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Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dyst... See more...
Aliases for CELF1 Gene
Aliases for CELF1 Gene
- CUGBP Elav-Like Family Member 1 2 3 4 5
- BRUNOL2 2 3 4
- CUGBP 2 3 4
- NAB50 2 3 4
- Embryo Deadenylation Element-Binding Protein Homolog 3 4
- Nuclear Polyadenylated RNA-Binding Protein, 50-KD 2 3
- 50 KDa Nuclear Polyadenylated RNA-Binding Protein 3 4
- Embryo Deadenylation Element Binding Protein 2 3
- CUG Triplet Repeat RNA-Binding Protein 1 3 4
- CUG-BP- And ETR-3-Like Factor 1 3 4
- RNA-Binding Protein BRUNOL-2 3 4
- Deadenylation Factor CUG-BP 3 4
- CUG RNA-Binding Protein 2 3
External Ids for CELF1 Gene
- HGNC: 2549
- NCBI Entrez Gene: 10658
- Ensembl: ENSG00000149187
- OMIM®: 601074
- UniProtKB/Swiss-Prot: Q92879
Previous HGNC Symbols for CELF1 Gene
- CUGBP1
Previous GeneCards Identifiers for CELF1 Gene
- GC11M047489
- GC11M047187
- GC11M047602
- GC11M048078
- GC11M048801
- GC11M049904
- GC11M047613
- GC11M047952
- GC11M055817
- GC11M056042
- GC11M056182
- GC11M059698
- GC11M050802
- GC11M051597
- GC11M052259
- GC11M052919
- GC11M053587
- GC11M054253
- GC11M054919
- GC11M055619
- GC11M061128
- GC11M063612
Summaries for CELF1 Gene
-
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for CELF1 Gene
CELF1 (CUGBP Elav-Like Family Member 1) is a Protein Coding gene. Diseases associated with CELF1 include Myotonic Dystrophy and Myotonic Dystrophy 1. Among its related pathways are Adipogenesis and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CELF2.
UniProtKB/Swiss-Prot Summary for CELF1 Gene
-
RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233).
Additional gene information for CELF1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CELF1 Gene
Genomics for CELF1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CELF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CELF1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CELF1
Genomic Locations for CELF1 Gene
Latest Assembly
- chr11:47,465,933-47,565,569
- (GRCh38/hg38)
- Size:
- 99,637 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:47,487,489-47,587,091
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 99,603 bases
- Orientation:
- Minus strand
Genomic View for CELF1 Gene
Genes around CELF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by HGNC
- 11p11.2 by Entrez Gene
- 11p11.2 by Ensembl
CELF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CELF1 Gene
Proteins for CELF1 Gene
-
Protein details for CELF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92879-CELF1_HUMAN
- Recommended name:
- CUGBP Elav-like family member 1
- Protein Accession:
- Q92879
- B4E2U5
- D3DQS0
- F8W940
- Q4LE52
- Q9NP83
- Q9NR06
Protein attributes for CELF1 Gene
- Size:
- 486 amino acids
- Molecular mass:
- 52063 Da
- Quaternary structure:
-
- Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Associates with polysomes (By similarity). Interacts with HNRNPH1; the interaction in RNA-dependent. Interacts with PARN.
- SequenceCaution:
-
- Sequence=BAE06101.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 1]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Three dimensional structures from OCA and Proteopedia for CELF1 Gene
Protein Expression for CELF1 Gene
Post-translational modifications for CELF1 Gene
- Phosphorylated. Its phosphorylation status increases in senescent cells.
-
Ubiquitination at Lys166
- NX_Q92879 (NX_Q92879-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CELF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_011518156.1
- XP_011518159.1
- XP_011518161.1
- XP_016872590.1
- XP_016872592.1
- XP_016872593.1
- XP_016872594.1
- XP_016872595.1
- XP_016872596.1
- XP_016872597.1
- XP_016872599.1
- XP_016872601.1
- XP_016872602.1
- XP_024304102.1
- NP_001020767.1
- NP_001166110.1
- NP_001166111.1
- NP_001317201.1
- NP_001363298.1
- NP_001363299.1
- NP_001363300.1
- NP_001363301.1
- NP_001363302.1
- NP_001363303.1
- NP_001363304.1
- NP_001363305.1
- NP_001363306.1
- NP_001363307.1
- NP_001363308.1
- NP_001363309.1
- NP_001363310.1
- NP_001363311.1
- NP_001363312.1
- NP_001363313.1
- NP_001363314.1
- NP_001363315.1
- NP_001363316.1
- NP_001363317.1
- NP_001363318.1
- NP_001363319.1
- NP_001363320.1
- NP_001363322.1
- NP_001363324.1
- NP_001363325.1
- NP_001363326.1
- NP_001363328.1
- NP_001363335.1
- NP_001363336.1
- NP_001363337.1
- NP_001363338.1
- NP_001363339.1
- NP_001363340.1
- NP_001363341.1
- NP_001363342.1
- NP_001363343.1
- NP_001363344.1
- NP_001363346.1
- NP_001363347.1
- NP_001363348.1
- NP_001363349.1
- NP_001363350.1
- NP_001363351.1
- NP_001363352.1
- NP_001363353.1
- NP_001363354.1
- NP_001363355.1
- NP_001363356.1
- NP_001363357.1
- NP_001363358.1
- NP_001363359.1
- NP_001363360.1
- NP_001363361.1
- NP_001363362.1
- NP_001363363.1
- NP_001363364.1
- NP_001363365.1
- NP_001363366.1
- NP_001363367.1
- NP_001363368.1
- NP_001363369.1
- NP_001363370.1
- NP_001363371.1
- NP_001363372.1
- NP_001363373.1
- NP_001363374.1
- NP_001363375.1
- NP_001363376.1
- NP_001363377.1
- NP_001363378.1
- NP_001363379.1
- NP_001363380.1
- NP_001363381.1
- NP_001363382.1
- NP_001363383.1
- NP_001363384.1
- NP_001363385.1
- NP_001363386.1
- NP_001363387.1
- NP_001363388.1
- NP_001363389.1
- NP_001363390.1
- NP_001363391.1
- NP_001363392.1
- NP_006551.1
- NP_941989.1
Antibodies for research
- LifeSpan BioSciences CELF1 / CUGBP1 Antibody and CELF1 / CUGBP1 Monoclonal Antibody
- G Biosciences Immunotagā¢ CELF-1 Antibody
- Novus Biologicals Antibodies for CELF1
-
Abcam antibodies for CELF1
- Invitrogen Antibodies for CELF1 (AFLGC-CELF1)
- antibodies-online: Show 26 available CELF1 Antibodies ranked by validation data
- Compare Top CELF1 Antibodies
-
Recommended
- 81 WB Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 42 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 37 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Biorbyt antibodies for CELF1
-
Custom Antibody ServicesProSci Antibodies for CELF1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CELF1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for CELF1
- Origene Custom Protein Services for CELF1
-
Abcam proteins for CELF1
Assay products for research
- antibodies-online: Show 13 available CELF1 Elisa Kits ranked by validation data
- Compare Top CELF1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CELF1 Gene
Domains & Families for CELF1 Gene
Gene Families for CELF1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CELF1 Gene
- InterPro:
- Blocks:
-
- RNA-binding region RNP-1 (RNA recognition motif)
Suggested Antigen Peptide Sequences for CELF1 Gene
- GenScript: Design optimal peptide antigens:
-
- RNA-binding protein BRUNOL-2 (CELF1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q92879UniProtKB/Swiss-Prot:
CELF1_HUMAN :- RRM1 and RRM2 domains preferentially target UGU(U/G)-rich mRNA elements.
- Belongs to the CELF/BRUNOL family.
- Domain:
-
- RRM1 and RRM2 domains preferentially target UGU(U/G)-rich mRNA elements.
- Family:
-
- Belongs to the CELF/BRUNOL family.
Function for CELF1 Gene
Molecular function for CELF1 Gene
- UniProtKB/Swiss-Prot Function:
- RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in myotonic dystrophy pathophysiology (DM).
Phenotypes From GWAS Catalog for CELF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000900 | translation repressor activity, mRNA regulatory element binding | NAS | 10893231 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,IDA | 16946708 |
| GO:0003729 | mRNA binding | IDA | 14726956 |
| GO:0003730 | mRNA 3'-UTR binding | IBA,ISS | 30508596 |
Phenotypes for CELF1 Gene
- GenomeRNAi human phenotypes for CELF1:
-
- Increased vaccinia virus (VACV) infection
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Decreased viability
- shRNA abundance <= 50%
- no effect
- Inconclusive
- Increased endosome-nucleus distance (endosomes dispersed in the cell periphery)
- Decreased caspase 3/7 activity
- Decreased viability in esophageal squamous lineage; decreased viability in pancreas lineage
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CELF1 - Starting at $85 >
- * CELF1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CELF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CELF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CELF1
miRNA for CELF1 Gene
- miRTarBase miRNAs that target CELF1
-
- mmu-miR-23a-3p (MIRT004480)
- mmu-miR-23b-3p (MIRT004481)
- mmu-miR-758-3p (MIRT007499)
- mmu-miR-541-5p (MIRT008179)
- mmu-miR-223-3p (MIRT009589)
- mmu-miR-26a-5p (MIRT011095)
- mmu-miR-19b-3p (MIRT012397)
- mmu-miR-297a-5p (MIRT012942)
- mmu-miR-181a-5p (MIRT014036)
- hsa-miR-1301-3p (MIRT036047)
- hsa-miR-18a-3p (MIRT040833)
- hsa-miR-1229-3p (MIRT059262)
- hsa-miR-6511a-3p (MIRT059267)
- hsa-miR-6515-3p (MIRT059268)
- hsa-miR-6511b-3p (MIRT059269)
- hsa-miR-6784-3p (MIRT059271)
- hsa-miR-6862-3p (MIRT059273)
- hsa-miR-4715-3p (MIRT180683)
- hsa-miR-3064-3p (MIRT180684)
- hsa-miR-875-3p (MIRT180725)
- hsa-miR-6124 (MIRT180737)
- hsa-miR-2355-3p (MIRT180753)
- hsa-miR-4521 (MIRT180757)
- hsa-miR-4646-3p (MIRT180758)
- hsa-miR-4279 (MIRT241409)
- hsa-miR-7162-3p (MIRT266306)
- hsa-miR-3180-5p (MIRT332968)
- hsa-miR-3613-3p (MIRT383167)
- hsa-miR-412-3p (MIRT396956)
- hsa-miR-6754-3p (MIRT396960)
- hsa-miR-208b-3p (MIRT448941)
- hsa-miR-208a-3p (MIRT448942)
- hsa-miR-4804-3p (MIRT448943)
- hsa-miR-4720-3p (MIRT448944)
- hsa-miR-2277-3p (MIRT448945)
- hsa-miR-541-5p (MIRT448946)
- hsa-miR-8087 (MIRT448947)
- hsa-miR-4432 (MIRT448948)
- hsa-miR-499a-5p (MIRT448949)
- hsa-miR-4644 (MIRT479360)
- hsa-miR-4261 (MIRT479361)
- hsa-miR-4496 (MIRT479362)
- hsa-miR-6848-3p (MIRT479363)
- hsa-miR-6843-3p (MIRT479364)
- hsa-miR-5011-3p (MIRT479365)
- hsa-miR-3925-5p (MIRT479366)
- hsa-miR-4773 (MIRT479367)
- hsa-miR-4727-5p (MIRT479368)
- hsa-miR-192-3p (MIRT479369)
- hsa-miR-6826-3p (MIRT479370)
- hsa-miR-513a-5p (MIRT479371)
- hsa-miR-6721-5p (MIRT479372)
- hsa-miR-4736 (MIRT479373)
- hsa-miR-657 (MIRT479374)
- hsa-miR-6774-5p (MIRT479375)
- hsa-miR-635 (MIRT479376)
- hsa-miR-6817-5p (MIRT479377)
- hsa-miR-4769-3p (MIRT479378)
- hsa-miR-3189-3p (MIRT479379)
- hsa-miR-6734-3p (MIRT479380)
- hsa-miR-6756-3p (MIRT479381)
- hsa-miR-3127-3p (MIRT479382)
- hsa-miR-4310 (MIRT479383)
- hsa-miR-7157-5p (MIRT479384)
- hsa-miR-3591-3p (MIRT479385)
- hsa-miR-21-3p (MIRT479386)
- hsa-miR-27b-3p (MIRT479387)
- hsa-miR-27a-3p (MIRT479388)
- hsa-miR-202-3p (MIRT502831)
- hsa-miR-8084 (MIRT502832)
- hsa-miR-3646 (MIRT502833)
- hsa-miR-1252-3p (MIRT502834)
- hsa-miR-429 (MIRT502835)
- hsa-miR-200c-3p (MIRT502836)
- hsa-miR-200b-3p (MIRT502837)
- hsa-miR-98-5p (MIRT502838)
- hsa-miR-4500 (MIRT502839)
- hsa-let-7d-5p (MIRT502840)
- hsa-miR-4458 (MIRT502841)
- hsa-let-7i-5p (MIRT502842)
- hsa-let-7f-5p (MIRT502843)
- hsa-let-7g-5p (MIRT502844)
- hsa-let-7e-5p (MIRT502845)
- hsa-let-7b-5p (MIRT502846)
- hsa-let-7c-5p (MIRT502847)
- hsa-let-7a-5p (MIRT502848)
- hsa-miR-6780a-3p (MIRT507755)
- hsa-miR-6501-5p (MIRT538544)
- hsa-miR-877-5p (MIRT538545)
- hsa-miR-4252 (MIRT538546)
- hsa-miR-4784 (MIRT538547)
- hsa-miR-3150b-3p (MIRT538548)
- hsa-miR-6859-5p (MIRT538549)
- hsa-miR-3916 (MIRT538550)
- hsa-miR-3125 (MIRT538551)
- hsa-miR-495-5p (MIRT538552)
- hsa-miR-6509-5p (MIRT538553)
- hsa-miR-525-5p (MIRT538554)
- hsa-miR-520a-5p (MIRT538555)
- hsa-miR-331-5p (MIRT538556)
- hsa-miR-3922-3p (MIRT538557)
- hsa-miR-3176 (MIRT538558)
- hsa-miR-32-3p (MIRT538559)
- hsa-miR-519e-5p (MIRT558789)
- hsa-miR-515-5p (MIRT558790)
- hsa-miR-593-5p (MIRT572167)
- hsa-miR-4791 (MIRT572168)
- hsa-miR-3201 (MIRT572169)
- hsa-miR-548z (MIRT572170)
- hsa-miR-548h-3p (MIRT572171)
- hsa-miR-548d-3p (MIRT572172)
- hsa-miR-548bb-3p (MIRT572173)
- hsa-miR-548ac (MIRT572174)
- hsa-miR-183-5p (MIRT572175)
- hsa-miR-6847-3p (MIRT574824)
- hsa-miR-3912-5p (MIRT574825)
- hsa-miR-4711-3p (MIRT574826)
- hsa-miR-6737-3p (MIRT574827)
- hsa-miR-7157-3p (MIRT574828)
- hsa-miR-5008-3p (MIRT574829)
- hsa-miR-6889-3p (MIRT574830)
- hsa-miR-4716-5p (MIRT574831)
- hsa-miR-4698 (MIRT574832)
- hsa-miR-3662 (MIRT574833)
- hsa-miR-5587-5p (MIRT659614)
- hsa-miR-6823-3p (MIRT659615)
- hsa-miR-2114-3p (MIRT659616)
- hsa-miR-7113-3p (MIRT659617)
- hsa-miR-6791-5p (MIRT659618)
- hsa-miR-4292 (MIRT659619)
- hsa-miR-4308 (MIRT659620)
- hsa-miR-6877-3p (MIRT659621)
- hsa-miR-6819-3p (MIRT659622)
- hsa-miR-6809-3p (MIRT669073)
- hsa-miR-6833-3p (MIRT669074)
- hsa-miR-4768-5p (MIRT669075)
- hsa-miR-4753-3p (MIRT669076)
- hsa-miR-3688-5p (MIRT669077)
- hsa-miR-6837-3p (MIRT669078)
- hsa-miR-1236-3p (MIRT669079)
- hsa-miR-3677-5p (MIRT669080)
- hsa-miR-23a-3p (MIRT669081)
- hsa-miR-23b-3p (MIRT669082)
- hsa-miR-23c (MIRT669083)
- hsa-miR-130a-5p (MIRT669084)
- hsa-miR-6757-3p (MIRT725578)
- hsa-miR-200a-3p (MIRT725579)
- hsa-miR-141-3p (MIRT725580)
- hsa-miR-330-3p (MIRT725581)
- hsa-miR-6835-3p (MIRT725582)
- hsa-let-7d-3p (MIRT735642)
- hsa-miR-1183 (MIRT735883)
- hsa-miR-1207-5p (MIRT736014)
- hsa-miR-1285-3p (MIRT737019)
- hsa-miR-138-5p (MIRT737532)
- hsa-miR-1537-5p (MIRT737893)
- hsa-miR-185-5p (MIRT738237)
- hsa-miR-1909-3p (MIRT738342)
- hsa-miR-1915-3p (MIRT738543)
- hsa-miR-30a-5p (MIRT739731)
- hsa-miR-30b-5p (MIRT739803)
- hsa-miR-30c-5p (MIRT739894)
- hsa-miR-30d-5p (MIRT739907)
- hsa-miR-30e-5p (MIRT739920)
- hsa-miR-3187-5p (MIRT740914)
- hsa-miR-3607-3p (MIRT741524)
- hsa-miR-3611 (MIRT741536)
- hsa-miR-3652 (MIRT741885)
- hsa-miR-3689a-5p (MIRT742305)
- hsa-miR-3689b-5p (MIRT742375)
- hsa-miR-3689e (MIRT742504)
- hsa-miR-3689f (MIRT742507)
- hsa-miR-3919 (MIRT742941)
- hsa-miR-4302 (MIRT743863)
- hsa-miR-4306 (MIRT743890)
- hsa-miR-4430 (MIRT744323)
- hsa-miR-4446-3p (MIRT744609)
- hsa-miR-4505 (MIRT745513)
- hsa-miR-4675 (MIRT746876)
- hsa-miR-4685-5p (MIRT746957)
- hsa-miR-4716-3p (MIRT747480)
- hsa-miR-4723-5p (MIRT747643)
- hsa-miR-4741 (MIRT748113)
- hsa-miR-4763-3p (MIRT748523)
- hsa-miR-493-3p (MIRT749247)
- hsa-miR-5011-5p (MIRT749523)
- hsa-miR-5189-5p (MIRT749874)
- hsa-miR-519a-3p (MIRT750105)
- hsa-miR-519b-3p (MIRT750123)
- hsa-miR-519c-3p (MIRT750141)
- hsa-miR-548q (MIRT750783)
- hsa-miR-5698 (MIRT751275)
- hsa-miR-570-3p (MIRT751376)
- hsa-miR-5787 (MIRT751463)
- hsa-miR-612 (MIRT752217)
- hsa-miR-6722-3p (MIRT753855)
- hsa-miR-6764-5p (MIRT755049)
- hsa-miR-6794-5p (MIRT756080)
- hsa-miR-6798-5p (MIRT756251)
- hsa-miR-6825-5p (MIRT756966)
- hsa-miR-6837-5p (MIRT757239)
- hsa-miR-6842-3p (MIRT757340)
- hsa-miR-6860 (MIRT757846)
- hsa-miR-6870-5p (MIRT757976)
- hsa-miR-7106-5p (MIRT758840)
- hsa-miR-7109-5p (MIRT758942)
- hsa-miR-7111-5p (MIRT759033)
- hsa-miR-765 (MIRT759546)
- hsa-miR-7854-3p (MIRT759915)
- hsa-miR-1199-5p (MIRT761218)
- hsa-miR-3194-5p (MIRT765483)
- hsa-miR-4303 (MIRT768500)
- hsa-miR-4319 (MIRT768594)
- hsa-miR-6751-3p (MIRT778343)
- hsa-miR-6778-3p (MIRT778794)
- hsa-miR-6849-3p (MIRT780262)
- hsa-miR-6858-3p (MIRT780514)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CELF1
- Browse OriGene Inhibitory RNA Products For CELF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CELF1
Clone products for research
- Applied Biological Materials (abm): Clones for CELF1 - Starting at $45 >
- * CELF1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG220691
- MG220707
- MR220691
- MR220691L3
- MR220691L4
- MR220707
- MR220707L3
- MR220707L4
- MR230155
- MR230156
- RC206275
- RC206275L1
- RC206275L2
- RC206275L3
- RC206275L4
- RC221943
- RC221943L3
- RC221943L4
- RC222434
- RC222434L3
- RC222434L4
- RC230163
- RC230163L3
- RC230163L4
- RC230208
- RC230208L3
- RC230208L4
- RG206275
- RG221943
- RG222434
- RG230163
- RG230208
- RR204942
- RR204942L3
- RR204942L4
- MR220691L3V
- MR220691L4V
- MR220707L3V
- MR220707L4V
- RC206275L1V
- RC206275L2V
- RC206275L3V
- RC206275L4V
- RC221943L3V
- RC221943L4V
- RC222434L3V
- RC222434L4V
- RC230163L3V
- RC230163L4V
- RC230208L3V
- RC230208L4V
- RR204942L3V
- RR204942L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CELF1
- Addgene plasmids for CELF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CELF1
Cell Lines for research
-
Horizon Cell Lines for CELF1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CELF1 Gene
Localization for CELF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CELF1 Gene
- Nucleus. Cytoplasm. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,NAS | 10893231 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
| GO:0010494 | cytoplasmic stress granule | IDA | 18164289 |
| GO:0016020 | membrane | HDA | 19946888 |
Pathways & Interactions for CELF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Adipogenesis | ||
| 2 | mRNA Splicing - Major Pathway |
.41
|
|
Pathways by source for CELF1 Gene
2 BioSystems pathways for CELF1 Gene
Interacting Proteins for CELF1 Gene
Selected Interacting proteins:
Q92879-CELF1_HUMAN
ENSP00000435926
for CELF1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CELF1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | IBA | 21873635 |
| GO:0006376 | mRNA splice site selection | IBA,ISS | -- |
| GO:0006397 | mRNA processing | TAS | 8948631 |
| GO:0007281 | germ cell development | NAS | 10893231 |
| GO:0007286 | spermatid development | IEA | -- |
Transcripts for CELF1 Gene
mRNA/cDNA for CELF1 Gene
- 91 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000310513 4583 nts (view in UCSC)
- ENST00000358597 2108 nts (view in UCSC)
- ENST00000361904 1580 nts (view in UCSC)
- ENST00000395290 7666 nts (view in UCSC)
- ENST00000395292 2191 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CELF1 - Starting at $85 >
- * CELF1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CELF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CELF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CELF1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CELF1
- Browse OriGene Inhibitory RNA Products For CELF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CELF1
Clone products for research
- Applied Biological Materials (abm): Clones for CELF1 - Starting at $45 >
- * CELF1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG220691
- MG220707
- MR220691
- MR220691L3
- MR220691L4
- MR220707
- MR220707L3
- MR220707L4
- MR230155
- MR230156
- RC206275
- RC206275L1
- RC206275L2
- RC206275L3
- RC206275L4
- RC221943
- RC221943L3
- RC221943L4
- RC222434
- RC222434L3
- RC222434L4
- RC230163
- RC230163L3
- RC230163L4
- RC230208
- RC230208L3
- RC230208L4
- RG206275
- RG221943
- RG222434
- RG230163
- RG230208
- RR204942
- RR204942L3
- RR204942L4
- MR220691L3V
- MR220691L4V
- MR220707L3V
- MR220707L4V
- RC206275L1V
- RC206275L2V
- RC206275L3V
- RC206275L4V
- RC221943L3V
- RC221943L4V
- RC222434L3V
- RC222434L4V
- RC230163L3V
- RC230163L4V
- RC230208L3V
- RC230208L4V
- RR204942L3V
- RR204942L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CELF1
- Addgene plasmids for CELF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CELF1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | · | 12f | ^ | 13 | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: |
| ExUns: | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||
| SP17: | - | ||||||||||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||||||||||||
| SP20: | - | - | |||||||||||||||||||||||||||||||||||
| SP21: |
Relevant External Links for CELF1 Gene
- GeneLoc Exon Structure for
- CELF1
Expression for CELF1 Gene
This gene is overexpressed in Breast (7.8), Peripheral blood mononuclear cells (7.8), and Lymph node (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CELF1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CELF1
SOURCE GeneReport for Unigene cluster for CELF1 Gene:
Hs.595333mRNA Expression by UniProt/SwissProt for CELF1 Gene:
Q92879-CELF1_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for CELF1 Gene
- Nervous system(5)
- Liver(4.7)
- Muscle(4.6)
- Lung(4.3)
- Eye(3.9)
- Intestine(3.6)
- Skin(3.1)
- Kidney(2.7)
- Heart(2.7)
- Blood(2.5)
- Pancreas(2.3)
- Thyroid gland(2)
- Lymph node(2)
Primer products for research
-
OriGene qPCR primer pairs for CELF1
-
OriGene qPCR primer pairs and template standards for CELF1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CELF1 Gene
Orthologs for CELF1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Cow (Bos Taurus) |
Mammalia | CUGBP1 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Celf1 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CELF1 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CELF1 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CELF1 29 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CELF1 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CELF1 30 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.25921 29 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.10819 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | celf1 30 |
|
OneToOne | |
| cugbp1 29 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | aret 30 |
|
ManyToMany | |
| bru-2 30 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | etr-1 30 |
|
OneToMany | |
| Rice (Oryza sativa) |
Liliopsida | Os.33686 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7203 30 |
|
OneToMany |
- Species where no ortholog for CELF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CELF1 Gene
- ENSEMBL:
- Gene Tree for CELF1 (if available)
- TreeFam:
- Gene Tree for CELF1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CELF1: view image
- Alliance of Genome Resources:
- Additional Orthologs for CELF1
Paralogs for CELF1 Gene
(20) SIMAP similar genes for CELF1 Gene using alignment to 10 proteins:
- CELF1_HUMAN
- E9PKA1_HUMAN
- E9PKU1_HUMAN
- E9PQK4_HUMAN
- E9PSH0_HUMAN
- F5H0D8_HUMAN
- F5H3J7_HUMAN
- F5H4Y5_HUMAN
- F5H7M7_HUMAN
- G5EA30_HUMAN
Variants for CELF1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CELF1 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs145495807 | Benign: not provided | 47,472,254(-) |
C/T NM_001172639.2(CELF1):c.1515G>A (p.Ser505=) |
SYNONYMOUS_VARIANT,THREE_PRIME_UTR |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1232065 | CNV | deletion | 17803354 |
| esv2664490 | CNV | deletion | 23128226 |
| esv2744438 | CNV | deletion | 23290073 |
| esv2744439 | CNV | deletion | 23290073 |
| esv3547707 | CNV | deletion | 23714750 |
| esv3626203 | CNV | loss | 21293372 |
| nsv1113387 | CNV | deletion | 24896259 |
| nsv1120085 | OTHER | inversion | 24896259 |
| nsv1124575 | CNV | deletion | 24896259 |
| nsv1134114 | CNV | deletion | 24896259 |
| nsv314 | CNV | deletion | 18451855 |
| nsv512223 | CNV | loss | 21212237 |
| nsv825872 | CNV | gain | 20364138 |
| nsv832141 | CNV | loss | 17160897 |
| nsv832142 | CNV | loss | 17160897 |
| nsv957884 | CNV | deletion | 24416366 |
| nsv972949 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.62;
13.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CELF1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELF1 Gene
Disorders for CELF1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myotonic dystrophy |
|
|
| myotonic dystrophy 1 |
|
|
| myotonic dystrophy 2 |
|
|
| myotonic disease |
|
|
| x-linked hereditary ataxia |
|
|
Search CELF1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CELF1
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CELF1 Gene
Publications for CELF1 Gene
- Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy. (PMID: 8948631) Timchenko LT ā¦ Swanson MS (Nucleic acids research 1996) 2 3 4 22
- Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. (PMID: 16946708) Paul S ā¦ Reddy S (The EMBO journal 2006) 3 4 22
- CUG-BP binds to RNA substrates and recruits PARN deadenylase. (PMID: 16601207) Moraes KC ā¦ Wilusz J (RNA (New York, N.Y.) 2006) 3 4 22
- A functional deadenylation assay identifies human CUG-BP as a deadenylation factor. (PMID: 12799066) Paillard L ā¦ Beverley Osborne H (Biology of the cell 2003) 3 4 22
- RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1. (PMID: 11124939) Timchenko NA ā¦ Timchenko LT (The Journal of biological chemistry 2001) 3 4 22
ExternalLinks
Products for CELF1 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CELF1
- Origene Custom Protein Services for CELF1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CELF1
- Browse OriGene Inhibitory RNA Products For CELF1
- OriGene qPCR primer pairs for CELF1
- OriGene qPCR primer pairs and template standards for CELF1
- OriGene CRISPR knockouts for CELF1
- MG220691
- MG220707
- MR220691
- MR220691L3
- MR220691L4
- MR220707
- MR220707L3
- MR220707L4
- MR230155
- MR230156
- RC206275
- RC206275L1
- RC206275L2
- RC206275L3
- RC206275L4
- RC221943
- RC221943L3
- RC221943L4
- RC222434
- RC222434L3
- RC222434L4
- RC230163
- RC230163L3
- RC230163L4
- RC230208
- RC230208L3
- RC230208L4
- RG206275
- RG221943
- RG222434
- RG230163
- RG230208
- RR204942
- RR204942L3
- RR204942L4
- MR220691L3V
- MR220691L4V
- MR220707L3V
- MR220707L4V
- RC206275L1V
- RC206275L2V
- RC206275L3V
- RC206275L4V
- RC221943L3V
- RC221943L4V
- RC222434L3V
- RC222434L4V
- RC230163L3V
- RC230163L4V
- RC230208L3V
- RC230208L4V
- RR204942L3V
- RR204942L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Invitrogen Antibodies for CELF1 (AFLGC-CELF1)
- VectorBuilder Custom and pre-made DNA vectors for CELF1 (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 26 available CELF1 Antibodies ranked by validation data
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- 81 WB Antibodies (anti-human)
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- 1 IHC (p) Antibody (anti-human)
- 42 WB Antibodies (anti-mouse)
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- 1 IHC (p) Antibody (anti-mouse)
- 37 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 13 available CELF1 Elisa Kits ranked by validation data
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- antibodies-online: Show 10 available CELF1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for CELF1
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CELF1
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Sources for CELF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128)