Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CEP192 Gene

Aliases for CEP192 Gene

  • Centrosomal Protein 192 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 62 2 3
  • Centrosomal Protein 192kDa 2 3
  • Centrosomal Protein Of 192 KDa 3
  • 192 KDa Centrosomal Protein 3
  • KIAA1569 4
  • PPP1R62 3
  • Cep192 4

External Ids for CEP192 Gene

Previous GeneCards Identifiers for CEP192 Gene

  • GC18U900257

Summaries for CEP192 Gene

GeneCards Summary for CEP192 Gene

CEP192 (Centrosomal Protein 192) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include phosphatase binding.

UniProtKB/Swiss-Prot for CEP192 Gene

  • Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.

Gene Wiki entry for CEP192 Gene

Additional gene information for CEP192 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP192 Gene

Genomics for CEP192 Gene

GeneHancer (GH) Regulatory Elements for CEP192 Gene

Promoters and enhancers for CEP192 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J012989 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 748 -0.2 -166 3.7 YBX1 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 NFYC CEP192 ENSG00000266969 PSMG2 PTPN2 PRELID3A CEP76 ENSG00000267249 ENSG00000267199 LINC01882 RNMT
GH18J012946 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 88.4 -43.6 -43614 3.3 CLOCK ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 ZNF610 GLIS1 SEH1L CEP192 PSMG2 PTPN2 RNMT ENSG00000267249 GC18M015299
GH18J012700 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 42.3 -288.8 -288813 4.9 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B PSMG2 CEP76 CEP192 SPIRE1 PTPN2 MPPE1 PIR52927 GC18M015675
GH18J013135 Enhancer 1.1 Ensembl ENCODE 69.4 +146.2 146163 3.5 PKNOX1 FOXA2 ARID4B DMAP1 ZNF48 YY1 RUNX3 RXRA NFYC REST CEP192 PTPN2 PSMG2 LOC646203 GC18P013134
GH18J012878 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.3 -108.6 -108620 8.2 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 PTPN2 GC18P012884 PSMG2 CEP192 CEP76 LINC01882 ENSG00000267199 ENSG00000267480 GC18M015277 GC18M015649
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEP192 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CEP192 gene promoter:
  • Nkx2-5
  • CUTL1
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1

Genomic Locations for CEP192 Gene

Genomic Locations for CEP192 Gene
chr18:12,991,321-13,125,053
(GRCh38/hg38)
Size:
133,733 bases
Orientation:
Plus strand
chr18:12,991,361-13,125,052
(GRCh37/hg19)
Size:
133,692 bases
Orientation:
Plus strand

Genomic View for CEP192 Gene

Genes around CEP192 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP192 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP192 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP192 Gene

Proteins for CEP192 Gene

  • Protein details for CEP192 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEP8-CE192_HUMAN
    Recommended name:
    Centrosomal protein of 192 kDa
    Protein Accession:
    Q8TEP8
    Secondary Accessions:
    • A0A060A9S4
    • B7ZMF0
    • E9PF99
    • Q8WYT8
    • Q9H0F4
    • Q9NW27

    Protein attributes for CEP192 Gene

    Size:
    1941 amino acids
    Molecular mass:
    213146 Da
    Quaternary structure:
    • Interacts with SHBG.
    SequenceCaution:
    • Sequence=AAL55870.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91559.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66752.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66752.1; Type=Frameshift; Positions=1196, 1239; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEP192 Gene

    Alternative splice isoforms for CEP192 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP192 Gene

Post-translational modifications for CEP192 Gene

  • Hydroxylation by PHD1/EGLN2 at Pro-1717 promotes ubiquitination.
  • Ubiquitinated by a SCF(SKP2) complex following proline hydroxylation.
  • Ubiquitination at Lys1482 and Lys1379
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP192 Gene

Domains & Families for CEP192 Gene

Gene Families for CEP192 Gene

Protein Domains for CEP192 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP192 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP192: view

No data available for UniProtKB/Swiss-Prot for CEP192 Gene

Function for CEP192 Gene

Molecular function for CEP192 Gene

UniProtKB/Swiss-Prot Function:
Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.

Phenotypes From GWAS Catalog for CEP192 Gene

Gene Ontology (GO) - Molecular Function for CEP192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19389623
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with CEP192: view
genes like me logo Genes that share phenotypes with CEP192: view

Animal Model Products

miRNA for CEP192 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP192 Gene

Localization for CEP192 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP192 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Pericentriolar location in mitotic centrosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP192 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEP192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 17980596
GO:0005814 centriole IEA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with CEP192: view

Pathways & Interactions for CEP192 Gene

genes like me logo Genes that share pathways with CEP192: view

Pathways by source for CEP192 Gene

Gene Ontology (GO) - Biological Process for CEP192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0071539 protein localization to centrosome IMP 17980596
GO:0090222 centrosome-templated microtubule nucleation IMP 17980596
genes like me logo Genes that share ontologies with CEP192: view

No data available for SIGNOR curated interactions for CEP192 Gene

Drugs & Compounds for CEP192 Gene

No Compound Related Data Available

Transcripts for CEP192 Gene

mRNA/cDNA for CEP192 Gene

(15) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEP192 Gene

Centrosomal protein 192kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP192 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
SP1: -
SP2: -
SP3: - - - - - -
SP4:
SP5: - - - - - -
SP6:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5:
SP6: - -

Relevant External Links for CEP192 Gene

GeneLoc Exon Structure for
CEP192
ECgene alternative splicing isoforms for
CEP192

Expression for CEP192 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP192 Gene

Protein differential expression in normal tissues from HIPED for CEP192 Gene

This gene is overexpressed in Platelet (13.5), CD8 Tcells (12.4), Peripheral blood mononuclear cells (11.3), Adipocyte (10.7), and Blymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEP192 Gene



Protein tissue co-expression partners for CEP192 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CEP192 Gene:

CEP192

SOURCE GeneReport for Unigene cluster for CEP192 Gene:

Hs.100914

Evidence on tissue expression from TISSUES for CEP192 Gene

  • Nervous system(4.4)
  • Spleen(4.2)
  • Blood(4.1)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with CEP192: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP192 Gene

Orthologs for CEP192 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP192 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP192 34 33
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CEP192 33
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Cep192 16 34 33
  • 76.63 (n)
cow
(Bos Taurus)
Mammalia CEP192 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CEP192 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP192 34 33
  • 60.19 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP192 34
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep192 33
  • 57.01 (n)
zebrafish
(Danio rerio)
Actinopterygii CEP192 34
  • 39 (a)
OneToOne
Species where no ortholog for CEP192 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP192 Gene

ENSEMBL:
Gene Tree for CEP192 (if available)
TreeFam:
Gene Tree for CEP192 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEP192: view image

Paralogs for CEP192 Gene

(1) SIMAP similar genes for CEP192 Gene using alignment to 13 proteins:

  • CE192_HUMAN
  • B7ZME9_HUMAN
  • B7ZMF0_HUMAN
  • C9JT09_HUMAN
  • E9PF99_HUMAN
  • H0Y966_HUMAN
  • H0Y9P3_HUMAN
  • K7ELX0_HUMAN
  • K7ENP4_HUMAN
  • K7EPA2_HUMAN
  • K7EQZ8_HUMAN
  • K7ERF9_HUMAN
  • V9GYM2_HUMAN
genes like me logo Genes that share paralogs with CEP192: view

No data available for Paralogs for CEP192 Gene

Variants for CEP192 Gene

Sequence variations from dbSNP and Humsavar for CEP192 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000017530 -- 13,016,038(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000019073 -- 13,038,094(+) C/T intron_variant
rs1000034216 -- 13,101,560(+) A/C genic_downstream_transcript_variant, intron_variant
rs1000036454 -- 13,025,563(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000059025 -- 12,996,954(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CEP192 Gene

Variant ID Type Subtype PubMed ID
esv2716816 CNV deletion 23290073
esv2716817 CNV deletion 23290073
esv2716819 CNV deletion 23290073
esv3139 CNV loss 18987735
esv3555072 CNV deletion 23714750
esv3582980 CNV loss 25503493
esv3641849 CNV loss 21293372
nsv1057083 CNV gain 25217958
nsv1113907 CNV deletion 24896259
nsv437176 CNV loss 16327808
nsv515878 CNV loss 19592680
nsv576524 CNV gain 21841781
nsv833591 CNV gain 17160897
nsv960255 CNV duplication 23825009

Variation tolerance for CEP192 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.29; 96.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEP192 Gene

Human Gene Mutation Database (HGMD)
CEP192
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP192

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP192 Gene

Disorders for CEP192 Gene

Additional Disease Information for CEP192

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CEP192 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP192 Gene

Publications for CEP192 Gene

  1. Human Cep192 is required for mitotic centrosome and spindle assembly. (PMID: 17980596) Gomez-Ferreria MA … Sharp DJ (Current biology : CB 2007) 3 4 22 58
  2. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen JS … Mann M (Nature 2003) 2 3 4 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  4. PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192. (PMID: 23932902) Moser SC … Rocha S (Developmental cell 2013) 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for CEP192 Gene

Sources for CEP192 Gene

Content
Loading form....