Free for academic non-profit institutions. Other users need a Commercial license
CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
CENPP (Centromere Protein P) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
GO:0005694 | chromosome | IEA | -- |
GO:0005730 | nucleolus | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell Cycle, Mitotic |
.83
|
.60
|
2 | Chromosome Maintenance | ||
3 | Mitotic Metaphase and Anaphase |
.94
|
|
4 | Mitotic Prometaphase | ||
5 | Signaling by Rho GTPases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0034080 | CENP-A containing nucleosome assembly | IEA,TAS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CENPP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CENPP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CENPP 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC679342 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cenpp 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CENPP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CENPP 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CENPP 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cenpp 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cenpp 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs3078372 | Risk Factor: Osteoarthritis susceptibility 3; Lumbar disc degeneration, susceptibility to. Uncertain Significance: not provided | 92,474,742(+) |
C/CTCAC/CTCATCATCA NM_001012267.3(CENPP):c.564+94884TCA[15] |
INFRAME_INSERTION,INTRON |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1019101 | CNV | insertion | 17803354 |
esv2658382 | CNV | deletion | 23128226 |
esv2738772 | CNV | deletion | 23290073 |
esv3621078 | CNV | loss | 21293372 |
esv3621079 | CNV | loss | 21293372 |
esv3621080 | CNV | loss | 21293372 |
esv3621081 | CNV | loss | 21293372 |
esv3621082 | CNV | loss | 21293372 |
esv3621084 | CNV | loss | 21293372 |
esv3621085 | CNV | loss | 21293372 |
esv3891693 | CNV | gain | 25118596 |
nsv1045165 | CNV | loss | 25217958 |
nsv1046733 | CNV | gain | 25217958 |
nsv1047337 | CNV | loss | 25217958 |
nsv1049599 | CNV | loss | 25217958 |
nsv1052846 | CNV | loss | 25217958 |
nsv1053205 | CNV | loss | 25217958 |
nsv1115209 | CNV | deletion | 24896259 |
nsv1124448 | CNV | deletion | 24896259 |
nsv1128504 | CNV | deletion | 24896259 |
nsv1137481 | CNV | deletion | 24896259 |
nsv527206 | CNV | loss | 19592680 |
nsv982321 | CNV | duplication | 23825009 |
No disorders were found for CENPP Gene.