Aliases for CENPN Gene
Aliases for CENPN Gene
External Ids for CENPN Gene
- HGNC: 30873
- Entrez Gene: 55839
- Ensembl: ENSG00000166451
- OMIM: 611509
- UniProtKB: Q96H22
Previous HGNC Symbols for CENPN Gene
- C16orf60
Previous GeneCards Identifiers for CENPN Gene
- GC16P079598
- GC16P081040
- GC16P066796
Summaries for CENPN Gene
-
The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
GeneCards Summary for CENPN Gene
CENPN (Centromere Protein N) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Signaling by Rho GTPases.
UniProtKB/Swiss-Prot for CENPN Gene
-
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPN Gene
Genomics for CENPN Gene
GeneHancer (GH) Regulatory Elements for CENPN Gene
Promoters and enhancers for CENPN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CENPN on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CENPN gene promoter:
-
- Nkx2-5
- TFIID
- TBP
- FOXC1
- AP-1
- POU2F1
- POU2F1a
- FOXO4
- Hand1
- E47
Regulatory Element Products
Genomic Locations for CENPN Gene
Genomic Locations for CENPN Gene
- chr16:81,006,498-81,033,114
- (GRCh38/hg38)
- Size:
- 26,617 bases
- Orientation:
- Plus strand
- chr16:81,040,103-81,066,719
- (GRCh37/hg19)
- Size:
- 26,617 bases
- Orientation:
- Plus strand
Genomic View for CENPN Gene
Genes around CENPN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q23.2 by Entrez Gene
- 16q23.2 by HGNC
- 16q23.2 by Ensembl
CENPN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CENPN Gene
Proteins for CENPN Gene
-
Protein details for CENPN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96H22-CENPN_HUMAN
- Recommended name:
- Centromere protein N
- Protein Accession:
- Q96H22
- A8MZE6
- B3KN53
- B4DJD1
- B4DPY7
- C9JJM5
- D3DUK8
- E7ES30
- E7ETS3
- Q9NZ83
Protein attributes for CENPN Gene
- Size:
- 339 amino acids
- Molecular mass:
- 39555 Da
- Quaternary structure:
-
- Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (PubMed:16622420, PubMed:16622419). The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts directly with CENPA (PubMed:19543270). Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292).
Protein Expression for CENPN Gene
Post-translational modifications for CENPN Gene
Other Protein References for CENPN Gene
Antibody Products
- Novus Biologicals Antibodies for CENPN
-
Abcam antibodies for CENPN
- Invitrogen Antibodies for CENPN (AFLGC-CENPN)
- GeneTex CENPN Antibody for CENPN
-
Biorbyt antibodies for CENPN
Protein Products
-
OriGene Purified Proteins for CENPN
- Search Origene for MassSpec and Protein Over-expression Lysates for CENPN
- Origene Custom Protein Services for CENPN
- antibodies-online: Search results for 7 available CENPN Proteins ranked by validation data
- Compare Top CENPN Proteins
-
Quality Products:
- Search GeneTex for Proteins for CENPN
-
Abcam proteins for CENPN
Assay Products
No data available for DME Specific Peptides for CENPN Gene
Domains & Families for CENPN Gene
Gene Families for CENPN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CENPN Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CENPN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96H22- Family:
-
- Belongs to the CENP-N/CHL4 family.
Function for CENPN Gene
Molecular function for CENPN Gene
- UniProtKB/Swiss-Prot Function:
- Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
Phenotypes From GWAS Catalog for CENPN Gene
Phenotypes for CENPN Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CENPN
-
CRISPR Products
-
OriGene CRISPR knockouts for CENPN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CENPN
- genomics-online: gRNA clones - Search results for available CENPN gene related products
- Applied Biological Materials CRISPR for CENPN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CENPN
- GenScript: Design CRISPR guide RNA sequences for CENPN
miRNA for CENPN Gene
- miRTarBase miRNAs that target CENPN
-
- hsa-mir-19b-3p (MIRT031109)
- hsa-mir-8081 (MIRT450214)
- hsa-mir-620 (MIRT450215)
- hsa-mir-1270 (MIRT450216)
- hsa-mir-627-5p (MIRT450217)
- hsa-mir-937-5p (MIRT450218)
- hsa-mir-6880-5p (MIRT450219)
- hsa-mir-4726-5p (MIRT450220)
- hsa-mir-4640-5p (MIRT450221)
- hsa-mir-4683 (MIRT450222)
- hsa-mir-6895-5p (MIRT450223)
- hsa-mir-5702 (MIRT450224)
- hsa-mir-361-5p (MIRT484150)
- hsa-mir-4693-3p (MIRT484151)
- hsa-mir-4774-5p (MIRT484152)
- hsa-mir-4490 (MIRT484153)
- hsa-mir-1298-3p (MIRT484154)
- hsa-mir-3126-3p (MIRT484155)
- hsa-mir-2115-3p (MIRT484156)
- hsa-mir-595 (MIRT484157)
- hsa-mir-1273e (MIRT551492)
- hsa-mir-6721-5p (MIRT551493)
- hsa-mir-6807-5p (MIRT551494)
- hsa-mir-1233-3p (MIRT551495)
- hsa-mir-6840-3p (MIRT551496)
- hsa-mir-1225-3p (MIRT551497)
- hsa-mir-4433a-3p (MIRT551498)
- hsa-mir-383-5p (MIRT551499)
- hsa-mir-665 (MIRT564004)
- hsa-mir-650 (MIRT620448)
- hsa-mir-3612 (MIRT620449)
- hsa-mir-7160-5p (MIRT620450)
- hsa-mir-4722-5p (MIRT620451)
- hsa-mir-1827 (MIRT620452)
- hsa-mir-676-5p (MIRT620453)
- hsa-mir-4649-3p (MIRT620454)
- hsa-mir-1236-3p (MIRT620455)
- hsa-mir-6515-3p (MIRT620456)
- hsa-mir-4459 (MIRT620457)
- hsa-mir-4768-3p (MIRT620458)
- hsa-mir-940 (MIRT620459)
- hsa-mir-6893-5p (MIRT620460)
- hsa-mir-6808-5p (MIRT620461)
- hsa-mir-4695-5p (MIRT620462)
- hsa-mir-216b-5p (MIRT620463)
- hsa-mir-1303 (MIRT641242)
- hsa-mir-6749-3p (MIRT641243)
- hsa-mir-6792-3p (MIRT641244)
- hsa-mir-4691-5p (MIRT641245)
- hsa-mir-7162-5p (MIRT641246)
- hsa-mir-6815-3p (MIRT641247)
- hsa-mir-516b-3p (MIRT641248)
- hsa-mir-4469 (MIRT641249)
- hsa-mir-516a-3p (MIRT641250)
- hsa-mir-136-5p (MIRT641251)
- hsa-mir-1470 (MIRT641252)
- hsa-mir-4667-3p (MIRT641253)
- hsa-mir-135b-5p (MIRT641254)
- hsa-mir-135a-5p (MIRT641255)
- hsa-mir-6884-5p (MIRT648194)
- hsa-mir-485-5p (MIRT648195)
- hsa-mir-4419b (MIRT648196)
- hsa-mir-4478 (MIRT648197)
- hsa-mir-3929 (MIRT648198)
- hsa-mir-4257 (MIRT664236)
- hsa-mir-6847-5p (MIRT664237)
- hsa-mir-510-5p (MIRT664238)
- hsa-mir-512-5p (MIRT664239)
- hsa-mir-129-5p (MIRT711042)
- hsa-mir-7850-5p (MIRT711043)
- hsa-mir-4742-3p (MIRT711044)
- hsa-mir-486-5p (MIRT711045)
- hsa-mir-6796-3p (MIRT711046)
- hsa-mir-99b-3p (MIRT711047)
- hsa-mir-99a-3p (MIRT711048)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CENPN
- Browse OriGene Inhibitory RNA Products For CENPN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPN
- genomics-online: shRNA clones - Search results for available CENPN gene related products
Clone Products
-
OriGene ORF clones in human for CENPN
- RC203426
- RC203426L1
- RC203426L2
- RC203426L3
- RC203426L4
- RC219371
- RC219371L1
- RC219371L2
- RC219371L3
- RC219371L4
- RC219420
- RC219420L1
- RC219420L2
- RC219420L3
- RC219420L4
- RC233703
- RC233747
- RG203426
- RG219371
- RG219420
- RG233703
- RG233747
- RC203426L1V
- RC203426L2V
- RC203426L3V
- RC203426L4V
- RC219371L1V
- RC219371L2V
- RC219371L3V
- RC219371L4V
- RC219420L1V
- RC219420L2V
- RC219420L3V
- RC219420L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CENPN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CENPN
- genomics-online: cdna clones - Search results for available CENPN gene related products
- orf clones - Search results for available CENPN gene related products
- Applied Biological Materials Clones for CENPN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPN Gene
Localization for CENPN Gene
Subcellular locations from UniProtKB/Swiss-Prot for CENPN Gene
- Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| peroxisome | 1 |
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | kinetochore | IEA | -- |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for CENPN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell Cycle, Mitotic |
.83
|
.60
|
| 2 | Chromosome Maintenance | ||
| 3 | Mitotic Metaphase and Anaphase |
.94
|
|
| 4 | Mitotic Prometaphase | ||
| 5 | Signaling by Rho GTPases | ||
Pathways by source for CENPN Gene
15 Reactome pathways for CENPN Gene
Interacting Proteins for CENPN Gene
GPS-Prot Interaction Network for CENPN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007059 | chromosome segregation | IEA | -- |
| GO:0007062 | sister chromatid cohesion | TAS | -- |
| GO:0034080 | CENP-A containing nucleosome assembly | TAS | -- |
| GO:0034508 | centromere complex assembly | IEA | -- |
| GO:0051382 | kinetochore assembly | IEA | -- |
No data available for SIGNOR curated interactions for CENPN Gene
Transcripts for CENPN Gene
mRNA/cDNA for CENPN Gene
- (7) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (102) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000305850 2481 bps (uc002ffx.3)
- ENST00000299572 1398 bps (uc002ffw.5)
- ENST00000439957 1699 bps (uc010vnm.2)
- ENST00000393335 1556 bps (uc002ffy.5)
- ENST00000569461 329 bps (uc059xns.1)
Unigene Clusters for CENPN Gene
- Centromere protein N:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CENPN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CENPN
- genomics-online: gRNA clones - Search results for available CENPN gene related products
- Applied Biological Materials CRISPR for CENPN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CENPN
- GenScript: Design CRISPR guide RNA sequences for CENPN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CENPN
- Browse OriGene Inhibitory RNA Products For CENPN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPN
- genomics-online: shRNA clones - Search results for available CENPN gene related products
Clone Products
-
OriGene ORF clones in human for CENPN
- RC203426
- RC203426L1
- RC203426L2
- RC203426L3
- RC203426L4
- RC219371
- RC219371L1
- RC219371L2
- RC219371L3
- RC219371L4
- RC219420
- RC219420L1
- RC219420L2
- RC219420L3
- RC219420L4
- RC233703
- RC233747
- RG203426
- RG219371
- RG219420
- RG233703
- RG233747
- RC203426L1V
- RC203426L2V
- RC203426L3V
- RC203426L4V
- RC219371L1V
- RC219371L2V
- RC219371L3V
- RC219371L4V
- RC219420L1V
- RC219420L2V
- RC219420L3V
- RC219420L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CENPN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CENPN
- genomics-online: cdna clones - Search results for available CENPN gene related products
- orf clones - Search results for available CENPN gene related products
- Applied Biological Materials Clones for CENPN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for CENPN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CENPN Gene
This gene is overexpressed in Prostate (x5.2).
This gene is overexpressed in Placenta (52.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CENPN Gene
NURSA nuclear receptor signaling pathways regulating expression of CENPN Gene:
CENPNSOURCE GeneReport for Unigene cluster for CENPN Gene:
Hs.726537Evidence on tissue expression from TISSUES for CENPN Gene
- Bone marrow(4.3)
- Intestine(4.2)
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for CENPN
-
OriGene qPCR primer pairs and template standards for CENPN
- genomics-online: primer clones - Search results for available CENPN gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPN Gene
Orthologs for CENPN Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CENPN 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CENPN 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cenpn 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cenpn 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | CENPN 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CENPN 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CENPN 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CENPN 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CENPN 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cenpn 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13228 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cenpn 34 33 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for CENPN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CENPN Gene
- ENSEMBL:
- Gene Tree for CENPN (if available)
- TreeFam:
- Gene Tree for CENPN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CENPN: view image
Paralogs for CENPN Gene
(1) SIMAP similar genes for CENPN Gene using alignment to 4 proteins:
- CENPN_HUMAN
- H3BMC7_HUMAN
- H3BMD5_HUMAN
- H3BRU7_HUMAN
Pseudogenes.org Pseudogenes for CENPN Gene
No data available for Paralogs for CENPN Gene
Variants for CENPN Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000100660 | -- | 81,022,280(+) | G/A | intron_variant | |
| rs1000176981 | -- | 81,007,757(+) | A/G | intron_variant | |
| rs1000359233 | -- | 81,012,341(+) | C/A | intron_variant | |
| rs1000407108 | -- | 81,021,960(+) | T/C | intron_variant | |
| rs1000455764 | -- | 81,008,244(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422360 | CNV | duplication | 17116639 |
| esv3639306 | CNV | gain | 21293372 |
| nsv1062724 | CNV | gain | 25217958 |
| nsv1897 | CNV | deletion | 18451855 |
| nsv522168 | CNV | gain | 19592680 |
| nsv573338 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.04;
37.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CENPN Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CENPN
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPN Gene
Disorders for CENPN Gene
Additional Disease Information for CENPN
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CENPN Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPN Gene
Publications for CENPN Gene
- The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz DR … Cleveland DW (Nature cell biology 2006) 2 3 4 58
- Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. (PMID: 19543270) Carroll CW … Straight AF (Nature cell biology 2009) 3 4 58
- The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M … Fukagawa T (Nature cell biology 2006) 3 4 58
- Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H … Yoda K (Genes to cells : devoted to molecular & cellular mechanisms 2006) 3 4 58
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
Products for CENPN Gene
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Sources for CENPN Gene
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