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Aliases for CELA3A Gene

Aliases for CELA3A Gene

  • Chymotrypsin Like Elastase Family Member 3A 2 3 5
  • Protease E 2 3 4
  • Elastase 3A, Pancreatic 2 3
  • Elastase IIIA 3 4
  • Elastase-3A 3 4
  • ELA3A 3 4
  • ELA3 3 4
  • Chymotrypsin-Like Elastase Family, Member 3A 2
  • Chymotrypsin-Like Elastase Family Member 3A 3
  • Elastase 3A, Pancreatic (Protease E) 2
  • EC 4
  • Elastase 1 3

External Ids for CELA3A Gene

Previous HGNC Symbols for CELA3A Gene

  • ELA3A

Previous GeneCards Identifiers for CELA3A Gene

  • GC01P022201
  • GC01P022328
  • GC01P020572

Summaries for CELA3A Gene

Entrez Gene Summary for CELA3A Gene

  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for CELA3A Gene

CELA3A (Chymotrypsin Like Elastase Family Member 3A) is a Protein Coding gene. Diseases associated with CELA3A include Holoprosencephaly 1. Among its related pathways are Collagen chain trimerization and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA3B.

UniProtKB/Swiss-Prot for CELA3A Gene

  • Efficient protease with alanine specificity but only little elastolytic activity.

Gene Wiki entry for CELA3A Gene

Additional gene information for CELA3A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELA3A Gene

Genomics for CELA3A Gene

GeneHancer (GH) Regulatory Elements for CELA3A Gene

Promoters and enhancers for CELA3A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J022001 Promoter/Enhancer 0.8 EPDnew dbSUPER 650.7 0.0 -15 0.1 SCRT2 CELA3A GC01P021996
GH01J022002 Enhancer 0.2 dbSUPER 650.7 +1.4 1365 1.2 CELA3A GC01M022003 LINC01635 CDC42
GH01J021996 Enhancer 1.1 Ensembl ENCODE dbSUPER 5.7 -2.7 -2672 5.3 FOXA2 JUN E4F1 RARA VEZF1 ZNF239 SCRT2 NR2F6 CREM EGR2 CDC42 LINC01635 CELA3B CELA3A GC01P021996
GH01J022140 Enhancer 0.5 FANTOM5 dbSUPER 7.1 +139.4 139356 0.3 SP1 LOC105376845 CELA3A CELA3B LINC00339 GC01P022144 WNT4
GH01J021995 Enhancer 0.3 dbSUPER 5.2 -5.9 -5912 0.8 E4F1 CDC42 CELA3A GC01P021996 CELA3B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CELA3A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CELA3A gene promoter:

Genomic Locations for CELA3A Gene

Genomic Locations for CELA3A Gene
10,887 bases
Plus strand

Genomic View for CELA3A Gene

Genes around CELA3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CELA3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CELA3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELA3A Gene

Proteins for CELA3A Gene

  • Protein details for CELA3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chymotrypsin-like elastase family member 3A
    Protein Accession:
    Secondary Accessions:
    • B1AQ53
    • Q9BRW4

    Protein attributes for CELA3A Gene

    270 amino acids
    Molecular mass:
    29489 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CELA3A Gene

Post-translational modifications for CELA3A Gene

Other Protein References for CELA3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CELA3A Gene

Domains & Families for CELA3A Gene

Gene Families for CELA3A Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CELA3A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family. Elastase subfamily.
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with CELA3A: view

Function for CELA3A Gene

Molecular function for CELA3A Gene

UniProtKB/Swiss-Prot Function:
Efficient protease with alanine specificity but only little elastolytic activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Ala- -Xaa. Does not hydrolyze elastin.

Enzyme Numbers (IUBMB) for CELA3A Gene

Gene Ontology (GO) - Molecular Function for CELA3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IBA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CELA3A: view
genes like me logo Genes that share phenotypes with CELA3A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CELA3A

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CELA3A Gene

Localization for CELA3A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CELA3A gene
Compartment Confidence
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CELA3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CELA3A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CELA3A Gene

Pathways & Interactions for CELA3A Gene

genes like me logo Genes that share pathways with CELA3A: view

Pathways by source for CELA3A Gene

2 KEGG pathways for CELA3A Gene

Gene Ontology (GO) - Biological Process for CELA3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CELA3A: view

No data available for SIGNOR curated interactions for CELA3A Gene

Drugs & Compounds for CELA3A Gene

(1) Drugs for CELA3A Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alvelestat Investigational Pharma NE inhibitor 0

(1) ApexBio Compounds for CELA3A Gene

Compound Action Cas Number
Alvelestat NE inhibitor 848141-11-7
genes like me logo Genes that share compounds with CELA3A: view

Drug Products

Transcripts for CELA3A Gene

mRNA/cDNA for CELA3A Gene

(497) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CELA3A Gene

Chymotrypsin-like elastase family, member 3A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CELA3A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CELA3A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP2: - -

Relevant External Links for CELA3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CELA3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CELA3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CELA3A Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for CELA3A Gene

This gene is overexpressed in Pancreatic juice (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CELA3A Gene

Protein tissue co-expression partners for CELA3A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CELA3A Gene:


SOURCE GeneReport for Unigene cluster for CELA3A Gene:


Evidence on tissue expression from TISSUES for CELA3A Gene

  • Pancreas(5)
genes like me logo Genes that share expression patterns with CELA3A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CELA3A Gene

Orthologs for CELA3A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CELA3A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CELA3A 34 33
  • 97.78 (n)
(Canis familiaris)
Mammalia -- 34
  • 82 (a)
(Bos Taurus)
Mammalia CELA3B 34
  • 81 (a)
(Mus musculus)
Mammalia Cela3b 34
  • 80 (a)
Gm13011 34 33
  • 79.06 (n)
Cela3a 16
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
(Gallus gallus)
Aves -- 34
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
-- 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ela3b 33
  • 67.45 (n)
(Danio rerio)
Actinopterygii si:ch73-44m9.5 34
  • 65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
Species where no ortholog for CELA3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CELA3A Gene

Gene Tree for CELA3A (if available)
Gene Tree for CELA3A (if available)
Evolutionary constrained regions (ECRs) for CELA3A: view image

Paralogs for CELA3A Gene

Paralogs for CELA3A Gene

genes like me logo Genes that share paralogs with CELA3A: view

Variants for CELA3A Gene

Sequence variations from dbSNP and Humsavar for CELA3A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000114694 -- 22,007,138(+) A/T intron_variant
rs1000737194 -- 22,000,618(+) C/T upstream_transcript_variant
rs1000886678 -- 22,000,159(+) C/A upstream_transcript_variant
rs1001785290 -- 22,010,097(+) A/T intron_variant
rs1001786832 -- 22,005,739(+) T/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CELA3A Gene

Variant ID Type Subtype PubMed ID
dgv11e201 CNV deletion 23290073
dgv16e214 CNV loss 21293372
dgv27n67 CNV loss 20364138
dgv8n111 CNV deletion 26073780
esv24116 CNV loss 19812545
esv2422105 CNV deletion 20811451
esv2672264 CNV deletion 23128226
esv2758927 CNV loss 17122850
esv2760299 CNV loss 21179565
esv2764236 CNV gain+loss 21179565
esv3556344 CNV deletion 23714750
esv3577781 CNV loss 25503493
esv3585460 CNV loss 21293372
esv3585461 CNV gain 21293372
esv3892859 CNV loss 25118596
esv7729 CNV loss 19470904
nsv1076255 CNV deletion 25765185
nsv1124206 CNV deletion 24896259
nsv1160262 CNV deletion 26073780
nsv441686 CNV loss 18776908
nsv469549 CNV loss 16826518
nsv470706 CNV loss 18288195
nsv528664 CNV gain 19592680
nsv834413 CNV loss 17160897
nsv945816 CNV duplication 23825009
nsv9657 CNV loss 18304495

Variation tolerance for CELA3A Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CELA3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELA3A Gene

Disorders for CELA3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for CELA3A Gene - From: DISEASES

Disorder Aliases PubMed IDs
holoprosencephaly 1
  • hpe1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CELA3A

genes like me logo Genes that share disorders with CELA3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CELA3A Gene

Publications for CELA3A Gene

  1. Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes. (PMID: 2460440) Shirasu Y … Ishida A (Journal of biochemistry 1988) 2 3 4 58
  2. Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. (PMID: 2826474) Tani T … Takiguchi Y (The Journal of biological chemistry 1988) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. (PMID: 27358403) Szabó A … Sahin-Tóth M (The Journal of biological chemistry 2016) 3 58

Products for CELA3A Gene

Sources for CELA3A Gene

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