The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with act... See more...

Aliases for CEBPD Gene

Aliases for CEBPD Gene

  • CCAAT Enhancer Binding Protein Delta 2 3 5
  • CCAAT/Enhancer Binding Protein (C/EBP), Delta 2 3
  • CCAAT/Enhancer-Binding Protein Delta 3 4
  • Nuclear Factor NF-IL6-Beta 3 4
  • C/EBP Delta 3 4
  • NF-IL6-Beta 3 4
  • CCAAT/Enhancer Binding Protein Delta 2
  • C/EBP-Delta 3
  • CELF 3
  • CRP3 3

External Ids for CEBPD Gene

Previous GeneCards Identifiers for CEBPD Gene

  • GC08M048640
  • GC08M048372
  • GC08M048699
  • GC08M048812
  • GC08M048649
  • GC08M044112

Summaries for CEBPD Gene

Entrez Gene Summary for CEBPD Gene

  • The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]

GeneCards Summary for CEBPD Gene

CEBPD (CCAAT Enhancer Binding Protein Delta) is a Protein Coding gene. Diseases associated with CEBPD include Expressive Language Disorder and Speech And Communication Disorders. Among its related pathways are IL-17 Family Signaling Pathways and C-MYB transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is CEBPA.

UniProtKB/Swiss-Prot Summary for CEBPD Gene

  • Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).

Gene Wiki entry for CEBPD Gene

Additional gene information for CEBPD Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEBPD Gene

Genomics for CEBPD Gene

GeneHancer (GH) Regulatory Elements for CEBPD Gene

Promoters and enhancers for CEBPD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J047733 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.5 1512 6.4 CTCF NRF1 TCF12 POLR2G NCOR1 GTF2E2 PHF8 ZFX POLR2A ZBTB10 CEBPD SPIDR ENSG00000253330 RPL29P19 ENSG00000253688 RPL10AP2 PRKDC piR-47282 RF00017-7027 RF00017-7026
GH08J047351 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +382.3 382323 8.2 ZSCAN5C TCF12 NCOR1 JUND POLR2A EP300 SKI MYC TEAD1 TBX3 CEBPD SPIDR MCM4 ENSG00000253330 RPL10AP2 piR-39341-383 piR-45932-095
GH08J047188 Promoter 1.3 Ensembl CraniofacialAtlas 10.8 +549.2 549175 1.6 ZFX ZNF10 ZIC2 ZNF423 ZBTB26 TGIF2 EZH2 ZNF341 OSR2 SIN3A ENSG00000254348 ENSG00000255366 LOC100287846 SPIDR CEBPD ENSG00000248347 piR-49423-260
GH08J047304 Enhancer 1.1 Ensembl ENCODE 12.1 +431.1 431063 5.8 CTCF TCF12 AFF1 TARDBP REST CUX1 ZBTB25 TOE1 MYC RAD21 SPIDR CEBPD piR-55948-113 piR-57460-639
GH08J047507 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 11.2 +229.7 229727 3.2 RELA CTCF POLR2A PBX2 SPI1 BATF IRF4 RAD21 RXRA HDGF CEBPD SPIDR RPL29P19 ENSG00000253330 piR-57195-235
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEBPD on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CEBPD

Top Transcription factor binding sites by QIAGEN in the CEBPD gene promoter:
  • AP-1
  • ATF-2
  • GR
  • GR-alpha
  • STAT3
  • TBP
  • TFIID

Genomic Locations for CEBPD Gene

Genomic Locations for CEBPD Gene
chr8:47,736,913-47,738,164
(GRCh38/hg38)
Size:
1,252 bases
Orientation:
Minus strand
chr8:48,649,471-48,651,648
(GRCh37/hg19)
Size:
2,178 bases
Orientation:
Minus strand

Genomic View for CEBPD Gene

Genes around CEBPD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEBPD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEBPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEBPD Gene

Proteins for CEBPD Gene

  • Protein details for CEBPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49716-CEBPD_HUMAN
    Recommended name:
    CCAAT/enhancer-binding protein delta
    Protein Accession:
    P49716
    Secondary Accessions:
    • Q14937
    • Q2M2X9

    Protein attributes for CEBPD Gene

    Size:
    269 amino acids
    Molecular mass:
    28467 Da
    Quaternary structure:
    • Binds DNA as a homodimer and as a heterodimer (PubMed:1741402). Can form stable heterodimers with CEBPB (PubMed:1741402). Can form stable heterodimers with CEBPA and CEBPE. Interacts with SPI1/PU.1. Interacts with PRDM16.

neXtProt entry for CEBPD Gene

Post-translational modifications for CEBPD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEBPD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEBPD Gene

Domains & Families for CEBPD Gene

Gene Families for CEBPD Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for CEBPD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEBPD Gene

GenScript: Design optimal peptide antigens:
  • Nuclear factor NF-IL6-beta (CEBPD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49716

UniProtKB/Swiss-Prot:

CEBPD_HUMAN :
  • Belongs to the bZIP family. C/EBP subfamily.
Family:
  • Belongs to the bZIP family. C/EBP subfamily.
genes like me logo Genes that share domains with CEBPD: view

Function for CEBPD Gene

Molecular function for CEBPD Gene

UniProtKB/Swiss-Prot Function:
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).
GENATLAS Biochemistry:
CCAAT enhancer binding protein delta (C/EBP),expressed in preadipocytes and inducing,conjointly with CEBPD,the induction of CEBPB and PPARG,required for adipocyte differentiation.

Phenotypes From GWAS Catalog for CEBPD Gene

Gene Ontology (GO) - Molecular Function for CEBPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with CEBPD: view
genes like me logo Genes that share phenotypes with CEBPD: view

Animal Models for CEBPD Gene

MGI Knock Outs for CEBPD:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CEBPD Gene

Localization for CEBPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEBPD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEBPD gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CEBPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CEBPD: view

Pathways & Interactions for CEBPD Gene

genes like me logo Genes that share pathways with CEBPD: view

Pathways by source for CEBPD Gene

1 R&D Systems pathway for CEBPD Gene
1 Qiagen pathway for CEBPD Gene
  • Growth Hormone Signaling
2 Cell Signaling Technology pathways for CEBPD Gene

SIGNOR curated interactions for CEBPD Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CEBPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006366 transcription by RNA polymerase II TAS 8314590
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with CEBPD: view

Drugs & Compounds for CEBPD Gene

(1) Additional Compounds for CEBPD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEBPD: view

Transcripts for CEBPD Gene

mRNA/cDNA for CEBPD Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEBPD Gene

No ASD Table

Relevant External Links for CEBPD Gene

GeneLoc Exon Structure for
CEBPD

Expression for CEBPD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEBPD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEBPD Gene

This gene is overexpressed in Blymphocyte (38.7), Monocytes (12.7), and Bone marrow stromal cell (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEBPD Gene



Protein tissue co-expression partners for CEBPD Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CEBPD

SOURCE GeneReport for Unigene cluster for CEBPD Gene:

Hs.440829

Evidence on tissue expression from TISSUES for CEBPD Gene

  • Kidney(4.7)
  • Nervous system(4.7)
  • Lung(4.6)
  • Liver(3.6)
  • Muscle(3.4)
  • Blood(2.8)
  • Intestine(2.8)
  • Heart(2.6)
  • Eye(2)
genes like me logo Genes that share expression patterns with CEBPD: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEBPD Gene

Orthologs for CEBPD Gene

This gene was present in the common ancestor of animals.

Orthologs for CEBPD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEBPD 31 30
  • 99.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CEBPD 30
  • 88.02 (n)
dog
(Canis familiaris)
Mammalia CEBPD 30
  • 87.52 (n)
mouse
(Mus musculus)
Mammalia Cebpd 17 30
  • 86.19 (n)
rat
(Rattus norvegicus)
Mammalia Cebpd 30
  • 85.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CEBPD 31
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEBPD 31
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEBPD 31
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cebpd 30
  • 67.56 (n)
Str.2213 30
zebrafish
(Danio rerio)
Actinopterygii cebpd 31 30
  • 61.41 (n)
OneToOne
-- 30
worm
(Caenorhabditis elegans)
Secernentea cebp-2 31
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
OneToMany
Species where no ortholog for CEBPD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CEBPD Gene

ENSEMBL:
Gene Tree for CEBPD (if available)
TreeFam:
Gene Tree for CEBPD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEBPD: view image

Paralogs for CEBPD Gene

Paralogs for CEBPD Gene

(2) SIMAP similar genes for CEBPD Gene using alignment to 2 proteins:

  • CEBPD_HUMAN
  • Q504X4_HUMAN
genes like me logo Genes that share paralogs with CEBPD: view

Variants for CEBPD Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CEBPD Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs34948549 - p.Arg248Trp

Additional dbSNP identifiers (rs#s) for CEBPD Gene

Variation tolerance for CEBPD Gene

Gene Damage Index Score: 1.77; 33.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEBPD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEBPD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CEBPD Gene

Disorders for CEBPD Gene

MalaCards: The human disease database

(15) MalaCards diseases for CEBPD Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
expressive language disorder
  • developmental expressive language disorder
speech and communication disorders
  • communication disorder
specific language impairment
  • language impairment, specific
atrial septal defect 1
  • asd1
myotonic disease
  • myotonic syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CEBPD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CEBPD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CEBPD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEBPD Gene

Publications for CEBPD Gene

  1. Genetic variations at the CCAAT/enhancer-binding protein delta are associated with metabolic phenotypes in the Japanese population. (PMID: 18370833) Kaji H … Tanida K (Metabolic syndrome and related disorders 2008) 3 23 41 54
  2. The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization. (PMID: 8314590) Cleutjens CB … Trapman J (Genomics 1993) 3 4 23 54
  3. CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. (PMID: 20460359) Bennett CE … Carter AM (Diabetes & vascular disease research 2010) 3 41 54
  4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y … Boer JM (Journal of lipid research 2008) 3 41 54
  5. Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. (PMID: 18753137) Ko CY … Wang JM (The Journal of biological chemistry 2008) 3 23 54

Products for CEBPD Gene

  • Boster Bio Antibodies for CEBPD
  • Boster Bio ELISA Kits for CEBPD

Sources for CEBPD Gene