Aliases for CENPC Gene
Aliases for CENPC Gene
External Ids for CENPC Gene
- HGNC: 1854
- Entrez Gene: 1060
- Ensembl: ENSG00000145241
- OMIM: 117141
- UniProtKB: Q03188
Previous HGNC Symbols for CENPC Gene
- CENPC1
Previous GeneCards Identifiers for CENPC Gene
- GC04M068337
Summaries for CENPC Gene
-
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]
GeneCards Summary for CENPC Gene
CENPC (Centromere Protein C) is a Protein Coding gene. Diseases associated with CENPC include Limited Scleroderma and Connective Tissue Disease. Among its related pathways are Chromosome Maintenance and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include centromeric DNA binding.
UniProtKB/Swiss-Prot for CENPC Gene
-
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPC Gene
Genomics for CENPC Gene
GeneHancer (GH) Regulatory Elements for CENPC Gene
Promoters and enhancers for CENPC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CENPC on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CENPC Gene
Genomic Locations for CENPC Gene
- chr4:67,468,748-67,545,606
- (GRCh38/hg38)
- Size:
- 76,859 bases
- Orientation:
- Minus strand
- chr4:68,337,521-68,411,324
- (GRCh37/hg19)
Genomic View for CENPC Gene
Genes around CENPC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.2 by Ensembl
- 4q13.2 by Entrez Gene
- 4q13.2 by HGNC
CENPC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CENPC Gene
Proteins for CENPC Gene
-
Protein details for CENPC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03188-CENPC_HUMAN
- Recommended name:
- Centromere protein C
- Protein Accession:
- Q03188
- Q6PIR0
- Q8IW27
- Q9P0M5
Protein attributes for CENPC Gene
- Size:
- 943 amino acids
- Molecular mass:
- 106834 Da
- Quaternary structure:
-
- Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (PubMed:16622419). The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX (PubMed:9645950). Interacts with DNMT3B (PubMed:19482874). Interacts directly with CENPA (PubMed:19503796). Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292). Interacts with MEIKIN (By similarity).
Protein Expression for CENPC Gene
Post-translational modifications for CENPC Gene
- Ubiquitination at posLast=1010, posLast=119119, Lys507, posLast=727727, posLast=746746, Lys807, and Lys871
Other Protein References for CENPC Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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-
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-
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Assay Products
No data available for DME Specific Peptides for CENPC Gene
Domains & Families for CENPC Gene
Gene Families for CENPC Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CENPC Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CENPC Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q03188UniProtKB/Swiss-Prot:
CENPC_HUMAN :- The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization.
- Belongs to the CENPC family.
- Domain:
-
- The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization.
- Family:
-
- Belongs to the CENPC family.
Function for CENPC Gene
Molecular function for CENPC Gene
- UniProtKB/Swiss-Prot Function:
- Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Phenotypes From GWAS Catalog for CENPC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS | 1339310 |
| GO:0019237 | centromeric DNA binding | IEA,IBA | -- |
Phenotypes for CENPC Gene
- MGI mutant phenotypes for CENPC:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CENPC:
Animal Models for CENPC Gene
- MGI Knock Outs for CENPC:
-
- Cenpc1 tm1Khac
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-
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CENPC Gene
Localization for CENPC Gene
Subcellular locations from UniProtKB/Swiss-Prot for CENPC Gene
- Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=Localizes exclusively in the kinetochore domain of centromeres. {ECO:0000269 PubMed:21529714}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
- Nuclear bodies (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IEA,IDA | 21529714 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0000778 | condensed nuclear chromosome kinetochore | IBA | -- |
| GO:0000780 | condensed nuclear chromosome, centromeric region | IDA | 11682612 |
Pathways & Interactions for CENPC Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell Cycle, Mitotic |
.83
|
.60
|
| 2 | Chromosome Maintenance | ||
| 3 | Mitotic Metaphase and Anaphase |
.94
|
|
| 4 | Mitotic Prometaphase | ||
| 5 | Signaling by Rho GTPases | ||
Pathways by source for CENPC Gene
15 Reactome pathways for CENPC Gene
Interacting Proteins for CENPC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000278 | mitotic cell cycle | IMP | 21529714 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007059 | chromosome segregation | IMP | 21529714 |
| GO:0007062 | sister chromatid cohesion | TAS | -- |
| GO:0034080 | CENP-A containing nucleosome assembly | TAS | -- |
No data available for SIGNOR curated interactions for CENPC Gene
Transcripts for CENPC Gene
mRNA/cDNA for CENPC Gene
- (3) REFSEQ mRNAs :
- (119) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CENPC
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CENPC
- GenScript: Design CRISPR guide RNA sequences for CENPC
miRNA Products
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Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CENPC
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- Overview of 81 available CENPC gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CENPC gene
Clone Products
- Sino Biological Human cDNA Clone for CENPC
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CENPC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CENPC
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CENPC
- Applied Biological Materials Clones for CENPC
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for CENPC Gene
This gene is overexpressed in Peripheral blood mononuclear cells (20.6), Skin (9.2), Blymphocyte (8.4), CD8 Tcells (7.0), and Testis (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CENPC Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CENPC Gene:
CENPCEvidence on tissue expression from TISSUES for CENPC Gene
- Blood(4.3)
Primer Products
-
OriGene qPCR primer pairs for CENPC
-
OriGene qPCR primer pairs and template standards for CENPC
- genomics-online: primer clones - Search results for 81 available CENPC gene related products
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPC Gene
Orthologs for CENPC Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CENPC1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CENPC1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CENPC 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cenpc 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cenpc1 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CENPC 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CENPC 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CENPC1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CENPC 34 |
|
OneToOne |
- Species where no ortholog for CENPC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CENPC Gene
(1) SIMAP similar genes for CENPC Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for CENPC Gene
No data available for Paralogs for CENPC Gene
Variants for CENPC Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000000868 | -- | 67,531,786(-) | G/A/C | intron_variant | |
| rs1000007497 | -- | 67,469,032(-) | ATAT/AT | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs1000197376 | -- | 67,484,457(-) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000204883 | -- | 67,529,277(-) | G/A | intron_variant | |
| rs1000224111 | -- | 67,491,912(-) | G/T | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv950046 | CNV | duplication | 24416366 |
| esv3600851 | CNV | loss | 21293372 |
| esv3600850 | CNV | loss | 21293372 |
| esv2727765 | CNV | deletion | 23290073 |
| esv2674936 | CNV | deletion | 23128226 |
| esv2669747 | CNV | deletion | 23128226 |
| esv2605147 | CNV | deletion | 19546169 |
| esv2512052 | CNV | deletion | 19546169 |
| esv24989 | CNV | loss | 19812545 |
| esv2356691 | CNV | deletion | 18987734 |
| esv22504 | CNV | loss | 19812545 |
| dgv5241n100 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.59;
44.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CENPC Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CENPC
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPC Gene
Disorders for CENPC Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| limited scleroderma |
|
|
| connective tissue disease |
|
|
Search CENPC in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CENPC
No data available for UniProtKB/Swiss-Prot and Genatlas for CENPC Gene
Publications for CENPC Gene
- Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. (PMID: 17651496) Alonso A … Warburton PE (Genome biology 2007) 3 4 22 58
- The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz DR … Cleveland DW (Nature cell biology 2006) 3 4 22 58
- Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death. (PMID: 9645950) Pluta AF … Goldberg IG (Journal of cell science 1998) 3 4 22 58
- CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. (PMID: 1339310) Saitoh H … Earnshaw WC (Cell 1992) 3 4 22 58
- Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes. (PMID: 21529714) Gascoigne KE … Cheeseman IM (Cell 2011) 3 4 58
Products for CENPC Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CENPC
- antibodies-online: Search results for 66 available CENPC1 Antibodies ranked by validation data
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Sources for CENPC Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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