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Aliases for CENPO Gene

Aliases for CENPO Gene

  • Centromere Protein O 2 3 3 5
  • Interphase Centromere Complex Protein 36 3 4
  • CENP-O 3 4
  • MCM21R 3 4
  • Centromeric Protein O 3
  • ICEN-36 3
  • ICEN36 4

External Ids for CENPO Gene

Previous GeneCards Identifiers for CENPO Gene

  • GC02P024869
  • GC02P025016
  • GC02P024754

Summaries for CENPO Gene

Entrez Gene Summary for CENPO Gene

  • This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for CENPO Gene

CENPO (Centromere Protein O) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Signaling by Rho GTPases.

UniProtKB/Swiss-Prot for CENPO Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex.

Gene Wiki entry for CENPO Gene

Additional gene information for CENPO Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPO Gene

Genomics for CENPO Gene

GeneHancer (GH) Regulatory Elements for CENPO Gene

Promoters and enhancers for CENPO Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J024791 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 656.1 +0.3 278 4.8 MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC GLIS1 PTRHD1 CENPO LOC105369164 ATAD2B DNMT3A ITSN2 WDCP FAM228B ADCY3 NCOA1
GH02J025338 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.2 +547.9 547889 4.2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF207 GC02P025342 DNMT3A ENSG00000271936 CENPO ASXL2 MIR1301
GH02J024358 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.2 -433.2 -433206 3.1 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 POLR2B ITSN2 LOC105374328 ATAD2B DNMT3A WDCP ENSG00000271936 CENPO FAM228A TP53I3 RPL36AP13
GH02J024121 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.2 -670.1 -670105 3.8 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZNF2 ZNF766 E2F8 ZNF207 FAM228B PFN4 ENSG00000276087 FAM228A ATAD2B ENSG00000223530 WDCP ENSG00000271936 CENPO TP53I3
GH02J024009 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -781.7 -781681 4.1 HDGF PKNOX1 SMAD1 ARNT ZFP64 YY1 POLR2B ZNF766 ZNF592 MEF2D MFSD2B UBXN2A WDCP ENSG00000271936 CENPO ATAD2B RNU6-370P GC02P023754
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CENPO on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CENPO gene promoter:
  • E4BP4
  • ATF-2
  • Pax-5
  • HOXA5
  • Pax-3
  • Sox5
  • Elk-1
  • Sox9
  • AP-2gamma
  • AP-2beta

Genomic Locations for CENPO Gene

Genomic Locations for CENPO Gene
chr2:24,793,136-24,822,376
(GRCh38/hg38)
Size:
29,241 bases
Orientation:
Plus strand
chr2:25,016,005-25,045,245
(GRCh37/hg19)
Size:
29,241 bases
Orientation:
Plus strand

Genomic View for CENPO Gene

Genes around CENPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPO Gene

Proteins for CENPO Gene

  • Protein details for CENPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU64-CENPO_HUMAN
    Recommended name:
    Centromere protein O
    Protein Accession:
    Q9BU64
    Secondary Accessions:
    • B2RDC0
    • D6W536
    • Q53T55
    • Q96JV3

    Protein attributes for CENPO Gene

    Size:
    300 amino acids
    Molecular mass:
    33786 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.

    Alternative splice isoforms for CENPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPO Gene

Post-translational modifications for CENPO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CENPO Gene

No data available for DME Specific Peptides for CENPO Gene

Domains & Families for CENPO Gene

Gene Families for CENPO Gene

Protein Domains for CENPO Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BU64

UniProtKB/Swiss-Prot:

CENPO_HUMAN :
  • Belongs to the CENP-O/MCM21 family.
Family:
  • Belongs to the CENP-O/MCM21 family.
genes like me logo Genes that share domains with CENPO: view

Function for CENPO Gene

Molecular function for CENPO Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex.

Phenotypes From GWAS Catalog for CENPO Gene

Gene Ontology (GO) - Molecular Function for CENPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CENPO: view
genes like me logo Genes that share phenotypes with CENPO: view

Animal Models for CENPO Gene

MGI Knock Outs for CENPO:
  • Cenpo Cenpo<tm1b(KOMP)Mbp>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPO

Clone Products

  • Addgene plasmids for CENPO

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CENPO Gene

Localization for CENPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPO Gene

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPO gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CENPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CENPO: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CENPO Gene

Pathways & Interactions for CENPO Gene

genes like me logo Genes that share pathways with CENPO: view

Gene Ontology (GO) - Biological Process for CENPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS --
GO:0034508 centromere complex assembly IEA --
genes like me logo Genes that share ontologies with CENPO: view

No data available for SIGNOR curated interactions for CENPO Gene

Drugs & Compounds for CENPO Gene

No Compound Related Data Available

Transcripts for CENPO Gene

mRNA/cDNA for CENPO Gene

Unigene Clusters for CENPO Gene

Centromere protein O:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPO

Clone Products

  • Addgene plasmids for CENPO

Alternative Splicing Database (ASD) splice patterns (SP) for CENPO Gene

No ASD Table

Relevant External Links for CENPO Gene

GeneLoc Exon Structure for
CENPO
ECgene alternative splicing isoforms for
CENPO

Expression for CENPO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CENPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CENPO Gene



NURSA nuclear receptor signaling pathways regulating expression of CENPO Gene:

CENPO

SOURCE GeneReport for Unigene cluster for CENPO Gene:

Hs.731569

Evidence on tissue expression from TISSUES for CENPO Gene

  • Lung(4.5)
  • Nervous system(3.9)
  • Skin(2.5)
  • Intestine(2)
genes like me logo Genes that share expression patterns with CENPO: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPO Gene

Orthologs for CENPO Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPO 34 33
  • 99.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CENPO 34 33
  • 82.09 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CENPO 34 33
  • 81.75 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpo 16 34 33
  • 75.39 (n)
rat
(Rattus norvegicus)
Mammalia Cenpo 33
  • 74.94 (n)
oppossum
(Monodelphis domestica)
Mammalia CENPO 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPO 34
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPO 34 33
  • 57.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPO 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpo 33
  • 51.5 (n)
zebrafish
(Danio rerio)
Actinopterygii cenpo 34 33
  • 46.41 (n)
OneToOne
Species where no ortholog for CENPO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPO Gene

ENSEMBL:
Gene Tree for CENPO (if available)
TreeFam:
Gene Tree for CENPO (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CENPO: view image

Paralogs for CENPO Gene

Pseudogenes.org Pseudogenes for CENPO Gene

genes like me logo Genes that share paralogs with CENPO: view

No data available for Paralogs for CENPO Gene

Variants for CENPO Gene

Sequence variations from dbSNP and Humsavar for CENPO Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1057519631 uncertain-significance, not provided 24,793,221(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs781442277 uncertain-significance, not provided 24,793,223(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000005738 -- 24,812,264(+) C/G intron_variant
rs1000037120 -- 24,812,730(+) C/G intron_variant
rs1000277142 -- 24,821,136(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CENPO Gene

Variant ID Type Subtype PubMed ID
nsv1000020 CNV gain 25217958
nsv1004529 CNV loss 25217958
nsv508831 CNV insertion 20534489
nsv997725 CNV gain 25217958

Variation tolerance for CENPO Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CENPO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPO

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPO Gene

Disorders for CENPO Gene

Additional Disease Information for CENPO

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CENPO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPO Gene

Publications for CENPO Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz DR … Cleveland DW (Nature cell biology 2006) 2 3 4 58
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M … Fukagawa T (Nature cell biology 2006) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity. (PMID: 18007590) McClelland SE … Meraldi P (The EMBO journal 2007) 3 4 58
  5. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H … Yoda K (Genes to cells : devoted to molecular & cellular mechanisms 2006) 3 4 58

Products for CENPO Gene

  • Addgene plasmids for CENPO

Sources for CENPO Gene

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