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Aliases for CEP44 Gene

Aliases for CEP44 Gene

  • Centrosomal Protein 44 2 3 5
  • KIAA1712 2 3 4
  • HBV PreS1-Transactivated Protein 3 3 4
  • Centrosomal Protein 44kDa 2 3
  • PS1TP3 3 4
  • Centrosomal Protein Of 44 KDa 3
  • Cep44 4

External Ids for CEP44 Gene

Previous HGNC Symbols for CEP44 Gene

  • KIAA1712

Previous GeneCards Identifiers for CEP44 Gene

  • GC04P175205

Summaries for CEP44 Gene

GeneCards Summary for CEP44 Gene

CEP44 (Centrosomal Protein 44) is a Protein Coding gene.

Additional gene information for CEP44 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP44 Gene

Genomics for CEP44 Gene

GeneHancer (GH) Regulatory Elements for CEP44 Gene

Promoters and enhancers for CEP44 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I174281 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 589.3 +0.1 87 3.5 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 CEP44 FBXO8
GH04I173331 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 33.4 -949.3 -949327 4.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A LOC105377541 HMGB2 GC04P173336 CEP44 SCRG1 ENSG00000248774 GC04M173250
GH04I173414 Enhancer 1.5 FANTOM5 Ensembl ENCODE 31.1 -867.5 -867477 2.8 HDGF PKNOX1 SMAD1 ARNT NEUROD1 YBX1 ZNF2 TCF12 ARID2 E2F8 CEP44 HMGB2 ENSG00000261646 HAND2-AS1 SAP30 RPL5P11 LOC101928383 SCRG1 GC04M173250
GH04I174423 Enhancer 1.1 Ensembl ENCODE 20.8 +139.9 139908 1.2 PKNOX1 ATF1 SMAD1 ARNT SIN3A NCOA2 TCF12 ZNF766 GATA2 ARID2 MIR4276 CEP44 FBXO8 ENSG00000261646 LINC02268 ENSG00000249875
GH04I173369 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.1 -912.6 -912576 4.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SAP30 LOC105377540 HMGB2 ENSG00000248774 SCRG1 CEP44 FBXO8 LOC101928383 GC04M173250
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CEP44 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CEP44 Gene

Genomic Locations for CEP44 Gene
chr4:174,283,677-174,334,355
(GRCh38/hg38)
Size:
50,679 bases
Orientation:
Plus strand
chr4:175,204,828-175,254,531
(GRCh37/hg19)

Genomic View for CEP44 Gene

Genes around CEP44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP44 Gene

Proteins for CEP44 Gene

  • Protein details for CEP44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0F1-CEP44_HUMAN
    Recommended name:
    Centrosomal protein of 44 kDa
    Protein Accession:
    Q9C0F1
    Secondary Accessions:
    • A8K8W9
    • A8MW11
    • B3KT53
    • D3DP42
    • Q8IXZ4

    Protein attributes for CEP44 Gene

    Size:
    390 amino acids
    Molecular mass:
    44140 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21803.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP44 Gene

Post-translational modifications for CEP44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CEP44 Gene

Domains & Families for CEP44 Gene

Gene Families for CEP44 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CEP44 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP44 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP44: view

No data available for UniProtKB/Swiss-Prot for CEP44 Gene

Function for CEP44 Gene

Phenotypes From GWAS Catalog for CEP44 Gene

Gene Ontology (GO) - Molecular Function for CEP44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CEP44: view

Phenotypes for CEP44 Gene

genes like me logo Genes that share phenotypes with CEP44: view

Animal Model Products

miRNA for CEP44 Gene

miRTarBase miRNAs that target CEP44

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP44 Gene

Localization for CEP44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP44 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=Localizes to centrosomes, spindle poles, and weakly in midbody.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP44 gene
Compartment Confidence
cytoskeleton 5
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for CEP44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 21399614
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CEP44: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CEP44 Gene

Pathways & Interactions for CEP44 Gene

SuperPathways for CEP44 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP44 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEP44 Gene

Drugs & Compounds for CEP44 Gene

No Compound Related Data Available

Transcripts for CEP44 Gene

Unigene Clusters for CEP44 Gene

Centrosomal protein 44kDa:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP44 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2:

Relevant External Links for CEP44 Gene

GeneLoc Exon Structure for
CEP44
ECgene alternative splicing isoforms for
CEP44

Expression for CEP44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEP44 Gene

This gene is overexpressed in Testis (19.3), Pancreas (12.2), and Heart (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEP44 Gene



Protein tissue co-expression partners for CEP44 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CEP44 Gene:

CEP44

SOURCE GeneReport for Unigene cluster for CEP44 Gene:

Hs.555989

Evidence on tissue expression from TISSUES for CEP44 Gene

  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with CEP44: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP44 Gene

Orthologs for CEP44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP44 33 34
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia CEP44 33 34
  • 88.43 (n)
cow
(Bos Taurus)
Mammalia CEP44 33 34
  • 86.58 (n)
rat
(Rattus norvegicus)
Mammalia Cep44 33
  • 77.63 (n)
mouse
(Mus musculus)
Mammalia Cep44 33 16 34
  • 76.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CEP44 34
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP44 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP44 33 34
  • 64.34 (n)
lizard
(Anolis carolinensis)
Reptilia CEP44 34
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep44 33
  • 56.63 (n)
Str.9363 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25493 33
zebrafish
(Danio rerio)
Actinopterygii cep44 33 34
  • 52.29 (n)
Species where no ortholog for CEP44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP44 Gene

ENSEMBL:
Gene Tree for CEP44 (if available)
TreeFam:
Gene Tree for CEP44 (if available)

Paralogs for CEP44 Gene

No data available for Paralogs for CEP44 Gene

Variants for CEP44 Gene

Sequence variations from dbSNP and Humsavar for CEP44 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000037425 -- 174,329,349(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000201384 -- 174,334,288(+) C/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000226578 -- 174,305,609(+) G/A intron_variant
rs1000243438 -- 174,303,675(+) TT/T intron_variant
rs1000336997 -- 174,312,078(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CEP44 Gene

Variant ID Type Subtype PubMed ID
esv1066081 CNV insertion 17803354
esv1614926 CNV insertion 17803354
esv995918 CNV insertion 20482838
nsv509025 CNV insertion 20534489
nsv510928 OTHER complex 20534489
nsv596234 CNV gain 21841781

Variation tolerance for CEP44 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEP44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP44

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP44 Gene

Disorders for CEP44 Gene

Additional Disease Information for CEP44

No disorders were found for CEP44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP44 Gene

Publications for CEP44 Gene

  1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L … Andersen JS (The EMBO journal 2011) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for CEP44 Gene

Sources for CEP44 Gene

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