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CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008] See more...
Aliases for CENPQ Gene
Aliases for CENPQ Gene
External Ids for CENPQ Gene
- HGNC: 21347
- NCBI Entrez Gene: 55166
- Ensembl: ENSG00000031691
- OMIM®: 611506
- UniProtKB/Swiss-Prot: Q7L2Z9
Previous HGNC Symbols for CENPQ Gene
- C6orf139
Previous GeneCards Identifiers for CENPQ Gene
- GC06P049540
- GC06P049431
- GC06P049160
Summaries for CENPQ Gene
-
CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CENPQ Gene
CENPQ (Centromere Protein Q) is a Protein Coding gene. Diseases associated with CENPQ include Crest Syndrome. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase.
UniProtKB/Swiss-Prot Summary for CENPQ Gene
-
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579).
Additional gene information for CENPQ Gene
- HGNC (21347)
- NCBI Entrez Gene (55166)
- Ensembl (ENSG00000031691)
- OMIM® (611506)
- UniProtKB/Swiss-Prot (Q7L2Z9)
- Open Targets Platform(ENSG00000031691)
- Search for CENPQ at DataMed
- Search for CENPQ at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CENPQ Gene
Genomics for CENPQ Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CENPQ Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CENPQ on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CENPQ
- Top Transcription factor binding sites by QIAGEN in the CENPQ gene promoter:
-
- Cart-1
- FAC1
- HSF1 (long)
- HSF1short
- Ik-2
- MRF-2
- Nkx3-1 v4
- Olf-1
- SRF
- SRF (504 AA)
Genomic Locations for CENPQ Gene
Latest Assembly
- chr6:49,463,327-49,493,107
- (GRCh38/hg38)
- Size:
- 29,781 bases
- Orientation:
- Plus strand
Previous Assembly
- chr6:49,431,083-49,460,820
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 29,738 bases
- Orientation:
- Plus strand
- chr6:49,431,091-49,460,820
- (GRCh37/hg19 by Ensembl)
- Size:
- 29,730 bases
- Orientation:
- Plus strand
Genomic View for CENPQ Gene
Genes around CENPQ on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.3 by HGNC
- 6p12.3 by Entrez Gene
- 6p12.3 by Ensembl
CENPQ Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CENPQ Gene
Proteins for CENPQ Gene
-
Protein details for CENPQ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7L2Z9-CENPQ_HUMAN
- Recommended name:
- Centromere protein Q
- Protein Accession:
- Q7L2Z9
- A8KAF1
- Q6IN61
- Q9NVS5
Protein attributes for CENPQ Gene
- Size:
- 268 amino acids
- Molecular mass:
- 30595 Da
- Quaternary structure:
-
- Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.
- SequenceCaution:
-
- Sequence=BAA91672.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CENPQ Gene
Post-translational modifications for CENPQ Gene
- Phosphorylation at Ser-50 is essential for CENPE recruitment to kinetochores and orderly chromosome congression.
-
Ubiquitination at Lys78
- NX_Q7L2Z9 (NX_Q7L2Z9-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CENPQ Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ CENPQ Antibody
- Novus Biologicals Antibodies for CENPQ
- Invitrogen Antibodies for CENPQ (AFLGC-CENPQ)
-
Boster Bio Antibodies for CENPQ
-
Custom Antibody ServicesProSci Antibodies for CENPQ
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for CENPQ
- Origene Custom Protein Services for CENPQ
- ProSpec Recombinant Proteins for CENPQ
- antibodies-online: Show 9 available CENPQ Proteins ranked by validation data
- Compare Top CENPQ Proteins
-
Quality Products:
-
Abcam proteins for CENPQ
Assay products for research
No data available for DME Specific Peptides for CENPQ Gene
Domains & Families for CENPQ Gene
Gene Families for CENPQ Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CENPQ Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CENPQ Gene
- GenScript: Design optimal peptide antigens:
-
- Centromere protein Q (CENPQ_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q7L2Z9- Family:
-
- Belongs to the CENP-Q/OKP1 family.
Function for CENPQ Gene
Molecular function for CENPQ Gene
- UniProtKB/Swiss-Prot Function:
- Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579).
Phenotypes From GWAS Catalog for CENPQ Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 32296183 |
Phenotypes for CENPQ Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CENPQ - Starting at $85 >
- * CENPQ CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CENPQ
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CENPQ
-
Santa Cruz Biotechnology (SCBT) CRISPR for CENPQ
miRNA for CENPQ Gene
- miRTarBase miRNAs that target CENPQ
-
- hsa-miR-193b-3p (MIRT016444)
- hsa-miR-361-5p (MIRT020077)
- hsa-miR-124-3p (MIRT022897)
- hsa-miR-26b-5p (MIRT029904)
- hsa-miR-17-5p (MIRT100944)
- hsa-miR-20a-5p (MIRT100945)
- hsa-miR-93-5p (MIRT100946)
- hsa-miR-106a-5p (MIRT100947)
- hsa-miR-106b-5p (MIRT100950)
- hsa-miR-20b-5p (MIRT100953)
- hsa-miR-448 (MIRT100954)
- hsa-miR-519c-3p (MIRT100955)
- hsa-miR-526b-3p (MIRT100956)
- hsa-miR-519b-3p (MIRT100957)
- hsa-miR-519d-3p (MIRT100958)
- hsa-miR-519a-3p (MIRT100959)
- hsa-miR-605-5p (MIRT100961)
- hsa-miR-3074-3p (MIRT100965)
- hsa-miR-4768-3p (MIRT100969)
- hsa-miR-6888-5p (MIRT100971)
- hsa-miR-590-3p (MIRT219198)
- hsa-miR-4775 (MIRT219202)
- hsa-miR-548u (MIRT318012)
- hsa-miR-4735-5p (MIRT318013)
- hsa-miR-7161-5p (MIRT318016)
- hsa-miR-1321 (MIRT318020)
- hsa-miR-3162-5p (MIRT318021)
- hsa-miR-4653-3p (MIRT318023)
- hsa-miR-4739 (MIRT318024)
- hsa-miR-4756-5p (MIRT318025)
- hsa-miR-5586-3p (MIRT318026)
- hsa-miR-6509-5p (MIRT318027)
- hsa-miR-6760-5p (MIRT318028)
- hsa-miR-374a-5p (MIRT440957)
- hsa-miR-21-5p (MIRT440958)
- hsa-miR-4433a-3p (MIRT513996)
- hsa-miR-4459 (MIRT513997)
- hsa-miR-4796-3p (MIRT513998)
- hsa-miR-548ah-5p (MIRT513999)
- hsa-miR-3609 (MIRT514000)
- hsa-miR-6126 (MIRT568072)
- hsa-miR-331-5p (MIRT568073)
- hsa-miR-4493 (MIRT568074)
- hsa-miR-605-3p (MIRT568075)
- hsa-miR-3910 (MIRT568076)
- hsa-miR-599 (MIRT704733)
- hsa-miR-548ax (MIRT704734)
- hsa-miR-548ao-5p (MIRT704735)
- hsa-miR-4760-3p (MIRT704736)
- hsa-miR-4282 (MIRT704737)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CENPQ
- Browse OriGene Inhibitory RNA Products For CENPQ
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPQ
Clone products for research
- Applied Biological Materials (abm): Clones for CENPQ - Starting at $45 >
- * CENPQ as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CENPQ
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CENPQ
Cell Lines for research
-
Horizon Cell Lines for CENPQ
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPQ Gene
Localization for CENPQ Gene
Subcellular locations from UniProtKB/Swiss-Prot for CENPQ Gene
- Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 4 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IBA | 21873635 |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for CENPQ Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell Cycle, Mitotic |
.83
|
.60
|
| 2 | Chromosome Maintenance | ||
| 3 | Mitotic Metaphase and Anaphase |
.94
|
|
| 4 | Mitotic Prometaphase | ||
| 5 | Signaling by Rho GTPases | ||
Pathways by source for CENPQ Gene
15 Reactome pathways for CENPQ Gene
Interacting Proteins for CENPQ Gene
Selected Interacting proteins:
Q7L2Z9-CENPQ_HUMAN
ENSP00000337289
for CENPQ Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CENPQ
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0034080 | CENP-A containing nucleosome assembly | TAS | -- |
| GO:0051310 | metaphase plate congression | IBA,IMP | 25395579 |
| GO:1905342 | positive regulation of protein localization to kinetochore | IMP | 25395579 |
No data available for SIGNOR curated interactions for CENPQ Gene
Transcripts for CENPQ Gene
mRNA/cDNA for CENPQ Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000335783 1741 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CENPQ - Starting at $85 >
- * CENPQ CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CENPQ
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CENPQ
-
Santa Cruz Biotechnology (SCBT) CRISPR for CENPQ
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CENPQ
- Browse OriGene Inhibitory RNA Products For CENPQ
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPQ
Clone products for research
- Applied Biological Materials (abm): Clones for CENPQ - Starting at $45 >
- * CENPQ as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CENPQ
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CENPQ
Relevant External Links for CENPQ Gene
- GeneLoc Exon Structure for
- CENPQ
Expression for CENPQ Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad
- Primary Oocyte Primary Follicle
- Secondary Spermatocyte Seminiferous Tubules
-
Ovary (Reproductive System)
- Primary Oocyte Primary Follicle
-
Testis (Reproductive System)
- Secondary Spermatocyte Seminiferous Tubules
This gene is overexpressed in Lung (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CENPQ Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CENPQ
SOURCE GeneReport for Unigene cluster for CENPQ Gene:
Hs.88663Evidence on tissue expression from TISSUES for CENPQ Gene
- Stomach(4.1)
Primer products for research
-
OriGene qPCR primer pairs for CENPQ
-
OriGene qPCR primer pairs and template standards for CENPQ
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPQ Gene
Orthologs for CENPQ Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CENPQ 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CENPQ 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CENPQ 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cenpq 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cenpq 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CENPQ 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CENPQ 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CENPQ 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CENPQ 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | LOC101885540 30 |
|
- Species where no ortholog for CENPQ was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CENPQ Gene
- ENSEMBL:
- Gene Tree for CENPQ (if available)
- TreeFam:
- Gene Tree for CENPQ (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CENPQ: view image
Paralogs for CENPQ Gene
No data available for Paralogs for CENPQ Gene
Variants for CENPQ Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10654n54 | CNV | gain | 21841781 |
| dgv10655n54 | CNV | gain | 21841781 |
| dgv10656n54 | CNV | gain | 21841781 |
| dgv1768e212 | CNV | gain | 25503493 |
| dgv1769e212 | CNV | gain | 25503493 |
| dgv1770e212 | CNV | gain | 25503493 |
| dgv5960n100 | CNV | gain | 25217958 |
| esv2763934 | CNV | gain | 21179565 |
| esv3424715 | CNV | duplication | 20981092 |
| esv3576156 | CNV | gain | 25503493 |
| esv3608946 | CNV | gain | 21293372 |
| nsv1019611 | CNV | gain | 25217958 |
| nsv441996 | CNV | gain | 18776908 |
Residual Variation Intolerance Score:
69.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.08;
96.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CENPQ Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CENPQ
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPQ Gene
Disorders for CENPQ Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| crest syndrome |
|
|
Search CENPQ in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CENPQ
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CENPQ Gene
Publications for CENPQ Gene
- The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz DR … Cleveland DW (Nature cell biology 2006) 2 3 4
- The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M … Fukagawa T (Nature cell biology 2006) 2 3 4
- Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways. (PMID: 25395579) Bancroft J … McAinsh AD (Journal of cell science 2015) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for CENPQ Gene
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins and lysates for CENPQ
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- Browse Peptides and Proteins
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- Abcam proteins for CENPQ
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- Browse Primary Antibodies
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- Custom Antibody ServicesProSci Antibodies for CENPQ
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- Boster Bio Antibodies for CENPQ
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Sources for CENPQ Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB