Aliases for CENPX Gene

Aliases for CENPX Gene

  • Centromere Protein X 2 3 4 5
  • CENP-X 2 3 4
  • FAAP10 2 3 4
  • Stimulated By Retinoic Acid Gene 13 Protein Homolog 3 4
  • Fanconi Anemia-Associated Polypeptide Of 10 KDa 3 4
  • Retinoic Acid-Inducible Gene D9 Protein Homolog 3 4
  • FANCM-Interacting Histone Fold Protein 2 3 4
  • FANCM Associated Histone Fold Protein 2 2 3
  • STRA13 3 4
  • MHF2 3 4
  • Stimulated By Retinoic Acid 13 Homolog (Mouse) 2
  • FANCM-Associated Histone Fold Protein 2 4
  • Stimulated By Retinoic Acid 13 Homolog 3
  • Stimulated By Retinoic Acid 13 2
  • MGC14480 2
  • CENPX 5
  • D9 3

External Ids for CENPX Gene

Previous HGNC Symbols for CENPX Gene

  • STRA13
  • MHF2

Summaries for CENPX Gene

GeneCards Summary for CENPX Gene

CENPX (Centromere Protein X) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and DNA Double-Strand Break Repair.

UniProtKB/Swiss-Prot Summary for CENPX Gene

  • DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:20347429). DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347429).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CENPX Gene

Genomics for CENPX Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CENPX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CENPX on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CENPX

Genomic Locations for CENPX Gene

Latest Assembly
chr17:82,018,702-82,024,107
(GRCh38/hg38)
Size:
5,406 bases
Orientation:
Minus strand

Previous Assembly
chr17:79,976,579-79,980,754
(GRCh37/hg19 by Entrez Gene)
Size:
4,176 bases
Orientation:
Minus strand

chr17:79,976,578-79,981,983
(GRCh37/hg19 by Ensembl)
Size:
5,406 bases
Orientation:
Minus strand

Genomic View for CENPX Gene

Genes around CENPX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPX Gene

Proteins for CENPX Gene

  • Protein details for CENPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MT69-CENPX_HUMAN
    Recommended name:
    Centromere protein X
    Protein Accession:
    A8MT69
    Secondary Accessions:
    • O00281
    • O00282
    • Q96DD4
    • Q96F51

    Protein attributes for CENPX Gene

    Size:
    81 amino acids
    Molecular mass:
    8959 Da
    Quaternary structure:
    • Heterodimer with CENPX, sometimes called MHF; this interaction stabilizes both partners (PubMed:19620631, PubMed:20347428, PubMed:20347429, PubMed:24522885). MHF heterodimers can assemble to form tetrameric structures (PubMed:22304917). MHF also coassemble with CENPT-CENPW heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex (PubMed:22304917, PubMed:24522885). Forms a discrete complex with FANCM and CENPX, called FANCM-MHF; this interaction, probably mediated by direct binding between CENPS and FANCM, leads to synergistic activation of double-stranded DNA binding and strongly stimulates FANCM-mediated DNA remodeling (PubMed:20347428, PubMed:20347429). Recruited by FANCM to the Fanconi anemia (FA) core complex, which consists of CENPS, CENPX, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FAAP24 and FAAP100. The FA core complex associates with Bloom syndrome (BLM) complex, which consists of at least BLM, DNA topoisomerase 3-alpha (TOP3A), RMI1/BLAP75, RPA1/RPA70 and RPA2/RPA32. The super complex between FA and BLM is called BRAFT (PubMed:20347428, PubMed:20347429).

    Three dimensional structures from OCA and Proteopedia for CENPX Gene

    Alternative splice isoforms for CENPX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPX Gene

Post-translational modifications for CENPX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for CENPX
  • Boster Bio Antibodies for CENPX

No data available for DME Specific Peptides for CENPX Gene

Domains & Families for CENPX Gene

Gene Families for CENPX Gene

Protein Domains for CENPX Gene

InterPro:

Graphical View of Domain Structure for InterPro Entry

A8MT69

UniProtKB/Swiss-Prot:

CENPX_HUMAN :
  • Belongs to the CENP-X/MHF2 family.
Family:
  • Belongs to the CENP-X/MHF2 family.
genes like me logo Genes that share domains with CENPX: view

No data available for Suggested Antigen Peptide Sequences for CENPX Gene

Function for CENPX Gene

Molecular function for CENPX Gene

UniProtKB/Swiss-Prot Function:
DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:20347429). DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347429).

Phenotypes From GWAS Catalog for CENPX Gene

Gene Ontology (GO) - Molecular Function for CENPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,IDA 20347429
GO:0003690 contributes_to double-stranded DNA binding IDA 20347428
GO:0005515 protein binding IPI 20347429
genes like me logo Genes that share ontologies with CENPX: view
genes like me logo Genes that share phenotypes with CENPX: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CENPX Gene

Localization for CENPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPX Gene

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPX being less stably bound at the kinetochore than CENPS. {ECO:0000269 PubMed:19620631, ECO:0000269 PubMed:24522885}.

Gene Ontology (GO) - Cellular Components for CENPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CENPX: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CENPX Gene

Pathways & Interactions for CENPX Gene

genes like me logo Genes that share pathways with CENPX: view

Pathways by source for CENPX Gene

SIGNOR curated interactions for CENPX Gene

Activates:

Gene Ontology (GO) - Biological Process for CENPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates IMP 20347428
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007049 cell cycle IEA --
GO:0031297 replication fork processing IMP 20347428
genes like me logo Genes that share ontologies with CENPX: view

Drugs & Compounds for CENPX Gene

No Compound Related Data Available

Transcripts for CENPX Gene

mRNA/cDNA for CENPX Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPX

Alternative Splicing Database (ASD) splice patterns (SP) for CENPX Gene

No ASD Table

Relevant External Links for CENPX Gene

GeneLoc Exon Structure for
CENPX

Expression for CENPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CENPX

genes like me logo Genes that share expression patterns with CENPX: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPX Gene

Orthologs for CENPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPX Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia STRA13 29 30
  • 99.18 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia STRA13 29 30
  • 81.58 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Stra13 29 30
  • 81.2 (n)
OneToOne
Cenpx 16
Rat
(Rattus norvegicus)
Mammalia LOC688314 29
  • 76 (n)
Dog
(Canis familiaris)
Mammalia STRA13 30
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia STRA13 30
  • 64 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii stra13 30
  • 52 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 45 (a)
OneToOne
Species where no ortholog for CENPX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CENPX Gene

ENSEMBL:
Gene Tree for CENPX (if available)
TreeFam:
Gene Tree for CENPX (if available)
Alliance of Genome Resources:
Additional Orthologs for CENPX

Paralogs for CENPX Gene

No data available for Paralogs for CENPX Gene

Variants for CENPX Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CENPX Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for CENPX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPX
Leiden Open Variation Database (LOVD)
CENPX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CENPX Gene

Disorders for CENPX Gene

Additional Disease Information for CENPX

No disorders were found for CENPX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPX Gene

Publications for CENPX Gene

  1. A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle. (PMID: 24522885) Dornblut C … Sullivan KF (Open biology 2014) 2 3 4
  2. FANCM-associated proteins MHF1 and MHF2, but not the other Fanconi anemia factors, limit meiotic crossovers. (PMID: 25038251) Girard C … Mercier R (Nucleic acids research 2014) 2 3
  3. CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold. (PMID: 22304917) Nishino T … Fukagawa T (Cell 2012) 3 4
  4. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. (PMID: 20347428) Yan Z … Wang W (Molecular cell 2010) 3 4
  5. MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. (PMID: 20347429) Singh TR … Meetei AR (Molecular cell 2010) 3 4

Products for CENPX Gene

Sources for CENPX Gene