Aliases for CEBPZ Gene
External Ids for CEBPZ Gene
Previous GeneCards Identifiers for CEBPZ Gene
This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). [provided by RefSeq, Jun 2016]
GeneCards Summary for CEBPZ Gene
CEBPZ (CCAAT Enhancer Binding Protein Zeta) is a Protein Coding gene. Diseases associated with CEBPZ include Congenital Bile Acid Synthesis Defect and Robinow Syndrome, Autosomal Dominant 1. Among its related pathways are Gastric Cancer Network 2 and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding.
UniProtKB/Swiss-Prot Summary for CEBPZ Gene
Stimulates transcription from the HSP70 promoter.