affecting neuronal mitosis. (PMID: 28264986) Frosk P … Davis EE (Journal of medical genetics 2017) 3 4 58
  5. Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. (PMID: 21310966) Guizetti J … Gerlich DW (Science (New York, N.Y.) 2011) 3 4 58

Products for CEP55 Gene

Sources for CEP55 Gene

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