Aliases for CEP170B Gene
Aliases for CEP170B Gene
External Ids for CEP170B Gene
- HGNC: 20362
- Entrez Gene: 283638
- Ensembl: ENSG00000099814
- UniProtKB: Q9Y4F5
Previous HGNC Symbols for CEP170B Gene
- KIAA0284
Previous GeneCards Identifiers for CEP170B Gene
- GC14P105332
Summaries for CEP170B Gene
GeneCards Summary for CEP170B Gene
CEP170B (Centrosomal Protein 170B) is a Protein Coding gene. An important paralog of this gene is CEP170.
UniProtKB/Swiss-Prot for CEP170B Gene
-
Plays a role in microtubule organization.
Additional gene information for CEP170B Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP170B Gene
Genomics for CEP170B Gene
GeneHancer (GH) Regulatory Elements for CEP170B Gene
Promoters and enhancers for CEP170B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CEP170B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CEP170B Gene
Genomic Locations for CEP170B Gene
- chr14:104,865,280-104,896,770
- (GRCh38/hg38)
- Size:
- 31,491 bases
- Orientation:
- Plus strand
- chr14:105,331,617-105,363,107
- (GRCh37/hg19)
Genomic View for CEP170B Gene
Genes around CEP170B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.33 by Ensembl
- 14q32.33 by Entrez Gene
- 14q32.33 by HGNC
CEP170B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CEP170B Gene
Proteins for CEP170B Gene
-
Protein details for CEP170B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y4F5-C170B_HUMAN
- Recommended name:
- Centrosomal protein of 170 kDa protein B
- Protein Accession:
- Q9Y4F5
- Q2KHR7
- Q86TI7
Protein attributes for CEP170B Gene
- Size:
- 1589 amino acids
- Molecular mass:
- 171688 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH47913.1; Type=Frameshift; Positions=1379; Evidence={ECO:0000305}; Sequence=BAA22953.3; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CEP170B Gene
Post-translational modifications for CEP170B Gene
Other Protein References for CEP170B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CEP170B
- Novus Biologicals Antibodies for CEP170B
- Invitrogen Antibodies for CEP170B
- GeneTex CEP170B antibody for CEP170B
Protein Products
-
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- Search GeneTex for Proteins for CEP170B
-
Abcam proteins for CEP170B
Assay Products
No data available for DME Specific Peptides for CEP170B Gene
Domains & Families for CEP170B Gene
Gene Families for CEP170B Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CEP170B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CEP170B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y4F5- Family:
-
- Belongs to the CEP170 family.
Function for CEP170B Gene
Molecular function for CEP170B Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in microtubule organization.
Phenotypes From GWAS Catalog for CEP170B Gene
Phenotypes for CEP170B Gene
- GenomeRNAi human phenotypes for CEP170B:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CEP170B gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for CEP170B
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- Applied Biological Materials CRISPR for CEP170B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEP170B
- GenScript: Design CRISPR guide RNA sequences for CEP170B
miRNA for CEP170B Gene
- miRTarBase miRNAs that target CEP170B
-
- hsa-mir-149-5p (MIRT045683)
- hsa-mir-25-3p (MIRT050289)
- hsa-let-7f-5p (MIRT051356)
- hsa-let-7c-5p (MIRT051731)
- hsa-let-7a-5p (MIRT052378)
- hsa-mir-1199-3p (MIRT735941)
- hsa-mir-147b (MIRT737662)
- hsa-mir-184 (MIRT738189)
- hsa-mir-1910-3p (MIRT738394)
- hsa-mir-3656 (MIRT741922)
- hsa-mir-3714 (MIRT742554)
- hsa-mir-3937 (MIRT743124)
- hsa-mir-3960 (MIRT743188)
- hsa-mir-4455 (MIRT744720)
- hsa-mir-4514 (MIRT745698)
- hsa-mir-4520-3p (MIRT745812)
- hsa-mir-4638-3p (MIRT746314)
- hsa-mir-4645-5p (MIRT746413)
- hsa-mir-4673 (MIRT746854)
- hsa-mir-4692 (MIRT747106)
- hsa-mir-4755-3p (MIRT748359)
- hsa-mir-5580-5p (MIRT750928)
- hsa-mir-605-3p (MIRT751642)
- hsa-mir-6125 (MIRT752067)
- hsa-mir-6511a-5p (MIRT753119)
- hsa-mir-6808-5p (MIRT756557)
- hsa-mir-6869-5p (MIRT757962)
- hsa-mir-6893-5p (MIRT758701)
- hsa-mir-8072 (MIRT760113)
- hsa-mir-940 (MIRT760798)
miRNA Products
- Search ViGene Biosciences for CEP170B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CEP170B
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-
ViGene Biosciences ready-to-package AAV shRNAs for CEP170B gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CEP170B
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available CEP170B gene related products
- orf clones - Search results for available CEP170B gene related products
- Applied Biological Materials Clones for CEP170B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CEP170B
-
ViGene Biosciences adenoviral particle packaged cDNA for CEP170B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CEP170B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CEP170B gene
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP170B Gene
Localization for CEP170B Gene
Subcellular locations from UniProtKB/Swiss-Prot for CEP170B Gene
- Cytoplasm, cytoskeleton.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 3 |
| nucleus | 3 |
| cytosol | 2 |
| mitochondrion | 1 |
- Centrosome (2)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005874 | microtubule | IEA | -- |
Pathways & Interactions for CEP170B Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for CEP170B Gene
Transcripts for CEP170B Gene
mRNA/cDNA for CEP170B Gene
- (10) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (122) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CEP170B Gene
- Centrosomal protein 170B:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CEP170B
- genomics-online: gRNA clones - Search results for available CEP170B gene related products
- Applied Biological Materials CRISPR for CEP170B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEP170B
- GenScript: Design CRISPR guide RNA sequences for CEP170B
miRNA Products
- Search ViGene Biosciences for CEP170B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CEP170B
- Browse OriGene Inhibitory RNA Products For CEP170B
- genomics-online: shRNA clones - Search results for available CEP170B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CEP170B gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CEP170B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CEP170B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available CEP170B gene related products
- orf clones - Search results for available CEP170B gene related products
- Applied Biological Materials Clones for CEP170B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: |
Expression for CEP170B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
This gene is overexpressed in Lung (23.6), Brain (13.4), Frontal cortex (10.4), and Fetal Brain (9.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEP170B Gene
NURSA nuclear receptor signaling pathways regulating expression of CEP170B Gene:
CEP170BSOURCE GeneReport for Unigene cluster for CEP170B Gene:
Hs.533721Evidence on tissue expression from TISSUES for CEP170B Gene
- Nervous system(4.4)
- Liver(4.2)
- Eye(4.1)
Primer Products
-
OriGene qPCR primer pairs for CEP170B
- genomics-online: primer clones - Search results for available CEP170B gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP170B Gene
Orthologs for CEP170B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KIAA0284 33 |
|
||
| CEP170B 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | KIAA0284 33 |
|
||
| CEP170B 34 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | KIAA0284 33 |
|
||
| CEP170B 34 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Cep170b 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cep170b 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CEP170B 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CEP170B 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KIAA0284 33 |
|
||
| CEP170B 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | CEP170B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cep170b 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13597 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CEP170B (3 of 3) 34 |
|
OneToMany | |
| si:ch73-212j7.1 33 |
|
||||
| CEP170B (2 of 3) 34 |
|
OneToMany | |||
| CEP170B (1 of 3) 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for CEP170B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CEP170B Gene
(3) SIMAP similar genes for CEP170B Gene using alignment to 3 proteins:
Variants for CEP170B Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000055506 | -- | 104,895,241(+) | G/A | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000067146 | -- | 104,883,807(+) | GGTGGG/GG | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000358416 | -- | 104,884,401(+) | C/T | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, upstream_transcript_variant | |
| rs1000477212 | -- | 104,865,338(+) | G/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000534006 | -- | 104,869,807(+) | C/T | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.00;
74.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CEP170B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP170B Gene
Disorders for CEP170B Gene
Additional Disease Information for CEP170B
No disorders were found for CEP170B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP170B Gene
Publications for CEP170B Gene
- The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle. (PMID: 23087211) Welburn JP … Cheeseman IM (Molecular biology of the cell 2012) 2 3 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
- Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for CEP170B Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 10 available CEP170B Antibodies ranked by validation data
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Sources for CEP170B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
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