Aliases for CEACAM5 Gene
External Ids for CEACAM5 Gene
Previous HGNC Symbols for CEACAM5 Gene
Previous GeneCards Identifiers for CEACAM5 Gene
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
GeneCards Summary for CEACAM5 Gene
CEACAM5 (CEA Cell Adhesion Molecule 5) is a Protein Coding gene. Diseases associated with CEACAM5 include Lung Cancer and Rectum Cancer. Among its related pathways are Cell surface interactions at the vascular wall and Hematopoietic Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and GPI anchor binding. An important paralog of this gene is CEACAM6.
UniProtKB/Swiss-Prot Summary for CEACAM5 Gene
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.