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Aliases for CENPL Gene

Aliases for CENPL Gene

  • Centromere Protein L 2 3 3 5
  • Interphase Centromere Complex Protein 33 3 4
  • C1orf155 3 4
  • CENP-L 3 4
  • Chromosome 1 Open Reading Frame 155 2
  • DJ383J4.3 3
  • ICEN33 4

External Ids for CENPL Gene

Previous HGNC Symbols for CENPL Gene

  • C1orf155

Previous GeneCards Identifiers for CENPL Gene

  • GC01M172035
  • GC01M144993

Summaries for CENPL Gene

Entrez Gene Summary for CENPL Gene

  • CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPL Gene

CENPL (Centromere Protein L) is a Protein Coding gene. Diseases associated with CENPL include Leukoencephalopathy With Brainstem And Spinal Cord Involvement And Lactate Elevation and Isolated Growth Hormone Deficiency, Type Ia. Among its related pathways are Cell Cycle, Mitotic and Signaling by Rho GTPases.

UniProtKB/Swiss-Prot for CENPL Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Gene Wiki entry for CENPL Gene

Additional gene information for CENPL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPL Gene

Genomics for CENPL Gene

GeneHancer (GH) Regulatory Elements for CENPL Gene

Promoters and enhancers for CENPL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J173861 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 672 -42.0 -42040 10.3 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZBTB37 CENPL SNORD76 SNORD75 GC01M174050 GC01M174048 GC01M174047 GC01M174046 GC01M174045 SNORD80
GH01J173823 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.2 186 3 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC GLIS1 RCOR2 DARS2 CENPL RC3H1 KLHL20 ZBTB37 GAS5
GH01J173473 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 9.7 +347.9 347899 7.1 CLOCK DMAP1 YY1 E2F8 SP3 NFYC MEF2D ZNF610 ZNF585B GLIS1 PRDX6 LOC100506023 TNFSF4 KLHL20 GAS5 GAS5-AS1 DARS2 CENPL LOC101928673
GH01J173409 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +414.3 414321 2.6 HDGF PKNOX1 RB1 BATF KLF5 IRF4 ZNF143 ATF7 ETV6 BCLAF1 KLHL20 CENPL DARS2 PRDX6 ENSG00000224228 TNFSF4 GC01M173428 LOC646870 LOC100506023
GH01J173412 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +410.4 410417 4.6 HDGF ATF1 FOXA2 BATF IRF4 ZNF766 EGR1 ETV6 ATF7 BCLAF1 CENPL DARS2 PRDX6 KLHL20 ENSG00000224228 GC01M173428 LOC646870 LOC100506023
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CENPL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CENPL gene promoter:

Genomic Locations for CENPL Gene

Genomic Locations for CENPL Gene
chr1:173,799,550-173,824,720
(GRCh38/hg38)
Size:
25,171 bases
Orientation:
Minus strand
chr1:173,768,688-173,793,858
(GRCh37/hg19)

Genomic View for CENPL Gene

Genes around CENPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPL Gene

Proteins for CENPL Gene

  • Protein details for CENPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0S6-CENPL_HUMAN
    Recommended name:
    Centromere protein L
    Protein Accession:
    Q8N0S6
    Secondary Accessions:
    • Q5TEL5
    • Q96ND4

    Protein attributes for CENPL Gene

    Size:
    344 amino acids
    Molecular mass:
    38998 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.

    Alternative splice isoforms for CENPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPL Gene

Post-translational modifications for CENPL Gene

  • Ubiquitination at posLast=6363
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPL Gene

No data available for DME Specific Peptides for CENPL Gene

Domains & Families for CENPL Gene

Gene Families for CENPL Gene

Protein Domains for CENPL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0S6

UniProtKB/Swiss-Prot:

CENPL_HUMAN :
  • Belongs to the CENP-L/IML3 family.
Family:
  • Belongs to the CENP-L/IML3 family.
genes like me logo Genes that share domains with CENPL: view

Function for CENPL Gene

Molecular function for CENPL Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Gene Ontology (GO) - Molecular Function for CENPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CENPL: view
genes like me logo Genes that share phenotypes with CENPL: view

Animal Models for CENPL Gene

MGI Knock Outs for CENPL:
  • Cenpl Cenpl<tm1b(EUCOMM)Wtsi>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CENPL Gene

Localization for CENPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPL Gene

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPL gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CENPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CENPL Gene

Pathways & Interactions for CENPL Gene

genes like me logo Genes that share pathways with CENPL: view

Gene Ontology (GO) - Biological Process for CENPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS --
genes like me logo Genes that share ontologies with CENPL: view

No data available for SIGNOR curated interactions for CENPL Gene

Drugs & Compounds for CENPL Gene

No Compound Related Data Available

Transcripts for CENPL Gene

mRNA/cDNA for CENPL Gene

Unigene Clusters for CENPL Gene

Centromere protein L:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for CENPL Gene

GeneLoc Exon Structure for
CENPL
ECgene alternative splicing isoforms for
CENPL

Expression for CENPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CENPL Gene

Protein differential expression in normal tissues from HIPED for CENPL Gene

This gene is overexpressed in Nasal epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CENPL Gene



Protein tissue co-expression partners for CENPL Gene

NURSA nuclear receptor signaling pathways regulating expression of CENPL Gene:

CENPL

SOURCE GeneReport for Unigene cluster for CENPL Gene:

Hs.720473

Evidence on tissue expression from TISSUES for CENPL Gene

  • Eye(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with CENPL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPL Gene

Orthologs for CENPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPL 34 33
  • 99.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CENPL 34 33
  • 91.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CENPL 34 33
  • 91.09 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpl 16 34 33
  • 87.81 (n)
rat
(Rattus norvegicus)
Mammalia Cenpl 33
  • 84.5 (n)
oppossum
(Monodelphis domestica)
Mammalia CENPL 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPL 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPL 34 33
  • 64.47 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPL 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpl 33
  • 61.52 (n)
Str.5928 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4198 33
zebrafish
(Danio rerio)
Actinopterygii cenpl 34 33
  • 52.64 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4945 34
  • 27 (a)
OneToOne
Species where no ortholog for CENPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPL Gene

ENSEMBL:
Gene Tree for CENPL (if available)
TreeFam:
Gene Tree for CENPL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CENPL: view image

Paralogs for CENPL Gene

Pseudogenes.org Pseudogenes for CENPL Gene

genes like me logo Genes that share paralogs with CENPL: view

No data available for Paralogs for CENPL Gene

Variants for CENPL Gene

Sequence variations from dbSNP and Humsavar for CENPL Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs533128814 uncertain-significance, Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation 173,824,697(-) G/A upstream_transcript_variant
rs869312918 pathogenic, Inborn genetic diseases 173,825,357(-) G/A upstream_transcript_variant
rs886045585 uncertain-significance, Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation 173,824,708(-) G/C upstream_transcript_variant
rs1000035024 -- 173,805,825(-) C/G intron_variant
rs1000060095 -- 173,821,555(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CENPL Gene

Variant ID Type Subtype PubMed ID
nsv831926 CNV gain+loss 17160897

Variation tolerance for CENPL Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CENPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPL Gene

Disorders for CENPL Gene

MalaCards: The human disease database

(2) MalaCards diseases for CENPL Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CENPL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CENPL

genes like me logo Genes that share disorders with CENPL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CENPL Gene

Publications for CENPL Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz DR … Cleveland DW (Nature cell biology 2006) 2 3 4 58
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M … Fukagawa T (Nature cell biology 2006) 2 3 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H … Yoda K (Genes to cells : devoted to molecular & cellular mechanisms 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CENPL Gene

Sources for CENPL Gene

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