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This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). [provided by RefSeq, Jun 2016]
CEBPZ (CCAAT Enhancer Binding Protein Zeta) is a Protein Coding gene. Diseases associated with CEBPZ include Congenital Bile Acid Synthesis Defect and Robinow Syndrome, Autosomal Dominant 1. Among its related pathways are Gastric Cancer Network 2 and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 2247079 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 2247079 |
GO:0003677 | DNA binding | TAS | 2247079 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL17 Signaling Pathway | ||
2 | Direct p53 effectors | ||
3 | Mesodermal Commitment Pathway | ||
4 | Gastric Cancer Network 2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006366 | transcription by RNA polymerase II | TAS | 2247079 |
GO:0042254 | ribosome biogenesis | IEA | -- |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 2247079 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CEBPZ 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CEBPZ 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CEBPZ 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cebpz 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cebpz 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CEBPZ 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CEBPZ 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CEBPZ 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CEBPZ 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cebpz 30 |
|
||
Str.7416 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.10705 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cebpz 30 31 |
|
OneToOne | |
wufi26d06 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6779 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG7839 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | CELE_F23B12.7 30 |
|
||
F23B12.7 31 |
|
OneToOne | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MAK21 30 31 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E12519g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER174W 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC4F10.09c 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU09894 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
761393 | Likely Benign: not provided | 37,228,257(-) | A/G | SYNONYMOUS_VARIANT | |
rs386352290 | Uncertain Significance: not provided | 37,228,554(-) | A/C | NONSENSE | |
rs17020328 | - | p.Lys303Arg | |||
rs2098386 | - | p.Val102Ile | |||
rs3180252 | - | p.Asn639Ser |
Disorder | Aliases | PubMed IDs |
---|---|---|
congenital bile acid synthesis defect |
|
|
robinow syndrome, autosomal dominant 1 |
|
|