Aliases for CEP20 Gene

Aliases for CEP20 Gene

  • Centrosomal Protein 20 2 3 4
  • FOP-Related Protein Of 20 KDa 2 3 4
  • FGFR1OP N-Terminal Like 2 3 5
  • PHSECRG2 2 3 4
  • FOPNL 3 4 5
  • FOR20 2 3 4
  • Pluripotent Embryonic Stem Cell-Related Protein 2 3
  • LisH Domain-Containing Protein FOPNL 3 4
  • C16orf63 3 4
  • LisH Domain-Containing Protein C16orf63 3
  • Chromosome 16 Open Reading Frame 63 2
  • FGFR1OP N-Terminal-Like Protein 4
  • DKFZp686N1651 2
  • FLJ31153 2

External Ids for CEP20 Gene

Previous HGNC Symbols for CEP20 Gene

  • C16orf63
  • FOPNL

Summaries for CEP20 Gene

GeneCards Summary for CEP20 Gene

CEP20 (Centrosomal Protein 20) is a Protein Coding gene. Diseases associated with CEP20 include Angular Cheilitis.

UniProtKB/Swiss-Prot Summary for CEP20 Gene

  • Involved in the biogenesis of cilia (PubMed:20551181). Required for the recruitment of PLK1 to centrosomes and S phase progression (PubMed:24018379).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEP20 Gene

Genomics for CEP20 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CEP20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J015884 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 606.1 +1.5 1529 4.8 CEBPG SP1 HNRNPL PRDM10 ZNF629 SIX5 IKZF1 NFKBIZ POLR2A NFRKB CEP20 MYH11 NDE1 ENSG00000262171
GH16J015897 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 605 -10.9 -10876 5 ARHGAP35 SP1 GATAD2A ZNF629 ZNF512 LEF1 SOX13 IKZF1 BACH1 JUND CEP20 HSALNG0109838 ABCC1 RNU6-213P MYH11 ENSG00000263065 HSALNG0109837 lnc-FOPNL-1
GH16J015854 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 22.2 +32.7 32674 6.3 ATF7 TEAD4 PRDM1 PHF21A RXRB PATZ1 NR2C1 EZH2 KLF9 FOXA1 MYH11 CEP20 ABCC1 RNU6-213P piR-57460-242 NDE1
GH16J016017 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -135.9 -135914 14.3 ARHGAP35 CEBPG HNRNPL GATAD2A TFE3 LEF1 IKZF1 NFKBIZ JUND FOXA1 BMERB1 CEP20 RNU6-213P MYH11 ABCC1 NDE1 piR-57133-223 piR-57460-243 ABCC6
GH16J015571 Enhancer 1.3 Ensembl ENCODE dbSUPER 13.2 +316.3 316325 5.8 GATAD2A RFX1 LEF1 SOX13 IKZF1 RCOR2 JUND DDX20 MTA2 PHF21A PARN RRN3 LOC100505915 PKD1P6 PKD1P1 PKD1P3 CEP20 BMERB1 BFAR PDXDC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEP20 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CEP20

Genomic Locations for CEP20 Gene

Genomic Locations for CEP20 Gene
chr16:15,865,719-15,888,625
(GRCh38/hg38)
Size:
22,907 bases
Orientation:
Minus strand
chr16:15,959,577-15,982,482
(GRCh37/hg19)
Size:
22,906 bases
Orientation:
Minus strand

Genomic View for CEP20 Gene

Genes around CEP20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP20 Gene

Proteins for CEP20 Gene

  • Protein details for CEP20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NB1-CEP20_HUMAN
    Recommended name:
    Centrosomal protein 20
    Protein Accession:
    Q96NB1
    Secondary Accessions:
    • B3KPU9

    Protein attributes for CEP20 Gene

    Size:
    174 amino acids
    Molecular mass:
    19778 Da
    Quaternary structure:
    • Homooligomer; probably required for localization to centrosomes (PubMed:20551181). Forms a complex with KIAA0753/OFIP and OFD1; within this complex may stabilize the interaction between OFD1 and KIAA0753/OFIP (PubMed:26643951). Interacts with PCM1; this interaction may be mediated by KIAA0753/OFIP (PubMed:26643951). Interacts with PLK1 in later G1, S, G2 and M phases of the cell cycle; this interaction recruits PLK1 to centrosomes (PubMed:24018379).

    Alternative splice isoforms for CEP20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP20 Gene

Post-translational modifications for CEP20 Gene

  • Ubiquitination at Lys8
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP20 Gene

Domains & Families for CEP20 Gene

Gene Families for CEP20 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CEP20 Gene

InterPro:
Blocks:
  • Lissencephaly type-1-like homology motif
ProtoNet:

Suggested Antigen Peptide Sequences for CEP20 Gene

GenScript: Design optimal peptide antigens:
  • FOP-related protein of 20 kDa (FOPNL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96NB1

UniProtKB/Swiss-Prot:

CEP20_HUMAN :
  • Belongs to the CEP43 family.
Family:
  • Belongs to the CEP43 family.
genes like me logo Genes that share domains with CEP20: view

Function for CEP20 Gene

Molecular function for CEP20 Gene

UniProtKB/Swiss-Prot Function:
Involved in the biogenesis of cilia (PubMed:20551181). Required for the recruitment of PLK1 to centrosomes and S phase progression (PubMed:24018379).

Phenotypes From GWAS Catalog for CEP20 Gene

Gene Ontology (GO) - Molecular Function for CEP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with CEP20: view
genes like me logo Genes that share phenotypes with CEP20: view

Animal Model Products

CRISPR Products

miRNA for CEP20 Gene

miRTarBase miRNAs that target CEP20

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEP20

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP20 Gene

Localization for CEP20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP20 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to the centrosome throughout cell cycle progression (PubMed:24018379). Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP (PubMed:26643951). {ECO:0000269 PubMed:24018379, ECO:0000269 PubMed:26643951}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP20 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CEP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with CEP20: view

Pathways & Interactions for CEP20 Gene

PathCards logo

SuperPathways for CEP20 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0034453 microtubule anchoring IEA --
GO:0060271 cilium assembly IBA,IMP 15616553
genes like me logo Genes that share ontologies with CEP20: view

No data available for Pathways by source and SIGNOR curated interactions for CEP20 Gene

Drugs & Compounds for CEP20 Gene

No Compound Related Data Available

Transcripts for CEP20 Gene

mRNA/cDNA for CEP20 Gene

6 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEP20

Alternative Splicing Database (ASD) splice patterns (SP) for CEP20 Gene

No ASD Table

Relevant External Links for CEP20 Gene

GeneLoc Exon Structure for
CEP20

Expression for CEP20 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CEP20

SOURCE GeneReport for Unigene cluster for CEP20 Gene:

Hs.514179

mRNA Expression by UniProt/SwissProt for CEP20 Gene:

Q96NB1-CEP20_HUMAN
Tissue specificity: Widely expressed. Detected in brain, heart, kidney, liver, lung, skeletal muscle, placenta and intestine.

Evidence on tissue expression from TISSUES for CEP20 Gene

  • Lung(4.3)
  • Nervous system(4.1)
  • Muscle(2.3)
  • Heart(2.2)
  • Skin(2.2)
  • Kidney(2.1)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP20 Gene

Orthologs for CEP20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP20 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FOPNL 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FOPNL 30 31
  • 87.55 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FOPNL 30 31
  • 85.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fopnl 30
  • 82.47 (n)
Mouse
(Mus musculus)
Mammalia Fopnl 30 31
  • 81.7 (n)
OneToOne
Cep20 17
Oppossum
(Monodelphis domestica)
Mammalia FOPNL 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FOPNL 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FOPNL 30 31
  • 65.9 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FOPNL 31
  • 46 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fopnl 30
  • 64.46 (n)
Str.3182 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7611 30
Zebrafish
(Danio rerio)
Actinopterygii fopnl 30 31
  • 59.95 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14123 30
Species where no ortholog for CEP20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CEP20 Gene

ENSEMBL:
Gene Tree for CEP20 (if available)
TreeFam:
Gene Tree for CEP20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEP20: view image

Paralogs for CEP20 Gene

No data available for Paralogs for CEP20 Gene

Variants for CEP20 Gene

Additional dbSNP identifiers (rs#s) for CEP20 Gene

Structural Variations from Database of Genomic Variants (DGV) for CEP20 Gene

Variant ID Type Subtype PubMed ID
dgv2773n100 CNV gain 25217958
dgv2774n100 CNV gain 25217958
dgv345n27 CNV gain 19166990
dgv4924n54 CNV gain 21841781
dgv4926n54 CNV gain 21841781
esv23840 CNV gain+loss 19812545
esv2421345 CNV duplication 20811451
esv2714015 CNV deletion 23290073
esv2760415 CNV gain 21179565
esv3570387 CNV gain 25503493
esv3638041 CNV gain 21293372
esv3638042 CNV gain 21293372
nsv1045194 CNV gain 25217958
nsv1047898 CNV loss 25217958
nsv1048188 CNV gain 25217958
nsv1049647 CNV gain+loss 25217958
nsv1125134 CNV deletion 24896259
nsv435664 CNV deletion 17901297
nsv442391 CNV gain 18776908
nsv457428 CNV gain 19166990
nsv457432 CNV gain 19166990
nsv457436 CNV gain 19166990
nsv471085 CNV gain 18288195
nsv514795 CNV gain 21397061
nsv571543 CNV gain 21841781
nsv833149 CNV loss 17160897

Variation tolerance for CEP20 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.45; 88.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEP20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CEP20 Gene

Disorders for CEP20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CEP20 Gene - From: DISEASES

Disorder Aliases PubMed IDs
angular cheilitis
  • angular cheilosis
- elite association - COSMIC cancer census association via MalaCards
Search CEP20 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CEP20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEP20 Gene

Publications for CEP20 Gene

  1. Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. (PMID: 20551181) Sedjaï F … Rosnet O (Journal of cell science 2010) 2 3 4
  2. Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes. (PMID: 24018379) Shen M … Zhou T (Cell research 2013) 3 4
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for CEP20 Gene

Sources for CEP20 Gene