This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-sp... See more...

Aliases for CEACAM3 Gene

Aliases for CEACAM3 Gene

  • CEA Cell Adhesion Molecule 3 2 3
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 2 3 4
  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 2 3 5
  • Carcinoembryonic Antigen CGM1 3 4
  • CD66d Antigen 3 4
  • CD66D 3 4
  • CGM1 3 4
  • Carcinoembryonic Antigen Gene Family Member 1 3
  • Nonspecific Cross-Reacting Antigen 3
  • W264 3
  • W282 3
  • CEA 3

External Ids for CEACAM3 Gene

Previous HGNC Symbols for CEACAM3 Gene

  • CGM1

Previous GeneCards Identifiers for CEACAM3 Gene

  • GC19P042940
  • GC19P042692
  • GC19P046976
  • GC19P046992
  • GC19P042300
  • GC19P038732

Summaries for CEACAM3 Gene

Entrez Gene Summary for CEACAM3 Gene

  • This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]

GeneCards Summary for CEACAM3 Gene

CEACAM3 (CEA Cell Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with CEACAM3 include Mucinous Cystadenocarcinoma and Polymorphous Low-Grade Adenocarcinoma. Among its related pathways are Innate Immune System and Cell surface interactions at the vascular wall. An important paralog of this gene is CEACAM1.

UniProtKB/Swiss-Prot Summary for CEACAM3 Gene

  • Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.

Gene Wiki entry for CEACAM3 Gene

Additional gene information for CEACAM3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CEACAM3 Gene

Genomics for CEACAM3 Gene

GeneHancer (GH) Regulatory Elements for CEACAM3 Gene

Promoters and enhancers for CEACAM3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J041797 Enhancer 0.9 ENCODE dbSUPER 500.7 -1.4 -1423 0.2 CTCF ZNF10 TRIM22 ARNT ZFHX2 EHMT2 IKZF1 ZNF654 RAD21 ZFP64 CEACAM3 CEACAM6 LYPD4 DMRTC2 CYP2G1P CEACAM5 MEGF8 CEACAM7 ENSG00000268833
GH19J041795 Enhancer 0.9 ENCODE dbSUPER 500.7 -1.2 -1203 0.2 CTCF ZNF10 TRIM22 ARNT ZFHX2 EHMT2 IKZF1 RAD21 MITF TBX21 CEACAM3 CEACAM6 LYPD4 DMRTC2 CYP2G1P CEACAM5 MEGF8 CEACAM7 ENSG00000268833
GH19J041796 Promoter 0.3 EPDnew 500.7 0.0 -4 0.1 CEACAM3 ENSG00000268833
GH19J041798 Promoter 0.3 Ensembl 500.7 +0.5 514 0.2 CEACAM3 HSALNG0126230
GH19J042267 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.9 +474.3 474283 6.9 EP300 FOXK2 ZBTB40 ZNF217 TCF12 SIN3A NRF1 MYC POLR2G USF1 CIC piR-36065 ZNF526 ZNF574 DEDD2 MEGF8 CEACAM3 PAFAH1B3 PRR19 GSK3A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CEACAM3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CEACAM3

Top Transcription factor binding sites by QIAGEN in the CEACAM3 gene promoter:
  • AREB6
  • Elk-1
  • FOXF2
  • GATA-1
  • GCNF
  • GCNF-1
  • GCNF-2
  • Nkx5-1
  • NRSF form 1
  • NRSF form 2

Genomic Locations for CEACAM3 Gene

Genomic Locations for CEACAM3 Gene
chr19:41,796,587-41,811,554
(GRCh38/hg38)
Size:
14,968 bases
Orientation:
Plus strand
chr19:42,300,369-42,315,591
(GRCh37/hg19)
Size:
15,223 bases
Orientation:
Plus strand

Genomic View for CEACAM3 Gene

Genes around CEACAM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM3 Gene

Proteins for CEACAM3 Gene

  • Protein details for CEACAM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40198-CEAM3_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 3
    Protein Accession:
    P40198
    Secondary Accessions:
    • G5E978
    • Q3KPH9

    Protein attributes for CEACAM3 Gene

    Size:
    252 amino acids
    Molecular mass:
    27091 Da
    Quaternary structure:
    • Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation.

    Three dimensional structures from OCA and Proteopedia for CEACAM3 Gene

    Alternative splice isoforms for CEACAM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM3 Gene

Post-translational modifications for CEACAM3 Gene

  • Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.
  • Glycosylation at Asn104 and Asn111
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM3 Gene

No data available for DME Specific Peptides for CEACAM3 Gene

Domains & Families for CEACAM3 Gene

Gene Families for CEACAM3 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CEACAM3 Gene

Blocks:
  • Immunoglobulin V-set
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEACAM3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51937, highly similar to Carcinoembryonic antigen-related celladhesion molecule 6 (B7Z5B4_HUMAN)
  • Carcinoembryonic antigen CGM1 (CEAM3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P40198

UniProtKB/Swiss-Prot:

CEAM3_HUMAN :
  • The cytosolic domain is involved in S100A9 interaction.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • The cytosolic domain is involved in S100A9 interaction.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM3: view

Function for CEACAM3 Gene

Molecular function for CEACAM3 Gene

UniProtKB/Swiss-Prot Function:
Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.
GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 3 (see CEA@)

Phenotypes From GWAS Catalog for CEACAM3 Gene

genes like me logo Genes that share phenotypes with CEACAM3: view

Animal Model Products

CRISPR Products

miRNA for CEACAM3 Gene

miRTarBase miRNAs that target CEACAM3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM3 Gene

Localization for CEACAM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
cytosol 1
lysosome 1
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for CEACAM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0035579 specific granule membrane TAS --
genes like me logo Genes that share ontologies with CEACAM3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CEACAM3 Gene

Pathways & Interactions for CEACAM3 Gene

genes like me logo Genes that share pathways with CEACAM3: view

Gene Ontology (GO) - Biological Process for CEACAM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with CEACAM3: view

No data available for SIGNOR curated interactions for CEACAM3 Gene

Drugs & Compounds for CEACAM3 Gene

(26) Drugs for CEACAM3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884

(27) Additional Compounds for CEACAM3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM3: view

Transcripts for CEACAM3 Gene

mRNA/cDNA for CEACAM3 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3: - - - -
SP4:

Relevant External Links for CEACAM3 Gene

GeneLoc Exon Structure for
CEACAM3

Expression for CEACAM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEACAM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM3 Gene

This gene is overexpressed in Whole Blood (x47.6).

Protein differential expression in normal tissues from HIPED for CEACAM3 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEACAM3 Gene



Protein tissue co-expression partners for CEACAM3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CEACAM3

SOURCE GeneReport for Unigene cluster for CEACAM3 Gene:

Hs.11

mRNA Expression by UniProt/SwissProt for CEACAM3 Gene:

P40198-CEAM3_HUMAN
Tissue specificity: CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.

Evidence on tissue expression from TISSUES for CEACAM3 Gene

  • Blood(4.2)
genes like me logo Genes that share expression patterns with CEACAM3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM3 Gene

Orthologs for CEACAM3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM3 31 30
  • 97.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CEACAM1 31
  • 22 (a)
ManyToMany
-- 31
  • 14 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg28 31
  • 15 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 4 (a)
ManyToMany
Species where no ortholog for CEACAM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM3 Gene

ENSEMBL:
Gene Tree for CEACAM3 (if available)
TreeFam:
Gene Tree for CEACAM3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CEACAM3: view image

Paralogs for CEACAM3 Gene

(24) SIMAP similar genes for CEACAM3 Gene using alignment to 4 proteins:

  • CEAM3_HUMAN
  • B7Z5B4_HUMAN
  • G5E978_HUMAN
  • M0QXR5_HUMAN
genes like me logo Genes that share paralogs with CEACAM3: view

Variants for CEACAM3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CEACAM3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1041999 - p.Ser7Pro

Additional dbSNP identifiers (rs#s) for CEACAM3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CEACAM3 Gene

Variant ID Type Subtype PubMed ID
esv2568775 CNV deletion 19546169
esv2670061 CNV deletion 23128226
esv3583420 CNV loss 25503493
esv3644395 CNV loss 21293372
nsv476906 CNV novel sequence insertion 20440878
nsv522854 CNV gain 19592680
nsv579615 CNV gain 21841781
nsv960845 CNV duplication 23825009
nsv960846 CNV duplication 23825009

Variation tolerance for CEACAM3 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CEACAM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM3 Gene

Disorders for CEACAM3 Gene

MalaCards: The human disease database

(40) MalaCards diseases for CEACAM3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mucinous cystadenocarcinoma
  • pseudomucinous cystadenocarcinoma
polymorphous low-grade adenocarcinoma
  • polymorphous low grade adenocarcinoma
aggressive digital papillary adenocarcinoma
sinonasal undifferentiated carcinoma
  • highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses
acute salpingitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CEACAM3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CEACAM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM3 Gene

Publications for CEACAM3 Gene

  1. Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family. (PMID: 8508798) Nagel G … Zimmermann W (European journal of biochemistry 1993) 3 4 23 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathway. (PMID: 17506820) Sarantis H … Gray-Owen SD (Cellular microbiology 2007) 3 23 54
  4. Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. (PMID: 14707113) Schmitter T … Hauck CR (The Journal of experimental medicine 2004) 3 4 54
  5. Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor. (PMID: 12864848) McCaw SE … Gray-Owen SD (Molecular microbiology 2003) 3 4 54

Products for CEACAM3 Gene

Sources for CEACAM3 Gene