Aliases for CELA1 Gene
External Ids for CELA1 Gene
Previous HGNC Symbols for CELA1 Gene
Previous GeneCards Identifiers for CELA1 Gene
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B. [provided by RefSeq, May 2009]
GeneCards Summary for CELA1 Gene
CELA1 (Chymotrypsin Like Elastase 1) is a Protein Coding gene. Diseases associated with CELA1 include Punctate Palmoplantar Keratoderma and Steatorrhea. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2A.
UniProtKB/Swiss-Prot Summary for CELA1 Gene
Acts upon elastin.