Aliases for CEBPB Gene
Aliases for CEBPB Gene
- CCAAT Enhancer Binding Protein Beta 2 3
- CCAAT/Enhancer Binding Protein (C/EBP), Beta 2 3
- Interleukin 6-Dependent DNA-Binding Protein 2 3
- CCAAT/Enhancer Binding Protein Beta 2 5
- Nuclear Factor Of Interleukin 6 2 3
- Transcription Factor 5 3 4
- Nuclear Factor NF-IL6 3 4
- TCF5 3 4
- Liver-Enriched Transcriptional Activator Protein 2
- CCAAT/Enhancer-Binding Protein Beta 3
- Liver-Enriched Inhibitory Protein 4
External Ids for CEBPB Gene
- HGNC: 1834
- Entrez Gene: 1051
- Ensembl: ENSG00000172216
- OMIM: 189965
- UniProtKB: P17676
Previous HGNC Symbols for CEBPB Gene
- TCF5
Previous GeneCards Identifiers for CEBPB Gene
- GC20P048535
- GC20P049445
- GC20P049492
- GC20P048240
- GC20P048807
- GC20P045555
Summaries for CEBPB Gene
-
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
GeneCards Summary for CEBPB Gene
CEBPB (CCAAT Enhancer Binding Protein Beta) is a Protein Coding gene. Diseases associated with CEBPB include Acute Promyelocytic Leukemia and Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly. Among its related pathways are ERK Signaling and Development IGF-1 receptor signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is CEBPA.
UniProtKB/Swiss-Prot for CEBPB Gene
-
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5-T[TG]NNGNAA[TG]-3. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity).
-
Isoform 2: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.
-
Isoform 3: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity).
Additional gene information for CEBPB Gene
- Monarch Initiative
- Search for CEBPB at DataMed
- Search for CEBPB at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPB Gene
Genomics for CEBPB Gene
GeneHancer (GH) Regulatory Elements for CEBPB Gene
Promoters and enhancers for CEBPB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CEBPB on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CEBPB gene promoter:
-
- c-Myb
- deltaCREB
- CREB
- GR-beta
- GR-alpha
- GR
Regulatory Element Products
Genomic Locations for CEBPB Gene
Genomic Locations for CEBPB Gene
- chr20:50,190,583-50,192,690
- (GRCh38/hg38)
- Size:
- 2,108 bases
- Orientation:
- Plus strand
- chr20:48,807,376-48,809,212
- (GRCh37/hg19)
- Size:
- 1,837 bases
- Orientation:
- Plus strand
Genomic View for CEBPB Gene
Genes around CEBPB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.13 by Entrez Gene
- 20q13.13 by HGNC
- 20q13.13 by Ensembl
CEBPB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CEBPB Gene
Proteins for CEBPB Gene
-
Protein details for CEBPB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17676-CEBPB_HUMAN
- Recommended name:
- CCAAT/enhancer-binding protein beta
- Protein Accession:
- P17676
- A8K671
- Q96IH2
- Q9H4Z5
Protein attributes for CEBPB Gene
- Size:
- 345 amino acids
- Molecular mass:
- 36106 Da
- Quaternary structure:
-
- Binds DNA as a homodimer and as a heterodimer (PubMed:11018027, PubMed:11257229, PubMed:11792321). Interacts with ATF4. Binds DNA as a heterodimer with ATF4 (PubMed:11018027). Interacts with MYB; within the complex, MYB and CEBPB bind to different promoter regions (PubMed:11792321). Can form stable heterodimers with CEBPD (PubMed:1741402). Can form stable heterodimers with CEBPA and CEBPE (By similarity). Isoform 2 and isoform 3 also form heterodimers. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms a complex with THOC5. Interacts with ZNF638; this interaction increases transcriptional activation. Interacts with CIDEA and CIDEC; these interactions increase transcriptional activation of a subset of CEBPB downstream target genes (By similarity). Interacts with DDIT3/CHOP (PubMed:20829347). Interacts with EP300; recruits EP300 to chromatin. Interacts with RORA; the interaction disrupts interaction with EP300. Interacts (not methylated) with MED23, MED26, SMARCA2, SMARCB1 and SMARCC1 (PubMed:20111005). Interacts with KAT2A and KAT2B (By similarity). Interacts with ATF5; EP300 is required for ATF5 and CEBPB interaction and DNA binding (By similarity). Interacts with NFE2L1; the heterodimer represses expression of DSPP during odontoblast differentiation (By similarity).
Three dimensional structures from OCA and Proteopedia for CEBPB Gene
Protein Expression for CEBPB Gene
Post-translational modifications for CEBPB Gene
- Methylated. Methylation at Arg-3 by CARM1 and at Lys-43 by EHMT2 inhibit transactivation activity. Methylation is probably inhibited by phosphorylation at Thr-235.
- Sumoylated by polymeric chains of SUMO2 or SUMO3 (PubMed:12810706). Sumoylation at Lys-174 is required for inhibition of T-cells proliferation. In adipocytes, sumoylation at Lys-174 by PIAS1 leads to ubiquitination and subsequent proteasomal degradation. Desumoylated by SENP2, which abolishes ubiquitination and stabilizes protein levels (By similarity).
- Ubiquitinated, leading to proteasomal degradation.
- Phosphorylated at Thr-235 by MAPK and CDK2, serves to prime phosphorylation at Thr-226 and Ser-231 by GSK3B and acquire DNA-binding as well as transactivation activities, required to induce adipogenesis. MAPK and CDK2 act sequentially to maintain Thr-235 in the primed phosphorylated state during mitotical cloning expansion and thereby progression of terminal differentiation. Phosphorylation at Thr-266 enhances transactivation activity. Phosphorylation at Ser-325 in response to calcium increases transactivation activity. Phosphorylated at Thr-235 by RPS6KA1 (PubMed:11684016).
- O-glycosylated, glycosylation at Ser-227 and Ser-228 prevents phosphorylation on Thr-235, Ser-231 and Thr-226 and DNA binding activity which delays the adipocyte differentiation program.
- Acetylated. Acetylation at Lys-43 is an important and dynamic regulatory event that contributes to its ability to transactivate target genes, including those associated with adipogenesis and adipocyte function. Deacetylation by HDAC1 represses its transactivation activity. Acetylated by KAT2A and KAT2B within a cluster of lysine residues between amino acids 129-133, this acetylation is strongly induced by glucocorticoid treatment and enhances transactivation activity.
- Glycosylation at Ser228 and Ser227
- Modification sites at PhosphoSitePlus
Other Protein References for CEBPB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CEBPB
- Novus Biologicals Antibodies for CEBPB
-
Abcam antibodies for CEBPB
- Invitrogen Antibodies for CEBPB
- GeneTex CEBPB Antibody for CEBPB
-
Santa Cruz Biotechnology (SCBT) Antibodies for CEBPB
- Sino Biological Antibodies for CEBPB
Protein Products
-
OriGene Purified Proteins for CEBPB
- Search Origene for MassSpec and Protein Over-expression Lysates for CEBPB
- Origene Custom Protein Services for CEBPB
- Search GeneTex for Proteins for CEBPB
-
Abcam proteins for CEBPB
Assay Products
No data available for DME Specific Peptides for CEBPB Gene
Domains & Families for CEBPB Gene
Gene Families for CEBPB Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for CEBPB Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CEBPB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P17676UniProtKB/Swiss-Prot:
CEBPB_HUMAN :- the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
- Belongs to the bZIP family. C/EBP subfamily.
- Domain:
-
- the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
- Family:
-
- Belongs to the bZIP family. C/EBP subfamily.
Function for CEBPB Gene
Molecular function for CEBPB Gene
- UniProtKB/Swiss-Prot Function:
- Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5-T[TG]NNGNAA[TG]-3. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity).
- UniProtKB/Swiss-Prot Function:
- Isoform 2: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.
- UniProtKB/Swiss-Prot Function:
- Isoform 3: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By ER stress.
- GENATLAS Biochemistry:
- CCAAT enhancer binding protein beta (C/EBP),expressed in preadipocytes and inducing,conjointly with CEBPD,the induction of CEBPA and PPARG,required for adipocyte differentiation.
Phenotypes From GWAS Catalog for CEBPB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 7959007 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS,IEA | 19274049 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
Phenotypes for CEBPB Gene
- MGI mutant phenotypes for CEBPB:
-
inferred from 12 alleles
- vision/eye phenotype
- homeostasis/metabolism phenotype
- no phenotypic analysis
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- normal phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for CEBPB:
-
- Decreased BBC3 mRNA expression
- Reduced mammosphere formation
- Decreased viability after ionizing radiation
- Decreased ionizing radiation sensitivity
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased hepcidin::fluc mRNA expression
- Increased cell number in S
- shRNA abundance <= 50%
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for CEBPB Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CEBPB
-
CRISPR Products
-
OriGene CRISPR knockouts for CEBPB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CEBPB
- genomics-online: gRNA clones - Search results for 106 available CEBPB gene related products
- Overview of 106 available CEBPB gene related products
- Applied Biological Materials CRISPR for CEBPB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEBPB
- GenScript: Design CRISPR guide RNA sequences for CEBPB
miRNA for CEBPB Gene
- miRTarBase miRNAs that target CEBPB
-
- hsa-mir-155-5p (MIRT001560)
- hsa-mir-34a-5p (MIRT005723)
- hsa-mir-663a (MIRT006090)
- hsa-mir-421 (MIRT016122)
- hsa-mir-423-5p (MIRT038165)
- hsa-mir-191-5p (MIRT154313)
- hsa-mir-2116-5p (MIRT154323)
- hsa-mir-561-3p (MIRT202308)
- hsa-mir-548n (MIRT202310)
- hsa-mir-548t-5p (MIRT202311)
- hsa-mir-3613-3p (MIRT202313)
- hsa-mir-548az-5p (MIRT202317)
- hsa-mir-4255 (MIRT235776)
- hsa-mir-374a-5p (MIRT296299)
- hsa-mir-4677-5p (MIRT407003)
- ssc-mir-374b-5p (MIRT437364)
- hsa-let-7c-5p (MIRT437806)
- rno-mir-92b-3p (MIRT438076)
- hsa-mir-514b-5p (MIRT564022)
- hsa-mir-513c-5p (MIRT564023)
- hsa-mir-4477a (MIRT564024)
- hsa-mir-22-5p (MIRT564025)
- hsa-mir-372-5p (MIRT564026)
- hsa-mir-371a-5p (MIRT564027)
- hsa-mir-616-5p (MIRT564028)
- hsa-mir-373-5p (MIRT564029)
- hsa-mir-371b-5p (MIRT564030)
- hsa-mir-21-5p (MIRT732461)
- hsa-mir-1254 (MIRT736557)
- hsa-mir-185-5p (MIRT738236)
- hsa-mir-2467-3p (MIRT739252)
- hsa-mir-3116 (MIRT739929)
- hsa-mir-3184-5p (MIRT740854)
- hsa-mir-374a-3p (MIRT742627)
- hsa-mir-382-3p (MIRT742794)
- hsa-mir-4254 (MIRT743364)
- hsa-mir-4306 (MIRT743889)
- hsa-mir-4419a (MIRT744169)
- hsa-mir-4434 (MIRT744394)
- hsa-mir-4510 (MIRT745608)
- hsa-mir-4516 (MIRT745747)
- hsa-mir-4644 (MIRT746362)
- hsa-mir-4688 (MIRT747004)
- hsa-mir-486-3p (MIRT749095)
- hsa-mir-5192 (MIRT749935)
- hsa-mir-566 (MIRT751115)
- hsa-mir-5703 (MIRT751350)
- hsa-mir-6127 (MIRT752083)
- hsa-mir-6129 (MIRT752155)
- hsa-mir-6130 (MIRT752244)
- hsa-mir-6133 (MIRT752348)
- hsa-mir-6720-3p (MIRT753739)
- hsa-mir-6743-5p (MIRT754405)
- hsa-mir-6760-5p (MIRT754917)
- hsa-mir-6873-5p (MIRT758058)
- hsa-mir-6878-5p (MIRT758199)
Targeted motifs for CEBPB Gene
HOMER Transcription Factor Regulatory Elements motif CEBPB
- Consensus sequence: ATTGCGCAAC Submotif: canonical Cell Type: ThioMac GEO ID: GSE21512
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CEBPB
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- genomics-online: shRNA clones - Search results for 106 available CEBPB gene related products
- Overview of 106 available CEBPB gene related products
Clone Products
- Sino Biological Human cDNA Clone for CEBPB
- VectorBuilder custom plasmid, inducible vectors for CEBPB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CEBPB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CEBPB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CEBPB
- Applied Biological Materials Clones for CEBPB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CEBPB
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for CEBPB Gene
Localization for CEBPB Gene
Subcellular locations from UniProtKB/Swiss-Prot for CEBPB Gene
- Nucleus. Cytoplasm. Note=Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity). {ECO:0000250 UniProtKB:P28033, ECO:0000269 PubMed:9374525}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| extracellular | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000779 | condensed chromosome, centromeric region | IEA | -- |
| GO:0000790 | nuclear chromatin | IEA | -- |
| GO:0005634 | nucleus | IDA,TAS | 20829347 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for CEBPB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-17 Family Signaling Pathways | ||
| 2 | Cellular Senescence (REACTOME) | ||
| 3 | G-protein signaling Ras family GTPases in kinase cascades (scheme) | ||
| 4 | Human Embryonic Stem Cell Pluripotency | ||
| 5 | IL-2 Pathway | ||
Pathways by source for CEBPB Gene
1 Sino Biological pathway for CEBPB Gene
22 BioSystems pathways for CEBPB Gene
5 Reactome pathways for CEBPB Gene
4 KEGG pathways for CEBPB Gene
10 GeneGo (Thomson Reuters) pathways for CEBPB Gene
2 R&D Systems pathways for CEBPB Gene
10 Qiagen pathways for CEBPB Gene
2 Cell Signaling Technology pathways for CEBPB Gene
Interacting Proteins for CEBPB Gene
Selected Interacting proteins:
P17676-CEBPB_HUMAN
ENSP00000305422
for CEBPB Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CEBPB
SIGNOR curated interactions for CEBPB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS | 15308669 |
| GO:0001541 | ovarian follicle development | IEA,ISS | -- |
| GO:0001889 | liver development | IEA | -- |
| GO:0001892 | embryonic placenta development | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
Drugs & Compounds for CEBPB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Quercetin | Experimental, Investigational | Nutra | Target, inhibitor | Antitumor agent, Non-selective PI 3-kinase inhibitor | 42 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CEBPB Gene
mRNA/cDNA for CEBPB Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (46) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000303004 1956 bps (uc002xvi.4)
Unigene Clusters for CEBPB Gene
CRISPR Products
-
OriGene CRISPR knockouts for CEBPB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CEBPB
- genomics-online: gRNA clones - Search results for 106 available CEBPB gene related products
- Overview of 106 available CEBPB gene related products
- Applied Biological Materials CRISPR for CEBPB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEBPB
- GenScript: Design CRISPR guide RNA sequences for CEBPB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CEBPB
- Browse OriGene Inhibitory RNA Products For CEBPB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEBPB
- genomics-online: shRNA clones - Search results for 106 available CEBPB gene related products
- Overview of 106 available CEBPB gene related products
Clone Products
- Sino Biological Human cDNA Clone for CEBPB
- VectorBuilder custom plasmid, inducible vectors for CEBPB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CEBPB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CEBPB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CEBPB
- Applied Biological Materials Clones for CEBPB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CEBPB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Subcutaneous White Preadipocytes Subcutaneous White Adipose
- Subcutaneous White Preadipocytes Facial Subcutaneous White Adipose
- Preadipocytes Cranial Subcutaneous White Adipose
- Subcutaneous White Adipocytes Subcutaneous White Adipose
- Lumbar Brown Adipocyte Cells Lumbar Brown Adipose Depot
-
Bone (Muscoskeletal System)
- Endochondral Osteoblasts Autopod Periosteum
- Endochondral Osteoblasts Zeugopod Periosteum
- Endochondral Osteoblasts Vertebrae
- Endochondral Osteoblasts Rib
- Endochondral Osteoblasts Stylopod Periosteum
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Monocytes Peripheral Blood
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Intestine (Gastrointestinal Tract)
- Breast (Uncategorized)
-
Adrenal Gland (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for CEBPB Gene
This gene is overexpressed in Whole Blood (x8.9).
This gene is overexpressed in Liver (22.6), Placenta (20.0), Peripheral blood mononuclear cells (9.8), and Monocytes (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEBPB Gene
NURSA nuclear receptor signaling pathways regulating expression of CEBPB Gene:
CEBPBSOURCE GeneReport for Unigene cluster for CEBPB Gene:
Hs.517106mRNA Expression by UniProt/SwissProt for CEBPB Gene:
P17676-CEBPB_HUMAN
Tissue specificity:
Expressed at low levels in the lung, kidney and spleen.
Evidence on tissue expression from TISSUES for CEBPB Gene
- Heart(5)
- Intestine(5)
- Lung(5)
- Muscle(4.7)
- Skin(4.5)
- Nervous system(4.3)
- Liver(3.9)
- Blood(3.5)
- Bone marrow(2.6)
- Spleen(2.3)
- Pancreas(2.2)
- Adrenal gland(2)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CEBPB
-
OriGene qPCR primer pairs for CEBPB
- genomics-online: primer clones - Search results for 106 available CEBPB gene related products
- Overview of 106 available CEBPB gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CEBPB Gene
Orthologs for CEBPB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CEBPB 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CEBPB 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CEBPB 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cebpb 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cebpb 33 |
|
||
| chicken (Gallus gallus) |
Aves | CEBPB 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CEBPB 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cebpb 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cebpb 34 |
|
OneToOne | |
| -- 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10599 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | cebp-2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for CEBPB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CEBPB Gene
- ENSEMBL:
- Gene Tree for CEBPB (if available)
- TreeFam:
- Gene Tree for CEBPB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CEBPB: view image
Paralogs for CEBPB Gene
Variants for CEBPB Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000008468 | -- | 50,191,091(+) | G/T | 5_prime_UTR_variant, coding_sequence_variant, missense_variant | |
| rs1000467250 | -- | 50,190,593(+) | G/C/T | 5_prime_UTR_variant | |
| rs1001174583 | -- | 50,192,700(+) | G/T | downstream_transcript_variant | |
| rs1001637314 | -- | 50,189,920(+) | T/G | upstream_transcript_variant | |
| rs1001870613 | -- | 50,189,604(+) | C/T | upstream_transcript_variant |
Gene Damage Index Score:
0.28;
6.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CEBPB Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CEBPB
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEBPB Gene
Disorders for CEBPB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute promyelocytic leukemia |
|
|
| short-rib thoracic dysplasia 2 with or without polydactyly |
|
|
| short-rib thoracic dysplasia 1 with or without polydactyly |
|
|
| histidine metabolism disease |
|
|
| metaphyseal chondrodysplasia, schmid type |
|
|
Search CEBPB in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CEBPB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CEBPB Gene
Publications for CEBPB Gene
- G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta. (PMID: 18647749) Pless O … Leutz A (The Journal of biological chemistry 2008) 3 4 22 58
- Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family. (PMID: 7635140) Toda K … Shizuta Y (European journal of biochemistry 1995) 3 4 22 58
- A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. (PMID: 1741402) Kinoshita S … Kishimoto T (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 22 58
- Transcriptional regulation of adipocyte differentiation: a central role for CCAAT/enhancer-binding protein (C/EBP) β. (PMID: 25451943) Guo L … Tang QQ (The Journal of biological chemistry 2015) 3 4 58
- CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. (PMID: 20460359) Bennett CE … Carter AM (Diabetes & vascular disease research 2010) 3 44 58
Products for CEBPB Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
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- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CEBPB
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CEBPB
- Search Origene for MassSpec and Protein Over-expression Lysates for CEBPB
- Origene Custom Protein Services for CEBPB
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CEBPB
- Browse OriGene Inhibitory RNA Products For CEBPB
- OriGene qPCR primer pairs and template standards for CEBPB
- OriGene qPCR primer pairs for CEBPB
- OriGene CRISPR knockouts for CEBPB
- OriGene ORF clones in human for CEBPB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CEBPB
- GenScript: Next-day shipping of latest version cDNA ORF clones for CEBPB in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CEBPB
- GenScript Custom Assay Services for CEBPB
- GenScript Custom overexpressing Cell Line Services for CEBPB
- GenScript: Design CRISPR guide RNA sequences for CEBPB
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CEBPB
- Sino Biological Human cDNA Clone for CEBPB
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for CEBPB
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CEBPB
- Novus Biologicals lysates and proteins for CEBPB
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CEBPB
- Abcam proteins for CEBPB
- Find your target
- Browse Primary Antibodies
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- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cyagen custom Knockout/knockin (KOKI) mouse models for CEBPB
- VectorBuilder custom plasmid, inducible vectors for CEBPB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CEBPB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CEBPB
- antibodies-online: Search results for 203 available CEBPB Antibodies ranked by validation data
- Compare Top CEBPB Antibodies
- antibodies-online: Search results for 43 available CEBPB Elisa Kits ranked by validation data
- Compare Top CEBPB Elisa Kits
- antibodies-online: Search results for 7 available CEBPB Proteins ranked by validation data
- Compare Top CEBPB Proteins
- GeneTex CEBPB Antibody for CEBPB
- Search GeneTex for Proteins for CEBPB
- Santa Cruz Biotechnology (SCBT) Antibodies for CEBPB
- Search Santa Cruz Biotechnology (SCBT) for CEBPB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CEBPB
- Horizon Cell Lines for CEBPB
- genomics-online: cdna clones - Search results for 106 available CEBPB gene related products
- Overview of 106 available CEBPB gene related products
- orf clones - Search results for 106 available CEBPB gene related products
- Overview of 106 available CEBPB gene related products
- genomics-online: gRNA clones - Search results for 106 available CEBPB gene related products
- Overview of 106 available CEBPB gene related products
- genomics-online: primer clones - Search results for 106 available CEBPB gene related products
- Overview of 106 available CEBPB gene related products
- genomics-online: shRNA clones - Search results for 106 available CEBPB gene related products
- Overview of 106 available CEBPB gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CEBPB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CEBPB
- GeneCopoeia miRNA 3'UTR Target clone products for CEBPB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEBPB
Sources for CEBPB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD