Aliases for CEBPG Gene
Aliases for CEBPG Gene
External Ids for CEBPG Gene
- HGNC: 1837
- Entrez Gene: 1054
- Ensembl: ENSG00000153879
- OMIM: 138972
- UniProtKB: P53567
Previous GeneCards Identifiers for CEBPG Gene
- GC19P034482
- GC19P034313
- GC19P038540
- GC19P038556
- GC19P033864
- GC19P030365
Summaries for CEBPG Gene
-
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for CEBPG Gene
CEBPG (CCAAT Enhancer Binding Protein Gamma) is a Protein Coding gene. Among its related pathways are Tuberculosis and Akt Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is CEBPB.
UniProtKB/Swiss-Prot for CEBPG Gene
-
Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPG Gene
Genomics for CEBPG Gene
GeneHancer (GH) Regulatory Elements for CEBPG Gene
Promoters and enhancers for CEBPG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CEBPG on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CEBPG gene promoter:
-
- C/EBPalpha
- AREB6
- FOXD1
- ATF-2
- Pax-5
- Olf-1
- Tal-1beta
- ITF-2
Regulatory Element Products
Genomic Locations for CEBPG Gene
Genomic Locations for CEBPG Gene
- chr19:33,373,330-33,382,686
- (GRCh38/hg38)
- Size:
- 9,357 bases
- Orientation:
- Plus strand
- chr19:33,864,236-33,873,592
- (GRCh37/hg19)
- Size:
- 9,357 bases
- Orientation:
- Plus strand
Genomic View for CEBPG Gene
Genes around CEBPG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.11 by Entrez Gene
- 19q13.11 by HGNC
- 19q13.11 by Ensembl
CEBPG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CEBPG Gene
Proteins for CEBPG Gene
-
Protein details for CEBPG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53567-CEBPG_HUMAN
- Recommended name:
- CCAAT/enhancer-binding protein gamma
- Protein Accession:
- P53567
- B2R946
- Q5U052
Protein attributes for CEBPG Gene
- Size:
- 150 amino acids
- Molecular mass:
- 16408 Da
- Quaternary structure:
-
- Binds DNA as a dimer and can form stable heterodimers with CEBPA and CEBPB. Interacts with ZNF638; this interaction increases transcriptional activation.
Protein Expression for CEBPG Gene
Post-translational modifications for CEBPG Gene
Other Protein References for CEBPG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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-
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-
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Protein Products
-
OriGene Purified Proteins for CEBPG
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-
Abcam proteins for CEBPG
No data available for DME Specific Peptides for CEBPG Gene
Domains & Families for CEBPG Gene
Gene Families for CEBPG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Suggested Antigen Peptide Sequences for CEBPG Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P53567- Family:
-
- Belongs to the bZIP family. C/EBP subfamily.
Function for CEBPG Gene
Molecular function for CEBPG Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.
Phenotypes From GWAS Catalog for CEBPG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 15833715 |
| GO:0003677 | DNA binding | IDA,IEA | 7665092 |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
Phenotypes for CEBPG Gene
- MGI mutant phenotypes for CEBPG:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CEBPG:
Animal Models for CEBPG Gene
- MGI Knock Outs for CEBPG:
-
- Cebpg Cebpg<tm1Aki>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
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- Overview of 130 available CEBPG gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for CEBPG Gene
- miRTarBase miRNAs that target CEBPG
-
- hsa-mir-125b-5p (MIRT002387)
- hsa-mir-361-5p (MIRT020090)
- hsa-mir-33a-5p (MIRT028205)
- hsa-mir-652-3p (MIRT039508)
- hsa-mir-186-5p (MIRT045272)
- hsa-mir-193a-5p (MIRT292602)
- hsa-mir-3151-3p (MIRT292604)
- hsa-mir-4311 (MIRT292616)
- hsa-mir-4639-5p (MIRT292617)
- hsa-mir-5008-3p (MIRT292618)
- hsa-mir-6737-3p (MIRT292619)
- hsa-mir-7157-3p (MIRT292621)
- hsa-mir-148a-3p (MIRT347400)
- hsa-mir-152-3p (MIRT347401)
- hsa-mir-148b-3p (MIRT347402)
- hsa-mir-512-3p (MIRT347403)
- hsa-mir-548t-3p (MIRT347413)
- hsa-mir-548aa (MIRT347418)
- hsa-mir-548ap-3p (MIRT347424)
- hsa-mir-548p (MIRT347497)
- hsa-mir-8081 (MIRT347517)
- hsa-mir-492 (MIRT347533)
- hsa-mir-631 (MIRT347535)
- hsa-mir-3661 (MIRT347536)
- hsa-mir-6886-5p (MIRT442357)
- hsa-mir-1276 (MIRT442359)
- hsa-mir-6739-5p (MIRT507756)
- hsa-mir-550b-3p (MIRT524510)
- hsa-mir-200b-5p (MIRT524511)
- hsa-mir-200a-5p (MIRT524512)
- hsa-mir-627-5p (MIRT568088)
- hsa-mir-937-5p (MIRT568089)
- hsa-mir-8075 (MIRT568090)
- hsa-mir-5702 (MIRT568091)
- hsa-mir-490-5p (MIRT568092)
- hsa-mir-6877-3p (MIRT568093)
- hsa-mir-6819-3p (MIRT568094)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for CEBPG
- Addgene plasmids for CEBPG
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- Applied Biological Materials Clones for CEBPG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CEBPG
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CEBPG Gene
Localization for CEBPG Gene
Subcellular locations from UniProtKB/Swiss-Prot for CEBPG Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 1 |
| cytosol | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | 7501458 |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for CEBPG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Tuberculosis | ||
| 2 | Akt Signaling |
.60
|
|
| 3 | Differentiation of white and brown adipocyte | ||
Pathways by source for CEBPG Gene
1 BioSystems pathway for CEBPG Gene
1 KEGG pathway for CEBPG Gene
1 Qiagen pathway for CEBPG Gene
Interacting Proteins for CEBPG Gene
Selected Interacting proteins:
P53567-CEBPG_HUMAN
ENSP00000284000
for CEBPG Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CEBPG
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001889 | liver development | ISS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IDA | 16255782 |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
No data available for SIGNOR curated interactions for CEBPG Gene
Transcripts for CEBPG Gene
mRNA/cDNA for CEBPG Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (225) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000284000 4109 bps (uc002nup.4)
- ENST00000585933 3845 bps (uc021usd.2)
Unigene Clusters for CEBPG Gene
CRISPR Products
-
OriGene CRISPR knockouts for CEBPG
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEBPG
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miRNA Products
Inhibitory RNA Products
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Clone Products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CEBPG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Lumbar Brown Adipocyte Cells Lumbar Brown Adipose Depot
- Thoracic Committed Brown Preadipocytes Thoracic Brown Adipose Depot
- Lumbar Committed Brown Preadipocytes Lumbar Brown Adipose Depot
- Cervical Brown Adipocyte Cells Cervical Brown Adipose Depot
- Thoracic Brown Adipocyte Cells Thoracic Brown Adipose Depot
- Brain (Nervous System)
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
-
Amnion (Extraembryonic Tissues)
This gene is overexpressed in Blymphocyte (49.1) and Fetal heart (19.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CEBPG Gene
NURSA nuclear receptor signaling pathways regulating expression of CEBPG Gene:
CEBPGSOURCE GeneReport for Unigene cluster for CEBPG Gene:
Hs.429666Evidence on tissue expression from TISSUES for CEBPG Gene
- Blood(4.3)
Primer Products
-
OriGene qPCR primer pairs for CEBPG
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEBPG Gene
Orthologs for CEBPG Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CEBPG 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CEBPG 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CEBPG 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CEBPG 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CEBPG 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cebpg 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cebpg 33 |
|
||
| chicken (Gallus gallus) |
Aves | C 34 |
|
OneToOne | |
| CEBPG 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | CEBPG 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cebpg 33 |
|
||
| Str.6360 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5240 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cebpg 34 33 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | cebp-2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for CEBPG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CEBPG Gene
- ENSEMBL:
- Gene Tree for CEBPG (if available)
- TreeFam:
- Gene Tree for CEBPG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CEBPG: view image
Paralogs for CEBPG Gene
Variants for CEBPG Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000446465 | -- | 33,377,969(+) | A/T | intron_variant | |
| rs1000448307 | -- | 33,373,274(+) | C/A | upstream_transcript_variant | |
| rs1000500390 | -- | 33,372,904(+) | C/A | upstream_transcript_variant | |
| rs1000569140 | -- | 33,371,821(+) | C/T | upstream_transcript_variant | |
| rs1000738517 | -- | 33,373,576(+) | A/C/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758755 | CNV | gain | 17122850 |
| nsv828526 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.14;
3.09% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CEBPG Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CEBPG
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEBPG Gene
Disorders for CEBPG Gene
Additional Disease Information for CEBPG
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CEBPG Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEBPG Gene
Publications for CEBPG Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters. (PMID: 12177065) Gao H … Schwartz RC (The Journal of biological chemistry 2002) 3 22 58
- Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter. (PMID: 7665092) Davydov IV … Li-Weber M (Gene 1995) 3 4 58
- A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. (PMID: 1884998) Williams SC … Johnson PF (Genes & development 1991) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
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Sources for CEBPG Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt