CEBPG Gene (Protein Coding)

CCAAT Enhancer Binding Protein Gamma

GC19P033373
GIFtS:
39
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, ... See more...

Aliases for CEBPG Gene

Aliases for CEBPG Gene

  • CCAAT Enhancer Binding Protein Gamma 2 3 5
  • CCAAT/Enhancer Binding Protein (C/EBP), Gamma 2 3
  • CCAAT/Enhancer-Binding Protein Gamma 3 4
  • C/EBP Gamma 3 4
  • CCAAT/Enhancer Binding Protein Gamma 2
  • IG/EBP-1 3
  • GPE1BP 3

External Ids for CEBPG Gene

Previous GeneCards Identifiers for CEBPG Gene

  • GC19P034482
  • GC19P034313
  • GC19P038540
  • GC19P038556
  • GC19P033864
  • GC19P030365

Summaries for CEBPG Gene

Entrez Gene Summary for CEBPG Gene

  • The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CEBPG Gene

CEBPG (CCAAT Enhancer Binding Protein Gamma) is a Protein Coding gene. Among its related pathways are Akt Signaling and Tuberculosis. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is CEBPE.

UniProtKB/Swiss-Prot Summary for CEBPG Gene

  • Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.

Gene Wiki entry for CEBPG Gene

Additional gene information for CEBPG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEBPG Gene

Genomics for CEBPG Gene

GeneHancer (GH) Regulatory Elements for CEBPG Gene

Promoters and enhancers for CEBPG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEBPG on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CEBPG

Top Transcription factor binding sites by QIAGEN in the CEBPG gene promoter:
  • AREB6
  • ATF-2
  • C/EBPalpha
  • FOXD1
  • ITF-2
  • Olf-1
  • Pax-5
  • Tal-1beta

Genomic Locations for CEBPG Gene

Genomic Locations for CEBPG Gene
chr19:33,373,669-33,382,686
(GRCh38/hg38)
Size:
9,018 bases
Orientation:
Plus strand
chr19:33,864,236-33,873,592
(GRCh37/hg19)
Size:
9,357 bases
Orientation:
Plus strand

Genomic View for CEBPG Gene

Genes around CEBPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEBPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEBPG Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CEBPG Gene

Proteins for CEBPG Gene

Products:

  1. Antibody
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  • Protein details for CEBPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53567-CEBPG_HUMAN
    Recommended name:
    CCAAT/enhancer-binding protein gamma
    Protein Accession:
    P53567
    Secondary Accessions:
    • B2R946
    • Q5U052

    Protein attributes for CEBPG Gene

    Size:
    150 amino acids
    Molecular mass:
    16408 Da
    Quaternary structure:
    • Binds DNA as a dimer and can form stable heterodimers with CEBPA and CEBPB. Interacts with ZNF638; this interaction increases transcriptional activation.

neXtProt entry for CEBPG Gene

Protein Expression for CEBPG Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CEBPG Gene

  • Ubiquitination at Lys113
  • Modification sites at PhosphoSitePlus

Other Protein References for CEBPG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEBPG Gene

Domains & Families for CEBPG Gene

Gene Families for CEBPG Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for CEBPG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEBPG Gene

GenScript: Design optimal peptide antigens:
  • CCAAT/enhancer-binding protein gamma (CEBPG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53567

UniProtKB/Swiss-Prot:

CEBPG_HUMAN :
  • Belongs to the bZIP family. C/EBP subfamily.
Family:
  • Belongs to the bZIP family. C/EBP subfamily.
genes like me logo Genes that share domains with CEBPG: view

Function for CEBPG Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
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  6. Cell Line

Molecular function for CEBPG Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.

Phenotypes From GWAS Catalog for CEBPG Gene

Gene Ontology (GO) - Molecular Function for CEBPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 15833715
GO:0003677 DNA binding IDA,IEA 7665092
GO:0003690 double-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with CEBPG: view
genes like me logo Genes that share phenotypes with CEBPG: view

Animal Models for CEBPG Gene

MGI Knock Outs for CEBPG:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for CEBPG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CEBPG Gene

Localization for CEBPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEBPG Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEBPG gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEBPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus ISS 7501458
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with CEBPG: view

Pathways & Interactions for CEBPG Gene

PathCards logo

SuperPathways for CEBPG Gene

genes like me logo Genes that share pathways with CEBPG: view

Pathways by source for CEBPG Gene

1 BioSystems pathway for CEBPG Gene
1 KEGG pathway for CEBPG Gene
1 Qiagen pathway for CEBPG Gene
  • p38 Signaling

SIGNOR curated interactions for CEBPG Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CEBPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development ISS,IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IDA,IEA 16255782
GO:0006955 immune response ISS,IEA --
GO:0016071 mRNA metabolic process IEA --
genes like me logo Genes that share ontologies with CEBPG: view

Drugs & Compounds for CEBPG Gene

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  1. Drug
No Compound Related Data Available

Transcripts for CEBPG Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CEBPG Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CEBPG

Alternative Splicing Database (ASD) splice patterns (SP) for CEBPG Gene

No ASD Table

Relevant External Links for CEBPG Gene

GeneLoc Exon Structure for
CEBPG

Expression for CEBPG Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEBPG Gene

mRNA expression in normal human tissues for CEBPG Gene
mRNA expression by GTEx for CEBPG GenemRNA expression by BioGPS for CEBPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEBPG Gene

This gene is overexpressed in Blymphocyte (49.1) and Fetal heart (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CEBPG Gene



Protein tissue co-expression partners for CEBPG Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CEBPG

SOURCE GeneReport for Unigene cluster for CEBPG Gene:

Hs.429666

Evidence on tissue expression from TISSUES for CEBPG Gene

  • Blood(4.3)
genes like me logo Genes that share expression patterns with CEBPG: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEBPG Gene

Orthologs for CEBPG Gene

This gene was present in the common ancestor of animals.

Orthologs for CEBPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CEBPG 31 30
  • 99.11 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CEBPG 31 30
  • 91.05 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CEBPG 31
  • 90 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CEBPG 31 30
  • 89.34 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CEBPG 31
  • 87 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cebpg 17 31 30
  • 85.56 (n)
rat
(Rattus norvegicus)
 Mammalia Cebpg 30
  • 84.89 (n)
chicken
(Gallus gallus)
 Aves C 31
  • 82 (a)
 OneToOne
CEBPG 30
  • 77.33 (n)
lizard
(Anolis carolinensis)
 Reptilia CEBPG 31
  • 77 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cebpg 30
  • 69.44 (n)
Str.6360 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.5240 30
zebrafish
(Danio rerio)
 Actinopterygii cebpg 31 30 30
  • 69.25 (n)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea cebp-2 31
  • 33 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 12 (a)
 OneToMany
Species where no ortholog for CEBPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CEBPG Gene

ENSEMBL:
Gene Tree for CEBPG (if available)
TreeFam:
Gene Tree for CEBPG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEBPG: view image

Paralogs for CEBPG Gene

Paralogs for CEBPG Gene

(2) SIMAP similar genes for CEBPG Gene using alignment to 1 proteins:

  • CEBPG_HUMAN
genes like me logo Genes that share paralogs with CEBPG: view

Variants for CEBPG Gene

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Additional dbSNP identifiers (rs#s) for CEBPG Gene

Structural Variations from Database of Genomic Variants (DGV) for CEBPG Gene

Variant ID Type Subtype PubMed ID
esv2758755 CNV gain 17122850
nsv828526 CNV loss 20364138

Variation tolerance for CEBPG Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEBPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEBPG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CEBPG Gene

Disorders for CEBPG Gene

Additional Disease Information for CEBPG

Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CEBPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEBPG Gene

Publications for CEBPG Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters. (PMID: 12177065) Gao H … Schwartz RC (The Journal of biological chemistry 2002) 3 23 54
  3. Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter. (PMID: 7665092) Davydov IV … Li-Weber M (Gene 1995) 3 4 54
  4. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. (PMID: 1884998) Williams SC … Johnson PF (Genes & development 1991) 2 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

ExternalLinks

View latest publications for CEBPG gene in Mastermind

Products for CEBPG Gene

  • Addgene plasmids for CEBPG

Sources for CEBPG Gene