Aliases for CEBPZ Gene
Aliases for CEBPZ Gene
External Ids for CEBPZ Gene
- HGNC: 24218
- Entrez Gene: 10153
- Ensembl: ENSG00000115816
- OMIM: 612828
- UniProtKB: Q03701
Previous GeneCards Identifiers for CEBPZ Gene
- GC02M037403
- GC02M037340
- GC02M037428
- GC02M037168
Summaries for CEBPZ Gene
-
This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). [provided by RefSeq, Jun 2016]
GeneCards Summary for CEBPZ Gene
CEBPZ (CCAAT Enhancer Binding Protein Zeta) is a Protein Coding gene. Among its related pathways are Direct p53 effectors and Gastric Cancer Network 2. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding.
UniProtKB/Swiss-Prot for CEBPZ Gene
-
Stimulates transcription from the HSP70 promoter.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPZ Gene
Genomics for CEBPZ Gene
GeneHancer (GH) Regulatory Elements for CEBPZ Gene
Promoters and enhancers for CEBPZ Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CEBPZ on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CEBPZ gene promoter:
-
- p53
- CUTL1
- AREB6
- Evi-1
- HNF-1A
- HNF-1
- POU2F1a
- POU2F1
- FOXO3b
- Oct-B1
Regulatory Element Products
Genomic Locations for CEBPZ Gene
Genomic Locations for CEBPZ Gene
- chr2:37,201,612-37,231,713
- (GRCh38/hg38)
- Size:
- 30,102 bases
- Orientation:
- Minus strand
- chr2:37,428,755-37,458,856
- (GRCh37/hg19)
- Size:
- 30,102 bases
- Orientation:
- Minus strand
Genomic View for CEBPZ Gene
Genes around CEBPZ on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p22.2 by Entrez Gene
- 2p22.2 by HGNC
- 2p22.2 by Ensembl
CEBPZ Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CEBPZ Gene
Proteins for CEBPZ Gene
-
Protein details for CEBPZ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03701-CEBPZ_HUMAN
- Recommended name:
- CCAAT/enhancer-binding protein zeta
- Protein Accession:
- Q03701
- Q8NE75
Protein attributes for CEBPZ Gene
- Size:
- 1054 amino acids
- Molecular mass:
- 120974 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAA51924.1; Type=Frameshift; Positions=998; Evidence={ECO:0000305};
Protein Expression for CEBPZ Gene
Post-translational modifications for CEBPZ Gene
Other Protein References for CEBPZ Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CEBPZ
- Novus Biologicals Antibodies for CEBPZ
-
Abcam antibodies for CEBPZ
- Invitrogen Antibodies for CEBPZ (AFLGC-CEBPZ)
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-
Boster Bio Antibodies for CEBPZ
Protein Products
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-
Abcam proteins for CEBPZ
Assay Products
- antibodies-online: Search results for 5 available CEBPZ Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for CEBPZ Gene
Domains & Families for CEBPZ Gene
Gene Families for CEBPZ Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CEBPZ Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CEBPZ Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q03701- Family:
-
- Belongs to the CBF/MAK21 family.
Function for CEBPZ Gene
Molecular function for CEBPZ Gene
- UniProtKB/Swiss-Prot Function:
- Stimulates transcription from the HSP70 promoter.
Phenotypes From GWAS Catalog for CEBPZ Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 2247079 |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 2247079 |
| GO:0003677 | DNA binding | TAS | 2247079 |
| GO:0003723 | RNA binding | HDA | 22658674 |
Phenotypes for CEBPZ Gene
Animal Model Products
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-
CRISPR Products
-
OriGene CRISPR knockouts for CEBPZ
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- Overview of 83 available CEBPZ gene related products
- Applied Biological Materials CRISPR for CEBPZ
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEBPZ
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miRNA for CEBPZ Gene
- miRTarBase miRNAs that target CEBPZ
miRNA Products
Inhibitory RNA Products
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- Overview of 83 available CEBPZ gene related products
Clone Products
- Sino Biological Human cDNA Clone for CEBPZ
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEBPZ Gene
Localization for CEBPZ Gene
Subcellular locations from UniProtKB/Swiss-Prot for CEBPZ Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| cytosol | 2 |
- Nucleus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IBA | -- |
Pathways & Interactions for CEBPZ Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Direct p53 effectors | ||
| 2 | Mesodermal Commitment Pathway | ||
| 3 | Gastric Cancer Network 2 | ||
Pathways by source for CEBPZ Gene
3 BioSystems pathways for CEBPZ Gene
Interacting Proteins for CEBPZ Gene
Selected Interacting proteins:
Q03701-CEBPZ_HUMAN
ENSP00000234170
for CEBPZ Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for CEBPZ
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | 2247079 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 2247079 |
No data available for SIGNOR curated interactions for CEBPZ Gene
Transcripts for CEBPZ Gene
mRNA/cDNA for CEBPZ Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (170) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000234170 3463 bps (uc002rpz.5)
- ENST00000489306 611 bps (uc061idp.1)
- ENST00000446769 526 bps (uc061ids.1)
Unigene Clusters for CEBPZ Gene
CRISPR Products
-
OriGene CRISPR knockouts for CEBPZ
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CEBPZ
- genomics-online: gRNA clones - Search results for 83 available CEBPZ gene related products
- Overview of 83 available CEBPZ gene related products
- Applied Biological Materials CRISPR for CEBPZ
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEBPZ
- GenScript: Design CRISPR guide RNA sequences for CEBPZ
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for CEBPZ
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CEBPZ Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Hematopoietic Bone Marrow
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Limb (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Testis (Reproductive System)
This gene is overexpressed in Testis (10.4), CD8 Tcells (7.8), Fetal testis (7.3), Fetal ovary (6.7), and Peripheral blood mononuclear cells (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEBPZ Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CEBPZ Gene:
CEBPZSOURCE GeneReport for Unigene cluster for CEBPZ Gene:
Hs.135406Evidence on tissue expression from TISSUES for CEBPZ Gene
- Liver(4.3)
- Nervous system(3.5)
- Blood(2.2)
Primer Products
-
OriGene qPCR primer pairs for CEBPZ
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEBPZ Gene
Orthologs for CEBPZ Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CEBPZ 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CEBPZ 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CEBPZ 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cebpz 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cebpz 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CEBPZ 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CEBPZ 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CEBPZ 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CEBPZ 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cebpz 33 |
|
||
| Str.7416 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10705 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cebpz 34 33 |
|
OneToOne | |
| wufi26d06 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6779 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7839 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | CELE_F23B12.7 33 |
|
||
| F23B12.7 34 |
|
OneToOne | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MAK21 36 34 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E12519g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER174W 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC4F10.09c 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU09894 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for CEBPZ was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CEBPZ Gene
- ENSEMBL:
- Gene Tree for CEBPZ (if available)
- TreeFam:
- Gene Tree for CEBPZ (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CEBPZ: view image
Paralogs for CEBPZ Gene
No data available for Paralogs for CEBPZ Gene
Variants for CEBPZ Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs536224171 | likely-benign, not specified | 37,232,270(-) | T/C/G | upstream_transcript_variant | |
| rs756442818 | likely-benign, not specified | 37,231,724(-) | T/A | upstream_transcript_variant | |
| rs386352290 | uncertain-significance, not provided | 37,228,554(-) | A/C | coding_sequence_variant, stop_gained | |
| rs73927405 | uncertain-significance, not specified | 37,231,728(-) | G/A/T | upstream_transcript_variant | |
| rs145277736 | benign, not specified | 37,231,669(-) | A/ | upstream_transcript_variant |
Residual Variation Intolerance Score:
36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.39;
77.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CEBPZ Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CEBPZ
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEBPZ Gene
Disorders for CEBPZ Gene
Additional Disease Information for CEBPZ
No disorders were found for CEBPZ Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEBPZ Gene
Publications for CEBPZ Gene
- A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter. (PMID: 2247079) Lum LS … Wu BJ (Molecular and cellular biology 1990) 2 3 4 22 58
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression. (PMID: 12534345) Uramoto H … Kohno K (The Biochemical journal 2003) 2 3 58
Products for CEBPZ Gene
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- Quality Products:
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- GeneTex CEBPZ Antibody for CEBPZ
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- Overview of 83 available CEBPZ gene related products
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- Overview of 83 available CEBPZ gene related products
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- Overview of 83 available CEBPZ gene related products
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CEBPZ
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Sources for CEBPZ Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
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