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The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]
CEBPG (CCAAT Enhancer Binding Protein Gamma) is a Protein Coding gene. Among its related pathways are Tuberculosis and Differentiation of white and brown adipocyte. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is CEBPA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 15833715 |
GO:0003677 | DNA binding | IEA,IDA | 7665092 |
GO:0003690 | double-stranded DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | ISS | 7501458 |
GO:0005654 | nucleoplasm | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Tuberculosis | ||
2 | Akt Signaling |
p38 Signaling
.60
|
|
3 | Differentiation of white and brown adipocyte |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001889 | liver development | IEA,ISS | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IDA | 16255782 |
GO:0006955 | immune response | IEA,ISS | -- |
GO:0016071 | mRNA metabolic process | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CEBPG 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CEBPG 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CEBPG 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CEBPG 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CEBPG 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cebpg 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cebpg 30 |
|
||
Chicken (Gallus gallus) |
Aves | C 31 |
|
OneToOne | |
CEBPG 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | CEBPG 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cebpg 30 |
|
||
Str.6360 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.5240 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cebpg 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | cebp-2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2758755 | CNV | gain | 17122850 |
nsv828526 | CNV | loss | 20364138 |
No disorders were found for CEBPG Gene.