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This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2011] See more...
Aliases for CENPS-CORT Gene
Aliases for CENPS-CORT Gene
External Ids for CENPS-CORT Gene
- HGNC: 38843
- NCBI Entrez Gene: 100526739
- Ensembl: ENSG00000251503
- UniProtKB/TrEMBL: A0A0U1RQL5
- UniProtKB/TrEMBL: A0A087WT10
Previous HGNC Symbols for CENPS-CORT Gene
- APITD1-CORT
Summaries for CENPS-CORT Gene
-
This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for CENPS-CORT Gene
CENPS-CORT (CENPS-CORT Readthrough) is a Protein Coding gene. Among its related pathways are Fanconi anemia pathway. An important paralog of this gene is CENPS.
Additional gene information for CENPS-CORT Gene
- HGNC (38843)
- NCBI Entrez Gene (100526739)
- Ensembl (ENSG00000251503)
- UniProtKB/TrEMBL (A0A0U1RQL5)
- UniProtKB/TrEMBL (A0A087WT10)
- Alliance of Genome Resources
- Search for CENPS-CORT at DataMed
- Search for CENPS-CORT at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CENPS-CORT Gene
Genomics for CENPS-CORT Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CENPS-CORT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CENPS-CORT on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CENPS-CORT
Genomic Locations for CENPS-CORT Gene
Latest Assembly
- chr1:10,430,102-10,452,153
- (GRCh38/hg38)
- Size:
- 22,052 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:10,490,490-10,512,210
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 21,721 bases
- Orientation:
- Plus strand
Genomic View for CENPS-CORT Gene
Genes around CENPS-CORT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.22 by HGNC
- 1p36.22 by Entrez Gene
- 1p36.22 by Ensembl
CENPS-CORT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CENPS-CORT Gene
Proteins for CENPS-CORT Gene
-
Protein details for CENPS-CORT Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A0U1RQL5-A0A0U1RQL5_HUMAN
- Recommended name:
- CENPS-CORT readthrough
- Protein Accession:
- A0A0U1RQL5
Protein attributes for CENPS-CORT Gene
- Size:
- 49 amino acids
- Molecular mass:
- 5699 Da
- Quaternary structure:
- No Data Available
-
Protein details for CENPS-CORT Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A087WT10-A0A087WT10_HUMAN
- Recommended name:
- Centromere protein S
- Protein Accession:
- A0A087WT10
Protein attributes for CENPS-CORT Gene
- Size:
- 143 amino acids
- Molecular mass:
- 16498 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for CENPS-CORT Gene
No Post-translational modifications
Other Protein References for CENPS-CORT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for CENPS-CORT
- Origene Custom Protein Services for CENPS-CORT
Assay products for research
No data available for DME Specific Peptides for CENPS-CORT Gene
Domains & Families for CENPS-CORT Gene
Gene Families for CENPS-CORT Gene
- Unknown:
-
- Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
- Belongs to the somatostatin family.
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CENPS-CORT Gene
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CENPS-CORT Gene
Function for CENPS-CORT Gene
Phenotypes From GWAS Catalog for CENPS-CORT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005179 | hormone activity | IEA | -- |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for CENPS-CORT Gene
- MGI mutant phenotypes for CENPS-CORT:
- inferred from 1 alleles
Animal Models for CENPS-CORT Gene
- MGI Knock Outs for CENPS-CORT:
-
- Cenps Cenps<tm1b(EUCOMM)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CENPS-CORT - Starting at $85 >
- * CENPS-CORT CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CENPS-CORT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CENPS-CORT
miRNA for CENPS-CORT Gene
- miRTarBase miRNAs that target CENPS-CORT
miRNA products for research
Inhibitory RNAs for research
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPS-CORT
Clone products for research
- Applied Biological Materials (abm): Clones for CENPS-CORT - Starting at $45 >
- * CENPS-CORT as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CENPS-CORT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CENPS-CORT
Cell Lines for research
-
Horizon Cell Lines for CENPS-CORT
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CENPS-CORT Gene
Localization for CENPS-CORT Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IEA | -- |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CENPS-CORT Gene
Pathways & Interactions for CENPS-CORT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fanconi anemia pathway | ||
Pathways by source for CENPS-CORT Gene
1 KEGG pathway for CENPS-CORT Gene
Interacting Proteins for CENPS-CORT Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| CCNB1IP1 |
GPS-Prot Interaction Network for CENPS-CORT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0051301 | cell division | IEA | -- |
No data available for SIGNOR curated interactions for CENPS-CORT Gene
Transcripts for CENPS-CORT Gene
mRNA/cDNA for CENPS-CORT Gene
- 4 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000400900 1469 nts (view in UCSC)
- ENST00000465026 494 nts (view in UCSC)
- ENST00000470413 626 nts (view in UCSC)
- ENST00000602296 1326 nts (view in UCSC)
- ENST00000602787 571 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CENPS-CORT - Starting at $85 >
- * CENPS-CORT CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CENPS-CORT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CENPS-CORT
miRNA products for research
Inhibitory RNAs for research
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPS-CORT
Clone products for research
- Applied Biological Materials (abm): Clones for CENPS-CORT - Starting at $45 >
- * CENPS-CORT as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CENPS-CORT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CENPS-CORT
Relevant External Links for CENPS-CORT Gene
- GeneLoc Exon Structure for
- CENPS-CORT
Expression for CENPS-CORT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CENPS-CORT
Primer products for research
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPS-CORT Gene
Orthologs for CENPS-CORT Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | APITD1 29 30 |
|
OneToMany | |
| Cow (Bos Taurus) |
Mammalia | APITD1 29 30 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | APITD1 29 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Apitd1 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Apitd1 29 30 |
|
OneToMany | |
| Cenps 16 |
|
||||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | APITD1 29 30 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | apitd1 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | apitd1 29 30 |
|
OneToMany |
- Species where no ortholog for CENPS-CORT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CENPS-CORT Gene
- ENSEMBL:
- Gene Tree for CENPS-CORT (if available)
- TreeFam:
- Gene Tree for CENPS-CORT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CENPS-CORT: view image
- Alliance of Genome Resources:
- Additional Orthologs for CENPS-CORT
Paralogs for CENPS-CORT Gene
Variants for CENPS-CORT Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758920 | CNV | gain+loss | 17122850 |
| esv2764192 | CNV | gain | 21179565 |
Residual Variation Intolerance Score:
30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.33;
7.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CENPS-CORT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CENPS-CORT
- Leiden Open Variation Database (LOVD)
- CENPS-CORT
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CENPS-CORT Gene
Disorders for CENPS-CORT Gene
Additional Disease Information for CENPS-CORT
No disorders were found for CENPS-CORT Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPS-CORT Gene
Publications for CENPS-CORT Gene
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. (PMID: 26487511) Han SJ … O'Malley BW (Molecular pharmacology 2016) 3
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 13
- A novel 1p36.2 located gene, APITD1, with tumour-suppressive properties and a putative p53-binding domain, shows low expression in neuroblastoma tumours. (PMID: 15328517) Krona C … Martinsson T (British journal of cancer 2004) 3
Products for CENPS-CORT Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CENPS-CORT
- Origene Custom Protein Services for CENPS-CORT
- Browse OriGene Inhibitory RNA Products For CENPS-CORT
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for CENPS-CORT
- OriGene ORF clones in human for CENPS-CORT
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CENPS-CORT
- Sino Biological Human cDNA Clone for CENPS-CORT
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- VectorBuilder Custom and pre-made DNA vectors for CENPS-CORT (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CENPS-CORT (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CENPS-CORT (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CENPS-CORT CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CENPS-CORT
- antibodies-online: Search results for available APITD1-CORT related products ranked by validation data
- antibodies-online: Search results for available APITD1-CORT related products ranked by validation data
- antibodies-online: Search results for available APITD1-CORT related products ranked by validation data
- Horizon Cell Lines for CENPS-CORT
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CENPS-CORT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CENPS-CORT
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CENPS-CORT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPS-CORT
Sources for CENPS-CORT Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources