Aliases for CENPH Gene
External Ids for CENPH Gene
Previous GeneCards Identifiers for CENPH Gene
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for CENPH Gene
CENPH (Centromere Protein H) is a Protein Coding gene. Diseases associated with CENPH include Hypopharynx Cancer. Among its related pathways are Chromosome Maintenance and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include kinetochore binding.
UniProtKB/Swiss-Prot for CENPH Gene
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.