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The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
CENPN (Centromere Protein N) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0000776 | kinetochore | IEA | -- |
GO:0000777 | condensed chromosome kinetochore | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell Cycle, Mitotic |
.83
|
.60
|
2 | Chromosome Maintenance | ||
3 | Mitotic Metaphase and Anaphase |
.94
|
|
4 | Mitotic Prometaphase | ||
5 | Signaling by Rho GTPases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007059 | chromosome segregation | IEA | -- |
GO:0034080 | CENP-A containing nucleosome assembly | TAS | -- |
GO:0051382 | kinetochore assembly | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CENPN 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CENPN 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cenpn 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cenpn 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CENPN 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CENPN 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CENPN 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CENPN 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CENPN 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cenpn 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.13228 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cenpn 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11641523 | - |
p.Gln223Arg |
|||
rs2549887 | - |
p.Glu288Lys |
|||
rs935939 | - |
p.Glu84Asp |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2422360 | CNV | duplication | 17116639 |
esv3639306 | CNV | gain | 21293372 |
nsv1062724 | CNV | gain | 25217958 |
nsv1897 | CNV | deletion | 18451855 |
nsv522168 | CNV | gain | 19592680 |
nsv573338 | CNV | loss | 21841781 |
No disorders were found for CENPN Gene.