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Aliases for CEMP1 Gene

Aliases for CEMP1 Gene

  • Cementum Protein 1 2 3 4 5
  • Cementum Protein 23 3 4
  • CP-23 3 4
  • Cementoblastoma-Derived Protein 1 3
  • Cementum Protein-23 2
  • CP23 3

External Ids for CEMP1 Gene

Summaries for CEMP1 Gene

GeneCards Summary for CEMP1 Gene

CEMP1 (Cementum Protein 1) is a Protein Coding gene. Diseases associated with CEMP1 include Coccidiosis.

UniProtKB/Swiss-Prot for CEMP1 Gene

  • May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum (PubMed:21929512, PubMed:17509525, PubMed:21465469). Binds hydroxyapatite and may promote the biomineralization of the cementum (PubMed:19393626). Also promotes cell proliferation (PubMed:17509525, PubMed:21929512, PubMed:26011628).

Additional gene information for CEMP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEMP1 Gene

Genomics for CEMP1 Gene

GeneHancer (GH) Regulatory Elements for CEMP1 Gene

Promoters and enhancers for CEMP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I002529 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 552.8 -0.4 -429 3.8 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF207 ZNF143 CEMP1 GC16P002995 MIR3178 TBC1D24 LOC652276 ATP6V0C PDPK1 AMDHD2 SRRM2 E4F1
GH16I002506 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +22.6 22623 4.4 PKNOX1 SMAD1 RAD21 ZNF143 ATF7 IKZF2 RUNX3 EGR2 SMARCA5 CBFB TBC1D24 PDPK1 CEMP1 ABCA3 ABCA17P CCNF SRRM2 ATP6V0C ENSG00000260272 GC16M002495
GH16I002523 Enhancer 1.1 ENCODE dbSUPER 0.4 +7.2 7158 2.3 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 RXRA SP5 MXD4 PPARG PRSS27 ATP6V0C AMDHD2 CEMP1 ENSG00000259784
GH16I002525 Enhancer 0.4 Ensembl 0.4 +5.3 5316 0.6 CEBPB ZIC2 MYC ATP6V0C CEMP1 AMDHD2 ENSG00000259784
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CEMP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CEMP1 gene promoter:

Genomic Locations for CEMP1 Gene

Genomic Locations for CEMP1 Gene
chr16:2,530,035-2,531,417
(GRCh38/hg38)
Size:
1,383 bases
Orientation:
Minus strand
chr16:2,577,081-2,581,420
(GRCh37/hg19)

Genomic View for CEMP1 Gene

Genes around CEMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEMP1 Gene

Proteins for CEMP1 Gene

  • Protein details for CEMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PRD7-CEMP1_HUMAN
    Recommended name:
    Cementoblastoma-derived protein 1
    Protein Accession:
    Q6PRD7
    Secondary Accessions:
    • B2RUY1

    Protein attributes for CEMP1 Gene

    Size:
    247 amino acids
    Molecular mass:
    25959 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CEMP1 Gene

Post-translational modifications for CEMP1 Gene

Other Protein References for CEMP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEMP1 Gene

Domains & Families for CEMP1 Gene

Gene Families for CEMP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CEMP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CEMP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEMP1: view

No data available for UniProtKB/Swiss-Prot for CEMP1 Gene

Function for CEMP1 Gene

Molecular function for CEMP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum (PubMed:21929512, PubMed:17509525, PubMed:21465469). Binds hydroxyapatite and may promote the biomineralization of the cementum (PubMed:19393626). Also promotes cell proliferation (PubMed:17509525, PubMed:21929512, PubMed:26011628).
UniProtKB/Swiss-Prot Induction:
Up-regulated by hypoxia (at protein level).

Gene Ontology (GO) - Molecular Function for CEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046848 hydroxyapatite binding IDA 19393626
genes like me logo Genes that share ontologies with CEMP1: view

Phenotypes for CEMP1 Gene

GenomeRNAi human phenotypes for CEMP1:
genes like me logo Genes that share phenotypes with CEMP1: view

Animal Model Products

CRISPR Products

miRNA for CEMP1 Gene

miRTarBase miRNAs that target CEMP1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEMP1 Gene

Localization for CEMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEMP1 Gene

Cytoplasm. Nucleus. Note=Localizes to the nucleus of some cementoblasts. {ECO:0000269 PubMed:21465469}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEMP1 gene
Compartment Confidence
nucleus 5
extracellular 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21465469
GO:0005737 cytoplasm IDA,IEA 21465469
genes like me logo Genes that share ontologies with CEMP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CEMP1 Gene

Pathways & Interactions for CEMP1 Gene

SuperPathways for CEMP1 Gene

No Data Available

Interacting Proteins for CEMP1 Gene

Gene Ontology (GO) - Biological Process for CEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation IDA 17509525
GO:0030154 cell differentiation IMP 21465469
GO:0031214 biomineral tissue development IDA 17509525
GO:0042476 odontogenesis IDA 21929512
genes like me logo Genes that share ontologies with CEMP1: view

No data available for Pathways by source and SIGNOR curated interactions for CEMP1 Gene

Drugs & Compounds for CEMP1 Gene

No Compound Related Data Available

Transcripts for CEMP1 Gene

mRNA/cDNA for CEMP1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEMP1 Gene

Cementum protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEMP1 Gene

No ASD Table

Relevant External Links for CEMP1 Gene

GeneLoc Exon Structure for
CEMP1
ECgene alternative splicing isoforms for
CEMP1

Expression for CEMP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEMP1 Gene

Protein differential expression in normal tissues from HIPED for CEMP1 Gene

This gene is overexpressed in Plasma (35.1), Serum (26.6), and Pancreatic juice (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CEMP1 Gene



Protein tissue co-expression partners for CEMP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CEMP1 Gene:

CEMP1

SOURCE GeneReport for Unigene cluster for CEMP1 Gene:

Hs.433499

mRNA Expression by UniProt/SwissProt for CEMP1 Gene:

Q6PRD7-CEMP1_HUMAN
Tissue specificity: Expressed by cementoblasts, a subpopulation of periodontal ligament cells and cells located around vessels in periodontium (at protein level).

Evidence on tissue expression from TISSUES for CEMP1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CEMP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEMP1 Gene

Orthologs for CEMP1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CEMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEMP1 33
  • 98.52 (n)
AMDHD2 34
  • 97 (a)
OneToOne
Species where no ortholog for CEMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEMP1 Gene

ENSEMBL:
Gene Tree for CEMP1 (if available)
TreeFam:
Gene Tree for CEMP1 (if available)

Paralogs for CEMP1 Gene

No data available for Paralogs for CEMP1 Gene

Variants for CEMP1 Gene

Sequence variations from dbSNP and Humsavar for CEMP1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000260221 -- 2,532,925(-) T/C upstream_transcript_variant
rs1000354027 -- 2,532,800(-) T/G upstream_transcript_variant
rs1000362781 -- 2,532,354(-) C/T upstream_transcript_variant
rs1000559638 -- 2,529,814(-) G/A downstream_transcript_variant
rs1001137527 -- 2,533,095(-) C/A/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CEMP1 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
esv2760067 CNV gain+loss 17122850
nsv1052260 CNV gain 25217958
nsv833122 CNV loss 17160897

Variation tolerance for CEMP1 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEMP1 Gene

Disorders for CEMP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CEMP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
coccidiosis
  • intestinal coccidiosis
- elite association - COSMIC cancer census association via MalaCards
Search CEMP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CEMP1

genes like me logo Genes that share disorders with CEMP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEMP1 Gene

Publications for CEMP1 Gene

  1. Molecular cloning, expression and immunolocalization of a novel human cementum-derived protein (CP-23). (PMID: 16263347) Alvarez-Pérez MA … Arzate H (Bone 2006) 2 3 4 58
  2. CEMP1 Induces Transformation in Human Gingival Fibroblasts. (PMID: 26011628) Bermúdez M … Mercado-Celis GE (PloS one 2015) 3 4 58
  3. Hypoxia promotes CEMP1 expression and induces cementoblastic differentiation of human dental stem cells in an HIF-1-dependent manner. (PMID: 24117017) Choi H … Choung PH (Tissue engineering. Part A 2014) 3 4 58
  4. Cementum protein 1 (CEMP1) induces a cementoblastic phenotype and reduces osteoblastic differentiation in periodontal ligament cells. (PMID: 21465469) Komaki M … Morita I (Journal of cellular physiology 2012) 3 4 58
  5. Cementum protein 1 (CEMP1) induces differentiation by human periodontal ligament cells under three-dimensional culture conditions. (PMID: 21929512) Hoz L … Arzate H (Cell biology international 2012) 3 4 58

Products for CEMP1 Gene

Sources for CEMP1 Gene

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