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CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
CENPQ (Centromere Protein Q) is a Protein Coding gene. Diseases associated with CENPQ include Crest Syndrome. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J049461 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 606 | -0.1 | -126 | 3.6 | SP1 CREB1 GATAD2A PRDM10 REST ZNF629 TFE3 SIX5 IKZF1 POLR2A | MMUT CENPQ HSALNG0050496 | |
GH06J049336 | Enhancer | 0.6 | Ensembl | 27.3 | -126.2 | -126226 | 2.2 | SOX6 TCF12 TRIM24 NCOR1 FOSL1 NFIC TAL1 CEBPB JUN POLR2A | CENPQ MMUT RNU7-65P RF00066-166 piR-59928-124 | |
GH06J049305 | Enhancer | 0.4 | Ensembl | 40 | -157.9 | -157926 | 0.4 | ZNF316 MAFF MAFK EMSY | CENPQ piR-42613-078 piR-33605-380 MMUT | |
GH06J049555 | Enhancer | 1.1 | ENCODE dbSUPER | 12.8 | +93.3 | 93259 | 2 | CEBPG CREB1 GATAD2A ATF7 ZNF629 TFE3 LEF1 SOX13 NFKBIZ JUND | CENPQ PGK2 ENSG00000235122 ENSG00000226707 MMUT lnc-GLYATL3-2 C6orf141 lnc-RHAG-1 RHAG | |
GH06J049142 | Enhancer | 0.6 | Ensembl ENCODE | 23.9 | -320.6 | -320626 | 3 | TEAD4 MAFF MAFK SIN3A | CENPQ piR-38562-067 HSALNG0050482 MMUT |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0000776 | kinetochore | IBA | 21873635 |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell Cycle, Mitotic |
.83
|
.60
|
2 | Chromosome Maintenance | ||
3 | Mitotic Metaphase and Anaphase |
.94
|
|
4 | Mitotic Prometaphase | ||
5 | Signaling by Rho GTPases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0034080 | CENP-A containing nucleosome assembly | TAS | -- |
GO:0051310 | metaphase plate congression | IBA,IMP | 25395579 |
GO:1905342 | positive regulation of protein localization to kinetochore | IMP | 25395579 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CENPQ 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CENPQ 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CENPQ 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cenpq 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cenpq 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CENPQ 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CENPQ 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CENPQ 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CENPQ 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | LOC101885540 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10654n54 | CNV | gain | 21841781 |
dgv10655n54 | CNV | gain | 21841781 |
dgv10656n54 | CNV | gain | 21841781 |
dgv1768e212 | CNV | gain | 25503493 |
dgv1769e212 | CNV | gain | 25503493 |
dgv1770e212 | CNV | gain | 25503493 |
dgv5960n100 | CNV | gain | 25217958 |
esv2763934 | CNV | gain | 21179565 |
esv3424715 | CNV | duplication | 20981092 |
esv3576156 | CNV | gain | 25503493 |
esv3608946 | CNV | gain | 21293372 |
nsv1019611 | CNV | gain | 25217958 |
nsv441996 | CNV | gain | 18776908 |
Disorder | Aliases | PubMed IDs |
---|---|---|
crest syndrome |
|
|