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This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
CEBPB (CCAAT Enhancer Binding Protein Beta) is a Protein Coding gene. Diseases associated with CEBPB include Alk-Positive Anaplastic Large Cell Lymphoma and Juvenile Polyposis Syndrome. Among its related pathways are Transcriptional misregulation in cancer and G-protein signaling Ras family GTPases in kinase cascades (scheme). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is CEBPA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 7959007 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | IEA | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IEA,ISS | -- |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA,ISS | 15308669 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000779 | condensed chromosome, centromeric region | IEA | -- |
GO:0000790 | nuclear chromatin | IEA,ISA | -- |
GO:0005634 | nucleus | TAS,IDA | 20829347 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-17 Family Signaling Pathways | ||
2 | Cellular Senescence (REACTOME) | ||
3 | G-protein signaling Ras family GTPases in kinase cascades (scheme) |
G-protein signaling Ras family GTPases in kinase cascades (scheme)
.44
Immune response Oncostatin M signaling via MAPK in human cells
.39
|
|
4 | Human Embryonic Stem Cell Pluripotency |
Factors Promoting Cardiogenesis in Vertebrates
.50
|
Human Embryonic Stem Cell Pluripotency
.50
|
5 | IL-2 Pathway |
Prolactin Signaling
.54
|
Growth Hormone Signaling
.49
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,ISS | 15308669 |
GO:0001541 | ovarian follicle development | IEA,ISS | -- |
GO:0001889 | liver development | IEA | -- |
GO:0001892 | embryonic placenta development | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IDA | 20829347 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Quercetin | Experimental, Investigational | Pharma | Target, inhibitor | Antitumor agent, Non-selective PI 3-kinase inhibitor | 54 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CEBPB 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CEBPB 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CEBPB 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cebpb 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cebpb 30 |
|
||
Chicken (Gallus gallus) |
Aves | CEBPB 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CEBPB 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cebpb 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cebpb 31 |
|
OneToOne | |
-- 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10599 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | cebp-2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
alk-positive anaplastic large cell lymphoma |
|
|
juvenile polyposis syndrome |
|
|
myxoid liposarcoma |
|
|
retinoblastoma |
|
|
acute promyelocytic leukemia |
|