This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus ... See more...

Aliases for CEACAM6 Gene

Aliases for CEACAM6 Gene

  • CEA Cell Adhesion Molecule 6 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen) 2 3
  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 2 3
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 3 4
  • Normal Cross-Reacting Antigen 3 4
  • CD66c 2 3
  • NCA 3 4
  • Non-Specific Crossreacting Antigen 4
  • Cluster Of Differentiation 66c 3
  • CD66c Antigen 4
  • CEACAM6 5
  • CEAL 3

External Ids for CEACAM6 Gene

Previous HGNC Symbols for CEACAM6 Gene

  • NCA

Previous GeneCards Identifiers for CEACAM6 Gene

  • GC19P042899
  • GC19P042652
  • GC19P046935
  • GC19P046952
  • GC19P046953
  • GC19P046954
  • GC19P042260
  • GC19P038692

Summaries for CEACAM6 Gene

Entrez Gene Summary for CEACAM6 Gene

  • This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]

GeneCards Summary for CEACAM6 Gene

CEACAM6 (CEA Cell Adhesion Molecule 6) is a Protein Coding gene. Diseases associated with CEACAM6 include Crohn's Disease and Pancreatic Adenocarcinoma. Among its related pathways are Degradation of the extracellular matrix and Cell surface interactions at the vascular wall. An important paralog of this gene is CEACAM1.

UniProtKB/Swiss-Prot Summary for CEACAM6 Gene

  • Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051). Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575).

Gene Wiki entry for CEACAM6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEACAM6 Gene

Genomics for CEACAM6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CEACAM6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEACAM6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CEACAM6

Top Transcription factor binding sites by QIAGEN in the CEACAM6 gene promoter:
  • AML1a
  • deltaCREB
  • p53
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for CEACAM6 Gene

Latest Assembly
chr19:41,750,977-41,772,211
(GRCh38/hg38)
Size:
21,235 bases
Orientation:
Plus strand

Previous Assembly
chr19:42,259,438-42,276,116
(GRCh37/hg19 by Entrez Gene)
Size:
16,679 bases
Orientation:
Plus strand

chr19:42,254,885-42,276,113
(GRCh37/hg19 by Ensembl)
Size:
21,229 bases
Orientation:
Plus strand

Genomic View for CEACAM6 Gene

Genes around CEACAM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM6 Gene

Proteins for CEACAM6 Gene

  • Protein details for CEACAM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40199-CEAM6_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 6
    Protein Accession:
    P40199
    Secondary Accessions:
    • Q13774
    • Q14920
    • Q53XP7

    Protein attributes for CEACAM6 Gene

    Size:
    344 amino acids
    Molecular mass:
    37195 Da
    Quaternary structure:
    • Homodimer; homodimerizes via its Ig-like V-type domain. Heterodimer with CEACAM8; heterodimerizes via its Ig-like V-type domain.

    Three dimensional structures from OCA and Proteopedia for CEACAM6 Gene

neXtProt entry for CEACAM6 Gene

Post-translational modifications for CEACAM6 Gene

  • Glycosylated.
  • Glycosylation at Asn104, Asn111, Asn115, Asn152, Asn173, Asn197, Asn224, Asn256, Asn274, Asn288, Asn292, and Asn309
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM6 Gene

No data available for DME Specific Peptides for CEACAM6 Gene

Domains & Families for CEACAM6 Gene

Gene Families for CEACAM6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CEACAM6 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin V-set

Suggested Antigen Peptide Sequences for CEACAM6 Gene

GenScript: Design optimal peptide antigens:
  • Normal cross-reacting antigen (CEAM6_HUMAN)
  • NCA protein (Q14921_HUMAN)
  • NCA protein (Q14922_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P40199

UniProtKB/Swiss-Prot:

CEAM6_HUMAN :
  • The extracellular N-terminus Ig-like V-type domain is necessary for homophilic and heterophilic intercellular adhesion.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • The extracellular N-terminus Ig-like V-type domain is necessary for homophilic and heterophilic intercellular adhesion.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM6: view

Function for CEACAM6 Gene

Molecular function for CEACAM6 Gene

UniProtKB/Swiss-Prot Function:
Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051). Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575).
UniProtKB/Swiss-Prot Induction:
Up-regulated in anoikis-resistant pancreatic adenocarcinoma cells (at protein level).
GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) see CEA@

Phenotypes From GWAS Catalog for CEACAM6 Gene

Gene Ontology (GO) - Molecular Function for CEACAM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
GO:0042802 identical protein binding IPI 21982860
GO:0046982 protein heterodimerization activity IDA 26483485
genes like me logo Genes that share ontologies with CEACAM6: view
genes like me logo Genes that share phenotypes with CEACAM6: view

miRNA for CEACAM6 Gene

miRTarBase miRNAs that target CEACAM6

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEACAM6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM6 Gene

Localization for CEACAM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM6 Gene

Cell membrane. Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface. Note=Localized to the apical glycocalyx surface. {ECO:0000269 PubMed:10436421}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM6 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 4
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for CEACAM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25645918
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA,IDA 2317824
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane IEA,IDA 10436421
genes like me logo Genes that share ontologies with CEACAM6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CEACAM6 Gene

Pathways & Interactions for CEACAM6 Gene

genes like me logo Genes that share pathways with CEACAM6: view

Gene Ontology (GO) - Biological Process for CEACAM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IMP 2803308
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP 2803308
GO:0007165 signal transduction IMP 14724575
genes like me logo Genes that share ontologies with CEACAM6: view

No data available for SIGNOR curated interactions for CEACAM6 Gene

Drugs & Compounds for CEACAM6 Gene

(4) Drugs for CEACAM6 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antibodies Pharma 8474
Immunoglobulins Pharma 8474

(2) Additional Compounds for CEACAM6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM6: view

Transcripts for CEACAM6 Gene

mRNA/cDNA for CEACAM6 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEACAM6

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM6 Gene

No ASD Table

Relevant External Links for CEACAM6 Gene

GeneLoc Exon Structure for
CEACAM6

Expression for CEACAM6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEACAM6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM6 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.2), Minor Salivary Gland (x11.8), Lung (x10.1), Colon - Transverse (x6.2), and Vagina (x4.2).

Protein differential expression in normal tissues from HIPED for CEACAM6 Gene

This gene is overexpressed in Neutrophil (37.7), Blymphocyte (14.2), and Lung (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEACAM6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CEACAM6

SOURCE GeneReport for Unigene cluster for CEACAM6 Gene:

Hs.466814

mRNA Expression by UniProt/SwissProt for CEACAM6 Gene:

P40199-CEAM6_HUMAN
Tissue specificity: Expressed in neutrophils (PubMed:1378450). Expressed in columnar epithelial and goblet cells of the colon (PubMed:10436421). Expressed in numerous tumor cell lines (at protein level) (PubMed:16204051).

Evidence on tissue expression from TISSUES for CEACAM6 Gene

  • Pancreas(4.8)
  • Intestine(4.6)
  • Liver(4.4)
  • Saliva(4)
  • Lung(3.2)
  • Stomach(3)
  • Blood(2.8)
  • Bone marrow(2.8)
  • Gall bladder(2.4)
genes like me logo Genes that share expression patterns with CEACAM6: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM6 Gene

Orthologs for CEACAM6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CEACAM6 29 30
  • 98.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CEACAM1 30
  • 36 (a)
ManyToMany
-- 30
  • 25 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Psg16 30
  • 20 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 10 (a)
ManyToMany
Species where no ortholog for CEACAM6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CEACAM6 Gene

ENSEMBL:
Gene Tree for CEACAM6 (if available)
TreeFam:
Gene Tree for CEACAM6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEACAM6: view image
Alliance of Genome Resources:
Additional Orthologs for CEACAM6

Paralogs for CEACAM6 Gene

(23) SIMAP similar genes for CEACAM6 Gene using alignment to 2 proteins:

  • CEAM6_HUMAN
  • M0QYD3_HUMAN

Pseudogenes.org Pseudogenes for CEACAM6 Gene

genes like me logo Genes that share paralogs with CEACAM6: view

Variants for CEACAM6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CEACAM6 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs61736638 Benign: not provided 41,756,789(+) G/A
NM_002483.7(CEACAM6):c.254G>A (p.Gly85Glu)
MISSENSE
rs7246116 Benign: not provided 41,762,045(+) C/T
NM_002483.7(CEACAM6):c.780C>T (p.His260=)
SYNONYMOUS
rs11548735 -- p.Gly239Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CEACAM6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CEACAM6 Gene

Variant ID Type Subtype PubMed ID
esv2718580 CNV deletion 23290073
esv2763205 CNV loss 21179565
esv3644394 CNV gain 21293372
esv3893209 CNV loss 25118596
nsv2495 CNV insertion 18451855
nsv477474 CNV novel sequence insertion 20440878
nsv522854 CNV gain 19592680
nsv579615 CNV gain 21841781
nsv960843 CNV duplication 23825009
nsv960844 CNV duplication 23825009

Variation tolerance for CEACAM6 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEACAM6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM6
Leiden Open Variation Database (LOVD)
CEACAM6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM6 Gene

Disorders for CEACAM6 Gene

MalaCards: The human disease database

(14) MalaCards diseases for CEACAM6 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
crohn's disease
  • crohn disease
pancreatic adenocarcinoma
  • adenocarcinoma of the pancreas
gastrointestinal carcinoma
  • gastrointestinal neoplasms
adenocarcinoma
  • adenocarcinomas
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CEACAM6

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CEACAM6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM6 Gene

Publications for CEACAM6 Gene

  1. Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). (PMID: 16204051) Blumenthal RD … Goldenberg DM (Cancer research 2005) 3 4 22
  2. CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells. (PMID: 14724575) Duxbury MS … Whang EE (Oncogene 2004) 3 4 22
  3. Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8. (PMID: 11590190) Kuroki M … Kuroki M (Journal of leukocyte biology 2001) 3 4 22
  4. Human carcinoembryonic antigen functions as a general inhibitor of anoikis. (PMID: 10910050) Ordoñez C … Stanners CP (Cancer research 2000) 3 4 22
  5. Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat. (PMID: 10436421) Frängsmyr L … Hammarström S (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1999) 3 4 22

Products for CEACAM6 Gene

  • Biorbyt antibodies for CEACAM6

Sources for CEACAM6 Gene