Aliases for CENPC Gene
External Ids for CENPC Gene
Previous HGNC Symbols for CENPC Gene
Previous GeneCards Identifiers for CENPC Gene
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]
GeneCards Summary for CENPC Gene
CENPC (Centromere Protein C) is a Protein Coding gene. Diseases associated with CENPC include Limited Scleroderma and Hyperinsulinemic Hypoglycemia, Familial, 5. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase. Gene Ontology (GO) annotations related to this gene include centromeric DNA binding.
UniProtKB/Swiss-Prot Summary for CENPC Gene
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.