Aliases for CENPS-CORT Gene
Aliases for CENPS-CORT Gene
External Ids for CENPS-CORT Gene
- HGNC: 38843
- Entrez Gene: 100526739
- Ensembl: ENSG00000251503
Previous HGNC Symbols for CENPS-CORT Gene
- APITD1-CORT
Summaries for CENPS-CORT Gene
-
This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for CENPS-CORT Gene
CENPS-CORT (CENPS-CORT Readthrough) is a Protein Coding gene. Among its related pathways are Fanconi anemia pathway. An important paralog of this gene is CENPS.
Additional gene information for CENPS-CORT Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPS-CORT Gene
Genomics for CENPS-CORT Gene
GeneHancer (GH) Regulatory Elements for CENPS-CORT Gene
Promoters and enhancers for CENPS-CORT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CENPS-CORT on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CENPS-CORT Gene
Genomic Locations for CENPS-CORT Gene
- chr1:10,430,102-10,452,153
- (GRCh38/hg38)
- Size:
- 22,052 bases
- Orientation:
- Plus strand
- chr1:10,490,159-10,512,210
- (GRCh37/hg19)
Genomic View for CENPS-CORT Gene
Genes around CENPS-CORT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.22 by Ensembl
- 1p36.22 by Entrez Gene
- 1p36.22 by HGNC
CENPS-CORT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CENPS-CORT Gene
Proteins for CENPS-CORT Gene
-
Protein details for CENPS-CORT Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A087WT10
- Recommended name:
- CENPS-CORT readthrough
- Protein Accession:
- A0A087WT10
Protein attributes for CENPS-CORT Gene
- Size:
- 143 amino acids
- Molecular mass:
- 16498 Da
- Quaternary structure:
- No Data Available
-
Protein details for CENPS-CORT Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A0U1RQL5
- Recommended name:
- CENPS-CORT readthrough
- Protein Accession:
- A0A0U1RQL5
Protein attributes for CENPS-CORT Gene
- Size:
- 49 amino acids
- Molecular mass:
- 5699 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for CENPS-CORT Gene
No Post-translational modifications
Other Protein References for CENPS-CORT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CENPS-CORT
- Origene Custom Protein Services for CENPS-CORT
- Search GeneTex for Proteins for CENPS-CORT
Assay Products
No data available for DME Specific Peptides for CENPS-CORT Gene
Domains & Families for CENPS-CORT Gene
Gene Families for CENPS-CORT Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CENPS-CORT Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CENPS-CORT Gene
Function for CENPS-CORT Gene
Phenotypes From GWAS Catalog for CENPS-CORT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IBA | -- |
| GO:0003690 | double-stranded DNA binding | IBA | -- |
| GO:0005179 | hormone activity | IEA | -- |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CENPS-CORT
-
-
ViGene Biosciences ready-to-package AAV shRNAs for CENPS-CORT gene
- Search ViGene Biosciences for CENPS-CORT
CRISPR Products
- Browse CRISPR knockouts for CENPS-CORT
- genomics-online: gRNA clones - Search results for available APITD1-CORT gene related products
- Applied Biological Materials CRISPR for CENPS-CORT
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for CENPS-CORT
miRNA for CENPS-CORT Gene
- miRTarBase miRNAs that target CENPS-CORT
miRNA Products
- Search ViGene Biosciences for CENPS-CORT
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for available APITD1-CORT gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CENPS-CORT gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CENPS-CORT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CENPS-CORT
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available APITD1-CORT gene related products
- orf clones - Search results for available APITD1-CORT gene related products
- Applied Biological Materials Clones for CENPS-CORT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CENPS-CORT
-
ViGene Biosciences adenoviral particle packaged cDNA for CENPS-CORT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CENPS-CORT gene
- Search ViGene Biosciences for CENPS-CORT
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPS-CORT Gene
Localization for CENPS-CORT Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| nucleus | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0043240 | Fanconi anaemia nuclear complex | IBA | -- |
| GO:0071821 | FANCM-MHF complex | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CENPS-CORT Gene
Pathways & Interactions for CENPS-CORT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fanconi anemia pathway | ||
Pathways by source for CENPS-CORT Gene
1 KEGG pathway for CENPS-CORT Gene
Interacting Proteins for CENPS-CORT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006312 | mitotic recombination | IBA | -- |
| GO:0010469 | regulation of receptor activity | IEA | -- |
| GO:0031297 | replication fork processing | IBA | -- |
| GO:0036297 | interstrand cross-link repair | IBA | -- |
No data available for SIGNOR curated interactions for CENPS-CORT Gene
Transcripts for CENPS-CORT Gene
mRNA/cDNA for CENPS-CORT Gene
- (4) REFSEQ mRNAs :
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for CENPS-CORT
- genomics-online: gRNA clones - Search results for available APITD1-CORT gene related products
- Applied Biological Materials CRISPR for CENPS-CORT
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for CENPS-CORT
miRNA Products
- Search ViGene Biosciences for CENPS-CORT
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for available APITD1-CORT gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CENPS-CORT gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for CENPS-CORT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CENPS-CORT
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available APITD1-CORT gene related products
- orf clones - Search results for available APITD1-CORT gene related products
- Applied Biological Materials Clones for CENPS-CORT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Relevant External Links for CENPS-CORT Gene
- GeneLoc Exon Structure for
- CENPS-CORT
- ECgene alternative splicing isoforms for
- CENPS-CORT
Expression for CENPS-CORT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Primer Products
- genomics-online: primer clones - Search results for available APITD1-CORT gene related products
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPS-CORT Gene
Orthologs for CENPS-CORT Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | APITD1 34 33 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | APITD1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | APITD1 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Apitd1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Apitd1 34 33 |
|
OneToMany | |
| Cenps 16 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | APITD1 34 33 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | apitd1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | apitd1 33 34 |
|
- Species where no ortholog for CENPS-CORT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CENPS-CORT Gene
- ENSEMBL:
- Gene Tree for CENPS-CORT (if available)
- TreeFam:
- Gene Tree for CENPS-CORT (if available)
Paralogs for CENPS-CORT Gene
Variants for CENPS-CORT Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000356299 | -- | 10,442,091(+) | G/A | intron_variant | |
| rs1000780672 | -- | 10,437,962(+) | A/G | intron_variant | |
| rs1000904944 | -- | 10,431,427(+) | C/T | intron_variant | |
| rs1001106622 | -- | 10,444,503(+) | C/T | intron_variant | |
| rs1001417607 | -- | 10,448,348(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758920 | CNV | gain+loss | 17122850 |
| esv2764192 | CNV | gain | 21179565 |
Residual Variation Intolerance Score:
30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.33;
7.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CENPS-CORT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CENPS-CORT
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPS-CORT Gene
Disorders for CENPS-CORT Gene
Additional Disease Information for CENPS-CORT
No disorders were found for CENPS-CORT Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPS-CORT Gene
Publications for CENPS-CORT Gene
- The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. (PMID: 26487511) Han SJ … O'Malley BW (Molecular pharmacology 2016) 3 58
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
- A novel 1p36.2 located gene, APITD1, with tumour-suppressive properties and a putative p53-binding domain, shows low expression in neuroblastoma tumours. (PMID: 15328517) Krona C … Martinsson T (British journal of cancer 2004) 3 58
- The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58
- Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58
Products for CENPS-CORT Gene
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- Invitrogen Antibodies for CENPS-CORT
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- VectorBuilder custom plasmid, inducible vectors for CENPS-CORT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CENPS-CORT
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available APITD1-CORT related products ranked by validation data
- antibodies-online: Search results for available APITD1-CORT related products ranked by validation data
- antibodies-online: Search results for available APITD1-CORT related products ranked by validation data
- Search GeneTex for Antibodies for CENPS-CORT
- Search GeneTex for Proteins for CENPS-CORT
- ViGene Biosciences adenoviral particle packaged cDNA for CENPS-CORT gene
- ViGene Biosciences ready-to-package AAV shRNAs for CENPS-CORT gene
- Search ViGene Biosciences for CENPS-CORT
- Horizon Cell Lines for CENPS-CORT
- genomics-online: cdna clones - Search results for available APITD1-CORT gene related products
- orf clones - Search results for available APITD1-CORT gene related products
- genomics-online: gRNA clones - Search results for available APITD1-CORT gene related products
- genomics-online: primer clones - Search results for available APITD1-CORT gene related products
- genomics-online: shRNA clones - Search results for available APITD1-CORT gene related products
Sources for CENPS-CORT Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew