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Aliases for CEACAM8 Gene

Aliases for CEACAM8 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 8 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8 2 3
  • Non-Specific Cross-Reacting Antigen NCA-95 3 4
  • Carcinoembryonic Antigen CGM6 3 4
  • CD67 Antigen 3 4
  • CGM6 3 4
  • Carcinoembryonic Antigen Gene Family Member 6 3
  • CD66b Antigen 4
  • NCA-95 3
  • CD66b 3
  • CD67 3

External Ids for CEACAM8 Gene

Previous HGNC Symbols for CEACAM8 Gene

  • CGM6

Previous GeneCards Identifiers for CEACAM8 Gene

  • GC19M043731
  • GC19M043476
  • GC19M047760
  • GC19M047776
  • GC19M043084
  • GC19M039517

Summaries for CEACAM8 Gene

GeneCards Summary for CEACAM8 Gene

CEACAM8 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 8) is a Protein Coding gene. Diseases associated with CEACAM8 include Endocarditis and Shwartzman Phenomenon. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Cell surface interactions at the vascular wall. An important paralog of this gene is CEACAM6.

Gene Wiki entry for CEACAM8 Gene

Additional gene information for CEACAM8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM8 Gene

Genomics for CEACAM8 Gene

GeneHancer (GH) Regulatory Elements for CEACAM8 Gene

Promoters and enhancers for CEACAM8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J042596 Enhancer 0.7 Ensembl 650.7 -1.4 -1446 0.2 CTCF ZNF777 ZNF133 KLF17 MAX KLF14 ZIC2 ZNF2 RAD21 ZFHX2 CEACAM8 ZNF526 XRCC1 CXCL17 CEACAMP1 LIPE-AS1
GH19J042594 Promoter 0.6 EPDnew 650.7 +0.1 112 0.1 ZSCAN4 CEACAM8 CEACAMP2 LIPE-AS1
GH19J042276 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 5.6 +313.1 313142 11.1 YBX1 E2F8 ZNF416 ZNF143 SP3 NFYC ZFP41 SSRP1 ZNF610 GLIS1 ZNF526 ZNF574 CCDC97 MEGF8 CEACAMP1 CEACAMP10 CIC PSG6 GRIK5 DEDD2
GH19J042267 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.9 +324.2 324167 6.9 MLX FEZF1 YBX1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 NFYC CIC PIR59110 ZNF526 ZNF574 CCDC97 DEDD2 MEGF8 CEACAM3 PAFAH1B3 PRR19
GH19J042569 Enhancer 0.7 Ensembl 11.5 +27.8 27755 0.2 BCOR CTCF ZNF384 ZNF2 RAD21 ZNF335 ZNF121 ZNF366 SMC3 ZNF143 CEACAM8 CXCL17 CEACAMP2 LIPE-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CEACAM8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CEACAM8 gene promoter:

Genomic Locations for CEACAM8 Gene

Genomic Locations for CEACAM8 Gene
14,815 bases
Minus strand

Genomic View for CEACAM8 Gene

Genes around CEACAM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM8 Gene

Proteins for CEACAM8 Gene

  • Protein details for CEACAM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 8
    Protein Accession:
    Secondary Accessions:
    • O60399
    • Q16574

    Protein attributes for CEACAM8 Gene

    349 amino acids
    Molecular mass:
    38154 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CEACAM8 Gene

neXtProt entry for CEACAM8 Gene

Post-translational modifications for CEACAM8 Gene

  • Glycosylation at Asn309, posLast=288288, posLast=274274, Asn256, Asn224, Asn197, posLast=173173, posLast=152152, Asn115, Asn111, and posLast=104104
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CEACAM8 (CEACAM-8/CD66b)

No data available for DME Specific Peptides for CEACAM8 Gene

Domains & Families for CEACAM8 Gene

Gene Families for CEACAM8 Gene

Protein Domains for CEACAM8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. CEA family.
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM8: view

Function for CEACAM8 Gene

Molecular function for CEACAM8 Gene

GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 8 (see CEA@,PSG@)

Gene Ontology (GO) - Molecular Function for CEACAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11994468
genes like me logo Genes that share ontologies with CEACAM8: view
genes like me logo Genes that share phenotypes with CEACAM8: view

Animal Model Products

miRNA for CEACAM8 Gene

miRTarBase miRNAs that target CEACAM8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM8 Gene

Localization for CEACAM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM8 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM8 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
cytosol 1

Gene Ontology (GO) - Cellular Components for CEACAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA,TAS 25645918
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2208113
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CEACAM8 Gene

Pathways & Interactions for CEACAM8 Gene

genes like me logo Genes that share pathways with CEACAM8: view

Gene Ontology (GO) - Biological Process for CEACAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 2208113
GO:0043312 neutrophil degranulation TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with CEACAM8: view

No data available for SIGNOR curated interactions for CEACAM8 Gene

Drugs & Compounds for CEACAM8 Gene

(1) Additional Compounds for CEACAM8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM8: view

Transcripts for CEACAM8 Gene

mRNA/cDNA for CEACAM8 Gene

Unigene Clusters for CEACAM8 Gene

Carcinoembryonic antigen-related cell adhesion molecule 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM8 Gene

No ASD Table

Relevant External Links for CEACAM8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CEACAM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEACAM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM8 Gene

This gene is overexpressed in Whole Blood (x46.9).

Protein differential expression in normal tissues from HIPED for CEACAM8 Gene

This gene is overexpressed in Neutrophil (45.4) and Blymphocyte (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CEACAM8 Gene

Protein tissue co-expression partners for CEACAM8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CEACAM8 Gene:


SOURCE GeneReport for Unigene cluster for CEACAM8 Gene:


mRNA Expression by UniProt/SwissProt for CEACAM8 Gene:

Tissue specificity: Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.

Evidence on tissue expression from TISSUES for CEACAM8 Gene

  • Lung(4.3)
  • Spleen(4.2)
  • Saliva(4)
  • Blood(3.2)
  • Bone marrow(3)
genes like me logo Genes that share expression patterns with CEACAM8: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM8 Gene

Orthologs for CEACAM8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CEACAM8 34 33
  • 99.43 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 38 (a)
(Bos Taurus)
Mammalia CEACAM1 34
  • 35 (a)
-- 34
  • 25 (a)
(Mus musculus)
Mammalia Psg26 34
  • 17 (a)
Species where no ortholog for CEACAM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM8 Gene

Gene Tree for CEACAM8 (if available)
Gene Tree for CEACAM8 (if available)
Evolutionary constrained regions (ECRs) for CEACAM8: view image

Paralogs for CEACAM8 Gene

(23) SIMAP similar genes for CEACAM8 Gene using alignment to 3 proteins:

  • M0R1X3_HUMAN
  • Q0Z7S6_HUMAN Pseudogenes for CEACAM8 Gene

genes like me logo Genes that share paralogs with CEACAM8: view

Variants for CEACAM8 Gene

Sequence variations from dbSNP and Humsavar for CEACAM8 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000088569 -- 42,596,393(-) C/G upstream_transcript_variant
rs1000347199 -- 42,582,077(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000940941 -- 42,583,523(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000968172 -- 42,588,029(-) T/C/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000972396 -- 42,596,921(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM8 Gene

Variant ID Type Subtype PubMed ID
dgv15e196 CNV deletion 17116639
esv2422471 CNV deletion 17116639
esv2758763 CNV gain+loss 17122850
esv3583425 CNV loss 25503493
nsv1058936 CNV gain 25217958
nsv1064734 CNV gain 25217958
nsv482221 CNV gain 20164927
nsv526186 CNV gain 19592680
nsv963055 CNV duplication 23825009
nsv978823 CNV duplication 23825009

Variation tolerance for CEACAM8 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEACAM8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM8 Gene

Disorders for CEACAM8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CEACAM8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
shwartzman phenomenon
  • shwartzman reaction
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CEACAM8

genes like me logo Genes that share disorders with CEACAM8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM8 Gene

Publications for CEACAM8 Gene

  1. Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. (PMID: 2208113) Berling B … Zimmermann W (Cancer research 1990) 2 3 4 22 58
  2. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. (PMID: 9427723) Eades-Perner AM … Zimmermann W (Blood 1998) 3 4 22 58
  3. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PMID: 1427854) Khan WN … Hammarström S (Genomics 1992) 3 4 22 58
  4. Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family. (PMID: 2306228) Arakawa F … Matsuoka Y (Biochemical and biophysical research communications 1990) 2 3 4 58
  5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P … Loo JA (Journal of proteome research 2006) 3 4 58

Products for CEACAM8 Gene

Sources for CEACAM8 Gene

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