This gene encodes a protein thought to contain a coiled coil motif. No function has been determined for the encoded protein. A pseudogene of this gene is located on chromosome 20. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] See more...

Aliases for CENATAC Gene

Aliases for CENATAC Gene

  • Centrosomal AT-AC Splicing Factor 2 3 4 5
  • Coiled-Coil Domain-Containing Protein 84 3 4
  • Coiled-Coil Domain Containing 84 2 3
  • DLNB14 2 3
  • CENATAC 5
  • CCDC84 3

External Ids for CENATAC Gene

Previous HGNC Symbols for CENATAC Gene

  • CCDC84

Previous GeneCards Identifiers for CENATAC Gene

  • GC11P119059
  • GC11P119068

Summaries for CENATAC Gene

Entrez Gene Summary for CENATAC Gene

  • This gene encodes a protein thought to contain a coiled coil motif. No function has been determined for the encoded protein. A pseudogene of this gene is located on chromosome 20. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for CENATAC Gene

CENATAC (Centrosomal AT-AC Splicing Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for CENATAC Gene

  • Negative regulator of centrosome duplication (PubMed:31722219). Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 (PubMed:31722219).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CENATAC Gene

Genomics for CENATAC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CENATAC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CENATAC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CENATAC

Genomic Locations for CENATAC Gene

Latest Assembly
chr11:118,998,117-119,015,793
(GRCh38/hg38)
Size:
17,677 bases
Orientation:
Plus strand

Previous Assembly
chr11:118,868,848-118,886,503
(GRCh37/hg19 by Entrez Gene)
Size:
17,656 bases
Orientation:
Plus strand

chr11:118,868,852-118,886,501
(GRCh37/hg19 by Ensembl)
Size:
17,650 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr11(PATCHES):19,738-37,393 (+)

Genomic View for CENATAC Gene

Genes around CENATAC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENATAC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENATAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENATAC Gene

Proteins for CENATAC Gene

  • Protein details for CENATAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UT8-CATAC_HUMAN
    Recommended name:
    Centrosomal AT-AC splicing factor
    Protein Accession:
    Q86UT8

    Protein attributes for CENATAC Gene

    Size:
    332 amino acids
    Molecular mass:
    37974 Da
    Quaternary structure:
    • Interacts with SASS6; the interaction increases with CENATAC acetylation.

neXtProt entry for CENATAC Gene

Post-translational modifications for CENATAC Gene

  • Acetylated. Acetylation oscillates throughout the cell cycle, and the acetylation state at Lys-31 is regulated by the deacetylase SIRT1 and the acetyltransferase NAT10. Deacetylated CENATAC is responsible for its centrosome targeting, and acetylated CENATAC promotes SASS6 degradation by enhancing the binding affinity of SASS6 for APC/C E3 ubiquitin-protein ligase complex/FZR1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CENATAC Gene

No data available for DME Specific Peptides for CENATAC Gene

Domains & Families for CENATAC Gene

Gene Families for CENATAC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CENATAC Gene

InterPro:

Suggested Antigen Peptide Sequences for CENATAC Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 84 (CCD84_HUMAN)
genes like me logo Genes that share domains with CENATAC: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CENATAC Gene

Function for CENATAC Gene

Molecular function for CENATAC Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of centrosome duplication (PubMed:31722219). Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 (PubMed:31722219).

Phenotypes From GWAS Catalog for CENATAC Gene

Gene Ontology (GO) - Molecular Function for CENATAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28514442
genes like me logo Genes that share ontologies with CENATAC: view
genes like me logo Genes that share phenotypes with CENATAC: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENATAC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CENATAC Gene

Localization for CENATAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENATAC Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the proximal end of the mother centriole. During the cell cycle, from G1 to metaphase, gradually accumulates on the centrosome and then decreased significantly upon entry into anaphase. {ECO:0000269 PubMed:31722219}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENATAC gene
Compartment Confidence
cytoskeleton 5
mitochondrion 2
nucleus 2
cytosol 1
extracellular 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CENATAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 31722219
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CENATAC: view

Pathways & Interactions for CENATAC Gene

PathCards logo

SuperPathways for CENATAC Gene

No Data Available

Gene Ontology (GO) - Biological Process for CENATAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010826 negative regulation of centrosome duplication IDA 31722219
GO:0042176 regulation of protein catabolic process IMP 31722219
genes like me logo Genes that share ontologies with CENATAC: view

No data available for Pathways by source and SIGNOR curated interactions for CENATAC Gene

Drugs & Compounds for CENATAC Gene

No Compound Related Data Available

Transcripts for CENATAC Gene

mRNA/cDNA for CENATAC Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CENATAC

Alternative Splicing Database (ASD) splice patterns (SP) for CENATAC Gene

No ASD Table

Relevant External Links for CENATAC Gene

GeneLoc Exon Structure for
CENATAC

Expression for CENATAC Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CENATAC

SOURCE GeneReport for Unigene cluster for CENATAC Gene:

Hs.534613

Evidence on tissue expression from TISSUES for CENATAC Gene

  • Nervous system(4.2)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENATAC Gene

Orthologs for CENATAC Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENATAC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC84 29 30
  • 99.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC84 29 30
  • 90.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC84 29 30
  • 90.56 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccdc84 29 16 30
  • 85.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc84 29
  • 84.84 (n)
Oppossum
(Monodelphis domestica)
Mammalia CCDC84 30
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCDC84 30
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCDC84 29 30
  • 60.42 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCDC84 30
  • 54 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccdc84 29
  • 58.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30684 29
Zebrafish
(Danio rerio)
Actinopterygii ccdc84 29 30
  • 56.16 (n)
OneToOne
Species where no ortholog for CENATAC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CENATAC Gene

ENSEMBL:
Gene Tree for CENATAC (if available)
TreeFam:
Gene Tree for CENATAC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CENATAC: view image
Alliance of Genome Resources:
Additional Orthologs for CENATAC

Paralogs for CENATAC Gene

Pseudogenes.org Pseudogenes for CENATAC Gene

genes like me logo Genes that share paralogs with CENATAC: view

No data available for Paralogs for CENATAC Gene

Variants for CENATAC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CENATAC Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs386352288 Uncertain Significance: not provided 119,015,316(+) A/G
NM_198489.3(CENATAC):c.815A>G (p.Gln272Arg)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs600648 -- p.Trp244Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CENATAC Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CENATAC Gene

Variant ID Type Subtype PubMed ID
esv3627880 CNV loss 21293372
nsv1127234 CNV deletion 24896259
nsv975231 CNV duplication 23825009
nsv983067 CNV duplication 23825009

Variation tolerance for CENATAC Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CENATAC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENATAC
Leiden Open Variation Database (LOVD)
CENATAC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENATAC Gene

Disorders for CENATAC Gene

Additional Disease Information for CENATAC

No disorders were found for CENATAC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENATAC Gene

Publications for CENATAC Gene

  1. CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by Modulating HsSAS-6 Degradation. (PMID: 31722219) Wang T … Chen J (Cell reports 2019) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Mapping the Genetic Landscape of Human Cells. (PMID: 30033366) Horlbeck MA … Gilbert LA (Cell 2018) 3
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3

Products for CENATAC Gene

Sources for CENATAC Gene