Aliases for CENATAC Gene
External Ids for CENATAC Gene
Previous HGNC Symbols for CENATAC Gene
Previous GeneCards Identifiers for CENATAC Gene
This gene encodes a protein thought to contain a coiled coil motif. No function has been determined for the encoded protein. A pseudogene of this gene is located on chromosome 20. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for CENATAC Gene
CENATAC (Centrosomal AT-AC Splicing Factor) is a Protein Coding gene.
UniProtKB/Swiss-Prot Summary for CENATAC Gene
Negative regulator of centrosome duplication (PubMed:31722219). Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 (PubMed:31722219).