Aliases for CEBPB Gene
- CCAAT/Enhancer Binding Protein Beta 2 3 5
- CCAAT/Enhancer Binding Protein (C/EBP), Beta 2 3
- Interleukin 6-Dependent DNA-Binding Protein 2 3
- Nuclear Factor Of Interleukin 6 2 3
- Transcription Factor 5 3 4
- Nuclear Factor NF-IL6 3 4
- TCF5 3 4
- Liver-Enriched Transcriptional Activator Protein 2
- CCAAT/Enhancer-Binding Protein Beta 3
- Liver-Enriched Inhibitory Protein 4
External Ids for CEBPB Gene
Previous HGNC Symbols for CEBPB Gene
Previous GeneCards Identifiers for CEBPB Gene
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
GeneCards Summary for CEBPB Gene
CEBPB (CCAAT/Enhancer Binding Protein Beta) is a Protein Coding gene. Diseases associated with CEBPB include Acute Promyelocytic Leukemia and Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly. Among its related pathways are PEDF Induced Signaling and PAK Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is CEBPA.
UniProtKB/Swiss-Prot for CEBPB Gene
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5-T[TG]NNGNAA[TG]-3. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis (By similarity).
Isoform 2: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.
Isoform 3: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity).