This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2011] See more...

Aliases for CENPS-CORT Gene

Aliases for CENPS-CORT Gene

  • CENPS-CORT Readthrough 2 3 5 13
  • APITD1-CORT Readthrough 2 3
  • Centromere Protein S 3 13
  • CENPS 3 13
  • Apoptosis-Inducing TAF9-Like Domain-Containing Protein 1 3
  • Fanconi Anemia-Associated Polypeptide Of 16 KDa 3
  • FANCM-Interacting Histone Fold Protein 1 3
  • FANCM-Associated Histone Fold Protein 1 3
  • APITD1-CORT Protein 3
  • APITD1-CORT 3
  • CENPS-CORT 5
  • APITD1 3
  • CENP-S 3
  • FAAP16 3
  • MHF1 3

External Ids for CENPS-CORT Gene

Previous HGNC Symbols for CENPS-CORT Gene

  • APITD1-CORT

Summaries for CENPS-CORT Gene

Entrez Gene Summary for CENPS-CORT Gene

  • This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CENPS-CORT Gene

CENPS-CORT (CENPS-CORT Readthrough) is a Protein Coding gene. Among its related pathways are Fanconi anemia pathway. An important paralog of this gene is CENPS.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CENPS-CORT Gene

Genomics for CENPS-CORT Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CENPS-CORT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CENPS-CORT on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CENPS-CORT

Genomic Locations for CENPS-CORT Gene

Latest Assembly
chr1:10,430,102-10,452,153
(GRCh38/hg38)
Size:
22,052 bases
Orientation:
Plus strand

Previous Assembly
chr1:10,490,490-10,512,210
(GRCh37/hg19 by Entrez Gene)
Size:
21,721 bases
Orientation:
Plus strand

chr1:10,490,159-10,512,210
(GRCh37/hg19 by Ensembl)
Size:
22,052 bases
Orientation:
Plus strand

Genomic View for CENPS-CORT Gene

Genes around CENPS-CORT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPS-CORT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPS-CORT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPS-CORT Gene

Proteins for CENPS-CORT Gene

  • Protein details for CENPS-CORT Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0U1RQL5-A0A0U1RQL5_HUMAN
    Recommended name:
    CENPS-CORT readthrough
    Protein Accession:
    A0A0U1RQL5

    Protein attributes for CENPS-CORT Gene

    Size:
    49 amino acids
    Molecular mass:
    5699 Da
    Quaternary structure:
    No Data Available
  • Protein details for CENPS-CORT Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087WT10-A0A087WT10_HUMAN
    Recommended name:
    Centromere protein S
    Protein Accession:
    A0A087WT10

    Protein attributes for CENPS-CORT Gene

    Size:
    143 amino acids
    Molecular mass:
    16498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CENPS-CORT Gene

Post-translational modifications for CENPS-CORT Gene

No Post-translational modifications

Other Protein References for CENPS-CORT Gene

No data available for DME Specific Peptides for CENPS-CORT Gene

Domains & Families for CENPS-CORT Gene

Gene Families for CENPS-CORT Gene

Unknown:
  • Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
  • Belongs to the somatostatin family.
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CENPS-CORT Gene

genes like me logo Genes that share domains with CENPS-CORT: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CENPS-CORT Gene

Function for CENPS-CORT Gene

Phenotypes From GWAS Catalog for CENPS-CORT Gene

Gene Ontology (GO) - Molecular Function for CENPS-CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with CENPS-CORT: view

Phenotypes for CENPS-CORT Gene

MGI mutant phenotypes for CENPS-CORT:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CENPS-CORT: view

Animal Models for CENPS-CORT Gene

MGI Knock Outs for CENPS-CORT:
  • Cenps Cenps<tm1b(EUCOMM)Wtsi>

miRNA for CENPS-CORT Gene

miRTarBase miRNAs that target CENPS-CORT

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPS-CORT

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CENPS-CORT Gene

Localization for CENPS-CORT Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPS-CORT gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CENPS-CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CENPS-CORT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CENPS-CORT Gene

Pathways & Interactions for CENPS-CORT Gene

PathCards logo

SuperPathways for CENPS-CORT Gene

SuperPathway Contained pathways
1 Fanconi anemia pathway
genes like me logo Genes that share pathways with CENPS-CORT: view

Pathways by source for CENPS-CORT Gene

1 KEGG pathway for CENPS-CORT Gene

Interacting Proteins for CENPS-CORT Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000383692 for CENPS-CORT Gene via STRING

Symbol External ID(s) Details
CCNB1IP1

Gene Ontology (GO) - Biological Process for CENPS-CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CENPS-CORT: view

No data available for SIGNOR curated interactions for CENPS-CORT Gene

Drugs & Compounds for CENPS-CORT Gene

No Compound Related Data Available

Transcripts for CENPS-CORT Gene

mRNA/cDNA for CENPS-CORT Gene

4 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPS-CORT

Alternative Splicing Database (ASD) splice patterns (SP) for CENPS-CORT Gene

No ASD Table

Relevant External Links for CENPS-CORT Gene

GeneLoc Exon Structure for
CENPS-CORT

Expression for CENPS-CORT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CENPS-CORT

genes like me logo Genes that share expression patterns with CENPS-CORT: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPS-CORT Gene

Orthologs for CENPS-CORT Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPS-CORT Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia APITD1 29 30
  • 99.52 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia APITD1 29 30
  • 88.11 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia APITD1 29
  • 86.5 (n)
Rat
(Rattus norvegicus)
Mammalia Apitd1 29
  • 81.94 (n)
Mouse
(Mus musculus)
Mammalia Apitd1 29 30
  • 81.2 (n)
OneToMany
Cenps 16
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 53 (a)
OneToMany
Chicken
(Gallus gallus)
Aves APITD1 29 30
  • 66.67 (n)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia apitd1 29
  • 66.38 (n)
Zebrafish
(Danio rerio)
Actinopterygii apitd1 29 30
  • 63.31 (n)
OneToMany
Species where no ortholog for CENPS-CORT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CENPS-CORT Gene

ENSEMBL:
Gene Tree for CENPS-CORT (if available)
TreeFam:
Gene Tree for CENPS-CORT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CENPS-CORT: view image
Alliance of Genome Resources:
Additional Orthologs for CENPS-CORT

Paralogs for CENPS-CORT Gene

Paralogs for CENPS-CORT Gene

genes like me logo Genes that share paralogs with CENPS-CORT: view

Variants for CENPS-CORT Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CENPS-CORT Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CENPS-CORT Gene

Variant ID Type Subtype PubMed ID
esv2758920 CNV gain+loss 17122850
esv2764192 CNV gain 21179565

Variation tolerance for CENPS-CORT Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CENPS-CORT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPS-CORT
Leiden Open Variation Database (LOVD)
CENPS-CORT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CENPS-CORT Gene

Disorders for CENPS-CORT Gene

Additional Disease Information for CENPS-CORT

No disorders were found for CENPS-CORT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPS-CORT Gene

Publications for CENPS-CORT Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. (PMID: 26487511) Han SJ … O'Malley BW (Molecular pharmacology 2016) 3
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 13
  5. A novel 1p36.2 located gene, APITD1, with tumour-suppressive properties and a putative p53-binding domain, shows low expression in neuroblastoma tumours. (PMID: 15328517) Krona C … Martinsson T (British journal of cancer 2004) 3

Products for CENPS-CORT Gene

Sources for CENPS-CORT Gene