Aliases for CEACAM8 Gene

Aliases for CEACAM8 Gene

  • CEA Cell Adhesion Molecule 8 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8 2 3 4
  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 8 2 3
  • Non-Specific Cross-Reacting Antigen NCA-95 3 4
  • Carcinoembryonic Antigen CGM6 3 4
  • CD67 Antigen 3 4
  • CD66b 2 3
  • CGM6 3 4
  • Carcinoembryonic Antigen Gene Family Member 6 3
  • CD66b Antigen 4
  • CEACAM8 5
  • NCA-95 3
  • CD67 3

External Ids for CEACAM8 Gene

Previous HGNC Symbols for CEACAM8 Gene

  • CGM6

Previous GeneCards Identifiers for CEACAM8 Gene

  • GC19M043731
  • GC19M043476
  • GC19M047760
  • GC19M047776
  • GC19M043084
  • GC19M039517

Summaries for CEACAM8 Gene

GeneCards Summary for CEACAM8 Gene

CEACAM8 (CEA Cell Adhesion Molecule 8) is a Protein Coding gene. Diseases associated with CEACAM8 include Hemoglobinuria and Paroxysmal Nocturnal Hemoglobinuria. Among its related pathways are Degradation of the extracellular matrix and Cell surface interactions at the vascular wall. An important paralog of this gene is CEACAM6.

UniProtKB/Swiss-Prot Summary for CEACAM8 Gene

  • Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764).

Gene Wiki entry for CEACAM8 Gene

Additional gene information for CEACAM8 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEACAM8 Gene

Genomics for CEACAM8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CEACAM8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J042594 Promoter/Enhancer 1.1 EPDnew Ensembl 600.7 +0.3 256 4.2 CTCF ZNF143 ZIC2 ZSCAN4 REST RAD21 TRIM22 MNT CEBPB ZXDB CEACAM8 ZNF526 XRCC1 CXCL17 piR-33279-002 CEACAM1 LIPE-AS1
GH19J042276 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.6 +313.2 313244 11.1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 PRDM10 ZNF629 SOX13 ZNF574 ZNF526 CCDC97 MEGF8 CIC GRIK5 DEDD2 CEACAM8 PAFAH1B3 TMEM145
GH19J042567 Enhancer 0.9 Ensembl ENCODE 11.6 +24.8 24756 14.4 CTCF ATF7 PRDM10 ZNF143 RAD21 TRIM22 CEBPB ZBTB20 ATF3 ZNF585B CEACAM8 CXCL17 CD177 CEACAMP2 CEACAM1 lnc-CEACAM1-1 piR-33279-002 LIPE-AS1
GH19J042267 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.9 +324.3 324287 6.9 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 TFE3 CIC piR-36065 ZNF526 ZNF574 CCDC97 DEDD2 MEGF8 CEACAM3 PAFAH1B3 PRR19
GH19J042561 Enhancer 0.5 Ensembl 11.5 +35.7 35656 3 ZNF7 MNT BHLHE40 KDM1A ZNF121 CEACAM1 piR-59655-006 CEACAM8 CXCL17 CEACAMP2 lnc-CEACAM1-1 LOC105372407 LIPE-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEACAM8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CEACAM8

Top Transcription factor binding sites by QIAGEN in the CEACAM8 gene promoter:
  • AML1a
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • NF-kappaB
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2

Genomic Locations for CEACAM8 Gene

Genomic Locations for CEACAM8 Gene
chr19:42,580,243-42,595,157
(GRCh38/hg38)
Size:
14,915 bases
Orientation:
Minus strand
chr19:43,084,393-43,099,207
(GRCh37/hg19)
Size:
14,815 bases
Orientation:
Minus strand

Genomic View for CEACAM8 Gene

Genes around CEACAM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM8 Gene

Proteins for CEACAM8 Gene

  • Protein details for CEACAM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31997-CEAM8_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 8
    Protein Accession:
    P31997
    Secondary Accessions:
    • O60399
    • Q16574

    Protein attributes for CEACAM8 Gene

    Size:
    349 amino acids
    Molecular mass:
    38154 Da
    Quaternary structure:
    • Monomer. Heterodimer with CEACAM6; heterodimerizes via its Ig-like V-type domain.

    Three dimensional structures from OCA and Proteopedia for CEACAM8 Gene

neXtProt entry for CEACAM8 Gene

Post-translational modifications for CEACAM8 Gene

  • Glycosylated.
  • Glycosylation at Asn104, Asn111, Asn115, Asn152, Asn173, Asn197, Asn224, Asn256, Asn274, Asn288, and Asn309
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CEAM8_HUMAN (1072)

Antibody Products

  • Abcam antibodies for CEACAM8

No data available for DME Specific Peptides for CEACAM8 Gene

Domains & Families for CEACAM8 Gene

Gene Families for CEACAM8 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CEACAM8 Gene

InterPro:
Blocks:
  • Immunoglobulin V-set
  • Immunoglobulin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for CEACAM8 Gene

GenScript: Design optimal peptide antigens:
  • Non-specific cross-reacting antigen NCA-95 (CEAM8_HUMAN)
  • cDNA, FLJ93041, Homo sapiens carcinoembryonic antigen-related cell adhesionmolecule 8 (CEACAM8), mRNA (Q0Z7S6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P31997

UniProtKB/Swiss-Prot:

CEAM8_HUMAN :
  • The N-terminus Ig-like V-type domain is necessary for heterophilic intercellular adhesion.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • The N-terminus Ig-like V-type domain is necessary for heterophilic intercellular adhesion.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM8: view

Function for CEACAM8 Gene

Molecular function for CEACAM8 Gene

UniProtKB/Swiss-Prot Function:
Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764).
GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 8 (see CEA@,PSG@)

Phenotypes From GWAS Catalog for CEACAM8 Gene

Gene Ontology (GO) - Molecular Function for CEACAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11994468
GO:0046982 protein heterodimerization activity IDA 26483485
genes like me logo Genes that share ontologies with CEACAM8: view
genes like me logo Genes that share phenotypes with CEACAM8: view

Animal Model Products

CRISPR Products

miRNA for CEACAM8 Gene

miRTarBase miRNAs that target CEACAM8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEACAM8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM8 Gene

Localization for CEACAM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM8 Gene

Cell membrane. Lipid-anchor, GPI-anchor. Cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM8 gene
Compartment Confidence
extracellular 5
plasma membrane 4
lysosome 4
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CEACAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS,IDA 25645918
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA,IDA 8776764
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CEACAM8 Gene

Pathways & Interactions for CEACAM8 Gene

genes like me logo Genes that share pathways with CEACAM8: view

Gene Ontology (GO) - Biological Process for CEACAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 2208113
GO:0007155 cell adhesion IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP 8776764
GO:0043312 neutrophil degranulation TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with CEACAM8: view

No data available for SIGNOR curated interactions for CEACAM8 Gene

Drugs & Compounds for CEACAM8 Gene

(1) Additional Compounds for CEACAM8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM8: view

Transcripts for CEACAM8 Gene

mRNA/cDNA for CEACAM8 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEACAM8

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM8 Gene

No ASD Table

Relevant External Links for CEACAM8 Gene

GeneLoc Exon Structure for
CEACAM8

Expression for CEACAM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEACAM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM8 Gene

This gene is overexpressed in Whole Blood (x46.9).

Protein differential expression in normal tissues from HIPED for CEACAM8 Gene

This gene is overexpressed in Neutrophil (45.4) and Blymphocyte (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CEACAM8 Gene



Protein tissue co-expression partners for CEACAM8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CEACAM8

SOURCE GeneReport for Unigene cluster for CEACAM8 Gene:

Hs.41

mRNA Expression by UniProt/SwissProt for CEACAM8 Gene:

P31997-CEAM8_HUMAN
Tissue specificity: Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.

Evidence on tissue expression from TISSUES for CEACAM8 Gene

  • Spleen(4.5)
  • Lung(4.5)
  • Saliva(4.2)
  • Blood(3.5)
  • Bone marrow(3.4)
  • Intestine(2.4)
  • Lymph node(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with CEACAM8: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM8 Gene

Orthologs for CEACAM8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CEACAM8 30 31
  • 99.43 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 38 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia CEACAM1 31
  • 35 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Psg26 31
  • 17 (a)
ManyToMany
Species where no ortholog for CEACAM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CEACAM8 Gene

ENSEMBL:
Gene Tree for CEACAM8 (if available)
TreeFam:
Gene Tree for CEACAM8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEACAM8: view image

Paralogs for CEACAM8 Gene

(23) SIMAP similar genes for CEACAM8 Gene using alignment to 3 proteins:

  • CEAM8_HUMAN
  • M0R1X3_HUMAN
  • Q0Z7S6_HUMAN

Pseudogenes.org Pseudogenes for CEACAM8 Gene

genes like me logo Genes that share paralogs with CEACAM8: view

Variants for CEACAM8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CEACAM8 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1041997 - p.Arg114Lys
rs1126458 - p.Leu322Val
rs28367882 - p.Gly17Val
rs35221575 - p.Ala45Val
rs8103051 - p.Ile340Met

Additional dbSNP identifiers (rs#s) for CEACAM8 Gene

Structural Variations from Database of Genomic Variants (DGV) for CEACAM8 Gene

Variant ID Type Subtype PubMed ID
dgv15e196 CNV deletion 17116639
esv2422471 CNV deletion 17116639
esv2758763 CNV gain+loss 17122850
esv3583425 CNV loss 25503493
nsv1058936 CNV gain 25217958
nsv1064734 CNV gain 25217958
nsv482221 CNV gain 20164927
nsv526186 CNV gain 19592680
nsv963055 CNV duplication 23825009
nsv978823 CNV duplication 23825009

Variation tolerance for CEACAM8 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEACAM8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM8 Gene

Disorders for CEACAM8 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CEACAM8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hemoglobinuria
paroxysmal nocturnal hemoglobinuria
  • marchiafava-micheli disease
infective endocarditis
  • endocarditis, infective
endocarditis
leukemia, chronic myeloid
  • cml
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CEACAM8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM8 Gene

Publications for CEACAM8 Gene

  1. Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. (PMID: 2208113) Berling B … Zimmermann W (Cancer research 1990) 2 3 4 23
  2. Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8. (PMID: 11590190) Kuroki M … Kuroki M (Journal of leukocyte biology 2001) 3 4 23
  3. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. (PMID: 9427723) Eades-Perner AM … Zimmermann W (Blood 1998) 3 4 23
  4. Preparation and characterization of two human carcinoembryonic antigen family proteins of neutrophils, CD66b and c, in silkworm larvae. (PMID: 8776764) Yamanaka T … Matsuoka Y (Protein expression and purification 1996) 3 4 23
  5. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PMID: 1427854) Khan WN … Hammarström S (Genomics 1992) 3 4 23

Products for CEACAM8 Gene

Sources for CEACAM8 Gene