Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave protein... See more...

Aliases for CELA2B Gene

Aliases for CELA2B Gene

  • Chymotrypsin Like Elastase 2B 2 3 5
  • ELA2B 2 3 4
  • Chymotrypsin-Like Elastase Family Member 2B 3 4
  • RP11-265F14.2 2 3
  • EC 3.4.21.71 4 51
  • Chymotrypsin-Like Elastase Family, Member 2B 2
  • Chymotrypsin Like Elastase Family Member 2B 3
  • Pancreatic Elastase IIB (ELA2B) 3
  • Pancreatic Elastase IIB 2
  • Elastase 2B 3
  • Elastase-2B 4
  • EC 3.4.21 51
  • CELA2B 5

External Ids for CELA2B Gene

Previous GeneCards Identifiers for CELA2B Gene

  • GC01P015677
  • GC01P015792
  • GC01P014326

Summaries for CELA2B Gene

Entrez Gene Summary for CELA2B Gene

  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, Jul 2008]

GeneCards Summary for CELA2B Gene

CELA2B (Chymotrypsin Like Elastase 2B) is a Protein Coding gene. Among its related pathways are Collagen chain trimerization and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2A.

UniProtKB/Swiss-Prot Summary for CELA2B Gene

Gene Wiki entry for CELA2B Gene

Additional gene information for CELA2B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CELA2B Gene

Genomics for CELA2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CELA2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J015462 Enhancer 1 Ensembl ENCODE 600.7 -1.5 -1489 3.6 CREB1 ZNF629 IKZF1 PKNOX1 HDAC1 SOX6 CTBP1 ZBTB10 ZEB1 TSHZ1 CELA2B CELA2A AGMAT SLC25A34 LOC105376767 piR-57133-008
GH01J015476 Promoter/Enhancer 1 EPDnew ENCODE 600.4 +10.1 10101 0.2 ZNF512 IKZF1 MTA1 HDAC1 EP300 HES1 FOXK2 ZNF384 TAL1 ADNP CELA2B LOC105376767 CASP9 lnc-CASP9-4
GH01J015467 Enhancer 0.2 Ensembl 600.7 +1.5 1492 0.4 CELA2B LOC105376767 AGMAT CELA2A CASP9 lnc-CASP9-4
GH01J015458 Enhancer 1.2 FANTOM5 Ensembl ENCODE 3.1 -5.9 -5927 2.4 PRDM10 ZNF629 IKZF1 JUND PATZ1 IKZF2 ZNF501 ZNF600 SOX6 ZNF341 AGMAT SLC25A34 CELA2A CELA2B CTRC PLEKHM2 piR-57133-008
GH01J015522 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.2 +59.4 59410 5.9 CEBPG SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 ZNF512 CASP9 DNAJC16 lnc-CASP9-4 ZBTB17 ENSG00000237938 AGMAT RPL22P3 SPEN CELA2B LOC105376767
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CELA2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CELA2B

Genomic Locations for CELA2B Gene

Genomic Locations for CELA2B Gene
chr1:15,465,909-15,491,395
(GRCh38/hg38)
Size:
25,487 bases
Orientation:
Plus strand
chr1:15,792,404-15,817,895
(GRCh37/hg19)
Size:
25,492 bases
Orientation:
Plus strand

Genomic View for CELA2B Gene

Genes around CELA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CELA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CELA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELA2B Gene

Proteins for CELA2B Gene

  • Protein details for CELA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08218-CEL2B_HUMAN
    Recommended name:
    Chymotrypsin-like elastase family member 2B
    Protein Accession:
    P08218
    Secondary Accessions:
    • Q14D16
    • Q6ISM5
    • Q96QV5

    Protein attributes for CELA2B Gene

    Size:
    269 amino acids
    Molecular mass:
    28810 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CELA2B Gene

Selected DME Specific Peptides for CELA2B Gene

P08218:
  • CNGDSGGP
  • VLTAAHC
  • GDSGGPL
  • CYVTGWGRLQTNGA
  • LVAGALSCG
  • AGTILPNNY
  • WVLTAAH
  • WPWQVSL

Post-translational modifications for CELA2B Gene

No Post-translational modifications

Other Protein References for CELA2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CELA2B Gene

Gene Families for CELA2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CELA2B Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
ProtoNet:

Suggested Antigen Peptide Sequences for CELA2B Gene

GenScript: Design optimal peptide antigens:
  • Elastase-2B (CEL2B_HUMAN)
  • Pancreatic elastase IIB (ELA2B) (Q5JRU4_HUMAN)
  • Elastase 2B (Q6ISP9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08218

UniProtKB/Swiss-Prot:

CEL2B_HUMAN :
  • Belongs to the peptidase S1 family. Elastase subfamily.
Family:
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with CELA2B: view

Function for CELA2B Gene

Molecular function for CELA2B Gene

UniProtKB/Swiss-Prot Function:
Acts upon elastin.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.; EC=3.4.21.71;.

Enzyme Numbers (IUBMB) for CELA2B Gene

Phenotypes From GWAS Catalog for CELA2B Gene

Gene Ontology (GO) - Molecular Function for CELA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA,IBA 21873635
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CELA2B: view
genes like me logo Genes that share phenotypes with CELA2B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CELA2B

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CELA2B Gene

Localization for CELA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CELA2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CELA2B gene
Compartment Confidence
extracellular 5
mitochondrion 1
lysosome 0

Gene Ontology (GO) - Cellular Components for CELA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 3646943
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with CELA2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CELA2B Gene

Pathways & Interactions for CELA2B Gene

PathCards logo

SuperPathways for CELA2B Gene

genes like me logo Genes that share pathways with CELA2B: view

Pathways by source for CELA2B Gene

2 KEGG pathways for CELA2B Gene

Gene Ontology (GO) - Biological Process for CELA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IBA 21873635
genes like me logo Genes that share ontologies with CELA2B: view

No data available for SIGNOR curated interactions for CELA2B Gene

Drugs & Compounds for CELA2B Gene

(1) Drugs for CELA2B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alvelestat Investigational Pharma NE inhibitor 0

(1) ApexBio Compounds for CELA2B Gene

Compound Action Cas Number
Alvelestat NE inhibitor 848141-11-7
genes like me logo Genes that share compounds with CELA2B: view

Drug Products

Transcripts for CELA2B Gene

mRNA/cDNA for CELA2B Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CELA2B

Alternative Splicing Database (ASD) splice patterns (SP) for CELA2B Gene

No ASD Table

Relevant External Links for CELA2B Gene

GeneLoc Exon Structure for
CELA2B

Expression for CELA2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CELA2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CELA2B Gene

This gene is overexpressed in Pancreas (x52.7).

Protein differential expression in normal tissues from HIPED for CELA2B Gene

This gene is overexpressed in Pancreatic juice (63.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CELA2B Gene



Protein tissue co-expression partners for CELA2B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CELA2B

SOURCE GeneReport for Unigene cluster for CELA2B Gene:

Hs.631871

mRNA Expression by UniProt/SwissProt for CELA2B Gene:

P08218-CEL2B_HUMAN
Tissue specificity: Pancreas.

Evidence on tissue expression from TISSUES for CELA2B Gene

  • Pancreas(4.6)
genes like me logo Genes that share expression patterns with CELA2B: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CELA2B Gene

Orthologs for CELA2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CELA2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CELA2B 30
  • 98.39 (n)
Cow
(Bos Taurus)
Mammalia ELA2A 31
  • 77 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 73 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Cela2a 31
  • 69 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 62 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CELA2A 31
  • 67 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ela3l 31
  • 61 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
OneToMany
Species where no ortholog for CELA2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CELA2B Gene

ENSEMBL:
Gene Tree for CELA2B (if available)
TreeFam:
Gene Tree for CELA2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CELA2B: view image

Paralogs for CELA2B Gene

Paralogs for CELA2B Gene

Pseudogenes.org Pseudogenes for CELA2B Gene

genes like me logo Genes that share paralogs with CELA2B: view

Variants for CELA2B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CELA2B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
782359 Benign: not provided 15,487,341(+) T/C SYNONYMOUS_VARIANT
rs3737703 - p.Gly235Ser
rs3766160 - p.Asp114Asn
rs3820071 - p.Gly79Arg
rs6429745 - p.Gln177Arg

Additional dbSNP identifiers (rs#s) for CELA2B Gene

Structural Variations from Database of Genomic Variants (DGV) for CELA2B Gene

Variant ID Type Subtype PubMed ID
esv2744319 CNV deletion 23290073
esv3585312 CNV loss 21293372
nsv1161190 CNV duplication 26073780
nsv441683 CNV loss 18776908
nsv818056 CNV loss 17921354
nsv833536 CNV loss 17160897

Variation tolerance for CELA2B Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CELA2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CELA2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELA2B Gene

Disorders for CELA2B Gene

Additional Disease Information for CELA2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for CELA2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CELA2B Gene

Publications for CELA2B Gene

  1. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. (PMID: 16327289) Szepessy E … Sahin-Tóth M (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2006) 2 3 23
  2. Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. (PMID: 3646943) Kawashima I … Takiguchi Y (DNA (Mary Ann Liebert, Inc.) 1987) 2 3 4
  3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 41
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for CELA2B Gene

  • Signalway ELISA kits for CELA2B

Sources for CELA2B Gene