CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008] See more...

Aliases for CENPP Gene

Aliases for CENPP Gene

  • Centromere Protein P 2 3 4 5
  • CENP-P 2 3 4
  • RP11-19J3.3 2
  • CENPP 5

External Ids for CENPP Gene

Previous GeneCards Identifiers for CENPP Gene

  • GC09P094127
  • GC09P095087
  • GC09P064765

Summaries for CENPP Gene

Entrez Gene Summary for CENPP Gene

  • CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPP Gene

CENPP (Centromere Protein P) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase.

UniProtKB/Swiss-Prot Summary for CENPP Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Additional gene information for CENPP Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CENPP Gene

Genomics for CENPP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CENPP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J092323 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 659.7 +0.1 144 3.6 SP1 CREB1 GATAD2A ATF7 TEAD4 PRDM10 ZNF629 TFE3 SIX5 LEF1 NOL8 CENPP HSALNG0072766 MTND4P15 IARS1 LINC00475 ZNF484 ENSG00000234537
GH09J092478 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 45.4 +156.6 156629 6.2 ARNT RELB RUNX3 OSR2 ZBTB40 JUN JUND FOSL1 MAX MXI1 ASPN CENPP OGN lnc-ECM2-1 OMD
GH09J092533 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 40.5 +210.5 210505 4.3 SP1 PKNOX1 CEBPB FOXA2 ASH2L YY1 JUND GATA3 SPI1 MAFK ECM2 CENPP ASPN OMD OGN IPPK BICD2 piR-55705-056
GH09J092668 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 25.4 +344.7 344721 3.8 SP1 CREB1 GATAD2A TEAD4 ZNF629 SIX5 IKZF1 KDM1A POLR2A NFRKB IPPK LOC107987095 lnc-CENPP-1 CENPP NOL8 PHF2 ECM2 piR-48554
GH09J092408 Enhancer 0.9 Ensembl ENCODE dbSUPER 61.2 +84.7 84746 3.2 ATF7 ZIC2 CEBPB ZNF316 ATF2 BHLHE40 ZNF18 ATF4 CEBPG ATF3 CENPP OGN NOL8 ECM2 OMD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CENPP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CENPP

Top Transcription factor binding sites by QIAGEN in the CENPP gene promoter:
  • AREB6
  • Cart-1
  • GATA-1
  • GATA-2
  • GATA-3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for CENPP Gene

Genomic Locations for CENPP Gene
chr9:92,325,457-92,620,529
(GRCh38/hg38)
Size:
295,073 bases
Orientation:
Plus strand
chr9:95,087,741-95,382,815
(GRCh37/hg19)
Size:
295,075 bases
Orientation:
Plus strand

Genomic View for CENPP Gene

Genes around CENPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPP Gene

Proteins for CENPP Gene

  • Protein details for CENPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IPU0-CENPP_HUMAN
    Recommended name:
    Centromere protein P
    Protein Accession:
    Q6IPU0
    Secondary Accessions:
    • B3KRA5
    • B3KS17
    • Q5T9F8
    • Q5T9F9

    Protein attributes for CENPP Gene

    Size:
    288 amino acids
    Molecular mass:
    33165 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.

    Alternative splice isoforms for CENPP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPP Gene

Post-translational modifications for CENPP Gene

  • Ubiquitination at Lys37
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CENPP Gene

Domains & Families for CENPP Gene

Gene Families for CENPP Gene

Protein Domains for CENPP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ33928 fis, clone CTONG2017444 (B3KRA5_HUMAN)
  • Centromere protein P (CENPP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IPU0

UniProtKB/Swiss-Prot:

CENPP_HUMAN :
  • Belongs to the CENP-P/CTF19 family.
Family:
  • Belongs to the CENP-P/CTF19 family.
genes like me logo Genes that share domains with CENPP: view

Function for CENPP Gene

Molecular function for CENPP Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Phenotypes From GWAS Catalog for CENPP Gene

Gene Ontology (GO) - Molecular Function for CENPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CENPP: view
genes like me logo Genes that share phenotypes with CENPP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPP Gene

Localization for CENPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPP Gene

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPP gene
Compartment Confidence
nucleus 4
cytosol 4
cytoskeleton 2
plasma membrane 0
extracellular 0
mitochondrion 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CENPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA,TAS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with CENPP: view

Pathways & Interactions for CENPP Gene

genes like me logo Genes that share pathways with CENPP: view

Gene Ontology (GO) - Biological Process for CENPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034080 CENP-A containing nucleosome assembly IEA,TAS --
genes like me logo Genes that share ontologies with CENPP: view

No data available for SIGNOR curated interactions for CENPP Gene

Drugs & Compounds for CENPP Gene

No Compound Related Data Available

Transcripts for CENPP Gene

mRNA/cDNA for CENPP Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPP

Alternative Splicing Database (ASD) splice patterns (SP) for CENPP Gene

No ASD Table

Relevant External Links for CENPP Gene

GeneLoc Exon Structure for
CENPP

Expression for CENPP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CENPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CENPP Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CENPP Gene



Protein tissue co-expression partners for CENPP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CENPP

SOURCE GeneReport for Unigene cluster for CENPP Gene:

Hs.713775

Evidence on tissue expression from TISSUES for CENPP Gene

  • Muscle(4.4)
  • Nervous system(3.6)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with CENPP: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPP Gene

Orthologs for CENPP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CENPP 30 31
  • 99.65 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CENPP 30 31
  • 83.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CENPP 30 31
  • 82.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC679342 30
  • 78.61 (n)
Mouse
(Mus musculus)
Mammalia Cenpp 30 17 31
  • 78.32 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CENPP 31
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CENPP 30 31
  • 63.45 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CENPP 31
  • 41 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cenpp 30
  • 55.31 (n)
Zebrafish
(Danio rerio)
Actinopterygii cenpp 30 31
  • 54.5 (n)
OneToOne
Species where no ortholog for CENPP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CENPP Gene

ENSEMBL:
Gene Tree for CENPP (if available)
TreeFam:
Gene Tree for CENPP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CENPP: view image

Paralogs for CENPP Gene

(1) SIMAP similar genes for CENPP Gene using alignment to 2 proteins:

  • CENPP_HUMAN
  • B3KRA5_HUMAN

Pseudogenes.org Pseudogenes for CENPP Gene

genes like me logo Genes that share paralogs with CENPP: view

No data available for Paralogs for CENPP Gene

Variants for CENPP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CENPP Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
2527 Risk Factor: Osteoarthritis susceptibility 3; Lumbar disc degeneration, susceptibility to 92,474,742(+) C/CTCA INFRAME_INSERTION,INTRON_VARIANT
rs3078372 Uncertain Significance: not provided 92,474,742(+) C/CTCATCATCA INFRAME_INSERTION,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CENPP Gene

Structural Variations from Database of Genomic Variants (DGV) for CENPP Gene

Variant ID Type Subtype PubMed ID
esv1019101 CNV insertion 17803354
esv2658382 CNV deletion 23128226
esv2738772 CNV deletion 23290073
esv3621078 CNV loss 21293372
esv3621079 CNV loss 21293372
esv3621080 CNV loss 21293372
esv3621081 CNV loss 21293372
esv3621082 CNV loss 21293372
esv3621084 CNV loss 21293372
esv3621085 CNV loss 21293372
esv3891693 CNV gain 25118596
nsv1045165 CNV loss 25217958
nsv1046733 CNV gain 25217958
nsv1047337 CNV loss 25217958
nsv1049599 CNV loss 25217958
nsv1052846 CNV loss 25217958
nsv1053205 CNV loss 25217958
nsv1115209 CNV deletion 24896259
nsv1124448 CNV deletion 24896259
nsv1128504 CNV deletion 24896259
nsv1137481 CNV deletion 24896259
nsv527206 CNV loss 19592680
nsv982321 CNV duplication 23825009

Variation tolerance for CENPP Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CENPP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPP Gene

Disorders for CENPP Gene

Additional Disease Information for CENPP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for CENPP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPP Gene

Publications for CENPP Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz DR … Cleveland DW (Nature cell biology 2006) 2 3 4
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M … Fukagawa T (Nature cell biology 2006) 2 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4

Products for CENPP Gene

  • Signalway Proteins for CENPP

Sources for CENPP Gene