Aliases for CEP170B Gene

Aliases for CEP170B Gene

  • Centrosomal Protein 170B 2 3 4 5
  • KIAA0284 2 3 4
  • FAM68C 2 3 4
  • Centrosomal Protein Of 170 KDa Protein B 3 4
  • Cep170-Related 2 3
  • CEP170R 3
  • CEP170B 5
  • Cep170R 2
  • Cep170B 4

External Ids for CEP170B Gene

Previous HGNC Symbols for CEP170B Gene

  • KIAA0284

Previous GeneCards Identifiers for CEP170B Gene

  • GC14P105332

Summaries for CEP170B Gene

GeneCards Summary for CEP170B Gene

CEP170B (Centrosomal Protein 170B) is a Protein Coding gene. An important paralog of this gene is CEP170.

UniProtKB/Swiss-Prot Summary for CEP170B Gene

Additional gene information for CEP170B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEP170B Gene

Genomics for CEP170B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CEP170B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEP170B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CEP170B

Genomic Locations for CEP170B Gene

Genomic Locations for CEP170B Gene
chr14:104,865,268-104,896,770
(GRCh38/hg38)
Size:
31,503 bases
Orientation:
Plus strand
chr14:105,331,617-105,363,107
(GRCh37/hg19)
Size:
31,491 bases
Orientation:
Plus strand

Genomic View for CEP170B Gene

Genes around CEP170B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP170B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP170B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP170B Gene

Proteins for CEP170B Gene

  • Protein details for CEP170B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4F5-C170B_HUMAN
    Recommended name:
    Centrosomal protein of 170 kDa protein B
    Protein Accession:
    Q9Y4F5
    Secondary Accessions:
    • Q2KHR7
    • Q86TI7

    Protein attributes for CEP170B Gene

    Size:
    1589 amino acids
    Molecular mass:
    171688 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47913.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA22953.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP170B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP170B Gene

Post-translational modifications for CEP170B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CEP170B Gene

Domains & Families for CEP170B Gene

Gene Families for CEP170B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CEP170B Gene

InterPro:
Blocks:
  • Forkhead-associated (FHA)
ProtoNet:

Suggested Antigen Peptide Sequences for CEP170B Gene

GenScript: Design optimal peptide antigens:
  • Protein KIAA0284 (K0284_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y4F5

UniProtKB/Swiss-Prot:

C170B_HUMAN :
  • Belongs to the CEP170 family.
Family:
  • Belongs to the CEP170 family.
genes like me logo Genes that share domains with CEP170B: view

Function for CEP170B Gene

Molecular function for CEP170B Gene

UniProtKB/Swiss-Prot Function:
Plays a role in microtubule organization.

Phenotypes From GWAS Catalog for CEP170B Gene

Gene Ontology (GO) - Molecular Function for CEP170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with CEP170B: view
genes like me logo Genes that share phenotypes with CEP170B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEP170B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP170B Gene

Localization for CEP170B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP170B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP170B gene
Compartment Confidence
cytoskeleton 3
nucleus 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEP170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with CEP170B: view

Pathways & Interactions for CEP170B Gene

PathCards logo

SuperPathways for CEP170B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP170B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEP170B Gene

Drugs & Compounds for CEP170B Gene

No Compound Related Data Available

Transcripts for CEP170B Gene

mRNA/cDNA for CEP170B Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEP170B

Alternative Splicing Database (ASD) splice patterns (SP) for CEP170B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for CEP170B Gene

GeneLoc Exon Structure for
CEP170B

Expression for CEP170B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEP170B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEP170B Gene

This gene is overexpressed in Lung (23.6), Brain (13.4), Frontal cortex (10.4), and Fetal Brain (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEP170B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CEP170B

SOURCE GeneReport for Unigene cluster for CEP170B Gene:

Hs.533721

Evidence on tissue expression from TISSUES for CEP170B Gene

  • Nervous system(4.5)
  • Liver(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with CEP170B: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP170B Gene

Orthologs for CEP170B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP170B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KIAA0284 30
  • 96.68 (n)
CEP170B 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia KIAA0284 30
  • 82.55 (n)
CEP170B 31
  • 76 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia KIAA0284 30
  • 80.95 (n)
CEP170B 31
  • 75 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cep170b 30 17 31
  • 80.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cep170b 30
  • 80.2 (n)
Oppossum
(Monodelphis domestica)
Mammalia CEP170B 31
  • 56 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CEP170B 31
  • 45 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KIAA0284 30
  • 62.34 (n)
CEP170B 31
  • 54 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CEP170B 31
  • 50 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cep170b 30
  • 54.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13597 30
Zebrafish
(Danio rerio)
Actinopterygii CEP170B (3 of 3) 31
  • 83 (a)
OneToMany
si:ch73-212j7.1 30
  • 53.29 (n)
CEP170B (2 of 3) 31
  • 37 (a)
OneToMany
CEP170B (1 of 3) 31
  • 33 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
OneToMany
Species where no ortholog for CEP170B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CEP170B Gene

ENSEMBL:
Gene Tree for CEP170B (if available)
TreeFam:
Gene Tree for CEP170B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEP170B: view image

Paralogs for CEP170B Gene

Paralogs for CEP170B Gene

(3) SIMAP similar genes for CEP170B Gene using alignment to 3 proteins:

  • C170B_HUMAN
  • E9PFC1_HUMAN
  • J3KQR7_HUMAN
genes like me logo Genes that share paralogs with CEP170B: view

Variants for CEP170B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CEP170B Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
781153 Benign: not provided 104,883,233(+) C/T MISSENSE_VARIANT
787955 Benign: not provided 104,880,392(+) A/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CEP170B Gene

Structural Variations from Database of Genomic Variants (DGV) for CEP170B Gene

Variant ID Type Subtype PubMed ID
dgv3964n54 CNV gain 21841781
dgv3965n54 CNV loss 21841781
dgv3966n54 CNV loss 21841781
dgv3967n54 CNV gain 21841781
dgv3968n54 CNV gain+loss 21841781
dgv3969n54 CNV loss 21841781
dgv3970n54 CNV gain 21841781
dgv3971n54 CNV loss 21841781
dgv3972n54 CNV loss 21841781
esv1296512 CNV deletion 17803354
esv21727 CNV loss 19812545
esv2673602 CNV deletion 23128226
esv2749248 CNV deletion 23290073
esv3635627 CNV gain 21293372
nsv1054574 CNV loss 25217958
nsv1069826 CNV deletion 25765185
nsv1108924 CNV deletion 24896259
nsv470677 CNV loss 18288195
nsv474570 CNV novel sequence insertion 20440878
nsv566099 CNV gain 21841781
nsv566101 CNV gain+loss 21841781
nsv566115 CNV gain 21841781
nsv566122 CNV gain+loss 21841781
nsv566133 CNV loss 21841781
nsv566135 CNV loss 21841781
nsv566137 CNV loss 21841781
nsv566138 CNV loss 21841781
nsv566139 CNV loss 21841781
nsv566140 CNV loss 21841781
nsv820719 CNV deletion 20802225
nsv827078 CNV gain 20364138
nsv827079 CNV gain 20364138
nsv84293 CNV deletion 16902084
nsv952272 CNV deletion 24416366
nsv952273 CNV deletion 24416366

Variation tolerance for CEP170B Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.00; 74.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEP170B Gene

Human Gene Mutation Database (HGMD)
CEP170B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP170B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP170B Gene

Disorders for CEP170B Gene

No disorders were found for CEP170B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP170B Gene

Publications for CEP170B Gene

  1. The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle. (PMID: 23087211) Welburn JP … Cheeseman IM (Molecular biology of the cell 2012) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4
  4. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for CEP170B Gene

Sources for CEP170B Gene