Aliases for CELA2A Gene
External Ids for CELA2A Gene
Previous GeneCards Identifiers for CELA2A Gene
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]
GeneCards Summary for CELA2A Gene
CELA2A (Chymotrypsin Like Elastase 2A) is a Protein Coding gene. Diseases associated with CELA2A include Abdominal Obesity-Metabolic Syndrome 4 and Hypertriglyceridemia, Familial. Among its related pathways are Salivary secretion and Keratinization. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine hydrolase activity. An important paralog of this gene is CELA2B.
UniProtKB/Swiss-Prot Summary for CELA2A Gene
Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity.