CEBPZ Gene (Protein Coding)

CCAAT Enhancer Binding Protein Zeta

GC02M037201
GIFtS:
37
This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCA... See more...

Aliases for CEBPZ Gene

Aliases for CEBPZ Gene

  • CCAAT Enhancer Binding Protein Zeta 2 3 5
  • CBF2 2 3 4
  • CCAAT/Enhancer Binding Protein (C/EBP), Zeta 2 3
  • CCAAT-Box-Binding Transcription Factor 3 4
  • CCAAT/Enhancer-Binding Protein Zeta 3 4
  • CBF 3 4
  • CCAAT/Enhancer Binding Proteincebp* Family Zeta 2
  • CCAAT/Enhancer Binding Protein Cebp Family Zeta 3
  • CCAAT/Enhancer Binding Protein Zeta 2
  • CCAAT-Binding Factor 4
  • HSP-CBF 3
  • CEBPZ 5
  • NOC1 3
  • CTF2 2

External Ids for CEBPZ Gene

Previous GeneCards Identifiers for CEBPZ Gene

  • GC02M037403
  • GC02M037340
  • GC02M037428
  • GC02M037168

Summaries for CEBPZ Gene

Entrez Gene Summary for CEBPZ Gene

  • This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). [provided by RefSeq, Jun 2016]

GeneCards Summary for CEBPZ Gene

CEBPZ (CCAAT Enhancer Binding Protein Zeta) is a Protein Coding gene. Diseases associated with CEBPZ include Congenital Bile Acid Synthesis Defect and Robinow Syndrome, Autosomal Dominant 1. Among its related pathways are Gastric Cancer Network 2 and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding.

UniProtKB/Swiss-Prot Summary for CEBPZ Gene

Gene Wiki entry for CEBPZ Gene

Additional gene information for CEBPZ Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEBPZ Gene

Genomics for CEBPZ Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CEBPZ Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEBPZ on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CEBPZ

Top Transcription factor binding sites by QIAGEN in the CEBPZ gene promoter:
  • AREB6
  • CUTL1
  • Evi-1
  • FOXO3b
  • HNF-1
  • HNF-1A
  • Oct-B1
  • p53
  • POU2F1
  • POU2F1a

Genomic Locations for CEBPZ Gene

Genomic Locations for CEBPZ Gene
chr2:37,201,612-37,231,596
(GRCh38/hg38)
Size:
29,985 bases
Orientation:
Minus strand
chr2:37,428,755-37,458,856
(GRCh37/hg19)
Size:
30,102 bases
Orientation:
Minus strand

Genomic View for CEBPZ Gene

Genes around CEBPZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEBPZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEBPZ Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CEBPZ Gene

Proteins for CEBPZ Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CEBPZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03701-CEBPZ_HUMAN
    Recommended name:
    CCAAT/enhancer-binding protein zeta
    Protein Accession:
    Q03701
    Secondary Accessions:
    • Q8NE75

    Protein attributes for CEBPZ Gene

    Size:
    1054 amino acids
    Molecular mass:
    120974 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA51924.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for CEBPZ Gene

Protein Expression for CEBPZ Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CEBPZ Gene

  • Ubiquitination at Lys314
  • Modification sites at PhosphoSitePlus

Other Protein References for CEBPZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEBPZ Gene

Domains & Families for CEBPZ Gene

Gene Families for CEBPZ Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CEBPZ Gene

InterPro:
Blocks:
  • CBF/Mak21 family
ProtoNet:

Suggested Antigen Peptide Sequences for CEBPZ Gene

GenScript: Design optimal peptide antigens:
  • CCAAT-box-binding transcription factor (CEBPZ_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q03701

UniProtKB/Swiss-Prot:

CEBPZ_HUMAN :
  • Belongs to the CBF/MAK21 family.
Family:
  • Belongs to the CBF/MAK21 family.
genes like me logo Genes that share domains with CEBPZ: view

Function for CEBPZ Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CEBPZ Gene

UniProtKB/Swiss-Prot Function:
Stimulates transcription from the HSP70 promoter.

Phenotypes From GWAS Catalog for CEBPZ Gene

Gene Ontology (GO) - Molecular Function for CEBPZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 2247079
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 2247079
GO:0003677 DNA binding TAS 2247079
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with CEBPZ: view
genes like me logo Genes that share phenotypes with CEBPZ: view

Animal Model Products

CRISPR Products

miRNA for CEBPZ Gene

miRTarBase miRNAs that target CEBPZ

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEBPZ

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEBPZ Gene

Localization for CEBPZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEBPZ Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEBPZ gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEBPZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IBA 21873635
genes like me logo Genes that share ontologies with CEBPZ: view

Pathways & Interactions for CEBPZ Gene

genes like me logo Genes that share pathways with CEBPZ: view

Pathways by source for CEBPZ Gene

1 Sino Biological pathway for CEBPZ Gene

Gene Ontology (GO) - Biological Process for CEBPZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription by RNA polymerase II TAS 2247079
GO:0042254 ribosome biogenesis IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 2247079
genes like me logo Genes that share ontologies with CEBPZ: view

No data available for SIGNOR curated interactions for CEBPZ Gene

Drugs & Compounds for CEBPZ Gene

Products:

  1. Drug

(1) Drugs for CEBPZ Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CEBPZ Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEBPZ: view

Transcripts for CEBPZ Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CEBPZ Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEBPZ

Alternative Splicing Database (ASD) splice patterns (SP) for CEBPZ Gene

No ASD Table

Relevant External Links for CEBPZ Gene

GeneLoc Exon Structure for
CEBPZ

Expression for CEBPZ Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEBPZ Gene

mRNA expression in normal human tissues for CEBPZ Gene
mRNA expression by GTEx for CEBPZ GenemRNA expression by BioGPS for CEBPZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEBPZ Gene

This gene is overexpressed in Testis (10.4), CD8 Tcells (7.8), Fetal testis (7.3), Fetal ovary (6.7), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEBPZ Gene



Protein tissue co-expression partners for CEBPZ Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CEBPZ

SOURCE GeneReport for Unigene cluster for CEBPZ Gene:

Hs.135406

Evidence on tissue expression from TISSUES for CEBPZ Gene

  • Liver(4.4)
  • Nervous system(3.7)
  • Blood(2.6)
  • Muscle(2.4)
  • Skin(2.4)
  • Heart(2.3)
  • Kidney(2.2)
  • Intestine(2.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with CEBPZ: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEBPZ Gene

Orthologs for CEBPZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CEBPZ Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CEBPZ 30 31
  • 99.37 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CEBPZ 30 31
  • 89.95 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CEBPZ 30 31
  • 87.85 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Cebpz 30 17 31
  • 83.09 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cebpz 30
  • 82.15 (n)
Oppossum
(Monodelphis domestica)
 Mammalia CEBPZ 31
  • 72 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia CEBPZ 31
  • 65 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CEBPZ 30 31
  • 68.87 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia CEBPZ 31
  • 64 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia cebpz 30
  • 65.23 (n)
Str.7416 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.10705 30
Zebrafish
(Danio rerio)
 Actinopterygii cebpz 30 31
  • 62.24 (n)
 OneToOne
wufi26d06 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.6779 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG7839 31
  • 25 (a)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea CELE_F23B12.7 30
  • 47.32 (n)
F23B12.7 31
  • 30 (a)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes MAK21 30 31 33
  • 48.93 (n)
 OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E12519g 30
  • 46.81 (n)
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AER174W 30
  • 41.3 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPAC4F10.09c 30
  • 50.24 (n)
Bread mold
(Neurospora crassa)
 Ascomycetes NCU09894 30
  • 46.02 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 30 (a)
 OneToOne
Species where no ortholog for CEBPZ was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CEBPZ Gene

ENSEMBL:
Gene Tree for CEBPZ (if available)
TreeFam:
Gene Tree for CEBPZ (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEBPZ: view image

Paralogs for CEBPZ Gene

No data available for Paralogs for CEBPZ Gene

Variants for CEBPZ Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CEBPZ Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
761393 Likely Benign: not provided 37,228,257(-) A/G SYNONYMOUS_VARIANT
rs386352290 Uncertain Significance: not provided 37,228,554(-) A/C NONSENSE
rs17020328 - p.Lys303Arg
rs2098386 - p.Val102Ile
rs3180252 - p.Asn639Ser

Additional dbSNP identifiers (rs#s) for CEBPZ Gene

Structural Variations from Database of Genomic Variants (DGV) for CEBPZ Gene

Variant ID Type Subtype PubMed ID
nsv2684 CNV insertion 18451855

Variation tolerance for CEBPZ Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEBPZ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEBPZ

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEBPZ Gene

Disorders for CEBPZ Gene

MalaCards: The human disease database

(2) MalaCards diseases for CEBPZ Gene - From: DISEASES

Disorder Aliases PubMed IDs
congenital bile acid synthesis defect
  • bile acid synthesis defect, congenital, 1
robinow syndrome, autosomal dominant 1
  • drs1
- elite association - COSMIC cancer census association via MalaCards
Search CEBPZ in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CEBPZ

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CEBPZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEBPZ Gene

Publications for CEBPZ Gene

  1. A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter. (PMID: 2247079) Lum LS … Wu BJ (Molecular and cellular biology 1990) 2 3 4 23
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression. (PMID: 12534345) Uramoto H … Kohno K (The Biochemical journal 2003) 2 3

ExternalLinks

View latest publications for CEBPZ gene in Mastermind

Products for CEBPZ Gene

Sources for CEBPZ Gene