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Aliases for CELA3B Gene

Aliases for CELA3B Gene

  • Chymotrypsin Like Elastase Family Member 3B 2 3 5
  • Cholesterol-Binding Pancreatic Protease 2 3
  • Pancreatic Endopeptidase E 2 3
  • Elastase 3B, Pancreatic 2 3
  • Elastase IIIB 3 4
  • Proteinase E 2 3
  • Elastase-3B 3 4
  • Protease E 3 4
  • ELA3B 3 4
  • Chymotrypsin-Like Elastase Family, Member 3B 2
  • Chymotrypsin-Like Elastase Family Member 3B 3
  • Pancreatic Elastase 1 3
  • Fecal Elastase 1 3
  • EC 4
  • Elastase 1 2
  • CBPP 3

External Ids for CELA3B Gene

Previous HGNC Symbols for CELA3B Gene

  • ELA3B

Previous GeneCards Identifiers for CELA3B Gene

  • GC01P022178
  • GC01P022303
  • GC01P020547

Summaries for CELA3B Gene

Entrez Gene Summary for CELA3B Gene

  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]

GeneCards Summary for CELA3B Gene

CELA3B (Chymotrypsin Like Elastase Family Member 3B) is a Protein Coding gene. Diseases associated with CELA3B include Maturity-Onset Diabetes Of The Young, Type 3 and Actinobacillosis. Among its related pathways are Collagen chain trimerization and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is CELA3A.

UniProtKB/Swiss-Prot for CELA3B Gene

  • Efficient protease with alanine specificity but only little elastolytic activity.

Gene Wiki entry for CELA3B Gene

Additional gene information for CELA3B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELA3B Gene

Genomics for CELA3B Gene

GeneHancer (GH) Regulatory Elements for CELA3B Gene

Promoters and enhancers for CELA3B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J021976 Promoter/Enhancer 0.8 EPDnew dbSUPER 650.7 +0.1 81 0.1 SCRT1 CELA3B GC01M021978
GH01J021977 Enhancer 0.2 dbSUPER 656 +1.5 1460 1.2 CELA3B GC01M021978 LINC01635 CDC42 RNU6-1022P
GH01J021918 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.3 -47.2 -47177 22.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 HSPG2 GC01P021930 USP48 CELA3B GC01M021926 RPL21P29
GH01J021955 Enhancer 1.3 Ensembl ENCODE dbSUPER 6.5 -20.0 -20042 3.5 CLOCK FOXA2 NFIB RARA ZNF335 GLIS2 FOS EGR2 SMARCA5 MXD4 ENSG00000283234 USP48 NBPF3 CELA3B
GH01J021996 Enhancer 1.1 Ensembl ENCODE dbSUPER 6.6 +22.1 22059 5.3 FOXA2 JUN E4F1 RARA VEZF1 ZNF239 SCRT2 NR2F6 CREM EGR2 CDC42 LINC01635 CELA3B CELA3A GC01P021996
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CELA3B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CELA3B gene promoter:
  • AP-4
  • Tal-1beta
  • ITF-2
  • Max1
  • c-Ets-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • NF-1

Genomic Locations for CELA3B Gene

Genomic Locations for CELA3B Gene
21,718 bases
Plus strand
21,718 bases
Plus strand

Genomic View for CELA3B Gene

Genes around CELA3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CELA3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CELA3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELA3B Gene

Proteins for CELA3B Gene

  • Protein details for CELA3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chymotrypsin-like elastase family member 3B
    Protein Accession:
    Secondary Accessions:
    • B2RE44
    • P11423
    • Q5VU28
    • Q5VU29
    • Q5VU30

    Protein attributes for CELA3B Gene

    270 amino acids
    Molecular mass:
    29263 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAH71872.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71873.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CELA3B Gene

Post-translational modifications for CELA3B Gene

  • Glycosylation at posLast=114114
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CEL3B_HUMAN (125)

Other Protein References for CELA3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CELA3B Gene

Domains & Families for CELA3B Gene

Gene Families for CELA3B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CELA3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family. Elastase subfamily.
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with CELA3B: view

Function for CELA3B Gene

Molecular function for CELA3B Gene

UniProtKB/Swiss-Prot Function:
Efficient protease with alanine specificity but only little elastolytic activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Ala- -Xaa. Does not hydrolyze elastin.

Enzyme Numbers (IUBMB) for CELA3B Gene

Gene Ontology (GO) - Molecular Function for CELA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 2737288
GO:0008233 peptidase activity TAS 2460440
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CELA3B: view
genes like me logo Genes that share phenotypes with CELA3B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CELA3B

miRNA for CELA3B Gene

miRTarBase miRNAs that target CELA3B

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CELA3B Gene

Localization for CELA3B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CELA3B gene
Compartment Confidence
extracellular 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CELA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CELA3B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CELA3B Gene

Pathways & Interactions for CELA3B Gene

genes like me logo Genes that share pathways with CELA3B: view

Pathways by source for CELA3B Gene

2 KEGG pathways for CELA3B Gene

Gene Ontology (GO) - Biological Process for CELA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CELA3B: view

No data available for SIGNOR curated interactions for CELA3B Gene

Drugs & Compounds for CELA3B Gene

(1) Drugs for CELA3B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alvelestat Investigational Pharma NE inhibitor 0
genes like me logo Genes that share compounds with CELA3B: view

Transcripts for CELA3B Gene

mRNA/cDNA for CELA3B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(497) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CELA3B Gene

Chymotrypsin-like elastase family, member 3B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CELA3B Gene

No ASD Table

Relevant External Links for CELA3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CELA3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CELA3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CELA3B Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for CELA3B Gene

This gene is overexpressed in Pancreatic juice (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CELA3B Gene

Protein tissue co-expression partners for CELA3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CELA3B Gene:


SOURCE GeneReport for Unigene cluster for CELA3B Gene:


mRNA Expression by UniProt/SwissProt for CELA3B Gene:

Tissue specificity: Pancreas. Not detectable in keratinocytes.

Evidence on tissue expression from TISSUES for CELA3B Gene

  • Pancreas(5)
  • Intestine(2)
genes like me logo Genes that share expression patterns with CELA3B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CELA3B Gene

Orthologs for CELA3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CELA3B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CELA3B 33
  • 99.01 (n)
(Canis familiaris)
Mammalia CELA3B 33
  • 85.38 (n)
-- 34
  • 85 (a)
(Bos Taurus)
Mammalia CELA3B 34 33
  • 84.57 (n)
(Rattus norvegicus)
Mammalia Cela3b 33
  • 83.52 (n)
(Mus musculus)
Mammalia Cela3b 16 34 33
  • 83.15 (n)
Gm13011 34
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
(Gallus gallus)
Aves LOC100857116 33
  • 67.16 (n)
-- 34
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
-- 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494627 33
  • 67.19 (n)
(Danio rerio)
Actinopterygii si:ch73-44m9.5 34
  • 67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
Species where no ortholog for CELA3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CELA3B Gene

Gene Tree for CELA3B (if available)
Gene Tree for CELA3B (if available)
Evolutionary constrained regions (ECRs) for CELA3B: view image

Paralogs for CELA3B Gene

Variants for CELA3B Gene

Sequence variations from dbSNP and Humsavar for CELA3B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000509788 -- 21,977,652(+) C/T intron_variant
rs1000637248 -- 21,982,931(+) T/C intron_variant
rs1001079154 -- 21,987,513(+) G/T intron_variant
rs1001353295 -- 21,981,340(+) G/A intron_variant
rs1001533503 -- 21,987,193(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CELA3B Gene

Variant ID Type Subtype PubMed ID
dgv11e201 CNV deletion 23290073
dgv16e214 CNV loss 21293372
esv24116 CNV loss 19812545
esv2672264 CNV deletion 23128226
esv2745119 CNV deletion 23290073
esv2758927 CNV loss 17122850
esv2760299 CNV loss 21179565
esv2764236 CNV gain+loss 21179565
esv3556232 CNV deletion 23714750
esv3556344 CNV deletion 23714750
esv3585457 CNV loss 21293372
esv3585458 CNV gain 21293372
esv3892859 CNV loss 25118596
esv3892970 CNV loss 25118596
esv7729 CNV loss 19470904
nsv1160262 CNV deletion 26073780
nsv436921 CNV insertion 17901297
nsv469549 CNV loss 16826518
nsv470706 CNV loss 18288195
nsv834402 CNV loss 17160897
nsv834413 CNV loss 17160897
nsv945816 CNV duplication 23825009
nsv9657 CNV loss 18304495

Variation tolerance for CELA3B Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CELA3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELA3B Gene

Disorders for CELA3B Gene

MalaCards: The human disease database

(7) MalaCards diseases for CELA3B Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CELA3B

genes like me logo Genes that share disorders with CELA3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CELA3B Gene

Publications for CELA3B Gene

  1. Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. (PMID: 2826474) Tani T … Takiguchi Y (The Journal of biological chemistry 1988) 2 3 4 58
  2. Identification of pancreatic juice proteins as biomarkers of pancreatic cancer. (PMID: 20428826) Gao J … Ma L (Oncology reports 2010) 3 22 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CELA3B Gene

Sources for CELA3B Gene

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