Aliases for CENPL Gene
External Ids for CENPL Gene
Previous HGNC Symbols for CENPL Gene
Previous GeneCards Identifiers for CENPL Gene
CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]
GeneCards Summary for CENPL Gene
CENPL (Centromere Protein L) is a Protein Coding gene. Diseases associated with CENPL include Leukoencephalopathy With Brainstem And Spinal Cord Involvement And Lactate Elevation and Isolated Growth Hormone Deficiency, Type Ia. Among its related pathways are Cell Cycle, Mitotic and Signaling by Rho GTPases.
UniProtKB/Swiss-Prot for CENPL Gene
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.