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Aliases for CELA2B Gene

Aliases for CELA2B Gene

  • Chymotrypsin Like Elastase 2B 2 3
  • Chymotrypsin-Like Elastase Family Member 2B 3 4
  • Chymotrypsin Like Elastase Family Member 2B 3 5
  • EC 4 56
  • ELA2B 3 4
  • Chymotrypsin-Like Elastase Family, Member 2B 2
  • Pancreatic Elastase IIB (ELA2B) 3
  • Pancreatic Elastase IIB 2
  • RP11-265F14.2 3
  • Elastase 2B 3
  • Elastase-2B 4
  • EC 3.4.21 56

External Ids for CELA2B Gene

Previous GeneCards Identifiers for CELA2B Gene

  • GC01P015677
  • GC01P015792
  • GC01P014326

Summaries for CELA2B Gene

Entrez Gene Summary for CELA2B Gene

  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, Jul 2008]

GeneCards Summary for CELA2B Gene

CELA2B (Chymotrypsin Like Elastase 2B) is a Protein Coding gene. Among its related pathways are Collagen chain trimerization and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2A.

UniProtKB/Swiss-Prot for CELA2B Gene

Gene Wiki entry for CELA2B Gene

Additional gene information for CELA2B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELA2B Gene

Genomics for CELA2B Gene

GeneHancer (GH) Regulatory Elements for CELA2B Gene

Promoters and enhancers for CELA2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J015476 Promoter/Enhancer 1.1 EPDnew ENCODE 600.4 +10.1 10101 0.2 SMARCA4 MTA1 IKZF1 ZNF512 HDAC1 EP300 FOXK2 TCF12 ADNP TAL1 CELA2B GC01P015468 CASP9
GH01J015462 Enhancer 1 Ensembl ENCODE 600.7 -1.5 -1489 3.6 TRIM24 SP7 SMARCA4 CREB1 IKZF1 ZEB2 PKNOX1 ZNF629 HDAC1 ZNF316 CELA2B LOC105376767 CELA2A AGMAT SLC25A34
GH01J015458 Enhancer 1.1 FANTOM5 ENCODE 3.1 -5.9 -5905 2.3 ZNF121 ZNF384 SP7 MZF1 SMARCA4 IKZF1 ZBTB8A ZNF600 PRDM10 IKZF2 AGMAT SLC25A34 CELA2A CELA2B CTRC PLEKHM2 LOC105376767
GH01J015469 Enhancer 0.4 ENCODE 0.7 +4.1 4094 1 POLR2A MNT AGMAT SLC25A34 CELA2B GC01P015468 CELA2A CASP9
GH01J015488 Enhancer 0.5 Ensembl ENCODE 0.3 +23.2 23247 1.6 POLR2A AGMAT CTRC ENSG00000233485 FHAD1 CELA2B GC01P015468 CASP9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CELA2B on UCSC Golden Path with GeneCards custom track

Genomic Locations for CELA2B Gene

Genomic Locations for CELA2B Gene
25,492 bases
Plus strand
25,492 bases
Plus strand

Genomic View for CELA2B Gene

Genes around CELA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CELA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CELA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELA2B Gene

Proteins for CELA2B Gene

  • Protein details for CELA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chymotrypsin-like elastase family member 2B
    Protein Accession:
    Secondary Accessions:
    • Q14D16
    • Q6ISM5
    • Q96QV5

    Protein attributes for CELA2B Gene

    269 amino acids
    Molecular mass:
    28810 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CELA2B Gene

Selected DME Specific Peptides for CELA2B Gene


Post-translational modifications for CELA2B Gene

No Post-translational modifications

Other Protein References for CELA2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CELA2B Gene

Gene Families for CELA2B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CELA2B Gene

GenScript: Design optimal peptide antigens:
  • Elastase-2B (CEL2B_HUMAN)
  • Pancreatic elastase IIB (ELA2B) (Q5JRU4_HUMAN)
  • Elastase 2B (Q6ISP9_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family. Elastase subfamily.
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with CELA2B: view

Function for CELA2B Gene

Molecular function for CELA2B Gene

UniProtKB/Swiss-Prot Function:
Acts upon elastin.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Preferential cleavage: Leu- -Xaa, Met- -Xaa and Phe- -Xaa. Hydrolyzes elastin.; EC=;.

Enzyme Numbers (IUBMB) for CELA2B Gene

Phenotypes From GWAS Catalog for CELA2B Gene

Gene Ontology (GO) - Molecular Function for CELA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IBA 21873635
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CELA2B: view
genes like me logo Genes that share phenotypes with CELA2B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CELA2B

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CELA2B Gene

Localization for CELA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CELA2B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CELA2B gene
Compartment Confidence
extracellular 5
mitochondrion 0
lysosome 0

Gene Ontology (GO) - Cellular Components for CELA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 3646943
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with CELA2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CELA2B Gene

Pathways & Interactions for CELA2B Gene

PathCards logo

SuperPathways for CELA2B Gene

genes like me logo Genes that share pathways with CELA2B: view

Pathways by source for CELA2B Gene

2 KEGG pathways for CELA2B Gene

Gene Ontology (GO) - Biological Process for CELA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IBA 21873635
genes like me logo Genes that share ontologies with CELA2B: view

No data available for SIGNOR curated interactions for CELA2B Gene

Drugs & Compounds for CELA2B Gene

(1) Drugs for CELA2B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alvelestat Investigational Pharma NE inhibitor 0

(1) ApexBio Compounds for CELA2B Gene

Compound Action Cas Number
Alvelestat NE inhibitor 848141-11-7
genes like me logo Genes that share compounds with CELA2B: view

Drug Products

Transcripts for CELA2B Gene

mRNA/cDNA for CELA2B Gene

Unigene Clusters for CELA2B Gene

Chymotrypsin-like elastase family, member 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CELA2B

Alternative Splicing Database (ASD) splice patterns (SP) for CELA2B Gene

No ASD Table

Relevant External Links for CELA2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CELA2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CELA2B Gene

mRNA differential expression in normal tissues according to GTEx for CELA2B Gene

This gene is overexpressed in Pancreas (x52.7).

Protein differential expression in normal tissues from HIPED for CELA2B Gene

This gene is overexpressed in Pancreatic juice (63.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CELA2B Gene

Protein tissue co-expression partners for CELA2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CELA2B Gene:


SOURCE GeneReport for Unigene cluster for CELA2B Gene:


mRNA Expression by UniProt/SwissProt for CELA2B Gene:

Tissue specificity: Pancreas.

Evidence on tissue expression from TISSUES for CELA2B Gene

  • Pancreas(4.5)
genes like me logo Genes that share expression patterns with CELA2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CELA2B Gene

Orthologs for CELA2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CELA2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CELA2B 34
  • 98.39 (n)
(Bos Taurus)
Mammalia ELA2A 35
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
(Mus musculus)
Mammalia Cela2a 35
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
(Gallus gallus)
Aves CELA2A 35
  • 67 (a)
(Danio rerio)
Actinopterygii ela3l 35
  • 61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
Species where no ortholog for CELA2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CELA2B Gene

Gene Tree for CELA2B (if available)
Gene Tree for CELA2B (if available)
Evolutionary constrained regions (ECRs) for CELA2B: view image

Paralogs for CELA2B Gene

Paralogs for CELA2B Gene Pseudogenes for CELA2B Gene

genes like me logo Genes that share paralogs with CELA2B: view

Variants for CELA2B Gene

Sequence variations from dbSNP and Humsavar for CELA2B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000144571 -- 15,490,532(+) A/C intron_variant
rs1000689687 -- 15,480,474(+) G/C intron_variant
rs1000881486 -- 15,486,349(+) G/A intron_variant
rs1000964687 -- 15,474,916(+) G/A upstream_transcript_variant
rs1001148117 -- 15,491,673(+) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CELA2B Gene

Variant ID Type Subtype PubMed ID
esv2744319 CNV deletion 23290073
esv3585312 CNV loss 21293372
nsv1161190 CNV duplication 26073780
nsv441683 CNV loss 18776908
nsv818056 CNV loss 17921354
nsv833536 CNV loss 17160897

Variation tolerance for CELA2B Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CELA2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELA2B Gene

Disorders for CELA2B Gene

Additional Disease Information for CELA2B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CELA2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CELA2B Gene

Publications for CELA2B Gene

  1. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. (PMID: 16327289) Szepessy E … Sahin-Tóth M (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2006) 2 3 23 58
  2. Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. (PMID: 3646943) Kawashima I … Takiguchi Y (DNA (Mary Ann Liebert, Inc.) 1987) 2 3 4 58
  3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 45 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CELA2B Gene

Sources for CELA2B Gene

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