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Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]
CENPC (Centromere Protein C) is a Protein Coding gene. Diseases associated with CENPC include Limited Scleroderma and Hyperinsulinemic Hypoglycemia, Familial, 5. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase. Gene Ontology (GO) annotations related to this gene include centromeric DNA binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | TAS | 1339310 |
GO:0005515 | protein binding | IPI | 19503796 |
GO:0019237 | centromeric DNA binding | IEA,IBA | 21873635 |
GO:0042802 | identical protein binding | IPI | 19503796 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0000776 | kinetochore | IEA,IDA | 21529714 |
GO:0000777 | condensed chromosome kinetochore | IEA | -- |
GO:0000778 | condensed nuclear chromosome kinetochore | IBA | 21873635 |
GO:0000780 | condensed nuclear chromosome, centromeric region | IDA | 11682612 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell Cycle, Mitotic |
.83
|
.60
|
2 | Chromosome Maintenance | ||
3 | Mitotic Metaphase and Anaphase |
.94
|
|
4 | Mitotic Prometaphase | ||
5 | Signaling by Rho GTPases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | IMP | 21529714 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007059 | chromosome segregation | IMP | 21529714 |
GO:0034080 | CENP-A containing nucleosome assembly | TAS | -- |
GO:0051301 | cell division | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CENPC1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CENPC1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CENPC 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cenpc 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cenpc1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CENPC 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CENPC 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CENPC1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CENPC 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5241n100 | CNV | gain | 25217958 |
esv22504 | CNV | loss | 19812545 |
esv2356691 | CNV | deletion | 18987734 |
esv24989 | CNV | loss | 19812545 |
esv2512052 | CNV | deletion | 19546169 |
esv2605147 | CNV | deletion | 19546169 |
esv2669747 | CNV | deletion | 23128226 |
esv2674936 | CNV | deletion | 23128226 |
esv2727765 | CNV | deletion | 23290073 |
esv3600850 | CNV | loss | 21293372 |
esv3600851 | CNV | loss | 21293372 |
nsv950046 | CNV | duplication | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
limited scleroderma |
|
|
hyperinsulinemic hypoglycemia, familial, 5 |
|
|
crest syndrome |
|
|
cowden syndrome 1 |
|
|
dyskinesia of esophagus |
|
|