Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CENPA Gene

Aliases for CENPA Gene

  • Centromere Protein A 2 3 4 5
  • Histone H3-Like Centromeric Protein A 2 3
  • Centromere Protein A, 17kDa 2 3
  • Centromere-Specific Histone 2 3
  • Centromere Autoantigen A 3 4
  • CENP-A 3 4
  • Centromere Protein A (17kD) 2
  • CenH3 3

External Ids for CENPA Gene

Previous GeneCards Identifiers for CENPA Gene

  • GC02P026908
  • GC02P027080
  • GC02P026962
  • GC02P026963
  • GC02P026898
  • GC02P026920
  • GC02P026988

Summaries for CENPA Gene

Entrez Gene Summary for CENPA Gene

  • Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

GeneCards Summary for CENPA Gene

CENPA (Centromere Protein A) is a Protein Coding gene. Diseases associated with CENPA include Systemic Scleroderma and Rheumatic Disease. Among its related pathways are Cell Cycle, Mitotic and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and chromatin binding.

UniProtKB/Swiss-Prot for CENPA Gene

  • Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292).

Gene Wiki entry for CENPA Gene

Additional gene information for CENPA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPA Gene

Genomics for CENPA Gene

GeneHancer (GH) Regulatory Elements for CENPA Gene

Promoters and enhancers for CENPA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J026763 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.5 530 2.9 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 POLR2B ZNF207 SP3 CENPA SLC35F6 EIF2B4 ATRAID CAD LOC105374363 ASXL2 NRBP1 GTF3C2 TMEM214
GH02J026784 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 664.9 +21.8 21819 2.3 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A CENPA ASXL2 PPM1G EIF2B4 NRBP1 ATRAID GPN1 GTF3C2 AGBL5 CAD
GH02J026717 Enhancer 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 20.8 -42.0 -42034 10.1 HDGF FOXA2 MLX SIN3A DMAP1 YY1 ZNF766 FOS SP5 REST EIF2B4 GPN1 CAD NRBP1 GTF3C2-AS1 ASXL2 CENPA LOC105374363 KCNK3 TMEM214
GH02J027122 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 7.3 +359.4 359376 1.7 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ATF7 SP3 ABHD1 TCF23 SLC5A6 ATRAID KHK EMILIN1 CAD CENPA SLC35F6 CGREF1
GH02J026740 Enhancer 0.5 ENCODE 18.1 -23.3 -23281 0.2 CTCF PKNOX1 POLR2A L3MBTL2 NRF1 SIN3A MNT CENPA SLC35F6 GC02P026705
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CENPA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CENPA gene promoter:
  • Sp1
  • FOXJ2
  • FOXJ2 (long isoform)
  • TBP
  • TFIID

Genomic Locations for CENPA Gene

Genomic Locations for CENPA Gene
chr2:26,764,289-26,801,067
(GRCh38/hg38)
Size:
36,779 bases
Orientation:
Plus strand
chr2:26,987,157-27,023,935
(GRCh37/hg19)
Size:
36,779 bases
Orientation:
Plus strand

Genomic View for CENPA Gene

Genes around CENPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPA Gene

Proteins for CENPA Gene

  • Protein details for CENPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49450-CENPA_HUMAN
    Recommended name:
    Histone H3-like centromeric protein A
    Protein Accession:
    P49450
    Secondary Accessions:
    • D6W544
    • Q53T74
    • Q9BVW2

    Protein attributes for CENPA Gene

    Size:
    140 amino acids
    Molecular mass:
    15991 Da
    Quaternary structure:
    • Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core (PubMed:23818633, PubMed:26878239, PubMed:20739937, PubMed:21743476). The octamer contains two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers (PubMed:23818633, PubMed:26878239, PubMed:20739937, PubMed:21743476). CENPA modulates the DNA-binding characteristics of nucleosomes so that protruding DNA ends have higher flexibility than in nucleosomes containing conventional histone H3 (PubMed:27499292, PubMed:21743476). Inhibits binding of histone H1 to nucleosomes, since histone H1 binds preferentially to rigid DNA linkers that protrude from nucleosomes (PubMed:27499292). Nucleosomes containing CENPA also contain histone H2A variants such as macroH2A H2AFY and H2A.Z/H2AFZ (Probable). The CENPA-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers (PubMed:15282608, PubMed:20739937). Can assemble into nucleosomes that contain both CENPA and histone H3.3; these nucleosomes interact with a single CENPC chain (PubMed:25408271). Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4 (PubMed:21478274). Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (PubMed:16622419). Interacts (via CATD domain) with HJURP; the interaction is direct and is required for its localization to centromeres (PubMed:15282608, PubMed:19410544, PubMed:19410545, PubMed:23818633, PubMed:25556658). Interacts with CENPC, CENPN and CENPT; interaction is direct. Part of a centromere complex consisting of CENPA, CENPT and CENPW (PubMed:19533040). Identified in centromere complexes containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292). Can self-associate (PubMed:9024683). The CENPA-H4 heterotetramer can bind DNA by itself (in vitro) (PubMed:20739937). Interacts with CDK1, PPP1CA and RBBP7 (PubMed:25556658). Interacts directly with herpes virus HSV-1 ICP0 protein (PubMed:11053442).
    Miscellaneous:
    • Antibodies against CENPA are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins.

    Three dimensional structures from OCA and Proteopedia for CENPA Gene

    Alternative splice isoforms for CENPA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPA Gene

Post-translational modifications for CENPA Gene

  • Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome pathway.
  • Trimethylated by NTMT1 at the N-terminal glycine after cleavage of Met-1. Methylation is low before incorporation into nucleosomes and increases with cell cycle progression, with the highest levels in mitotic nucleosomes.
  • Phosphorylated by CDK1 at Ser-68 during early mitosis; this abolishes association with chromatin and centromeres, prevents interaction with HJURP and thereby prevents premature assembly of CENPA into centromeres (PubMed:25556658). Dephosphorylated at Ser-68 by PPP1CA during late mitosis (PubMed:25556658). Phosphorylation of Ser-7 by AURKA and AURKB during prophase is required for localization of AURKA and AURKB at inner centromere and is essential for normal cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18239465). Initial phosphorylation during prophase is mediated by AURKA and is maintained by AURKB.
  • Poly-ADP-ribosylated by PARP1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CENPA Gene

No data available for DME Specific Peptides for CENPA Gene

Domains & Families for CENPA Gene

Gene Families for CENPA Gene

Protein Domains for CENPA Gene

Suggested Antigen Peptide Sequences for CENPA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49450

UniProtKB/Swiss-Prot:

CENPA_HUMAN :
  • The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes containing CENPA (PubMed:15282608). It is necessary and sufficient to mediate the localization into centromeres (PubMed:7962047, PubMed:15282608).
  • Belongs to the histone H3 family.
Domain:
  • The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes containing CENPA (PubMed:15282608). It is necessary and sufficient to mediate the localization into centromeres (PubMed:7962047, PubMed:15282608).
Family:
  • Belongs to the histone H3 family.
genes like me logo Genes that share domains with CENPA: view

Function for CENPA Gene

Molecular function for CENPA Gene

UniProtKB/Swiss-Prot Function:
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292).
GENATLAS Biochemistry:
centromeric protein A,histone H3 related,likely replaying H3 to form a centromere unique nucleosomal structure

Gene Ontology (GO) - Molecular Function for CENPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding TAS 7962047
GO:0005515 protein binding IPI 19410544
GO:0031492 nucleosomal DNA binding IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with CENPA: view
genes like me logo Genes that share phenotypes with CENPA: view

Animal Models for CENPA Gene

MGI Knock Outs for CENPA:

Animal Model Products

Clone Products

  • Addgene plasmids for CENPA

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CENPA Gene

Localization for CENPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPA Gene

Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (PubMed:19114591). Phosphorylation at Ser-68 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location (PubMed:25556658). {ECO:0000269 PubMed:19114591, ECO:0000269 PubMed:25556658}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPA gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CENPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA,TAS 11084331
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000778 condensed nuclear chromosome kinetochore IDA 18195732
GO:0000780 condensed nuclear chromosome, centromeric region IDA 11682612
genes like me logo Genes that share ontologies with CENPA: view

Pathways & Interactions for CENPA Gene

genes like me logo Genes that share pathways with CENPA: view

Pathways by source for CENPA Gene

Gene Ontology (GO) - Biological Process for CENPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IMP 19468067
GO:0000281 mitotic cytokinesis IMP 27499292
GO:0006334 nucleosome assembly IBA --
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
genes like me logo Genes that share ontologies with CENPA: view

No data available for SIGNOR curated interactions for CENPA Gene

Drugs & Compounds for CENPA Gene

(1) Drugs for CENPA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CENPA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CENPA: view

Transcripts for CENPA Gene

mRNA/cDNA for CENPA Gene

Unigene Clusters for CENPA Gene

Centromere protein A:
Representative Sequences:

Clone Products

  • Addgene plasmids for CENPA

Alternative Splicing Database (ASD) splice patterns (SP) for CENPA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:
SP3: -
SP4: -
SP5: -
SP6: - - - - - - - - - - -
SP7: - - -

Relevant External Links for CENPA Gene

GeneLoc Exon Structure for
CENPA
ECgene alternative splicing isoforms for
CENPA

Expression for CENPA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CENPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CENPA Gene

This gene is overexpressed in Plasma (45.1) and NK cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CENPA Gene



NURSA nuclear receptor signaling pathways regulating expression of CENPA Gene:

CENPA

SOURCE GeneReport for Unigene cluster for CENPA Gene:

Hs.1594

Evidence on tissue expression from TISSUES for CENPA Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with CENPA: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPA Gene

Orthologs for CENPA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CENPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPA 34 33
  • 97.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CENPA 34 33
  • 84.2 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CENPA 33
  • 82.13 (n)
-- 34
  • 80 (a)
OneToMany
-- 34
  • 74 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cenpa 33
  • 81.52 (n)
mouse
(Mus musculus)
Mammalia Cenpa 16 34 33
  • 72.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CENPA 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPA 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPA 34 33
  • 61.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPA 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpa 33
  • 62.37 (n)
zebrafish
(Danio rerio)
Actinopterygii seph 34
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F20D6.9 34
  • 33 (a)
OneToMany
cpar-1 34
  • 20 (a)
OneToMany
hcp-3 34
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CSE4 34
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3908 34
  • 32 (a)
OneToOne
Species where no ortholog for CENPA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CENPA Gene

ENSEMBL:
Gene Tree for CENPA (if available)
TreeFam:
Gene Tree for CENPA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CENPA: view image

Paralogs for CENPA Gene

(18) SIMAP similar genes for CENPA Gene using alignment to 2 proteins:

  • CENPA_HUMAN
  • F8WD88_HUMAN
genes like me logo Genes that share paralogs with CENPA: view

No data available for Paralogs for CENPA Gene

Variants for CENPA Gene

Sequence variations from dbSNP and Humsavar for CENPA Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000190001 -- 26,787,838(+) C/T intron_variant
rs1000201191 -- 26,787,511(+) G/A/T intron_variant
rs1000754062 -- 26,788,441(+) C/A intron_variant
rs1000849399 -- 26,789,725(+) A/G intron_variant
rs1000956442 -- 26,787,967(+) T/G intron_variant

Variation tolerance for CENPA Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CENPA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CENPA Gene

Disorders for CENPA Gene

MalaCards: The human disease database

(3) MalaCards diseases for CENPA Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
systemic scleroderma
  • scleroderma, familial progressive
rheumatic disease
  • collagen diseases
limited scleroderma
  • crest syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CENPA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CENPA

genes like me logo Genes that share disorders with CENPA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CENPA Gene

Publications for CENPA Gene

  1. Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. (PMID: 19410544) Foltz DR … Cleveland DW (Cell 2009) 3 4 22 58
  2. HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. (PMID: 19410545) Dunleavy EM … Almouzni-Pettinotti G (Cell 2009) 3 4 22 58
  3. Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. (PMID: 19543270) Carroll CW … Straight AF (Nature cell biology 2009) 3 4 22 58
  4. Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells. (PMID: 18072184) Orthaus S … Diekmann S (Chembiochem : a European journal of chemical biology 2008) 3 4 22 58
  5. Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B. (PMID: 19412974) Hellwig D … Diekmann S (Journal of biophotonics 2008) 3 4 22 58

Products for CENPA Gene

Sources for CENPA Gene

Content
Loading form....