The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell divisio... See more...

Aliases for CENPM Gene

Aliases for CENPM Gene

  • Centromere Protein M 2 3 4 5
  • CENP-M 2 3 4
  • Proliferation-Associated Nuclear Element Protein 1 3 4
  • Interphase Centromere Complex Protein 39 3 4
  • C22orf18 3 4
  • PANE1 3 4
  • Chromosome 22 Open Reading Frame 18 2
  • MGC861 2
  • ICEN39 4
  • CENPM 5
  • Pane1 2

External Ids for CENPM Gene

Previous HGNC Symbols for CENPM Gene

  • C22orf18

Previous GeneCards Identifiers for CENPM Gene

  • GC22M040664
  • GC22M042334
  • GC22M025300
  • GC22M041938
  • GC22M042798
  • GC22M042911
  • GC22M042967
  • GC22M044572
  • GC22M042070
  • GC22M042081
  • GC22M042338
  • GC22M042684
  • GC22M045414

Summaries for CENPM Gene

Entrez Gene Summary for CENPM Gene

  • The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for CENPM Gene

CENPM (Centromere Protein M) is a Protein Coding gene. Diseases associated with CENPM include Childhood Oligodendroglioma. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase.

UniProtKB/Swiss-Prot Summary for CENPM Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.

Gene Wiki entry for CENPM Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CENPM Gene

Genomics for CENPM Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CENPM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J041945 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 261.1 +0.2 223 2.7 ZSCAN16 TBP MXD4 ZBTB10 SP1 FEZF1 MNT SMAD5 ETS1 MBD2 CENPM lnc-TNFRSF13C-2 WBP2NL SMDT1 MEI1 SNU13 HSALNG0135675 TNFRSF13C
GH22J041931 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 263.9 +10.5 10481 10.7 BCL11A POLR2A CTCF ZIC2 THAP11 SIN3A REST ZNF639 TRIM22 IRF4 CENPM HSALNG0135675 TNFRSF13C MEI1 SMDT1 CYP2D6 SHISA8 CSDC2 lnc-TNFRSF13C-2
GH22J041948 Enhancer 0.3 ENCODE dbSUPER 250.7 -1.5 -1471 0 CENPM lnc-TNFRSF13C-2 LINC00634 SEPTIN3
GH22J042519 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -572.5 -572549 3.4 ZBTB10 CEBPA SIX5 SMAD5 ETS1 POLR2A ZNF610 KDM6A THAP11 FOXA2 RRP7A HSALNG0135717 RF00017-3862 RRP7BP CENPM RN7SKP80 CSDC2 piR-42600-001 NFAM1
GH22J041856 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16.4 +86.7 86651 11.8 BCL11A FEZF1 ZFP64 POLR2A CTCF ZIC2 CEBPB REST TRIM22 SAP130 MEI1 NDUFA6 CENPM CYP2D6 SREBF2 SREBF2-AS1 TNFRSF13C RNU6ATAC22P SMDT1 POLR3H
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CENPM on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CENPM

Top Transcription factor binding sites by QIAGEN in the CENPM gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • HSF1 (long)
  • HSF1short

Genomic Locations for CENPM Gene

Latest Assembly
chr22:41,927,747-41,947,152
(GRCh38/hg38)
Size:
19,406 bases
Orientation:
Minus strand

Previous Assembly
chr22:42,334,741-42,343,156
(GRCh37/hg19 by Entrez Gene)
Size:
8,416 bases
Orientation:
Minus strand

chr22:42,334,725-42,343,168
(GRCh37/hg19 by Ensembl)
Size:
8,444 bases
Orientation:
Minus strand

Genomic View for CENPM Gene

Genes around CENPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPM Gene

Proteins for CENPM Gene

  • Protein details for CENPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSP4-CENPM_HUMAN
    Recommended name:
    Centromere protein M
    Protein Accession:
    Q9NSP4
    Secondary Accessions:
    • A7LM22
    • B1AHQ9
    • Q6I9W3

    Protein attributes for CENPM Gene

    Size:
    180 amino acids
    Molecular mass:
    19737 Da
    Quaternary structure:
    • Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.
    Miscellaneous:
    • [Isoform 2]: Due to intron retention.

    Three dimensional structures from OCA and Proteopedia for CENPM Gene

    Alternative splice isoforms for CENPM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPM Gene

Post-translational modifications for CENPM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

No data available for DME Specific Peptides for CENPM Gene

Domains & Families for CENPM Gene

Gene Families for CENPM Gene

Protein Domains for CENPM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPM Gene

GenScript: Design optimal peptide antigens:
  • Proliferation-associated nuclear element protein 1 (CENPM_HUMAN)
genes like me logo Genes that share domains with CENPM: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CENPM Gene

Function for CENPM Gene

Molecular function for CENPM Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.

Phenotypes From GWAS Catalog for CENPM Gene

genes like me logo Genes that share phenotypes with CENPM: view

miRNA for CENPM Gene

miRTarBase miRNAs that target CENPM

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPM

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPM Gene

Localization for CENPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPM Gene

Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPM gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CENPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CENPM: view

Pathways & Interactions for CENPM Gene

genes like me logo Genes that share pathways with CENPM: view

Gene Ontology (GO) - Biological Process for CENPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034080 CENP-A containing nucleosome assembly TAS --
genes like me logo Genes that share ontologies with CENPM: view

No data available for SIGNOR curated interactions for CENPM Gene

Drugs & Compounds for CENPM Gene

No Compound Related Data Available

Transcripts for CENPM Gene

mRNA/cDNA for CENPM Gene

7 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENPM

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for CENPM Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - -
SP7:

Relevant External Links for CENPM Gene

GeneLoc Exon Structure for
CENPM

Expression for CENPM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CENPM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lymph (Hematopoietic System)

Protein differential expression in normal tissues from HIPED for CENPM Gene

This gene is overexpressed in Fetal ovary (24.8), Fetal heart (23.3), and Fetal gut (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CENPM Gene



Protein tissue co-expression partners for CENPM Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CENPM

SOURCE GeneReport for Unigene cluster for CENPM Gene:

Hs.208912

mRNA Expression by UniProt/SwissProt for CENPM Gene:

Q9NSP4-CENPM_HUMAN
Tissue specificity: Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells.

Evidence on tissue expression from TISSUES for CENPM Gene

  • Nervous system(4.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with CENPM: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPM Gene

Orthologs for CENPM Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPM Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CENPM 30 31
  • 99.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CENPM 30 31
  • 87.78 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CENPM 30 31
  • 85.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cenpm 30
  • 83.52 (n)
Mouse
(Mus musculus)
Mammalia Cenpm 30 17 31
  • 82.41 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CENPM 31
  • 59 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CENPM 31
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CENPM 30 31
  • 65.62 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cenpm 30
  • 58.54 (n)
Zebrafish
(Danio rerio)
Actinopterygii pane1 30 31
  • 53.8 (n)
OneToOne
Species where no ortholog for CENPM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CENPM Gene

ENSEMBL:
Gene Tree for CENPM (if available)
TreeFam:
Gene Tree for CENPM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CENPM: view image

Paralogs for CENPM Gene

No data available for Paralogs for CENPM Gene

Variants for CENPM Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CENPM Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CENPM Gene

Variant ID Type Subtype PubMed ID
esv1711771 CNV insertion 17803354
esv2543828 CNV insertion 19546169
esv3401962 CNV duplication 20981092
esv3893485 CNV loss 25118596
nsv1057208 CNV gain 25217958
nsv508736 CNV insertion 20534489
nsv955163 CNV deletion 24416366

Variation tolerance for CENPM Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CENPM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPM

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CENPM Gene

Disorders for CENPM Gene

MalaCards: The human disease database

(1) MalaCards diseases for CENPM Gene - From: COP

Disorder Aliases PubMed IDs
childhood oligodendroglioma
  • pediatric oligodendroglioma
- elite association - COSMIC cancer census association via MalaCards
Search CENPM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CENPM

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CENPM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CENPM Gene

Publications for CENPM Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz DR … Cleveland DW (Nature cell biology 2006) 2 3 4
  2. The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL. (PMID: 16391015) Brickner AG … Warren EH (Blood 2006) 3 4 23
  3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 41
  4. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H … Yoda K (Genes to cells : devoted to molecular & cellular mechanisms 2006) 3 4
  5. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M … Fukagawa T (Nature cell biology 2006) 2 3

Products for CENPM Gene

Sources for CENPM Gene