Aliases for CELA3B Gene
External Ids for CELA3B Gene
Previous HGNC Symbols for CELA3B Gene
Previous GeneCards Identifiers for CELA3B Gene
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]
GeneCards Summary for CELA3B Gene
CELA3B (Chymotrypsin Like Elastase 3B) is a Protein Coding gene. Diseases associated with CELA3B include Pleuropneumonia and Exocrine Pancreatic Insufficiency. Among its related pathways are Collagen chain trimerization and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is CELA3A.
UniProtKB/Swiss-Prot Summary for CELA3B Gene
Efficient protease with alanine specificity but only little elastolytic activity.