This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and ... See more...

Aliases for CEACAM5 Gene

Aliases for CEACAM5 Gene

  • CEA Cell Adhesion Molecule 5 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 2 3 4
  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 5 2 3
  • Meconium Antigen 100 3 4
  • CD66e 2 3
  • CEA 3 4
  • Carcinoembryonic Antigen 4
  • CD66e Antigen 4
  • CEACAM5 5

External Ids for CEACAM5 Gene

Previous HGNC Symbols for CEACAM5 Gene

  • CEA

Previous GeneCards Identifiers for CEACAM5 Gene

  • GC19P042852
  • GC19P042604
  • GC19P046888
  • GC19P046904
  • GC19P042212
  • GC19P038644
  • GC19P041576

Summaries for CEACAM5 Gene

Entrez Gene Summary for CEACAM5 Gene

  • This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for CEACAM5 Gene

CEACAM5 (CEA Cell Adhesion Molecule 5) is a Protein Coding gene. Diseases associated with CEACAM5 include Lung Cancer and Rectum Cancer. Among its related pathways are Cell surface interactions at the vascular wall and Hematopoietic Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and GPI anchor binding. An important paralog of this gene is CEACAM6.

UniProtKB/Swiss-Prot Summary for CEACAM5 Gene

  • Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
  • (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

Gene Wiki entry for CEACAM5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEACAM5 Gene

Genomics for CEACAM5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CEACAM5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J041706 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 600.7 -1.5 -1496 1 CTCF PRDM10 REST ZNF692 MTA2 ZNF143 ZIC2 ZSCAN4 PKNOX1 PATZ1 CEACAM7 CEACAM5 ENSG00000267881 ZNF574
GH19J041708 Promoter/Enhancer 0.6 EPDnew dbSUPER 600.7 +0.0 22 0.1 KLF4 CEACAM5 CEACAM7 ENSG00000267881
GH19J041709 Promoter/Enhancer 0.6 EPDnew dbSUPER 600.7 +1.1 1057 0.1 ZNF274 CEACAM5 ENSG00000267881 ZNF526 HNRNPUL1 SNRPA ENSG00000269843 CCDC97 L17043-001 CEACAM6
GH19J041721 Promoter/Enhancer 0.5 EPDnew dbSUPER 600.4 +12.6 12601 0.1 CEACAM5 CEACAM4 BCKDHA EXOSC5 L17043-001 ENSG00000267881 CEACAM6
GH19J041715 Promoter 0.3 EPDnew 600.4 +6.7 6662 0.1 CEACAM5 ENSG00000267881 L17043-001 CEACAM6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEACAM5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CEACAM5

Top Transcription factor binding sites by QIAGEN in the CEACAM5 gene promoter:
  • AP-1
  • c-Fos
  • NF-kappaB
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2

Genomic Locations for CEACAM5 Gene

Genomic Locations for CEACAM5 Gene
chr19:41,708,585-41,730,433
(GRCh38/hg38)
Size:
21,849 bases
Orientation:
Plus strand
chr19:42,212,504-42,234,437
(GRCh37/hg19)
Size:
21,934 bases
Orientation:
Plus strand

Genomic View for CEACAM5 Gene

Genes around CEACAM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM5 Gene

Proteins for CEACAM5 Gene

  • Protein details for CEACAM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06731-CEAM5_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 5
    Protein Accession:
    P06731
    Secondary Accessions:
    • H9KVA7

    Protein attributes for CEACAM5 Gene

    Size:
    702 amino acids
    Molecular mass:
    76795 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAA62835.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEACAM5 Gene

    Alternative splice isoforms for CEACAM5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM5 Gene

Post-translational modifications for CEACAM5 Gene

  • Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
  • Glycosylation at Asn104, Asn115, Asn152, Asn182, Asn197, Asn204, Asn208, Asn246, Asn256, Asn274, Asn288, Asn292, Asn309, Asn330, Asn351, Asn360, Asn375, Asn432, Asn466, Asn480, Asn508, Asn529, Asn553, Asn560, Asn580, Asn612, Asn650, and Asn665
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Antibody Products

No data available for DME Specific Peptides for CEACAM5 Gene

Domains & Families for CEACAM5 Gene

Gene Families for CEACAM5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CEACAM5 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin V-set
ProtoNet:

Suggested Antigen Peptide Sequences for CEACAM5 Gene

GenScript: Design optimal peptide antigens:
  • Meconium antigen 100 (CEAM5_HUMAN)
  • Carcinoembryonic antigen (Q13982_HUMAN)
  • CEA protein (Q13984_HUMAN)
  • Carcinoembryonic antigen (Q13985_HUMAN)
  • Carcinoembryonic antigen (Q7KZ28_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P06731

UniProtKB/Swiss-Prot:

CEAM5_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM5: view

Function for CEACAM5 Gene

Molecular function for CEACAM5 Gene

UniProtKB/Swiss-Prot Function:
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 5

Phenotypes From GWAS Catalog for CEACAM5 Gene

Gene Ontology (GO) - Molecular Function for CEACAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27489282
GO:0034235 GPI anchor binding IMP 10931872
GO:0042802 identical protein binding IPI 10864933
GO:0042803 protein homodimerization activity IDA 18086185
genes like me logo Genes that share ontologies with CEACAM5: view
genes like me logo Genes that share phenotypes with CEACAM5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEACAM5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM5 Gene

Localization for CEACAM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM5 Gene

Cell membrane. Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface. Note=Localized to the apical glycocalyx surface. {ECO:0000269 PubMed:10436421}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM5 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
nucleus 3
cytosol 3
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEACAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS,IDA 10931872
GO:0009986 cell surface IEA,IDA 2317824
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CEACAM5: view

Pathways & Interactions for CEACAM5 Gene

genes like me logo Genes that share pathways with CEACAM5: view

Pathways by source for CEACAM5 Gene

1 GeneGo (Thomson Reuters) pathway for CEACAM5 Gene
  • Cell adhesion_Cell-matrix glycoconjugates
1 R&D Systems pathway for CEACAM5 Gene
2 Cell Signaling Technology pathways for CEACAM5 Gene

Gene Ontology (GO) - Biological Process for CEACAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IMP 2803308
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP 2803308
GO:0010832 negative regulation of myotube differentiation IDA 8408226
genes like me logo Genes that share ontologies with CEACAM5: view

No data available for SIGNOR curated interactions for CEACAM5 Gene

Drugs & Compounds for CEACAM5 Gene

(28) Drugs for CEACAM5 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate Experimental Pharma Target 0
Labetuzumab Investigational Pharma Target, inhibitor 8
CEA/MUC-1/VF/TRICOM Pharma 0
TF2 Pharma 0

(33) Additional Compounds for CEACAM5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM5: view

Transcripts for CEACAM5 Gene

mRNA/cDNA for CEACAM5 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CEACAM5

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1:
SP2: - - - - - - - - - - - - - - -
SP3:
SP4:
SP5: -
SP6: - - - - - - - - -
SP7:
SP8: - - - - -
SP9:

Relevant External Links for CEACAM5 Gene

GeneLoc Exon Structure for
CEACAM5

Expression for CEACAM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEACAM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM5 Gene

This gene is overexpressed in Colon - Transverse (x30.9) and Esophagus - Mucosa (x11.7).

Protein differential expression in normal tissues from HIPED for CEACAM5 Gene

This gene is overexpressed in Nasal epithelium (44.1) and Cervix (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEACAM5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CEACAM5

SOURCE GeneReport for Unigene cluster for CEACAM5 Gene:

Hs.709196

mRNA Expression by UniProt/SwissProt for CEACAM5 Gene:

P06731-CEAM5_HUMAN
Tissue specificity: Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

Evidence on tissue expression from TISSUES for CEACAM5 Gene

  • Intestine(5)
  • Liver(4.7)
  • Saliva(4.4)
  • Stomach(4.1)
  • Blood(3.5)
  • Lymph node(3.4)
  • Pancreas(3.4)
  • Kidney(3.2)
  • Lung(3.1)
  • Gall bladder(2.9)
  • Skin(2.8)
  • Thyroid gland(2.7)
  • Spleen(2.7)
  • Bone marrow(2.6)
  • Urine(2.6)
  • Nervous system(2.5)
  • Muscle(2.5)
  • Heart(2.3)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with CEACAM5: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM5 Gene

Orthologs for CEACAM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEACAM5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CEACAM5 30
  • 98.77 (n)
-- 31
  • 97 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ceacam1 31
  • 43 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia CEACAM1 31
  • 43 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 39 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-264f5.6 30
  • 44.03 (n)
Species where no ortholog for CEACAM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CEACAM5 Gene

ENSEMBL:
Gene Tree for CEACAM5 (if available)
TreeFam:
Gene Tree for CEACAM5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEACAM5: view image

Paralogs for CEACAM5 Gene

(25) SIMAP similar genes for CEACAM5 Gene using alignment to 6 proteins:

  • CEAM5_HUMAN
  • M0QX98_HUMAN
  • M0R3J1_HUMAN
  • Q8N4D0_HUMAN
  • T2HUW8_HUMAN
  • T2HVB7_HUMAN

Pseudogenes.org Pseudogenes for CEACAM5 Gene

genes like me logo Genes that share paralogs with CEACAM5: view

Variants for CEACAM5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CEACAM5 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
716790 Benign: not provided 41,718,340(+) A/G MISSENSE_VARIANT
737699 Likely Benign: not provided 41,721,043(+) G/C SYNONYMOUS_VARIANT
769001 Benign: not provided 41,720,199(+) G/A MISSENSE_VARIANT
769975 Benign: not provided 41,715,065(+) C/T SYNONYMOUS_VARIANT
769976 Benign: not provided 41,715,848(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CEACAM5 Gene

Structural Variations from Database of Genomic Variants (DGV) for CEACAM5 Gene

Variant ID Type Subtype PubMed ID
esv2718577 CNV deletion 23290073
nsv1061309 CNV gain 25217958
nsv482220 CNV gain 20164927
nsv522854 CNV gain 19592680
nsv579615 CNV gain 21841781
nsv963052 CNV duplication 23825009
nsv978820 CNV duplication 23825009
nsv978821 CNV duplication 23825009

Variation tolerance for CEACAM5 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEACAM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM5 Gene

Disorders for CEACAM5 Gene

MalaCards: The human disease database

(271) MalaCards diseases for CEACAM5 Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
rectum cancer
  • cancer of rectum
papillary adenocarcinoma
  • infiltrating and papillary adenocarcinoma
pancreatic cystadenoma
  • cystadenoma of pancreas
esophageal disease
  • esophageal ulcer
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CEACAM5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM5 Gene

Publications for CEACAM5 Gene

  1. Human carcinoembryonic antigen functions as a general inhibitor of anoikis. (PMID: 10910050) Ordoñez C … Stanners CP (Cancer research 2000) 3 4 23
  2. Diverse oligomeric states of CEACAM IgV domains. (PMID: 26483485) Bonsor DA … Sundberg EJ (Proceedings of the National Academy of Sciences of the United States of America 2015) 3 4
  3. The impact of carcinoembryonic antigen flare in patients with advanced colorectal cancer receiving first-line chemotherapy. (PMID: 19861580) Strimpakos AS … Chau I (Annals of oncology : official journal of the European Society for Medical Oncology 2010) 3 23
  4. Lead time of carcinoembryonic antigen elevation in the postoperative follow-up of colorectal cancer did not affect the survival rate after recurrence. (PMID: 20162425) Chen CH … Wang JY (International journal of colorectal disease 2010) 3 23
  5. DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools. (PMID: 20034698) Samsen A … Wagener C (European journal of cell biology 2010) 3 23

Products for CEACAM5 Gene

Sources for CEACAM5 Gene